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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia Jurnal Pendidikan Biologi Undiksha Jurnal Sumberdaya Hayati BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Quagga: Jurnal Pendidikan dan Biologi Maximus: Journal of Biological and Life Sciences TeknoKreatif: Jurnal Pengabdian kepada Masyarakat JPEMAS: Jurnal Pengabdian Kepada Masyarakat
Riana, Elisa Nurma
Institut Teknologi Sumatera
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Immunology & microbiology Law, Crime, Criminology & Criminal Justice Nursing Other

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Quantitative Analysis of Phytochemical Compounds and Antihyperglycemic Potential of Robusta Coffee from West Lampung Khairani, Iffa Afiqa; Mulyana, Jeane Siswitasari; Olivia, Rahel Noviantika; Riana, Elisa Nurma; Anisa, Hida Arliani Nur
Jurnal Sumberdaya Hayati Vol. 10 No. 1 (2024): 2024
Publisher : Departemen Biologi, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jsdh.10.1.1-6

Abstract

West Lampung Regency in Lampung Province produces high quality robusta coffee with a distinct, strong bitter flavour. Bitter flavour indicates the amount of bioactive substances produced by plants called phytochemicals. The aim of this study is to analyse the phytochemical compounds and antihyperglycemic potential of robusta coffee beans from West Lampung, Indonesia. Quantitative phytochemical analysis was carried out using the thin layer chromatography method and spectrophotometry. Animal experimental design using robusta coffee on hyperglycemia conditions in mice which was induced by alloxan 170 mg/kgBW subcutaneously and given by 1 ml of brewed robusta coffee for 10 days. The robusta coffee from West Lampung contained total caffeine 4,014.87 µg/g, total flavonoid content (TFC) 93.6 mg quercetin equivalent per gram of sample, with total alkaloid content (TAC) 0.848 mg of quinine equivalent per gram of sample, total tannin content (TTC) 182.3 mg of tannic acid equivalent per gram of sample, and total saponin content (TSC) 24.2 mg of quillaja bark equivalent per gram of sample. The administration of 1 ml/mice/day of robusta coffee brewed for 10 days did not show a decrease in blood sugar level in hyperglycemic mice, due to the short duration of the study, so the role of coffee in decreasing hyperglycemia conditions has not been optimally observed.
Antioxidant Activity and Immunomodulatory Effect of Stachytarpheta sp. Leaf Extract on Phagocytic Activity of Mice Peritoneal Macrophages in Alloxan Induction Iffa Afiqa Khairani; Wahyuni Dian Lestari; Elisa Nurma Riana; Jeane Siswitasari Mulyana; Hida Arliani Nur Anisa; Rizka Fatriani; Silvia Andriani
Quagga: Jurnal Pendidikan dan Biologi Vol 17 No 2 (2025): QUAGGA : Jurnal Pendidikan dan Biologi
Publisher : Program Studi Pendidikan Biologi, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25134/quagga.v17i2.404

Abstract

Hyperglycemia is a condition characterized by elevated blood glucose levels, which is a hallmark of diabetes mellitus. Prolonged hyperglycemia not only disrupts glucose homeostasis but also impairs the immune response. The condition of hyperglycemia in the body can increase free radicals and oxidative stress, thus can impair various macrophage functions, including their ability to engulf and eliminate pathogens. The bioactive constituents in Stachytarpheta sp. may contribute to reducing oxidative damage and enhancing immune system function. This study aims to evaluate both the antioxidant capacity and the immunomodulatory effects of Stachytarpheta sp. leaf extract on the phagocytic activity of peritoneal macrophages in alloxan-induced diabetic mice. Alloxan is widely used in research to induce hyperglycemia (diabetic conditions) in experimental animals. The antioxidant activity of the extract was evaluated using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay, while phagocytic activity of peritoneal macrophages was performed in vivo using male mice. Stachytarpheta sp. leaf extract from Beteng Sari Village, East Lampung has very strong antioxidant activity against DPPH with IC50 value 14,85 ± 0,30 μg/mL. This extract at doses of 200, 300, and 400 mg/kgBW can be an immunomodulator that maintains the phagocytic activity of macrophage cells in alloxan-induced mice.
Co-Authors Andri Jaya Kesuma Andriyana, Ahmad Dodi ANDY DARMAWAN Anisa, Hida Arliani Nur Antonius Antonius Apriza Yuswan Ayda T. Yusuf Azizah, Najla Nur Dwi Retnowati Erma Suryanti Fauziyya, Riri Gres Maretta, Gres Hida Arliani Nur Anisa Iffa Afiqa Khairani Imaniar, Lisana Husna Indah D. Dewijanti Indri Yati Irmanida Batubara Jeane Siswitasari Mulyana Kurnia Wahyuni Leksikowati, Sovia Santi Maruli, Berkat Afni Muhammad Asril Muhammad Eka Prastya Mulyadi, Salsa Pratiwi Mulyana, Jeane Siswitasari Novita Ariani Novriadi, Novriadi Nurcahya, Gebriel Nurhayu, Winati Olivia, Rahel Noviantika Prastya, Muhammad Eka Primahana, Gian Putri, Isnaini Anggraini Rahayyu, Annisa Maulidia Rizka Fatriani Sari, Dian Anggria Silvia Andriani Sitanggang, Fajar Islam Suryanti, Erma Tjandrawati Mozef Vera Permatasari Wahyuni Dian Lestari Wijayanti, Hendry Windari, Nurul Irna Winni Nur Auli Yanti Ariyanti, Yanti Yanti Ariyanti, Yanti Ariyanti Zahra, Anisa Mumtaz