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All Journal Pharmaciana: Jurnal Kefarmasian Biolearning Journal Jurnal Abdimasa Jurnal Promotif Preventif Jurnal Kesehatan Tambusai Jurnal EduHealth Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Sains dan Teknologi Sci-Tech Journal Jurnal Sehat Indonesia (JUSINDO) Jurnal Ilmiah Ilmu Terapan Universitas Jambi Journal of Pharmaceutical and Sciences. Jurnal Etnofarmasi Jurnal Mahasiswa Ilmu Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Science: Indonesian Journal of Science Jurnal Etnofarmasi
Astuti, Ratih Arum
Universitas Pendidikan Muhammadiah Sorong
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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Formulasi Dan Aktivitas Antioksidan Sirup Air Kelapa Tua (Cocos nucifera L) Dan Ekstrak Buah Merah (Pandanus conoideus L) Dengan Metode DPPH Siti Mun Muhliza Ahmad; Ratih Arum Astuti; A.M. Muslihin
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1496

Abstract

Background: Mature coconut water (Cocos nucifera L.) has the potential as a health drink but is often discarded as waste. Red fruit (Pandanus conoideus L.) is an endemic plant of Papua that is rich in antioxidants. The combination of both is expected to produce a beneficial herbal syrup preparation. Objective: To formulate a combination syrup of mature coconut water and red fruit extract and to determine its antioxidant activity using the DPPH method. Methods: Red fruit extract was obtained by maceration using 96% ethanol. Phytochemical screening was performed on both ingredients. The syrup was prepared with the addition of sugar, citric acid, vanilla, and CMC. Physical evaluation included organoleptic, homogeneity, pH, viscosity, and clarity tests. Antioxidant activity was tested using the DPPH method at a wavelength of 517 nm using a UV-Vis spectrophotometer. Results: Phytochemical screening showed that mature coconut water contains alkaloids, while red fruit extract contains flavonoids, tannins, saponins, and alkaloids. The syrup evaluation met SNI requirements: organoleptic (reddish-orange color, characteristic odor, sweet taste), homogeneous, pH 5–6, viscosity 250 mPa·s, and clear. The IC50 values of the syrup in three consecutive replicates were 550.34 μg/mL, 2282.3 μg/mL, and 2863.4 μg/mL, which are classified as weak antioxidant activity (IC50 > 200 ppm). Conclusion: The combination syrup of mature coconut water and red fruit extract exhibits weak antioxidant activity but meets the physical quality standards of the preparation. This preparation has the potential to be developed as a herbal health drink.
Aktivitas Sedatif Ekstrak Etanol Batang Tali Kuning (Anamirta cocculus (L.) Wight & Arn.) Terhadap Mencit (Mus musculus) Jantan Wiwit Ayu Fitrianti; A.M. Muslihin; Ratih Arum Astuti
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1513

Abstract

Mental health is a state of well-being that includes where individuals recognize their personal potential, enabling them to manage life's pressures and be able to work productively. Treatment of mental health disorders usually involves the use of sedative drugs such as benzodiazepines, barbiturates, and several other drugs. This study aims to evaluate the sedative activity of the ethanol extract of tali kuning (A. cocculus (L.) Wight & Arn.) stem in male mice as an alternative therapy requiring sedative effects. The study was conducted using a quantitative experimental approach with a pretest–posttest control group design and the rotarod method. The experimental animals were divided into five groups: positive control, negative control, and three extract dose groups treated with the ethanol extract of tali kuning stem at 19.25 mg/kgBW, 38.5 mg/kgBW, and 77 mg/kgBW. The results indicated that the ethanol extract of tali kuning stem at all three doses produced sedative activity, as validated by a paired sample t‑test that revealed significant differences condition between pre‑ and post‑treatment measurements. The ethanol extract of tali kuning stem at doses of 19.25 mg/kgBW, 38.5 mg/kgBW, and 77 mg/kgBW demonstrated sedative activity, although statistical comparison with the positive control showed variable results depending on dose and observation time.
Phytochemical Screening and Antioxidant Activity Test of Ethanol Extract of Nelambosuon (Rubiaceae) Leaves Using the DPPH Method Natalia Aksamina Sagisolo; Ratih Arum Astuti; Wahyuni Watora; A.M. Muslihin
Jurnal EduHealth Vol. 17 No. 02 (2026): Jurnal EduHealt, April - June
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indonesia is recognized as one of the world’s megabiodiversity countries, possessing a vast diversity of medicinal plants that have long been utilized in traditional medicine. Nelambo suon (Rubiaceae) is an indigenous plant traditionally used by the Tehit Imian tribe in South Sorong, Southwest Papua, for treating wounds, skin infections, and inflammatory conditions. However, scientific information regarding its phytochemical profile and antioxidant activity remains limited. This study aimed to evaluate the phytochemical constituents and antioxidant activity of the ethanol extract of Nelambo suon leaves using the DPPH method. Fresh, undamaged green leaves were dried at room temperature without direct sunlight and extracted by maceration using 96% ethanol. Phytochemical screening was performed to identify major secondary metabolites, while antioxidant activity was assessed using the DPPH free radical scavenging assay and expressed as IC₅₀ values. The phytochemical screening revealed the presence of flavonoids and tannins in the ethanol extract, whereas alkaloids, saponins, steroids, and terpenoids were not detected. The antioxidant assay demonstrated a concentration-dependent increase in radical scavenging activity. The ethanol extract of Nelambo suon leaves exhibited an IC₅₀ value of 83.7 µg/mL, indicating strong antioxidant activity. These findings suggest that Nelambo suon leaves are a promising source of natural antioxidants, likely attributed to their flavonoid and tannin contents. This study provides preliminary scientific evidence supporting the traditional use of Nelambo suon and highlights its potential for further development as a natural antioxidant agent in pharmaceutical and herbal product applications.
Identifikasi Senyawa Flavonoid Fraksi Etil Asetat Bunga Pacing Tawar (Costus speciosus) Metode FTIR sebagai Analgesik Indri Maharani Syahputri; A.M.Muslihin; Ratih Arum Astuti
INSOLOGI: Jurnal Sains dan Teknologi Vol. 4 No. 6 (2025): Desember 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v4i6.7017

Abstract

Pain is a natural signal to tissue damage in the body. One of the plants that has the potential as a natural analgesic is the pacing tawar flower (Costus speciosus) which is known to contain compounds that play a role in providing analgesic effects. This research method uses a pre-post test design to see the effectiveness before and after being given a test suspension in the form of (mefenamic acid, Na CMC, and ethyl acetate fraction of pacing tawar flowers at doses of 125 mg/kgBB, 250 mg/kgBB, and 500 mg/kgBB) in mice induced by pain with the tail flick method. The results of the phytochemical screening study showed that only the ethyl acetate fraction of pacing tawar flowers (Costus speciosus) was positive for containing flavonoid compounds with the formation of a yellow color compared to the n-hexane fraction and the water fraction. Functional groups identified in flavonoid compounds are C-H, C=O, C-O groups. Ethyl acetate fraction of pacing tawar flower at doses of 250 mg/kgBB and 500 mg/kgBB can provide analgesic effects with a p value (<0.05). Based on the research that has been done, it can be concluded that the ethyl acetate fraction of pacing tawar flower contains flavonoid compounds that can inhibit pain with the most optimal and stable fraction dose at a dose fraction of 500 mg/kgBB with a p value (<0.05).
Co-Authors A. M. Muslihin A.M.Muslihin Achmad Noerkhaerin Putra Angga Bayu Budianto Angga Bayu Budianto Angga Bayu Budiyanto Arif Radhika Mentari Assem, Vincentia Santy Bagaskara, Muhammad Raihan Budianto, Angga Bayu Devi Kumala Dewi Eka Sakti Wahyuningtyas Eka Wahyuning Tyas Fadhilah, Windi Nur fania, vikafania Hardiansyah, La Ode Heni Lutfiyati Iis Wahyuningsih Indah Diah Ningrum Indri Maharani Syahputri Irwandi , Irwandi Irwandi Irwandi Irwandi Irwandi Isabella Meliawati Sikumbang Isabella Meliawati Sikumbang Laela Hayu Nurani Lamarunga, Nur Hasana Lanipi, Retna Paricca Lisna Lisna, Lisna Lukman Hardia Maria Gloria Yeuyanan Mohammad Usman Nur Muhammad Raihan Bagaskara Nasruddin Nasruddin Natalia Aksamina Sagisolo Ningrum, Indah Diah Nur Hasana Lamarunga Nur ‘Azah Nur, Mohammad Usman Pasulu, Yusran Timang Pratama, Agus Sangka Rahakratat, Ayub M N Rahayu, Mellawati Yuningtyas Ratna Wijayatri Retna Paricca Lanipi Rohmania, Siti Rumbewas, Aulia Bella Miranda Salim, Fathiyah Siswahyudianto Siti Mun Muhliza Ahmad Tunnazilah, Nurhikmah Umpain, Agnes Nesa Wahyuni Watora Wailegi, Muslika WaOde Suriani Wiwit Ayu Fitrianti yunus, sri ulan dari Zf, Siti Fatma