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PERBANDINGAN UJI AKTIVITAS ANTI DIABETES EKSTRAK ETANOL BUAH PARE (Momordicacharantia L.) DAN DAUN LIDAH BUAYA (Aloe vera L.) PADA MENCIT JANTAN Sitompul, Erly; Supartiningsih, Supartiningsih; Harefa, Karnerius; Sari, Samsia Yolanda
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Diabetes is a non-communicable degenerative disease that will increase in number in the future. This is evidenced by the increasing incidence of diabetes every decade. Bitter gourd and aloe vera are an alternative in treating Diabetes Mellitus because these plants contain saponins, flavonoids, and polyphenols (strong antioxidants), as well as glycosides cucurbitacin, momordicin, and charantin that can lower blood sugar, saponins, flavonoids, and alkaloids. This study aims to determine secondary metabolite compounds, anti-diabetic activity, and the combination of aloe vera extract and bitter melon extract that has antidiabetic activity. The method used in this study is an experimental method, namely testing the antidiabetic effect of extracts obtained from ethanol of bitter melon and aloe vera leaves on alloxan-induced mice. The results obtained from the research are that the administration of aloe vera extract 150 mg/kg BW and 200 mg/Kg BW, the group with the ethanol extract of bitter melon 150 mg/kg BW and 200 mg/Kg BW showed a very good effect on reducing BGD. This means that aloe vera extract 150 mg/kg BW and 200 mg/Kg BW, the group given ethanol extract of bitter melon 150 mg/kg BW and 200 mg/Kg BW had good antidiabetic activity.
PERBANDINGAN UJI AKTIVITAS ANTIDIABETES EKSTRAK DAUN LIDAH BUAYA DAN LIDAH MERTUA PADA MENCIT PUTIH JANTAN Sianipar, Artha Yuliana; Supartiningsih, Supartiningsih; Nasution, Pandapotan; Maimunah, Siti; Gloria, Rifka
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v5i2.2734

Abstract

Diabetes mellitus (DM) is a disease whose prevalence is increasing from year to year. This increase was accompanied by an increase in the cost of treatment and the number of complications. The use of traditional medicine is an alternative for the community to control blood sugar levels (KGD). Considering that synthetic drugs have various side effects, one of the medicinal plants used as traditional medicine is aloe vera leaf and mother-in-law's tongue leaf which contain flavonoid compounds, alkaloids, tannins, saponins, and steroids/triterpenoids. The purpose of this study was to determine the antidiabetic activity of aloe vera leaf extract and mother-in-law's tongue and to compare the activities of the two. The results of the analysis of the glucose tolerance ANOVA test showed a significant difference in the percentage reduction at 60, 90, and 120 minutes for all treatment preparations. The alloxan induction test showed a significant difference in the percentage decrease from days 3, 5, 7, 9, 11, 13, and 15. Based on these results, it can be concluded that Aloe Vera Leaf Ethanol Extract (EEDLB) and LidahMertua Leaf Ethanol Extract (EEDLM) with each dose of 150 and 200 mg/kg BW and the combination of the two gave antidiabetic activity against mice as well as differences in effectiveness between samples of aloe vera leaf and LidahMertua leaf as well as a single dose with a combination.
PEMBUATAN KERTAS RAMAH LINGKUNGAN KOMBINASI LIMBAH AMPAS TAHU DAN LIMBAH KULIT PISANG KEPOK DENGAN METODE PEMISAHAN ALKALISASI Aritonang, Barita; Sinaga, Eka M; Supartiningsih, Supartiningsih; Sitorus, Elly
Jurnal Farmanesia Vol 6 No 2 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v6i2.2753

Abstract

Tofu dregs waste contains 30.4% cellulose content, while kepok banana peel has high cellulose content (60-65%), hemicellulose 6-8%, and lignin 5-10%. The purpose of this study was to determine the process of making natural paper from tofu dregs waste and kepok banana peel waste as an alternative raw material for wood substitutes and to find out the characteristics of natural paper produced from tofu waste fiber and kepok banana peel waste based on SNI 287:2010 (including test water content) and SNI 6588-1:2010 (including pH acidity test). Based on the results of research that has been carried out, the optimum composition in making paper from tofu dregs and kepok banana peels is 50:50% variation. The temperature and time of heating and the optimum concentration of sodium hydroxide solution was 120 oC for 90 minutes with sodium hydroxide solution concentration of 10.0%, pulp content of 46.45%, cellulose content of 53.3%, and lignin content of 46.67%. All levels obtained have met the requirements of SNI. Based on the FT-IR spectrum analysis, tofu dregs and kepok banana peels are suitable for use as raw materials for making paper because they contain cellulose. Based on the SEM analysis, the morphological surface structure, the tighter the fiber bonds, this proves that the diameter of the resulting fiber is very small, because the smaller the fiber diameter, the better the mechanical properties.
IDENTIFIKASI ANTALGIN DALAM JAMU PEGAL LINU SECARA KROMATOGRAFI LAPIS TIPIS Supartiningsih, Supartiningsih; Sinaga, Eka Margaret; Silitonga, Maringan
Jurnal Farmanesia Vol 6 No 2 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v6i2.2754

Abstract

Traditional medicine is an ingredient or ingredient in the form of plant material, animal material, mineral material, preparation of extracts (galenic), or a mixture of these materials which have been used for generations. Jamu is traditional medicine, in general, herbal medicine cannot cure all kinds of diseases and its natural effect is not as fast as chemical drugs. Lately, medicinal chemicals are often added which are prohibited under the provisions of BPOM (Food and Drug Supervisory Agency). Antalgin is an analgesic-antipyretic and anti-inflammatory drug. Identification of antalgin in herbal aches and pains by thin layer chromatography aims to determine whether the herbal aches and pains circulating around Jalan Captain Muslim, Medan city contain levorphanoll drug chemicals or not. Antalgin identification in herbal pain relief was applied using Thin Layer Chromatography method with 60 F Silica gel stationary phase and chloroform-acetone-toluene (65: 25:10) mobile phase. From the results of identification by thin-layer chromatography (TLC) on herbal pain relief, it was found that the Rf value of the chromatogram spot on the levorphanol 0.16 reference standard was close to the sample Rf value (E) of 0.12. Based on the examination that has been carried out, it can be concluded that the positive herbal pain relief contains levorphanol drug chemicals so that the sample (E) tested does not meet the requirements.
ISOLASI DAN IDENTIFIKASI PEKTIN DARI KULIT PISANG MAS (Musa acuminata Colla) Sitorus, Panal; Supartiningsih, Supartiningsih; Marpaung, Jon Kenedy; Munthe, Bernadetta R.
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v7i1.2763

Abstract

Pectin is one of the types of carbohydrate from polysacharide compound derivatives found in plan cell walls. pectin can be used in the viscosity, stability, texture and appearance of the food. The use of pectin in pharmacy is used for diarrhea, where pectin works as absordent in the intestine and also used as wound medicine as the hemostatic agent. The purpose of this research is utilize the mas banana peel as the source of pectin. This research was conducted by using the reflux extraction method using 1N hydrochloric acid as a solvent. Pectin isolation at pH 2, temperature 70-80-C for 60 minutes. The result of the precipitate is then added ethanol into the filtrate to precipitate the pectin and the final process is drying to obtain dry pectin which is 2.2975 gr. Dried pectin is obtained in the form of a fine powder, reddish brown in color and practically insoluble in ethanol. From the result of the identification that was carried out positive for the reaction with the addition of 96% ethanol and 2N NaOH, there was a gel which when added with 3N HCI and heated it formed brownish yellow lumps and had a distinctive odor. Physical specific characterization of pectin was also carried out, including moisture content (31.37%) and ash content (38.79%). Pure pectin standard for maximum moisture content of 12%, and maximum ash content of 10%. Pectin from mas banana (Musa acuminataColla) does not meet IPPA (International Pectin Producers Association) quality standards. Keywords: Banana peel, pectin, extraction, Reflux
UJI PENINGKATAN KADAR ASAM AMINO PADA TAPE KETAN HITAM DENGAN PENAMBAHAN SARI BUAH NANAS DENGAN METODE SPEKTROFOTOMETRI SINAR TAMPAK Supartiningsih, Supartiningsih; Maimunah, Siti; Silalahi, Yosy Cinthya Eriwaty
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v7i1.2764

Abstract

Amino acid levels in sticky rice tape are still relatively low, while amino acids themselves are food substances for body growth. Pineapple contains the enzyme bromelain. This enzyme is one of the protease enzymes that can hydrolyze protein, therefore it can increase amino acid levels. This study aims to determine the increase in amino acid levels in black sticky rice tape with the addition of pineapple juice and to determine the effect of adding pineapple juice to amino acid levels in black sticky rice tape. In the process of making black sticky rice tape, 25 ml 50 ml of pineapple juice was added per 500 grams each, while one treatment did not add pineapple juice as a control. Black glutinous rice that has been fermented for 2-3 days was tested for increased levels of amino acids by using visible light spectrophotometry. The sample of black glutinous tape without the addition of pineapple juice obtained an average content of 4.73%, on the sample of black glutinous tape with the addition of 25 ml of pineapple juice the average content obtained was 6.50%, and the sample of black sticky rice tape with the addition of 50 ml pineapple juice the average level obtained was 7.76% and gave the effect of increasing amino acid levels on black sticky rice tape.
ANALISA CEMARAN LOGAM MERKURI PADA IKAN AIR LAUT DAN UDANG SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA) Silalahi, Yosy Cinthya Eriwaty; Marpaung, Jon Kenedy; Supartiningsih, Supartiningsih
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v7i2.2771

Abstract

Mercury is a heavy metal that can have a toxic effect on the body so it can cause death. Mercury metal contamination in food is regulated in SNI number 7387 of 2009 regarding the Maximum Heavy Metal Limit. Some metal waste disposal ends up in rivers, lakes, or sea waters so that metal pollution can occur in the ecosystem. This study aims to determine levels of mercury metal contamination in seawater fish, including shark, mackerel, salmon, tuna, red snapper, and white shrimp. Sample preparation was carried out by wet digestion method using a microwave digestion device. Mercury analysis was carried out using the AAS (Atomic Absorption Spectrophotometry) method. The wavelength used is 253.7 nm. The results showed that mercury in sharks was 0.2045 ± 0.0099 mg/kg, mackerel 0.4184 ± 0.0297 mg/kg, salmon 0.3848 ± 0.0794 mg/kg, tuna fish 0.3706 ± 0.0674 mg/kg, snapper 0.4088 ± 0.0397 mg/kg, and shrimp 0.4289 ± 0.0813 mg/kg. The results of the analysis showed that of the six samples of seawater fish that had been tested, the maximum metal contamination limit determined by SNI 7387 the Year 2009 was 0.5 mg/kg.
PENENTUAN KADAR PROTEIN PADA SUSU KEDELAI (Glycinemax L. Merril) DENGAN MENGGUNAKAN METODE Kjeldahl Nurbaya, Siti; Supartiningsih, Supartiningsih; Hafizullah, Ahmad
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v7i2.2777

Abstract

Soy milk has a combination of nutrients that are almost the same as cow's milk, but soy milk has low cholesterol, gluten, and lactose levels so that soy milk is safe for consumption by people with lactose intolerance, vegetarians, and is also safe for health. Determination of protein content that is most often done is the determination of crude protein which aims to determine the total amount of protein in food ingredients. The most commonly used protein assay method is the Kjeldahlmethod. This study aims to determine the protein content of soy milk packaged in boxes that are made by themselves and sold in traditional markets. The samples used in this study used packaged soy milk, traditional soy milk, and homemade soy milk. The results showed that the protein content of the three samples determined by the Kjeldahlmethod was 3.35±0.0816% traditional soy milk, 2.31±0.3562% box-packed soy milk, and 2.62±0.2495% whole milk. Homemade soybeans. The protein content in box-packed soy milk, homemade soy milk, and traditional soy milk haveeach met the requirements of SNI (1995). The results showed that the protein content of traditional soy milk was greater than that of packaged soy milk and homemade soy milk.
PENENTUAN KADAR KAFEIN DALAM KOPI INSTAN SECARA SPEKTROFOTOMETRI ULTRAVIOLET Supartiningsih, Supartiningsih; Zuhairiah, Zuhairiah; Thaib, Cut Masyithah
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v7i2.2778

Abstract

Caffeine in coffee has clinically beneficial pharmacological effects, such as stimulating the central nervous system, relieving fatigue, drowsiness and also increasing concentration. However, excessive use of caffeine can cause heart palpitations and stomach upset. According to SNI 01-7152-2006, the maximum limit of caffeine in food and beverages is 150 mg/day and 50 mg/serving. The purpose of this study was to determine the level of caffeine in instant coffee circulating in supermarkets in Medan City by Ultraviolet Spectrophotometry. Determination of caffeine content was carried out by the UV Spectrophotometry method after extraction using chloroform in an alkaline environment. The caffeine concentration can be calculated from the calibration curve regression equation. The results showed that the three instant coffee samples were determined to have different levels of caffeine, namely instant coffee sample code A 5.2585 mg/gram, code sample B 4.2348 mg/gram, and code C 133564. mg/gram. When viewed from the requirements, the caffeine content in the instant coffee samples coded A and B has exceeded the portion limit of 131.4625 mg and 84,768 mg, respectively, but is still within the limits set by SNI 01-7152-2006 if consumed in one pack. per day, henceforth the code C sample does not exceed the caffeine content limit of serving, which is 26.7128 mg of caffeine.
UJI AKTIVITAS ANTIBAKTERI MADU HUTAN TERHADAP BAKTERI Bacillus cereus Maimunah, Siti; Supartiningsih, Supartiningsih; Marpaung, Jon Kenedy; Silalahi, Yosy Cinthya Eriwaty; Turnip, Icha Wahyuni
Jurnal Farmanesia Vol 8 No 1 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v8i1.2780

Abstract

Honey is a thick sweet liquid which comes from bees which can cure many diseases and is antibacterial. Antibacterial potential of honey caused by the content of active compounds, low moisture content, high osmolarity, hydrogen peroxide content, and low pH.The aim of this study was to determine the antibacterial activity of forest honey on Doloksaribu, Simalungun district on the growth of Bacillus cereus bacteria.Experiment research method includes the analysis quality of honey, includes checking moisture content, ash content, pH tested, acidity, viscosity, spesific gravityphytochemical screening, and antibacterial activity test ith disk diffusion method use blank disk with each concentration 25%, 35%, 45%, 55%, and 65%, positive control using erythromycin and negative control sterile distilled water. Organoleptic test conducted on forest honey gave results that honey reach the requirements for good quality. The result of moisture and ash content test and pH test reach of SNI 3545: 2013 about honey. Antibacterial activity test of forest honey with concentration 25%, 35%, 45%, 55%, and 65% against Bacillus cereus showed that there was an inhibitory around the blank disc, namely 10,16 mm, 13 mm, 15,6 mm, 21,6 mm, and 22,6 mm. The greatest inhibition of forest honey occurred at the highest concentration that is 65% (22,6 mm).
Co-Authors Abbas, Aisyah Agus Sutono Ahmad Gazali, Ahmad Aritonang, Barita Chandra, Devina Devina Candra Dicky Yuswardi Wiratma Eka Margareta Sinaga Eriwaty Silalahi, Yosy Cinthya Erni Erni Feriyansyah Feriyansyah Fitri, Anisa Fridelly Mairani Apt Ghufron Abdullah Gloria, Rifka Hardono Hadi Harefa, Karnerius Harianja, Ester Saripati Hartati, Nanda Hertanti, Rachmi Humairah, Humairah Hutauruk, Dumartina Jenie Palupi Khairunnisa Khairunnisa Laila, Asmuni Lulut Sasmito Manahan Situmorang Manurung, Kesaktian Marbun, Eva Diansari Marpaung, Jon Kenedy Monica Suryani Munthe, Bernadetta R. Nasution, Pandapotan Noorzeha, Fuad Nugraha, Rizky Anandasigit Nurkolis Nurkolis, Nurkolis Panggabean, Indah Elsayanti Pratisto Tinarso Purba, Sri Dearmaita Putri, Ananda Dwi Restanty, Dian Aby Rika Febriani, Rika Sari, Samsia Yolanda Sianipar, Artha Yuliana Silitonga, Maringan Sinaga, Eka M Sindung Tjahyadi Sipayung, Inri Priskila Siti Maimunah Siti Nurbaya Sitompul, Erly Sitompul, Hestin Novalina Sitorus, Elly Sitorus, Elly Nurita Sitorus, Panal Situmorang, Imelda Stefani Overia Situmorang, Manahan Sofwan, Ahmad Ghazali Steven Tandiono SULASTRI Tampubolon, Manuppak Irianto Telaumbanua, May Fransisca Thaib, Cut Masyithah Turnip, Icha Wahyuni Utami, Rona Yosy Cinthya Eriwaty Silalahi Yuliantoro, Moch Najib Zubaidi, Peri Aisyah Zuhairiah Nasution, Zuhairiah