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All Journal JURNAL PENGABDIAN KEPADA MASYARAKAT Universa Medicina JURNAL IBNU SINA BIOMEDIKA Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Sumatera Medical Journal Abdimas Universal JURNAL ILMIAH MAKSITEK Bioscientia Medicina : Journal of Biomedicine and Translational Research
Delyuzar, Delyuzar
Universitas Sumatera Utara
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Immunohistochemistry Expression Gata3 Based on Subtypes of Ovarian Carcinoma at Haji Adam Malik General Hospital Medan 2019-2021 Alamanda, Intan Nefia; Betty, Betty; Delyuzar, Delyuzar; Laksmi, Lidya Imelda; Chrestela, Jessy; Soekimin, Soekimin
Majalah Patologi Indonesia Vol. 33 No. 3 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i2.604

Abstract

Background Ovarian carcinoma is a cancer with high mortality in women and although comprehensive management with surgery and chemotherapy at an advanced stage, the resistance rate is still low. GATA3 contributes to the progression of malignancy and its expression is one of the predictors in some malignancies, but the results are mixed in ovarian carcinoma. High GATA3 expression is associated with the aggressiveness of tumor growth and poor prognosis of ovarian carcinoma.   Methods This research is an cross-sectional descriptive-analytical study with 33 histological specimens diagnosed with ovarian carcinoma from medical records/archives at H. Adam Malik Hospital Medan. Each sample specimen was stain with GATA3, and several various histopathological subtypes of ovarian carcinoma.   Results From a total of 33 samples, 14 samples were serous carcinoma, 6 samples were mucinous carcinoma, 7 samples were endometrioid carcinoma, and 6 samples were clear cell carcinoma. GATA3 was expressed in 42.5% of serous carcinoma. Positive expression of GATA3 is mostly found in advanced ovarian carcinoma, older age, and histopathological type of serous carcinoma.    Conclusion Immunohistochemistry GATA3 expression was expressed in 42.4% of serous carcinoma, 21.2% in endometrioid carcinoma, 18.2% in clear cell carcinoma, and 18.2% in mucinous carcinoma.   Keywords: ovarian carcinoma, GATA3, immunohistochemistry
The Correlation of Light Chain 3B Immunohistochemical Expression with Histopathological Grading in Colorectal Adenocarcinoma Fiandani, Fatma; Betty, Betty; Delyuzar, Delyuzar; Laksmi, Lidya Imelda; Lukito, Joko S.
Majalah Patologi Indonesia Vol. 33 No. 3 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i3.610

Abstract

Background Colorectal cancer ranks third highest of all malignancies worldwide and ranks fourth out of the 10 most common cancers encountered in Indonesia. More than 90% of colorectal cancers are adenocarcinoma type. The mechanism of autophagy has a dual role in tumorigenesis, namely as a tumor suppressor and as a tumor promoter. Microtubule-associated protein 1 light chain 3B (LC3B) is one of the widely used autophagy markers. The role of autophagy requires further research so that LC3B can be considered as one of the predictors of prognosis, especially in colorectal adenocarcinoma. The aim of this research is to determine the correlation of Light Chain 3B immunohistochemical expression with histopathological grading of colorectal adenocarcinoma. Methods Cross-sectional analytic study of 41 samples diagnosed with colorectal carcinoma at H. Adam Malik General Hospital Medan. Staining was performed using a polyclonal antibody rabbit Light Chain 3B immunohistochemistry (GeneTex) which would appear positive in the cytoplasm of tumor cells at a dilution of 1: 500. LC3B expression was assessed semiquantitatively with low and high expression categories. Data analysis was tested with the Spearman correlation test. Results LC3B immunohistochemical expression has a very strong correlation with the histopathological grading of colorectal adenocarcinoma and in a positive direction where the higher the colorectal adenocarcinoma grade, the higher the LC3B immunohistochemical expression, and vice versa (p=0,0001; r=0,763). Conclusion There was a significant relationship between LC3B immunohistochemical expression and histopathological grading of colorectal adenocarcinoma.
Pemetaan Kebersihan dan Perilaku Aman Pangan (PEKA-PANGAN) Sebagai Upaya Peningkatan Derajat Kesehatan Masyarakat Tanjung Beringin Amelia, Sri; Lubis, Nenni Dwi Aprianti; Lubis, Fahrurrozi; Delyuzar, Delyuzar
Abdimas Universal Vol. 7 No. 1 (2025): April
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Balikpapan (LPPM UNIBA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36277/abdimasuniversal.v7i1.526

Abstract

Food safety is a global issue that directly affects a person's health. Foods that are unsafe to consume will cause various diseases from diarrhea to cancer. Around 420,000 people die every year from food poisoning. Various measures to prevent food poisoning must be taken from an early age, such as washing hands before and during food processing, preventing cross contamination, cooking food thoroughly and so on. Various measures to prevent food poisoning must be taken from an early age, such as washing hands before and during food processing, preventing cross contamination, cooking food thoroughly and so on. This community service was carried out in Pekan Tanjung Beringin Village with the aim of knowing food safety in the area. Service activities are carried out through five stages, namely socialization, data collection, data analysis and mapping, counseling and focus group discussions, and cross-sectoral outreach. From the results of data collection and analysis, policies are created that aim to improve the level of public health, especially in terms of food safety. A total of 15 hamlets with 398 participants were included in this service activity. In general, hamlets 1-15 are considered good in terms of food processing. There are certain points that must be improved together by the community, the Community Health Center, and the local government in assisting proper and safe food processing in the Tanjung Beringin area.
Hubungan Ekspresi Transforming Growth Factor-β1, Fibroblast Activated Protein, pola Tumor-Associated Collagen Signature dan derajat Tumor-Infiltrating Lymphocytes terhadap Grading International Society of Urological Pathology pada Clear Cell Renal Cell Ca Kharismawaty, Dina; Delyuzar, Delyuzar; Betty, Betty; S Lukito, Joko; Chrestella, Jessy
Majalah Patologi Indonesia Vol. 32 No. 1 (2023): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v32i1.568

Abstract

BackgroundClear cell renal cell carcinoma (ccRCC) is a very aggressive cancer and is often diagnosed at an advanced stage. The stromal component around the tumor is thought to have contributed greatly to these findings.MethodsAnalytical study with cross sectional design on 23 histological specimens diagnosed by ccRCC based on data from medical records/pathology archives in 2012-2021. Each specimen was stained with hematoxylin and eosin, TGF-β and FAP immunohistochemistry and Masson's trichrome. Fisher's exact test (p<0.05) was used to assess the association between the expressions of all variables with the ISUP grading.ResultsMost cases were high grade ccRCC (87%) samples, of which 73.9% samples expressed strong TGF-β, 82.7% samples expressed positive intratumoral FAP, 78.3% samples expressed positive stromal FAP, 47.8% showed a TACS-3-pattern, 56.5% of samples with positive stromal TILs and 47.8% of samples with negative intratumoral TILs. There was no significant association between all of these variables and the ISUP grading of the ccRCC (p<0.05).ConclusionExpression of TGF-β1, intratumoral and stromal FAP, TACS pattern and the degree of intratumoral and stromal TILs were not significantly associated with ISUP grading in ccRCC.
Hubungan Ekspresi Imunohistokimia CD31 dengan Subtipe Histopatologi, Lymphovascular Invasion dan Angiogenesis pada Papillary Thyroid Carcinoma sinambela, Roy Herbon; Delyuzar; T Kemala Intan
Majalah Patologi Indonesia Vol. 33 No. 2 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i3.634

Abstract

ABSTRACT Background Thyroid carcinoma is a malignancy of the thyroid gland originating from thyroid follicular cells or parafollicles. The incidence increases slowly and is rare, occurring in approximately 1% of all-body malignancies. Papillary thyroid carcinoma ( PTC ) is influenced by radiation factors, geographic variations, age, and gender. Lymphovascular invasion (LVI) is an independent predictor of lymph node metastases. Angiogenesis is the process of forming new blood vessels and estimating angiogenesis is carried out using a microscopic approach to tumor tissue microvessel density ( MVD ) through CD31 immunohistochemistry . Increased MVD is associated with poor prognosis as an endothelial marker used in calculating MVD using CD31 . Method Cross-sectional analytic study with 32 samples diagnosed with PTC from the Anatomic Pathology Unit of H.Adam Malik General Hospital, Medan. MVD is the number of small blood vessels in terms of size and diameter ( arterioles and venules) with a round lumen stained positively with CD31 which are categorized as low (1-9 blood vessels/10 LPB), moderate (10-19 blood vessels/10 LPB) and high (>20 blood vessels/10 LPB). The relationship of CD31 immunohistochemical expression with histopathological subtypes, LVI and angiogenesis was analyzed by Eta and Somers'd tests . Results There was a significant relationship between CD31 and histopathological subtype (p=0.05 ) , lymphovascular invasion and angiogenesis with a p=0.01 ( p value<0.05 ). Conclusion MVD is significantly associated with histopathological and lymphovascular subtypes . Keywords: CD31 , PTC , LVI , MVD
Hubungan Ekspresi Imunohistokimia Matrix Metalloproteinase-9 dengan Tumor Budding Peritumoral dan Subtipe molekuler pada Invasive Breast Carcinoma of No Special Type Indriani Saragih, Septina; Delyuzar, Delyuzar; Intan, T. Kemala
Majalah Patologi Indonesia Vol. 34 No. 1 (2025): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i1.642

Abstract

Abstract Background Breast cancer ranks first most often in the world and is a malignant cancer that often occurs in women. Matrix metalloproteinase-9 (MMP-9) has been the focus of attention in several previous studies in the field of breast cancer. MMP-9 plays a role in the degradation of the extracellular matrix. High expression of MMP-9 is associated with tumor aggressiveness, metastatic potential and poor prognosis. The presence of tumor budding and molecular subtypes also indicates tumor aggressiveness, one of which is the potential for metastasis through extracellular matrix degradation. The aim of this study was to analyze the association of MMP-9 mmunohistochemistry expression with peritumoral tumor budding and molecular subtypes in IBC-NST. Methods This study is an analytic study with a cross sectional approach on 41 samples of paraffin block cases of IBC-NST which had been diagnosed histopathologically and then performed with MMP-9 mmunohistochemistry staining. The correlation between the immunohistochemical expression of MMP-9 with peritumoral tumor buds and molecular subtypes in IBC-NST was tested statistically using Somers'd test and Eta test. Results There was a significant relationship between the immunohistochemistry expression of MMP-9 with peritumoral tumor budding and molecular subtypes. Conclusion Reporting the results of MMP-9 expression on IBC-NST can be one of the prognostic criteria that can be applied in routine examinations. However, the relationship with prognosis cannot be concluded from this study because it is not associated with survival rate
Correlation between GATA3 Immunohitsochemistry and TP53 on some Ovarium Carcinoma Histopathology Subtype intan nefia alamanda; Betty, Betty; Delyuzar, Delyuzar; Chrestella, Jessy; Soekimin, Soekimin
Majalah Patologi Indonesia Vol. 34 No. 3 (2025): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background Ovarian carcinoma is a cancer with high mortality in women, although comprehensive treatment with surgery and chemotherapy is at an advanced stage, survival rates are still low. GATA3 and p53 are predictors of some malignancies, but results vary in ovarian carcinoma. Objective To examine correlation between immunohistochemical expression of GATA3 and p53 in patients with ovarian carcinoma with various histopathological subtypes. Materials and Methods Cross sectional design is the method of this study conducted on slides of 28 ovarian carcinoma patients in several subtypes of hitopathology. Each slide was stained with hematoxylin and eosin (H&E) to assesses hitopathological subtypes and stained with GATA3 and p53 antibodies. Expression GATA3 was assessed using H-score and p53 quick score. A logistic regression assay (p<0.005) was used to assessed the association of GATA3 and TP53 immunohistochemical expression in several histopathological subtypes of ovarian carcinoma. Statistical analysis between GATA3 and p53 was performed using the eta correlation test is used because the data is nominal-ordinal. Results Among 28 specimens in patients with ovarian carcinoma, Cases was most prevalent in the age group >50-60 years (age range 58 years), history of nullipara parity, and most in the group of stage III ovarian malignancy. Positive immunohistochemical p53 expression is more prevalent in serous carcinoma. Positive GATA3 immunohistochemical expression is more prevalent in serous carcinoma. Conclusion There is no significant relationship. Immunohistochemical expression of GATA3 and TP53 in some histopathological subtypes of ovarian carcinoma. However, immunohistochemical expression of GATA3 high p53 positive tends to be found in high-grade serous carcinoma. Keywodrs: GATA3, p53, karsinoma ovarium, Serous carcinoma, Mucinous carcinoma, Endometrioid carcinoma, Clear cell carcinoma.
Co-Authors Ahyar Riza Alamanda, Intan Nefia Alferraly, T. Ibnu betty betty Chairani, Rizki Chrestela, Jessy Chrestella, Jessy CINDY CLARA AWE Dedy Suryadi Diana Rizki DITA ANNISA DIARA NASUTION Dr. Endang Sjamsudin, drg, Sp.BMMF, Subsp.TMF-TMJ[K] Edi Kerina Sembiring, Edy Fachrial Eka Airlangga Emita Sabri Feby Yanti Harahap Fiandani, Fatma Fitri Dewi Ismida fitriani Lumongga Harahap, Rini Syahrani HENDRA SUTYSNA Hidayat Hidayat Hidayat Hilda Fitriyani Humairah Medina Liza Lubis Ibnu Alferally Indri Mahrani Indriani Saragih, Septina intan nefia alamanda Intan, T. Kemala Jessy Chrestella Joko S. Lukito Kharismawaty, Dina Laksmi, Lidya Imelda Lidya Imelda Laksmi Lita Feriyawati Lokot Donna Lubis Lubis, Fahrurrozi Lubis, Nenni Dwi Aprianti Lukito, Joko S. M. Nadjib D. Lubis Mariedina, Causa Trisna Muhammad Nadjib D Lubis Muhammad Ramli Nadjib Dahlan Lubis Nasution, Annio Indah Lestari Nurcahaya Sinaga Nurlela Nurlela P. Poida B. Gurning Ren Astrid Allail Siregar Reza Aditya Digambiro Rita Juliana Pohan Roza Rita S Lukito, Joko Sihotang, Marisi Cintya Debby sinambela, Roy Herbon Soekimin Soekimin Soekimin Soekimin Soekimin Soekimin Soekimin, Soekimin Sri Amelia, Sri Sufitni Sunarti Sunarti Syafruddin Ilyas T Kemala Intan T. Ibnu Alferally T. Ibnu Alferally T. Ibnu Alferraly tengku ibnu alferraly Tri Widyawati Urip Harahap Utami, Tania Mulia