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All Journal JURNAL PENGABDIAN KEPADA MASYARAKAT Universa Medicina JURNAL IBNU SINA BIOMEDIKA Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Sumatera Medical Journal Abdimas Universal JURNAL ILMIAH MAKSITEK Bioscientia Medicina : Journal of Biomedicine and Translational Research
Delyuzar, Delyuzar
Universitas Sumatera Utara
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Ekspresi H19 dan Insulin-Like Growth Factor 2 (IGF2) pada Tumor Epitel Permukaan Ovarium Tipe Serosum dan Musinosum Rita Juliana Pohan; Nadjib Dahlan Lubis; Delyuzar Delyuzar
Majalah Patologi Indonesia Vol 27 No 2 (2018): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

Latar belakang Tumor-tumor epitel permukaan ovarium merupakan neoplasma ovarium yang paling sering. Kanker ovarium mempunyai prognosis buruk karena gejalanya tidak spesifik dan kebanyakan dijumpai sudah stadium lanjut. Genomic imprinting adalah proses epigenetik yang menyebabkan ekspresi allel yang berbeda dari gen parental dalam sel-sel somatik. Adanya loss of imprinting gen IGF2 dan H19 diperkirakan terlibat dalam terjadinya kanker ovarium. Tujuan penelitian ini adalah menjelaskan adanya perbedaan ekspresi H19 dan IGF2 pada tumor jinak dan ganas yang berasal dari epitel permukaan ovarium, tipe serosum dan musinosum, mendeteksi kekambuhan dini dan terapi target.MetodePenelitian ini bersifat deskriptif analitik dengan rancangan cross sectional. Sampel penelitian sebanyak 80 blok parafin jaringan ovarium dari operasi ooforektomi yang telah didiagnosis tumor jinak dan ganas ovarium, tipe serosum dan musinosum dengan pewarnaan hematoksilin eosin. Sampel akan dievaluasi intensitas dan kuantitas ekspresi immunohistokimia H19 dan insulin-like growth factor 2 (IGF2), kemudian diamati dan dianalisa dengan uji Fisher’s exact. Hasil H19 terekspresi kuat (81,82%) pada tumor serosum jinak, sedang pada tumor serosum ganas sebagian besar terekspresi lemah (88,89%), nilai p 0,005. Pada tumor musinosum jinak, H19 terekspresi kuat (77,78%) dan pada yang ganas terekspresi lemah (72,73%), dengan nilai p 0,070. IGF2 terekspresi kuat (90,91%) pada sebagian besar tumor serosum ganas, sedang pada tumor serosum jinak semuanya (100%) terekspresi lemah, dengan nilai p = 0,001. Pada tumor musinosum, IGF2 terekspresi kuat pada yang ganas (62,50), pada yang jinak (37,50%) juga terekpresi kuat, nilai p 0,087.Kesimpulan Expresi H19 dan IGF2 dapat menyokong kepastian diagnosis histologik tumor serosum jinak dan ganas. Ekspresi kuat H19 menunjukkan prognosis baik, ekspresi kuat IGF2 menunjukkan prognosis buruk pada tumor serosum.
Ekspresi Epidermal Growth Factor Reseptor (EGFR) dan B-Cell Leukemia/Lymphoma-2 (BCL-2) pada Subtipe Histopatologik Karsinoma Sel Basal nurlela nurlela; Delyuzar Delyuzar; tengku ibnu alferraly
Majalah Patologi Indonesia Vol 27 No 3 (2018): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

Latar belakangKarsinoma sel basal (KSB) adalah tumor ganas pada kulit yang berasal dari sel-sel primordial pluripotensial di lapisan basal epidermis, dapat juga berasal dari selubung luar folikel rambut atau kelenjar sebasea, atau adneksa kulit lainnya. KSB merupakan jenis kanker terbanyak pada kulit dan keganasan tersering pada manusia. Penelitian yang telah dilakukan untuk melihat adanya kecenderungan faktor risiko rekuren dan perkembangan terapi target, dengan beberapa petanda biologik seperti epidermal growth faktor reseptor (EGFR) dan B-cell leukemia/lymphoma-2 (BCL-2) pada KSB. Tujuan penelitian ini bertujuan untuk mengetahui ekspresi EGFR dan BCL-2 pada subtipe histopatologik karsinoma sel basal.MetodePenelitian ini adalah penelitian deskriptif analitik dengan pendekatan cross sectional. Sampel penelitian adalah blok parafin yang didiagnosa sebagai KSB. Sejumlah 40 sampel terdiri dari mikro-nodular 17 sampel, nodular 12 sampel, infiltrating 4 sampel, pigmented 4 sampel, superfisial 2 sampel dan basoskuamous 1 sampel. Seluruh sampel dipulas dengan immunohistokimia dengan antibodi primer anti EGFR dan BCL-2 dan dilakukan interpretasi dengan menilai intensitas dan kuantitas tampilan warna pada sel tumor.HasilPada 20 sampel EGFR dengan ekspresi lemah, dijumpai 12 sampel (60%) juga menunjukkan ekspresi BCL-2 lemah dan 20 sampel dengan ekspresi EGFR kuat dijumpai 12 sampel (60%) juga menunjukkan ekspresi BCL-2 kuat. Hasil ekspresi EGFR dan BCL-2 terdapat kesesuaian yang dianalisis dengan uji McNemar.KesimpulanHasil penelitian menunjukkan bahwa ada kesesuaian ekspresi antara EGFR dan BCL-2 yang signifikan dengan (p-value <0,001) pada penderita KSB.
PENGEMBANGAN UNIT USAHA USU PELAYANAN LABORATORIUM PATOLOGI ANATOMIK TAHUN 2020 Delyuzar Delyuzar; Muhammad Ramli; Tengku Ibnu Alferraly; Hidayat Hidayat; Dedy Suryadi
JURNAL PENGABDIAN KEPADA MASYARAKAT Vol 27, No 1 (2021): JANUARI-MARET
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jpkm.v27i1.21587

Abstract

Seiring dengan perkembangan zaman dan teknologi di semua bidang, termasuk laboratorium patologi anatomik, maka laboratorium patologi anatomik FK USU juga harus ikut berperan terhadap segala perubahan, terutama dalam hal kepentingan USU, baik dalam hal akreditasi maupun usaha meningkatkan pendapatan melalui unit usaha mandiri. Potensi yang dimiliki unit usaha pelayanan patologi anatomik sangat besar untuk dikembangkan, diantaranya pelayanan patologi anatomik terhadap pasien dan masyarakat, pendidikan dan penelitian terhadap mahasiswa, ini semua harus difasilitasi dan dikembangkan dengan cara dukungan unit usaha berbasis sistem teknologi informasi. Ada beberapa kendala yang dihadapi pada program ini, diantaranya keterbatasan tenaga kesehatan dan peralatan.Pengabdian ini bertujuan untuk meningkatkan kunjungan pasien dan penghasilan laboratorium patologi anatomik FK USU, solusi berupa perbaikan manajemen professional dan promosi laboratorium patologi anatomik yang dapat melakukan pelayanan yang lebih lengkap berbasis biologi molekuler dan teknologi informatika untuk kepentingan akreditasi dan pendapatan dari unit usaha pelayanan patologi anatomik FK USU. Tahun 2021 kita harapkan unit usaha ini telah berkembang sebagi laboratorium patologi anatomik dengan pemeriksaan biologi molekuler dan menjadi pusat konsultasi berbasis web dan teknologi informatika. Kata kunci: Laboratorium, Patologi Anatomik, Web, Teknologi Informatika 
PENEGAKAN DIAGNOSIS TUBERKULOSIS ANAK DI PUSKESMAS BANDAR KHALIFAH KABUPATEN DELI SERDANG TAHUN 2014 - 2015 CINDY CLARA AWE; H. DELYUZAR
JURNAL ILMIAH MAKSITEK Vol 5 No 4 (2020): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Tuberculosis (TB) in children is a particular problem which is different from TB in adults. The development of TB disease inchildren is currently very rapidly. At least 500,000 children in the world suffering from TB every year. In Indonesia kasusTBproportion of children among all TB cases in 2010 was 9.4%, then to 8.5% in 2011 and 8.2% in 2012. In the diagnosis of TBin children, all diagnostic procedures can be done, namunapabila encountered limitations of available diagnostic, may use adifferent approach known as the scoring system. TB high incidence of children in Deli Serdang, encourage researchers tofind out how the child's diagnosis of TB in Puskesmas Bandar Khalifah District of Deli Serdang years 2014-2015.This research to know how the diagnosis of TB in children Bandar Khalifah Health Center Deli Serdang years 2014-2015.This study is descriptive. The design is done is a cross sectional study. Researchers assessed the diagnosis of TB inchildren Bandar Khalifah Health Center Deli Serdang, by using secondary data and total sampling method. All medicalrecord files contained child TB in Puskesmas Bandar Khalifah Deli Serdang years 2014-2015 were collected and then do therecording. From the results obtained penellitian enforcement of child TB diagnosis in Puskesmas Bandar Khalifah DeliSerdang of 135 respondents who diagnose children TB amounted to 94 people with a percentage (69.6%). enforcement ofTB diagnosis in children by using the tuberculin skin test result is positive is 67 people (49.6%), while those with negative testresults tuberkulinnya child TB diagnosis by 27 people with the percentage (20.0%), and the child using the TB TB scoringchildren who screen positive are 94 people (69.6%), while the results of scoring TB negative children with TB diagnosis childof this data can not be found.
GAMBARAN KARAKTERISTIK ANAK PENDERITA TB PARU PADA ANAK USIA 0 – 17 TAHUN DI RUMAH SAKIT UMUM HAJI MEDAN DITA ANNISA DIARA NASUTION; EKA AIRLANGGA; DELYUZAR .; NURCAHAYA SINAGA
JURNAL ILMIAH MAKSITEK Vol 6 No 2 (2021): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Tuberculosis (TB) is a potentially fatal contagious disease caused Mycobacterium tuberculosis, that can affect almost anypart of the body but is mainly an infection of the lungs. If left untreated or treated inadequately, the outcome is dangerouscomplication and death. According to WHO (World Health Organization) in 2013, incidence of pulmonary TB in the world isestimated that there were 9 million cases. The purpose of this study was to discover description of characteristic patient withpulmonary TB age of 0-17 years at Haji General Hospital Medan. This is a descriptive study with collecting medical record tofind out TB characteristic in children at Haji General Hospital Medan. The subjects of this study are all children who affectedpulmonary TB in accordance with the inclusion criteria. This study use total sampling method. Total of children withpulmonary TB is 128 people, those who were more affected pulmonary TB is boys, 66 children (51.6%), the age mostaffected pulmonary TB is age 1 - 5 years, namely 49 children (38.3%). Based on immunization status, the most affectedpulmonary TB is those which not given BCG immunization, 119 children (93.0%), based on history of contact with adult TBpatient was found that more children did not have a history contact with other patients, 106 children (82.8%), based oncharacteristic of symptoms by scoring pulmonary TB in children is fever, 128 children (100%), and for cough is 122 children(95.3%), then based on nutritional status malnutrition is most widely found, 105 (82%). The most affected pulmonary TB ischildren with male sex, with age of 0 - 5 years, and BCG negative immunization status. Based on characteristic of symptomsby scoring pulmonary TB the most common is fever and chronic cough, with poor nutritional status.
Hepatoprotective effect of red ginger rhizome extract in deep frying oil-fed male wistar rats Sunarti Sunarti; Edy Fachrial; Urip Harahap; Delyuzar Delyuzar; Tri Widyawati; Lokot Donna Lubis
Universa Medicina Vol. 36 No. 3 (2017)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.228-235

Abstract

BACKGROUNDNon-alcoholic steatohepatitis (NASH) is a chronic liver disease associated with increased free fatty acids, trans fatty acids and free radical compounds due to the consumption of deep frying oil (DFO). Ginger has hypolipidemic and antioxidant properties, and acts as an insulin sensitizer. The present study was conducted to evaluate the hepatoprotective effect of an ethanol extract of Zingiber officinale Roxb var rubrum (EEZO) in DFO-fed male Wistar rats.METHODSA study of experimental design was conducted involving 24 non-alcoholic steatohepatitis (NASH) male Wistar rats that were randomly divided into 4 groups. Group K1 (control) was given DFO-3 (3 times heated DFO) at a dose of 10 ìl/g BW/day. The treatment groups (P1, P2, P3) were given DFO-3 and red ginger rhizome extract at doses of 100, 200, and 400 mg/kg BW orally for 30 days. The histopathology examination assessed fatty degeneration, and degree of fibrosis. The data were analyzed with the Kruskal-Wallis and Mann-whitney test.RESULTS    The Kruskal-Wallis test showed that fatty degeneration (steatosis, lobular inflammation, hepatocyte ballooning and NASH) were significantly different among the four groups (p<0.05). Mann-Whitney test proved that fatty degeneration was not significantly different between control and treatment groups (p>0.05).CONCLUSIONDeep frying oil increased fatty degeneration and NASH, and none of red ginger rhizome extract doses was able to inhibit fatty degeneration significantly. For the future research it is intended to prolong the induction time and the administration of red ginger rhizome extract.
Relationship of Stromal Tumor Infiltrating Lymphocytes (STILs) with Grading Histopathology in Penis Squamous Cell Carcinoma Sihotang, Marisi Cintya Debby; Intan, T. Kemala; Alferraly, T. Ibnu; Betty, Betty; Soekimin, Soekimin; Delyuzar, Delyuzar
Majalah Patologi Indonesia Vol. 33 No. 2 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i2.580

Abstract

ABSTRACT Background:Penile squamous cell carcinoma is the most common penile malignance found in the world. Assessment of stromal tumor infiltrating lymphocytes (STILs) associated with grading against penile squamous cell carcinoma can provide a potential prognostic picture and help determine the action. Method:Cross-sectional analytical study with 32 samples of histopathological preparations diagnosed as penile squamous cell carcinoma at H. Adam Malik Hospital Medan. The assessment of stromal TILs was carried out by assessing the number of lymphocyte inflammatory cells in the peritumoral stroma and then determined the assessment score, zero score no lymphocytes (minimum), score one found 0-10% lymphocytes (moderately), score two found 20-40% lymphocytes (massive) , score three found 50-90% lymphocytes. Grading assessments are categorized into grade I (well differentiated), grade II (moderately differentiated), and grade III (poorly differentiated). Result:The most grading found was grade II (43.8%) and the most STILs found were score three (50.0%). There is a significant relationship between grading and STILs in penile squamous cell carcinoma (p value=0.0001) i.e. the higher the STILs score , the lower the tumor grade. Conclusion:There is a relationship between STILs and histopathological grading in Penile Squamous Cell Carcinoma so that it can be used as an indikasi prognosis in patients with penile squamous cell carcinoma.
Immunohistochemistry Expression Gata3 Based on Subtypes of Ovarian Carcinoma at Haji Adam Malik General Hospital Medan 2019-2021 Alamanda, Intan Nefia; Betty, Betty; Delyuzar, Delyuzar; Laksmi, Lidya Imelda; Chrestela, Jessy; Soekimin, Soekimin
Majalah Patologi Indonesia Vol. 33 No. 3 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i2.604

Abstract

Background Ovarian carcinoma is a cancer with high mortality in women and although comprehensive management with surgery and chemotherapy at an advanced stage, the resistance rate is still low. GATA3 contributes to the progression of malignancy and its expression is one of the predictors in some malignancies, but the results are mixed in ovarian carcinoma. High GATA3 expression is associated with the aggressiveness of tumor growth and poor prognosis of ovarian carcinoma.   Methods This research is an cross-sectional descriptive-analytical study with 33 histological specimens diagnosed with ovarian carcinoma from medical records/archives at H. Adam Malik Hospital Medan. Each sample specimen was stain with GATA3, and several various histopathological subtypes of ovarian carcinoma.   Results From a total of 33 samples, 14 samples were serous carcinoma, 6 samples were mucinous carcinoma, 7 samples were endometrioid carcinoma, and 6 samples were clear cell carcinoma. GATA3 was expressed in 42.5% of serous carcinoma. Positive expression of GATA3 is mostly found in advanced ovarian carcinoma, older age, and histopathological type of serous carcinoma.    Conclusion Immunohistochemistry GATA3 expression was expressed in 42.4% of serous carcinoma, 21.2% in endometrioid carcinoma, 18.2% in clear cell carcinoma, and 18.2% in mucinous carcinoma.   Keywords: ovarian carcinoma, GATA3, immunohistochemistry
The Correlation of Light Chain 3B Immunohistochemical Expression with Histopathological Grading in Colorectal Adenocarcinoma Fiandani, Fatma; Betty, Betty; Delyuzar, Delyuzar; Laksmi, Lidya Imelda; Lukito, Joko S.
Majalah Patologi Indonesia Vol. 33 No. 3 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i3.610

Abstract

Background Colorectal cancer ranks third highest of all malignancies worldwide and ranks fourth out of the 10 most common cancers encountered in Indonesia. More than 90% of colorectal cancers are adenocarcinoma type. The mechanism of autophagy has a dual role in tumorigenesis, namely as a tumor suppressor and as a tumor promoter. Microtubule-associated protein 1 light chain 3B (LC3B) is one of the widely used autophagy markers. The role of autophagy requires further research so that LC3B can be considered as one of the predictors of prognosis, especially in colorectal adenocarcinoma. The aim of this research is to determine the correlation of Light Chain 3B immunohistochemical expression with histopathological grading of colorectal adenocarcinoma. Methods Cross-sectional analytic study of 41 samples diagnosed with colorectal carcinoma at H. Adam Malik General Hospital Medan. Staining was performed using a polyclonal antibody rabbit Light Chain 3B immunohistochemistry (GeneTex) which would appear positive in the cytoplasm of tumor cells at a dilution of 1: 500. LC3B expression was assessed semiquantitatively with low and high expression categories. Data analysis was tested with the Spearman correlation test. Results LC3B immunohistochemical expression has a very strong correlation with the histopathological grading of colorectal adenocarcinoma and in a positive direction where the higher the colorectal adenocarcinoma grade, the higher the LC3B immunohistochemical expression, and vice versa (p=0,0001; r=0,763). Conclusion There was a significant relationship between LC3B immunohistochemical expression and histopathological grading of colorectal adenocarcinoma.
Pemetaan Kebersihan dan Perilaku Aman Pangan (PEKA-PANGAN) Sebagai Upaya Peningkatan Derajat Kesehatan Masyarakat Tanjung Beringin Amelia, Sri; Lubis, Nenni Dwi Aprianti; Lubis, Fahrurrozi; Delyuzar, Delyuzar
Abdimas Universal Vol. 7 No. 1 (2025): April
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Balikpapan (LPPM UNIBA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36277/abdimasuniversal.v7i1.526

Abstract

Food safety is a global issue that directly affects a person's health. Foods that are unsafe to consume will cause various diseases from diarrhea to cancer. Around 420,000 people die every year from food poisoning. Various measures to prevent food poisoning must be taken from an early age, such as washing hands before and during food processing, preventing cross contamination, cooking food thoroughly and so on. Various measures to prevent food poisoning must be taken from an early age, such as washing hands before and during food processing, preventing cross contamination, cooking food thoroughly and so on. This community service was carried out in Pekan Tanjung Beringin Village with the aim of knowing food safety in the area. Service activities are carried out through five stages, namely socialization, data collection, data analysis and mapping, counseling and focus group discussions, and cross-sectoral outreach. From the results of data collection and analysis, policies are created that aim to improve the level of public health, especially in terms of food safety. A total of 15 hamlets with 398 participants were included in this service activity. In general, hamlets 1-15 are considered good in terms of food processing. There are certain points that must be improved together by the community, the Community Health Center, and the local government in assisting proper and safe food processing in the Tanjung Beringin area.
Co-Authors Alamanda, Intan Nefia Alferraly, T. Ibnu betty betty Chairani, Rizki Chrestela, Jessy Chrestella, Jessy CINDY CLARA AWE Dedy Suryadi DITA ANNISA DIARA NASUTION Edi Kerina Sembiring, Edy Fachrial Eka Airlangga Emita Sabri Endang Sjamsudin Feby Yanti Harahap Fiandani, Fatma Fitri Dewi Ismida fitriani Lumongga Harahap, Rini Syahrani HENDRA SUTYSNA Hidayat Hidayat Hidayat Hilda Fitriyani Humairah Medina Liza Lubis Ibnu Alferally Indri Mahrani Indriani Saragih, Septina Intan, T. Kemala Jessy Chrestella Joko S. Lukito Kharismawaty, Dina Laksmi, Lidya Imelda Lidya Imelda Laksmi Lita Feriyawati Lokot Donna Lubis Lubis, Fahrurrozi Lubis, Nenni Dwi Aprianti Lukito, Joko S. M. Nadjib D. Lubis Mariedina, Causa Trisna Muhammad Nadjib D Lubis Muhammad Ramli Nadjib Dahlan Lubis Nasution, Annio Indah Lestari Nurcahaya Sinaga Nurlela Nurlela P. Poida B. Gurning Ren Astrid Allail Siregar Reza Aditya Digambiro Rita Juliana Pohan Riza, Ahyar Rizki, Diana Roza Rita S Lukito, Joko S. Lukito, Joko Sihotang, Marisi Cintya Debby sinambela, Roy Herbon Siregar, Ren Astrid Allail Soekimin Soekimin Soekimin Soekimin Soekimin, Soekimin Sri Amelia, Sri Sufitni Sunarti Sunarti Syafruddin Ilyas T Kemala Intan T. Ibnu Alferally T. Ibnu Alferally T. Ibnu Alferraly tengku ibnu alferraly Tri Widyawati Urip Harahap Utami, Tania Mulia