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All Journal Indonesian Journal of Chemistry Jurnal Litbang Sukowati : Media Penelitian dan Pengembangan Indian Journal of Forensic Medicine & Toxicology Narra J Al-Khidmah Jurnal Pengabdian Masyarakat Narra X Journal Of Carbazon
Iqhrammullah, Muhammad
Faculty Of Public Health, Universitas Muhammadiyah Aceh, Banda Aceh, Indonesia
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences

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Acute severe hepatitis of unknown etiology in children: A mini-review Andri Frediansyah; Malik Sallam; Amanda Yufika; Khan Sharun; Muhammad Iqhrammullah; Deepak Chandran; Sukamto S. Mamada; Dina E. Sallam; Yousef Khader; Yohannes K. Lemu; Fauzi Yusuf; James-Paul Kretchy; Ziad Abdeen; J. Smith Torres-Roman; Yogesh Acharya; Anastasia Bondarenko; Aamer Ikram; Kurnia F. Jamil; Katarzyna Kotfis; Ai Koyanagi; Lee Smith; Dewi Megawati; Marius Rademaker; Talha B. Emran; Ziad A. Memish; Sandro Vento; Firzan Nainu; Harapan Harapan
Narra J Vol. 2 No. 2 (2022): August 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i2.83

Abstract

The emergence of acute, severe non hepA–E hepatitis of unknown etiology (ASHUE) has attracted global concern owing to the very young age of the patients and its unknown etiology. Although this condition has been linked to several possible causes, including viral infection, drugs and/or toxin exposure, the exact cause remains unknown; this makes treatment recommendation very difficult. In this review, we summarize recent updates on the clinical manifestations, complemented with laboratory results, case numbers with the global distribution and other epidemiological characteristics, and the possible etiologies. We also provide the proposed actions that could be undertaken to control and prevent further spread of this hepatitis. Since many etiological and pathological aspects of the acute non hepA–E hepatitis remain unclear, further research is needed to minimize the severe impact of this disease.
Acute severe hepatitis of unknown etiology in children: A mini-review Frediansyah, Andri; Sallam, Malik; Yufika, Amanda; Sharun, Khan; Iqhrammullah, Muhammad; Chandran, Deepak; Mamada, Sukamto S.; Sallam, Dina E.; Khader, Yousef; Lemu, Yohannes K.; Yusuf, Fauzi; Kretchy, James-Paul; Abdeen, Ziad; Torres-Roman, J. Smith; Acharya, Yogesh; Bondarenko, Anastasia; Ikram, Aamer; Jamil, Kurnia F.; Kotfis, Katarzyna; Koyanagi, Ai; Smith, Lee; Megawati, Dewi; Rademaker, Marius; Emran, Talha B.; Memish, Ziad A.; Vento, Sandro; Nainu, Firzan; Harapan, Harapan
Narra J Vol. 2 No. 2 (2022): August 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i2.83

Abstract

The emergence of acute, severe non hepA–E hepatitis of unknown etiology (ASHUE) has attracted global concern owing to the very young age of the patients and its unknown etiology. Although this condition has been linked to several possible causes, including viral infection, drugs and/or toxin exposure, the exact cause remains unknown; this makes treatment recommendation very difficult. In this review, we summarize recent updates on the clinical manifestations, complemented with laboratory results, case numbers with the global distribution and other epidemiological characteristics, and the possible etiologies. We also provide the proposed actions that could be undertaken to control and prevent further spread of this hepatitis. Since many etiological and pathological aspects of the acute non hepA–E hepatitis remain unclear, further research is needed to minimize the severe impact of this disease.
The role of mediator suppressor of cytokine signaling (SOCS), toll-like receptor 3 (TLR-3) and nuclear factor kappa B (NFκB) on cytokine production during dengue virus infection Masyeni, Sri; Kuntaman, Kuntaman; Aryati , Aryati; Sofro, Muchlis AU.; Hadi, Usman; Mastutik, Gondo; Purnomo, Windu; Santosa, Agus; Iqhrammullah, Muhammad; Yohan, Benediktus; Nelwan, Erni J.; Sasmono, R. Tedjo
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.167

Abstract

Inability to understand the pathogenesis of severe dengue, in particular the control mechanism of immune responses, has led to high mortality rate for patients with dengue shock syndrome (DSS). The aim of this study was to determine the control mechanism of cytokine production by mediator suppressor of cytokine signaling (SOCS), toll-like receptor 3 (TLR-3) and nuclear factor kappa B (NFκB) during DENV infection. Peripheral blood mononuclear blood cells (PBMC), isolated from healthy individuals, were infected with dengue virus (DENV)-2 strain SJN-006 Cosmopolitan genotype (isolated from Bali, Indonesia). The relative gene expression of SOCS-3, TLR-3, NFκB, and the cytokine genes (interleukin (IL)-6, IL-8, interferon inducible protein 10 (IP-10), and macrophage inflammatory protein-1 beta (MIP-1β)) were measured using qRT-PCR at 6, 12 and 24 hours post infection (hpi). Student t-test and Mann-Whitney test were used to compare the gene expressions while causal correlations were analyzed using regression test and path analyses. DENV-2 infection increased the gene expression of SOCS-3, TLR-3, and NFκB after 12 and 24 hpi. The expression of IL-6, IL-8, IP-10, and MIP-1β genes was increased and peaked at different times post-infection. NFκB and SOCS-3 genes likely have role in the upregulation of IL-8 and IL-6 gene expression, respectively. MIP-1β gene expression was significantly induced by both NFκB and SOCS-3. In conclusion, our study suggested that SOCS-3, TLR-3, and NFκB are important in regulating the production of IL-6, IL-8, IP-10, MIP-1β during early phase of DENV-2 infection. This enriches our understanding on pathogenesis pathway of DENV-associated cytokine storm.
Effectiveness of Tai Chi as a non-invasive intervention for mild cognitive impairment in the elderly: A comprehensive review and meta-analysis Rampengan, Derren DCH.; Gunawan, Felicia A.; Rampengan, Jade AH.; Ramadhan, Roy N.; Iqhrammullah, Muhammad; Yufika, Amanda
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.724

Abstract

The aging population warrants the increase of mild cognitive impairment (MCI) prevalence, a condition that could progress to dementia. Efforts have been made to improve the MCI and prevent its progression, including the introduction of Tai Chi, a Chinese traditional exercise. The aim of this systematic review and meta-analysis was to evaluate the efficacy of Tai Chi in attenuating MCI among the elderly population. Records investigating the effect of Tai Chi exercise intervention on cognitive function among elderly patients were searched systematically from PubMed, ScienceDirect, Google Scholar, and Europe PMC as of April 13, 2023. The risk of bias (RoB 2.0) quality assessment was employed in the quality appraisal of the studies included. Review Manager 5.4.1 was used for data extraction and meta-analysis, where the standard mean difference (SMD) and 95% confidence interval (95%CI) were computed. Eight randomized control trials with a total of 1379 participants were included in this meta-analysis. Six trials assessed Montreal Cognitive Assessment scores, where its pooled analysis suggested that Tai Chi was as effective as conventional exercise (SMD=0.15, 95%CI: -0.11 to 0.40, p=0.26). However, pooled analysis of the Mini-Mental Status Examination suggested that Tai Chi intervention more effectively improved cognitive function and reduced the rate of cognitive impairment in elderly patients (SMD=0.36, 95%CI: 0.18 to 0.54, p<0.01) as compared to the control group. This systematic review and meta-analysis suggest that, in some extent, Tai Chi is efficacious in improving cognitive function and slowing down the rate of cognitive impairment among elderly patients.
Diagnostic accuracy of preoperative ultrasonography-guided fine-needle aspiration biopsy in distinguishing malignancy in large thyroid nodules: A systematic review, meta-analysis, and meta-regression Zulfa, Putri O.; Iqhrammullah, Muhammad; Zufry, Hendra
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1120

Abstract

Controversy persists regarding the effectiveness of ultrasonography-guided fine-needle aspiration biopsy (US-FNAB) in distinguishing malignancies in large thyroid nodules. The prevailing belief that larger thyroid nodules inherently pose a higher risk of malignancy has led to a common practice of suggesting thyroidectomy for large thyroid nodules. Herein, the aim of this study was to assess the diagnostic accuracy of preoperative US-FNAB for distinguishing malignancy in large thyroid nodules. A search for published records was carried out on 20 October 2023, utilizing the search feature available on PubMed, Scopus, Embase, and Google Scholar. Patients with large thyroid nodules (3 cm or larger) who underwent preoperative US-FNAB and postoperative histopathological tests were included. Related outcomes, including false positive (FP), false negative (FN), true negative (TN), true positive (TP), specificity, and sensitivity, were extracted from each study. Pooled specificity and sensitivity were estimated, and the summarized receiver operating characteristic (sROC) curve, along with the summarized area under the curve (sAUC), was calculated. Out of 133 articles identified across four databases, 10 studies with a total sample of 2752 patients were included. The overall diagnostic sensitivity was 72% (95%CI: 50–86%; p=0.00) and specificity was 96% (95%CI: 87–90%; p=0.00). The positive predictive value (PPV) and negative predictive value (NPV) were 93% (95%CI: 89–98%) and 75% (95%CI: 72–79%), respectively. sAUC was 93%, suggesting the diagnostic tool is accurate. Meta-regression analysis revealed that factors such as the number of samples, country (high-income vs upper-middle income), demographic characteristics (age and gender), and different thyroid size cut-off values did not significantly impact the sensitivity or specificity of US-FNAB. In conclusion, the present study confirms the reliability of US-FNAB in distinguishing malignancy in large thyroid nodules, emphasizing its role in reducing unnecessary thyroidectomy by identifying high-risk patients and challenging the conventional practice of routine thyroidectomy for large thyroid nodules.
Co-Authors Aamer Ikram Abdeen, Ziad Acharya, Yogesh Agus Santosa Ahmad, Khairunnas Ai Koyanagi Akbar, Fahrisal Amanda Yufika Anak Agung Dewi Megawati, Anak Agung Dewi Anastasia Bondarenko Andika, Fina F. Andri Frediansyah Andri Frediansyah, Andri Aryati , Aryati Bondarenko, Anastasia Chandran, Deepak Deepak Chandran Dewi Megawati Dina E. Sallam Elin Yusibani Elly Sufriadi Emran, Talha B. Erni J. Nelwan, Erni J. Farrah Fahdhienie Fauzi Yusuf Fauzi Yusuf, Fauzi Febriani Fina F. Andika Firzan Nainu Gondo Mastutik Gunawan, Felicia A. Hajjah Hajjah Hajjah, Hajjah Hamisah, Irma Harapan Harapan Harapan Harapan Hendra Zufry, Hendra Ikram, Aamer J. Smith Torres-Roman James-Paul Kretchy Katarzyna Kotfis Khader, Yousef KHAIRI SUHUD Khan Sharun Kotfis, Katarzyna Koyanagi, Ai Kretchy, James-Paul Kuntaman Kuntaman Kurnia F. Jamil Kurnia F. Jamil Lee Smith Lemu, Yohannes K. Leni Heliawati Linda Julisafrida Malik Sallam Mamada, Sukamto S. Marius Rademaker Marlina Marlina Marlina Marlina Masyeni, Sri Memish, Ziad A. Muhammad Farhan Muhammad Isa Ningsih, Ratna Nurul Fajri Purnomo, Windu Rademaker, Marius Ramadhan, Roy N. Rampengan, Derren DCH. Rampengan, Jade AH. Randa Y. Refin Rasmi, Rika I. Ratna Idayati Ratna Ningsih Refin, Randa Y. Rika I. Rasmi Sagir Alva Saiful Saiful Sakdiah Sakdiah Sallam, Dina E. Sallam, Malik Saminan Saminan Sandro Vento Sasmono, R. Tedjo Sharun, Khan Smith, Lee Sofro, Muchlis AU. Sukamto S. Mamada Surbakti, Muhammad Syukri Syahrun Nur Talha B. Emran Torres-Roman, J. Smith Usman Hadi Vento, Sandro Yogesh Acharya Yohan, Benediktus Yohannes K. Lemu Yousef Khader Yufika, Amanda Zakaria Zakaria Ziad A. Memish Ziad Abdeen Zulfa, Putri O.