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Journal : Sains dan Matematika

POTENSI DAUN KAYU BAWANG (PROTIUM JAVANICUM) SEBAGAI PENGHAMBAT KERJA ENZIM TIROSINASE Batubara, Irmanida; Adfa, Morina
Sains & Matematika Vol 1, No 2 (2013): April, Sains & Matematika
Publisher : Sains & Matematika

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Abstract

Utilization of Kayu Bawang (Protium javanicum) plant is needed beside its utilization for building material, especially the utilization of the leaves which easily to get. The aim of this research was to describe the potency of Kayu Bawang leaves as tyrosinase inhibitor, an enzyme which responsible to synthesis melanin as natural color of the skin. The leaves of Kayu Bawang macerated with methanol. The methanol extract then partitioned with n-hexane, EtOAc, n-BuOH, and water. All fractions were concentrated and tested its ability to inhibit tyrosinase with two substrates namely L-DOPA (diphenolase reaction) and L-tyrosine (monophenolase reaction). The result showed that n-hexane fraction could inhibit diphenolase reaction with IC50 value of 114.2 ppm. EtOAc fraction could inhibit monophenolase reaction (IC50 834.0 ppm). Methanol extract, n-BuOH fraction, and water fraction could not inhibit tyrosinase activities. The conclusion is nonpolar and semi polar compounds in Kayu Bawang leaves could be utilized as whitening agent. 
Potensi Daun Kayu Bawang (Protium javanicum) sebagai Penghambat Kerja Enzim Tirosinase Irmanida Batubara; Morina Adfa
Sains dan Matematika Vol. 1 No. 2 (2013): April, Sains & Matematika
Publisher : Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Utilization of Kayu Bawang (Protium javanicum) plant is needed beside its utilization for building material, especially the utilization of the leaves which easily to get. The aim of this research was to describe the potency of Kayu Bawang leaves as tyrosinase inhibitor, an enzyme which responsible to synthesis melanin as natural color of the skin. The leaves of Kayu Bawang macerated with methanol. The methanol extract then partitioned with n-hexane, EtOAc, n-BuOH, and water. All fractions were concentrated and tested its ability to inhibit tyrosinase with two substrates namely L-DOPA (diphenolase reaction) and L-tyrosine (monophenolase reaction). The result showed that n-hexane fraction could inhibit diphenolase reaction with IC50 value of 114.2 ppm. EtOAc fraction could inhibit monophenolase reaction (IC50 834.0 ppm). Methanol extract, n-BuOH fraction, and water fraction could not inhibit tyrosinase activities. The conclusion is nonpolar and semi polar compounds in Kayu Bawang leaves could be utilized as whitening agent. 
Co-Authors A.A. Ketut Agung Cahyawan W Afif, Muhammad adli Agus Martono Agus Martono H. Putranto Alvin Reagen, Muhammad Andini, Vicka Arif Juliari Kusnanda Aswanda Aswin Falahudin Aswin Falahudin Aswin Falahudin Aswin Falahudin Avidlyandi, Avidlyandi Azizah Khusnul Cahlia, Uci Charles Banon Della Faronica Della Indah Medani Deni Agus Triawan Devi Nurhasana Diana Andari Dina Erliana Dwita Oktiarni Eka Angasa Eka Angasa Elsi Silvia Endarwati Wiwik Endarwati Evi Maryanti Evi Maryanti Fahmi, Riziq Ilham Nur Falahudin, Aswin Febriansyah, Rahmaga Fitriani, Dyah Ghufira Ghufira Harlianto, Budi Helfi Eka Saputra Hendri Bustamam Herlina Herlina Herlina Herlina Herlita Widiyanti Hidayah, Thoriqul Indah Medani, Della Insin, Numpon Irfan Gustian Irfan Gustian Irfan Gustian Irfan Gustian Irfan Gustian Irmanida Batubara Juliari Kusnanda, Arif Khafit Wiradimafan Khafit Wirdimafan Khairani, Nurliza Khusnul Azizah Kurnia Farah Andina Liana Wahyuni Lisna Hamni M. Rafi Martono H.P, Agus Meyola, Fenti Mohamad Rafi Mudyanto, Andre Muhamad Alvin Reagen Muhammad Alvin Reagen Munifilia Ekasari Munifilia Ekasari Nesbah Nesbah, Nesbah Novrianto Tarigan Nurhasana, Devi Nurwidiyani, Ria Pasaribu, Cahaya Perdani, Meka Saima Prastya, M. Eka Puspasari, Jesi Rahmaga Febriansyah Reagen, Muhamad Alvin Reza Pertiwi Reza Wahyuni Ria Nurwidiyani Risky Hadi Wibowo Risky Hadi Wibowo Rochmah Supriati Rothman, Dita Delia Sal Prima Yudha S Sal Prima Yudha S SALPRIMA YUDHA S Salprima Yudha S. Shari Winda Silvia, Elsi Sipriyadi Sri Wahyu Kurnia Putri Suci Sukma Taruna Asral Supriati, Rochmah Suryadi Jaya Swadexi Istiqphara Swadexi Istiqphara Swadexi Istiqphara, Swadexi Teja Dwi Sutanto Thoriqul Hidayah Triawan Deni Agus Triawan, Deni Agus Wafa Syahidah Wahyuni, Reza Welly Darwis Wibowo Risky Hadi Wibowo, Risky Hadi Winda Shari Wulan Aprilia Syafitri Yudha S Yudha S