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All Journal Jurnal Ilmiah Psikologi Terapan IBDA` : Jurnal Kajian Islam dan Budaya REKA KARSA LiNGUA: Jurnal Ilmu Bahasa dan Sastra Jurnal Theologia Students´ Journal of Economic and Management Jurnal Online Mahasiswa (JOM) Bidang Ilmu Ekonomi ARABIYAT SHAHIH : Journal of Islamicate Multidisciplinary Asy-Syir'ah: Jurnal Ilmu Syari'ah dan Hukum The Indonesian Biomedical Journal Jurnal Geologi dan Sumberdaya Mineral (Journal of Geology and Mineral Resources) RETORIKA: Jurnal Bahasa, Sastra, dan Pengajarannya Jurnal Akuntansi dan Ekonomika Al-I´lam: Jurnal Komunikasi dan Penyiaran Islam FENOMENA KABILAH : Journal of Social Community Al-Ma'rifah : Jurnal Budaya, Bahasa dan Sastra Arab Jurnal Inovasi Penelitian dan Pengabdian Masyarakat JILSA (Jurnal Ilmu Linguistik dan Sastra Arab) Cermin Dunia Kedokteran Journal Of Human And Education (JAHE) Jurnal Pengabdian Masyarakat Bestari (JPMB) TEKNOLOGI NUSANTARA Transform : Journal of English Language Teaching and Learning Research Horizon AL-MAFAZI: JOURNAL OF ISLAMIC EDUCATION MANAGEMENT Jurnal Geologi dan Sumberdaya Mineral (Journal of Geology and Mineral Resources) Lughawiyyat: Jurnal Pendidikan Bahasa dan Sastra Arab ALMUSTOFA: Journal of Islamic Studies and Research Service
Luthfi, Muhammad
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Journal : The Indonesian Biomedical Journal

 1 
Risk Assessment in Hereditary Colorectal Cancer Family by Using APC and MSH2 mRNA Gene Expression and Bayesian Analysis Tjahjadi Robert Tedjasaputra; Mochammad Hatta; Muhammad Nasrum Massi; Rosdiana Natzir; Ilhamjaya Patellongi; Marcellus Simadibrata; Ibrahim Labeda; Rina Masadah; Muhammad Luthfi Parewangi; Prihantono Prihantono; Andi Asadul Islam; Agussalim Bukhari; Budu Budu; Rinda Nariswati
The Indonesian Biomedical Journal Vol 12, No 4 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i4.1329

Abstract

BACKGROUND: Some of colorectal cancers (CRCs) are familial, however, heterozygote relatives have approximately 80% lifetime risk of cancer. Risk assessment of CRC’s family could be calculated by direct measurement of mRNA gene expression and Bayesian theorem which is modifying initial background of pedigree risk with additional conditional information. This application has not been reported.METHODS: The cross-sectional translational sequential studies were performed: (1) adenomatous polyposis coli (APC) and MutS homolog (MSH)2 mRNA quantitative RT PCR gene expressions in tissue and whole blood CRC patients; (2) gene expression was determined in matched controls; and (3) pedigree and Bayesian analysis was calculated in the patient’s family of Proband.RESULTS: Fourty CRC and 31 control subjects were enrolled. The mean blood APC level control’s group was 13,261±670 fold-change (fc) and blood MSH2 level was 12,219±756 fc. The cut-off points for hereditary APC was 12,195 fc and MSH2 was 11,059 fc. The mean APC blood level in CRC subject was 11,578±2,638 fc and MSH2 blood level was 11,411±2,912 fc. There were significant differences APC and MSH level between tissue and blood level in CRC. Eight of 40 CRC subjects had a history of familial CRC. Four patients and 10 Probands were available for recurrence risk evaluation of pedigree analysis, RNA PCR quantitative and Bayesian calculation.CONCLUSION: There was determined a cut-off point of hereditary mRNA quantitative expression. The APC and MSH2 levels in CRC subjects were significantly lower than controls. Bayesian analysis allowed for the calculation of relative risk in CRC family members and considered in clinical practice.KEYWORDS: hereditary CRC, APC gene, MSH gene, Bayesian analysis
Co-Authors -, Irmayanti Adhi Syahbani Ahmidi, Ahmidi Akbar Cita Aldo Yanuarto, Aldo Yanuarto Alfananda, Rizqi Alfarizi, Muhammad Imam Alfiati Silfi Alhamdani, Alhamdani Ali Akbar Amie Kusumawardhani, Amie Andi Asadul Islam Arifuddin Arifuddin Arifudin arifudin Arummi, Afnan Azhari, Jihan Dzakiyyah Bachtiar, Rini R Bachtiar, Rini R Budu - Bukhari, Agussalim Claudianty, Grandita Satira Daud, Numan AS Delyara, Dea Ayu Dian Novita Eva Farhah, Eva Fajar Nugraha Fardah Akil Fatman, Yenni Fionasari, Dwi Fitriani Agustin, Fitriani Himmawan, Gathot Ibrahim Labeda Ilhamjaya Patellongi Inge Triguri Iwan Satriyo Nugroho, Iwan Satriyo Nugroho Khairul Umam Kusuma, Susanto H Laili, Aizzatul Luqman Hakim, Luqman Hakim Marcellus Simadibrata Masita, Tuti Syaima Maylana, Aninda Nisa Mochammad Hatta Mochammad Rafi, Mochammad Rafi Moh.Ibnu Sholeh Muh. Nasrum Massi Muhammad Alfikri Muhammad Dhiyaurrahman Hanafi Muhammad Iqbal Arrasid Muhammad Natsir Muhammad Natsir Muhammad Ridwan Muhammad Sahdan Siregar, Muhammad Sahdan Siregar Muhammad Yunus Anis Musyrifa, Furaida Ayu Nasir, Yazid Qomar Abdul Nur Azlina Nur Ila Ifawati NUR, siti Nurul Hak Popy Yuliarty, Popy Prastowo, Dwi Ady Prihantono Prihantono Putri, Annie Mustika Rafika Ratik Srimurni, Rafika Ratik Srimurni Rantiyo, Rantiyo Regia Dwi Umbara Reza Sukma Nugraha, Reza Sukma Rifai, Amelia Rina Masadah Rinda Nariswati Rizqia, Asa Qubaila Sitta Zidna Rohman Rosdiana Natzir Roseptry, Ricky Samad, Ibrahim Abd. Siti Nur, Siti Nur Suci, Rama Gita Suhadah Suhadah, Suhadah Susilo Toto Raharjo Syaf Putra, Rudi Syahnaz Khairunnisa Syihabuddin Syihabuddin Tjahjadi Robert Tedjasaputra Triyanti Nurul Hidayati Uleng Bahrun, Uleng Varhah, Eva Widji Indahing Tyas Wildana Wargadinata Yuliana Fatmawati, Yuliana Fatmawati Zamzami Dhiyaul Ulum