Article Per Year (5 Year)
p-Index From 2020 - 2025
2.304
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences Jurnal Hortikultura Indonesia (JHI) Microbiology Indonesia Media Penelitian dan Pengembangan Kesehatan Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati PROSIDING SEMINAR KIMIA BERITA BIOLOGI JURNAL BIOLOGI INDONESIA ZOO INDONESIA International Journal of Applied Biology Jurnal Fitofarmaka Indonesia ANNALES BOGORIENSES Journal of Tropical Crop Science Teknologi Indonesia Zoo Indonesia Makara Journal of Science Molekul: Jurnal Ilmiah Kimia Indonesian Journal of Jamu Annales Bogorienses Berita Biologi
ANDRIA AGUSTA
Research Center For Biology, Indonesia Institute Of Sciences (LIPI), Cibinong, Bogor 16911, Indonesia
Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

Published : 62 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 62 Documents
Search

 3   4   5   6   7 
ISOLATION AND IN VITRO BIOASSAYS OF ENDOPHYTIC FUNGI ASSOCIATED WITH LIDAH BUAYA (Aloe vera (L.) Burm.f.) Raunsai, Marlin Megalestin; Octavia Siti Nurhayati; Andi Saptaji Kamal; Praptiwi; Kartika Dyah Palupi; Muhammad Ilyas; Rahmawati Ridwan; Evana; Andria Agusta
Berita Biologi Vol 23 No 2 (2024): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/beritabiologi.2024.3879

Abstract

Endophytic fungi are fungi that live in plant tissues that do not cause disease symptoms, do not harm the host plant, and can produce secondary metabolites such as antibacterial, antifungal, and antiviral compounds. This study was conducted to isolate and evaluate the antibacterial and antioxidant activities of endophytic fungi from Aloe vera (L.) Burm.f. against Staphylococcus aureus and Escherichia coli bacteria. The antibacterial activity test was carried out qualitatively by thin layer chromatography-direct-bioautography (TLC-DB), and microdilution methods were used for the antibacterial assay against Staphylococcus aureus and Escherichia coli. Antioxidant activity was determined against DPPH using TLC-DB and the microdilution assay. Antibacterial results showed that the extracts LBB-2.4, LBB-2.2, LBAu-1.1 and LBAu-2.1 could inhibit the growth of S. aureus. Meanwhile, extracts of endophytic fungi with the isolate codes LBB-2.4, LBB-2.1, LBAp-3, LBAp-1, LBAu-1.1 and LBAu-2.1 could inhibit the growth of E.coli. The results of Minimum Inhibitory Concentration (MIC) showed that isolate LBB-2.1 had moderate antibacterial activity with a MIC value of 256 μg/mL against S.aureus. The extracts showed weak antioxidant activity against DPPH. It can be concluded that endophytic fungi extracts from Aloe vera have potential activity as antibacterial agents.
Colletotrichum sp. from Nutmeg Leaves Shows Antiproliferative Activity Against MCF-7 Cancer Cells: In Vitro Evaluation, Metabolite Profiling, and Docking Analysis Aisyah, Siti; Suryati, Suryati; Putra, Agus Budiawan Naro; Palupi, Kartika Dyah; Rahmi, Dwinna; Ilyas, Muhammad; Agusta, Andria
Molekul Vol 20 No 3 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.3.16748

Abstract

ABSTRACT. Endophytic fungi are recognized as a valuable source of bioactive compounds with significant therapeutic potential, with species from the genus Colletotrichum being particularly noted for their prolific production of structurally diverse secondary metabolites. This study aimed to evaluate the antiproliferative activity of the endophytic fungus Colletotrichum sp., isolated from the leaves of Myristica fragrans Houtt., commonly known as nutmeg against MCF-7 human breast cancer cells using an integrated in vitro and in silico approach. Bioassay-guided fractionation of the fungal extract followed by LC-HRMS analysis led to the identification of three major compounds: 2-amino-1,3,4-octadecanetriol, L-α-palmitin, and muscone-like compound. The antiproliferative activity of each subfraction was assessed using the MTT assay, while molecular docking studies were conducted to evaluate their binding affinities and interaction profiles with estrogen receptor α (ERα). Among the tested subfractions, F2.3 demonstrated the strongest antiproliferative activity, reducing MCF-7 cell viability to 22.08% at a concentration of 50 µg mL-1. The identified compounds demonstrated notable antiproliferative potential, with L-α-Palmitin showing the moderate binding affinity to ERα as indicated by a binding energy of -6.406 kcal mol-1. Molecular docking analyses revealed key interactions, including hydrogen bonding and hydrophobic contacts, contributing to receptor-ligand stability. These findings highlight Colletotrichum sp. as a promising source of antiproliferative agents, thus warranting further investigation into the isolation, structural characterization, and in vivo validation of its active constituents for potential pharmaceutical development. Keywords: antiproliferative, Colletotrichum sp., endophytic fungi, LC-HRMS, Myristica fragrans Houtt., secondary metabolites.
Co-Authors A.A. Ketut Agung Cahyawan W Agus Budiawan Naro Putra Ahmad Fathoni AHMAD FATHONI Ahmad Fathoni Andi Saptaji Kamal Anita, Syahfitri Antonius Herry Cahyana Antonius Herry Cahyana ARIEF NURKANTO Arif Nurkanto Arif Nurkanto Arif Nurkanto Atit Kanti Chairul Chairul Chairul Chairul DEWI WULANSARI Dewi Wulansari Dwinna Rahmi Edi Santosa Efendi, Darda Efendi, Sintia Frisky Efendy, Oscar Efendy, Oscar Effendi, Oscar Elsera Br Tarigan, Elsera Br Evana Farida, Yunahara Hafid, Lukman Hartutiningsih-M. Siregar Heddy Julistiono HEDDY JULISTIONO Herjuno Ari Nugroho, Herjuno Ari Inanpi Hidayati Sumiasih, Inanpi Hidayati Kamal, Andi Saptaji Kartika D. Palupi Kartika Dyah Palupi Kartika Dyah Palupi Kartika Dyah Palupi Keim, Ary P Koraag, Alfa Michael Gabriel Lestari, Vera Budi lina marlina, lina Listyaningsih, Febrianti Listyaningsih, Febrianti Marlin Megalestin Raunsai Mohammad Fathi Royyani, Mohammad Fathi Muhamad Ilyas Muhamad Ilyas, Muhamad Muhammad Ilyas Muhammad Ilyas N.L.P. Rischa Phadmacanty Octavia Siti Nurhayati Palupi, Kartika D. Pariwidjayanti, Aris Medta Pariwidjayanti, Aris Medta Partomuan Simanjuntak Phadmacanty, N.L.P. Rischa Pipit Irawati Praptiwi Praptiwi Praptiwi Praptiwi Praptiwi Praptiwi Praptiwi Praptiwi, Praptiwi, - Putra, Aldho Pramana Putri, Ade Lia R. Subekti Purwantoro Rahmat Budiarto Rahmawati Ridwan Raunsai, Marlin Megalestin Roedhy Poerwanto Rofiq, Muhamad Abdul Royani, M Fathi S. Achmadi, Suminar S. Achmadi, Suminar Siti Aisyah Sri Yuliani SUDARMONO SUDARMONO Suryati Suryati Tarigan, Elsera Br. Taruna Shafa Arzam, Taruna Shafa Tiwi, Praptiwi Wartika Rosa Farida Wellyzar Sjamsuridzal Yuliasri Jamal YULIASRI JAMAL