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All Journal Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia Pharmascience Jurnal Surya Medika As-syifaa Jurnal Farmasi Jurnal Kesehatan Medika Saintika JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Katalisator JFIOnline Majalah Kedokteran Andalas Jurnal Farmasi Higea Medical and Health Science Journal Human Care Journal Jurnal Ners JPK: Jurnal Proteksi Kesehatan Indonesian Journal of Multidisciplinary Science

Helmi Arifin

Universitas Andalas

Author-ID : 232638

Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Pengaruh Ekstrak Etanol Daun Binahong (Anredera Cordifolia (Tenore) Steen) Terhadap Penyembuhan Luka Sayat Pada Tikus Putih Jantan Aried Eriadi; Helmi Arifin; Zet Rizal; Barmitoni Barmitoni
Jurnal Farmasi Higea Vol 7, No 2 (2015)
Publisher : STIFARM Padang

Wound healing is a normal process as responds by the skin tissue injury. This research is purposed to see the effects of ethanol extract in binahong leaf to healing the wound of male white rats. There are rats which are divided into five treatment groups, group I (negative control), group II is given providone iodine 10% (positive control), group III, IV and V are given the extract of binahong leaf ointment consist of 5%, 10%, 15% for each. By making a wound on the back of the rats about 20 mm long and 2 mm deep. The ointment is applied based on the treatment for each group twice a day during ten days, the lenght count every day by using caliper. The data is analyzed by using two ways ANOVA and continued by Duncan Test. The result showed that ethanol extract in binahong leaf can heal the wound in scale concentration about 10%-15%, length of wound was decrease on seventh day. The more extract concentration given, the more effect in wound healing

Pengaruh Ekstrak Etanol Daun Binahong (Anredera Cordifolia (Ten.) Steenis Terhadap Ph Dan Tukak Lambung Pada Tikus Putih Betina Helmi Arifin; Rosa Julia Wijaya; Zet Rizal
Jurnal Farmasi Higea Vol 6, No 1 (2014)
Publisher : STIFARM Padang

The effect of binahong (Anredera cordifolia (Ten.) Stennisleaves extract ethanol on pH and gastric ulcers in female rats were induced by 1 ml/200 gram body weight by oral admistration. The parameter taken to asses antiulcer activity were change of gastric acid pH and ulcer index to normal condition. The result indicated that the binahong leaves extract at doses of 30 mg, 100 mg and 300 mg/Kg BB body weight significantly decreased the ulcer index with curative ratio were 38.62 %, 52.41 % and 57.01 % (for one daily of extracts for two days), 60.84 %, 78.74 % and 82.32 % (for one daily of extracts for four days) and 79.91 %, 93.86 % and 95.98 % (for one daily of extracts for two days) with respect to control group. The extracts at 30 mg, 10 mg and 300 mg/Kg BB body weigth also significanthy decreased the gastric acid pH to its normal value (P<0.05).

Toksisitas Akut Ekstrak Etanol Daun Jambu Bol (Eugenia malccensis L.) Helmi Arifin; Novika Maulina; Zet Rizal
Jurnal Farmasi Higea Vol 1, No 2 (2009)
Publisher : STIFARM Padang

The research of acute toxicity of the etanolic extract of the leave of Jambu Bol (Eugenia malaccencis L.) has been done. Parameter measure were LD50 and the delay toxic effect during 14 day observation covering body weight, water intake, urine output, and relative weight of the liver, heart, and kidney. The toxicity by oral administration of the leave of Jambu Bol (Eugenia malaccencis L.) with dose 16 g/kg BB. that showed the etanolic extract of leave Jambu Bol (Eugenia malaccencis L.) is practical not toxic category (LD50 > 15 g/kg BB). The delay toxic effect was seen by significant changes in body weight and water intake, and was not see significant changes in urine output and the relative weight.

Efek Diuretik dan Daya Larut Batu Ginjal Dari Ekstrak Daun Mangkokan (Nothopanax scutellarium. Merr) Elisma Elisma; Fitri Maya Sari; Helmi Arifin
Jurnal Farmasi Higea Vol 2, No 1 (2010)
Publisher : STIFARM Padang

Research on the effects of diuretics and solubility of kidney stones of Mangkokan leaf (Nothopanax scutellarium Merr.) extract has been done. Testing the solubility of kidney stones performed on 4 groups of test animals, namely the control group (without extract), The treatment dose groups of 0.5%, 1%, and 2%. Level of kidney stones are dissolved in the control group, 0.5%, 1% and 2% are 0.00521%, 0.01232%, 0.02433% and 0.05669% respectively. These result indicate a difference in dissolving kidney stones. Diuretic effect tested on 15 white male rats were divided into 5 groups of tests, one positive control group (furosemide), 1 negative control group (tween 80 1%), 3 treatment groups (doses of 125; 250 and 500 mg/kg BW). The result showed that all of three doses of extract have diuretic effect.

Pengaruh Ekstrak Etanol Herba Pecut Kuda Stachytarpheta jamaicensis (l.) Vahl Terhadap Fungsi Hati Dan Kreatinin Urin Mencit Putih Jantan Elisma Elisma; Deni Kurniati; Helmi Arifin
Jurnal Farmasi Higea Vol 2, No 2 (2010)
Publisher : STIFARM Padang

Research on the effect of ethanol extract of pecut kuda (Stachytarpheta jamaicensis (L) Vahl) against liver and kidney function in male white mice have been done. Extracts administered orally with various doses of 150, 300 and 600 mg / kg bw once daily for 15, 30 and of 45 days. As a control group used white males mice who were given only 0.5% Na CMC. Activity SGPT and SGOT, creatinine clearance, renal function and the percentage ratio of organ weight were measured. The result showed that the extract at given doses effects liver function (p<0.05) and not effects the urinary creatinine levels (p> 0.05)

Pengaruh Ekstrak Etanol Daun Sukun (Artocarpus Altilis (Parkinson Ex F.A. Zorn) Fosberg) terhadap Kadar LDL (Low Density Lipoprotein) pada Mencit Putih Jantan Hiperkolesterol Helmi Arifin; Zet Rizal; Meri Susilawati
Jurnal Farmasi Higea Vol 7, No 1 (2015)
Publisher : STIFARM Padang

The research has been about effect of ethanol extract of breadfruit leaves (Artocarpus altillis (Parkinson ex F.A. Zorn) Forsberg) to cholesterol levels in white male mice. Mice used 45 individuals were divided into 5 groups of animal that group I as a negative control group was given only the standard diet food. Group II is the positive control induced hight-fat foods and suspension PTU. Group III, IV and V are given foods containing high fat and suspension PTU with extract variations along with dose of 100, 300, and 900 mg/kg body weight once a day for 7,14 and 21. Then LDL levels measured on day 7, 14, and 21. The results of resarch showed that there are variations influence the dose and duration of administration of the decreased levels of blood LDL white male mice. The highest levels decrease at a dose of 900 mg/kg for 21 day.

Kajian Efek Stimulan Dari Beberapa Minuman Energi Kemasan Sachet Yang Beredar Di Pasaran Zet Rizal; Candra Syuryani; Helmi Arifin
Jurnal Farmasi Higea Vol 5, No 2 (2013)
Publisher : STIFARM Padang

A research of some sachet energy drinks on the market on the activity of the central nervous system stimulant for white mice (Mus musculus, L.) has been done. The samples labelled Minuman Energi Sachet MES 1, MES 2, MES 3, MES 4 and MES 5 and administered perorally. Parameters used for stimulant activity were endurance tested using Rotary road, while motoric activity and curiosity tested using Automatic Hole Board. Each sample has administration volume of 0.52 ml/20 g BW. Comparator ued is caffeine 0.13 mg/ 20 g BW. From the research that has been done, it is known that MES 1, MES 2, MES 3, MES 4 and MES 5 has a central nervous system stimulant activity by increasing endurance, motoric activity and curiosity in mice significantly.

Penggunaan Antibiotik Pada Bangsal Mata RSUP Dr. M. Djamil Padang Tahun 2005 sampai dengan Tahun 2007 Zet Rizal; Rostin Rostin; Helmi Arifin
Jurnal Farmasi Higea Vol 1, No 2 (2009)
Publisher : STIFARM Padang

Research about usage of antibiotic at Barn Eye of RSUP DR. M. Djamil Padang to year 2005 up to 2007. Result of obtained research pursuant to data of retrospective at cataract patient, pterigium, tumor and conjunctivitis show eye patient which is higher infection of year 2005 equal to 19.49 % year 2006 equal to 18.57 % year 2007 equal to 25.67 %. So that usage of high antibiotic also in the year 2005 equal to 47.37 %. year 2006 equal to 79.79 %. year 2007 equal to 45.26 %. Usage of antibiotic pursuant to precisely indication at disease of cataract, pterigium, tumor and conjunctivitis at precise eye patient 100 % in the year 2005 up to 2007. Precisely dose usage of antibiotic at cataract patient of pterigium, tumor and konjungtivitis at precise eye 100 % in the year 2005 up to 2007. Usage of correct antibiotic of patient, precise of drug, precise is way of wearing, at type medicines amoxicillin, chloramphenicol, and precise siprofloxacin 100 % in the year 2005 up to 2007. From result of interview obtained at patient which less than five day taken care of to get continuation recipe to go home.

Studi Cross Sectional Pelayanan Informasi Obat Diabetes Melitus Tipe 2 Terhadap Keberhasilan Terapi Pasien Usia Lanjut Di Rawatan Inap Penyakit Dalam RSUP Dr. M. Djamil Padang Helmi Arifin; Widya Kardela; Hafizah Hafizah
Jurnal Farmasi Higea Vol 12, No 1 (2020)
Publisher : STIFARM Padang

Diabetes melitus tipe 2 adalah penyakit gangguan metabolik yang ditandai oleh kenaikan gula darah akibat penurunan sekresi insulin oleh sel beta pankreas dan atau gangguan fungsi insulin. Diabetes pada usia lanjut berbeda secara metabolik dengan diabetes pada kelompok usia lainnya, sehingga diperlukan pendekatan terapi pada kelompok usia ini. Salah satu permasalahan utama pengobatan Diabetes melitus (DM) tipe 2 adalah rendahnya kepatuhan pasien terhadap pengobatan dan kurangnya pemahaman terhadap instruksi pengobatan hipoglikemik oral pada terapi DM tipe 2. Kepatuhan dalam mencapai keberhasilan pengobatan dapat ditingkatkan dengan pemberian informasi obat (PIO) yang dapat mempengaruhi tingkat pemahaman pengobatan. Penelitian ini bertujuan untuk mengetahui pengaruh pelayanan informasi obat Diabetes melitus tipe 2 terhadap keberhasilan terapi pasien usia lanjut di RSUP DR. M. DJAMIL Padang. Penelitian ini menggunakan metode cross sectional yang dilakukan pada bulan April - Juli 2019 dengan sampel 18 responden pasien Diabetes melitus tipe 2. Kuesioner yang digunakan telah dilakukan uji validitas serta reabilitas. Penentuan sampel dilakukan dengan cara non probability sampling, berdasarkan kriteria inklusi dari penelitian. Berdasarkan uji regresi linear didapatkan nilai T = 1,999 p= 0,000 (p < 0,05) dan nilai R square sebesar 0,382 atau 38,25%. Pelayanan informasi obat berpengaruh terhadap keberhasilan terapi pasien diabetes melitus tipe 2 usia lanjut.

Pengaruh Ekstrak Daun Binahong (Anredera Cordifolia (Tenore) Steen) Terhadap Volume Urin Dan Hambatan Pembentukan Batu Ginjal Pada Tikus Terinduksi Etilen Glikol Helmi Arifin; Vivi Resviana; Elisma Elisma
Jurnal Farmasi Higea Vol 6, No 2 (2014)
Publisher : STIFARM Padang

Research on the effect of binahong leaf extract (Anredera Cordifolia (Tenore) Steen) on urine volume and resistance kidney stone formation in rat induced by ethylene glycol has been done. It purposed to look up the ability of the binahong leaf extract to increase the urine volume and kidney stones shed on rats white males. That kidney stone formation induced by 0,75% ethylene glycol and 2% ammonium chloride for 7 days. 25 white male rats were divided into 5 groups, group I were given drinking water (negative control), group II in the induction for 7 days (positive control), group III, IV and V were induced dose groups and given the extract at a dose of 50 mg/kg BB, 150mg/kg BB and 450mg/kg BB. Extracts was given on day 8-28, 24-hour urine volume were collected on days 7, 14, 21 and 28 for calcium level was measured by atomic absorption spectrophotometer and oxalat levels with ultraviolet and visible spectrophotometer. Data were analyzed by two-way ANOVA followed by advenced Duncan test. The urine volume was not significantly influenced by treatment factors and the duration of administration (P>0.05), while the levels of calcium and oxalat significantly influenced by treatment factors and the long time of administration (P<0.05) based on these results it could be concluded that binahong leaf extract could increase the urine volume and kidney stones shed. The effective dose is the dose kidney stone shed 450mg/kgBB. So the higher the dose and the longer the time of administration of calcium and oxalate levels also increased in the urine volume of rat white males.

Co-Authors -, Risfaheri ., Nirwanto Agustini, Tiara Tri Akmal M. Hanif Almahdy Almahdy Ariadi, Aried Aried Ariadi Aried Eriadi Arina Widya Murni Asram Ahmad Barmitoni Barmitoni Benny Benny Bobbi Hemriyantton Candra Syuryani Dahlyanti, Rina Delladari Mayefis Deni Kurniati Deswinar Darwin Dewi Eka Putri Dian Ayu Juwita Diana Idrifa Dwisari Dillasamola Eddy Duarto Elisma Elisma Elisma Elisma Elka Elka Ella Handalia Endang Purwati RN Erlina Rustam Fajrian Aulia Putra Fathul Jannah Feni Efrianti Fitri Maya Sari Gina Sonia Harto H. Havizur Rahman Havizur Rahman Hengki Afdhal Henny Lucida Heppy Riyono Hesti Effendi Hidayat, Zoni Hidayati Hidayati Hilmarni Hilmarni Ifora Ifora Ira Oktaviani Rz Jaka Perdana Leli Sriyani Machdawaty Masri Masitah Masitah Menkher Manjas Meri Andani Meri Susilawati Merry C, Ann Murni, Yulia Nasrul Zubir Nela Andriani Nelfa Yulianti Nelwati, Nelwati Netty Suharti Nirwanto . Nirwanto Nirwanto Nofiza, Welli Novi Priyoka Putra Novika Maulina Octy Aisyahharma Rahimatul Uthia Rahimatul Uthia Rahman, Havizur Rahmi Yosmar Rahmi Yulia Nesia Randika Fransiska RAVEINAL RAVEINAL Raveinal Raveinal Raveinal Raveinal Rella Silvia Reni Trevia Ria Irawati Rina Dahlyanti Ririn Anjelin Risfaheri - Rizky Yulion Rosa Julia Wijaya Rostin Rostin Rusdi Rusdi Rusdi Saputra, Harry Saputra, Harry Satrina Chania Sinata, Novia Solly Aryza Sri Ana Setianingsih Sri Oktavia Sri Oktavia Suci Ahda Novitri Suhatri Suhatri Sumanti, Titi Sumaryati Syukur Surya Dharma Susi Handayani Tesa Inmerka Alwi Titi Sumanti Vivi Resviana Wesnawati, Wesnawati Widya Kardela Wildra Martoni Yulia Murni Yuliana Arsil Yuni Andriani Zet Rizal Zet Rizal ZK Abdurahman Baizal Zoni Hidayat

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