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All Journal Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia Pharmascience Jurnal Surya Medika As-syifaa Jurnal Farmasi Jurnal Kesehatan Medika Saintika JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Katalisator JFIOnline Majalah Kedokteran Andalas Jurnal Farmasi Higea Medical and Health Science Journal Human Care Journal Jurnal Ners JPK: Jurnal Proteksi Kesehatan Indonesian Journal of Multidisciplinary Science

Helmi Arifin

Universitas Andalas

Author-ID : 232638

Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Efek Diuretik dan Daya Melarutkan Batu Ginjal Dari Ekstrak Herba Pecut Kuda (Stachytarpheta jamaicensis (L)Vahl) Helmi Arifin; Masitah Masitah; Elisma Elisma
Jurnal Farmasi Higea Vol 2, No 1 (2010)
Publisher : STIFARM Padang

The herbal extract of pecut kuda’s potencies on dissolving kidney stones and it’s diuretic effect has been studied. Test dissolve kidney stones performed in vitro by dissolving the crystals or stones are usually found in the kidney. Test were carried out at 4 treatment groups, control (no extract), 0.1%; 1% and and 2% groups. In the control group, the levels of dissolved kidney stones at 52.116 ppm, while the group of 0.5%, 1% and 2% at 56.140 ppm, 61.592 ppm and 76.602 ppm respectively. One-way ANOVA test result and test advanced non-parametric Kruskal-wallis test showed that of the three consentrations of the extract has a difference in dissolving kidney stones. Diuretic effect tested on 15 white male rats were divided into 5 groups, where in the extract is administered orally. The test group was divided into a positive group (furosemide), 1 negative group (given Na-CMC) and the 3 treatment groups (125; 250 and 500 mg/kg BW). Volume of rat urine into variable observations. Based on the results of two-way ANOVA test and test advanced non-parametric Friedman test show that all three doses of the test has diuretic effect. So that the conclutions of this study are horse whip herbal extracts can dissolve kidney stones and has a diuretic effect on test animals.

Pengaruh Hasil Fraksinasi Ekstrak Daun Kemangi (Ocimum sanctum L.) Terhadap Aktivitas Susunan Saraf Pusat Pada Mencit Putih Jantan Rahimatul Uthia; Helmi Arifin; Feni Efrianti
Jurnal Farmasi Higea Vol 9, No 1 (2017)
Publisher : STIFARM Padang

Study about activity of the central nervous system stimulant of breadfruit’s leaf the water fraction Ocimum santum L. Using experimental animals male white mice (Mus musculus, L) has been done. Breadfruit’s leaf the water fraction at a dose of 25 mg/kg BW, 50 mg/kg BW and 100 mg/kg BW given to mice orally 15 days. Stimulant activity was tested on day -5, -10 and -15. As a comparison used caffeine 13 mg/kg BW while luminal 50 mg/kg BW is used to test a long sleep induction and sleep in mice. Parameters used stimulant activity is endurance test with Rotary road equipment, test sensor activity and test motor activity wiht a Automotic hole board and sleep induction test and a long sleep. From the research that has been done, it is know that kemangi leaf the water fraction at a 25 mg/kg BW, 50 mg/kg BW and 100 mg/kg BW have a central nervous system stimulan activity by increasing endurance, sensor activity and motor activity as well as increase the time to accelerate the induction of sleep and long sleep in mice sigficantly (P>0,05).

Pengaruh Ekstrak Etanol Daun Mangkokan (Nothopanax scutellarium. Merr) Terhadap Fungsi Hati Dan Kadar Kreatinin Urin Mencit Putih Jantan Helmi Arifin; Rahmi Yulia Nesia; Elisma Elisma
Jurnal Farmasi Higea Vol 3, No 2 (2011)
Publisher : STIFARM Padang

The effect of ethanolic extract of Nothopanax scutellarium. Merr on liver function and urine creatinine level of male white mices had been done. The extract was administered orally with variation of dose at 150, 300, 600 mg/kg BB one times a day for 15, 30, 45 days. As a control group was used male white mices that administered only Na CMC 0,5% solution. The result showed that administered of ethanolic extract Nothopanax scutellarium. Merr at variation of dose did not influence on liver function and urine creatinine level (p>0,05).

Efek Ekstrak Etanol Daun Cacao Theobroma Cacao L. terhadap Aktifitas Sistem Saraf Pusat Zet Rizal; Harto H.; Helmi Arifin
Jurnal Farmasi Higea Vol 1, No 1 (2009)
Publisher : STIFARM Padang

The research about stimulant activity of the central nervous system from the ethanol extract of cacao leaves ( Theobroma cacao L.) to mice ( Mus musculus ) has been done. The observation of stimulant activity from the other doses gives to experiment of animal with oral. It does with rota – road tools, the motoric of activity test, automatichole board tools and the times of inductive sleep and the long time sleep by mice with 50 mg/Kg BB i.p doses. The finalty reseach knows that ethanol extract of cacao leaves with 250 and 500 mg/Kg BB doses characteristic stimulant. It looks that mount the power of venture, activity motoric, feel knows, the time of inductive sleep and the short time with experiment of animal if it compare with control group.

Pengaruh Pemberian Ekstrak Etanol Daun Sisik Naga (Pyrrosia piloselloides (L.) M. G Price) Terhadap Waktu Pendarahan, Waktu Pembekuan Darah dan Jumlah Trombosit Mencit Putih Jantan Sri Oktavia; Helmi Arifin; Eddy Duarto
Jurnal Farmasi Higea Vol 9, No 1 (2017)
Publisher : STIFARM Padang

Research on the effect of ethanol extract of leaf dragon scales (Pyrrosia piloselloides (L.) M. G Price) against clotting time, bleeding time and the number of platelet cells in mice white male. The parameters observed owere the bleeding time, clotting time of blood by the method of the slide and the number of platelet cells by direct calculation method. Animal experiment was divided into 5 groups: negative control group, the dose of 100 mg/kg BW, a dose of 200 mg / kg BW, a dose of 400 mg/kg BW, and by comparison of vitamin K at a dose of 0,026 mg / kg orally. Effects were observed on day 7, 14 and 21. The study showed that ethanol extract leaf dragon scales (Pyrrosia piloselloides (L.) M. G Price) can shorten the bleeding time, shorten the clotting time of blood and increase the number of cells platelet white male mice. A dose of 400 mg/kg BW has been giving maximum effect in shorten bleeding time, shorten the clotting time of blood and can increase the number of platelet cells in mice white male.

Pengaruh Ekstrak Etanol Daun Kemangi (Ocimum sanctum L.) Terhadap pH dan Tukak Lambung Pada Tikus Putih Jantan Sri Oktavia; Helmi Arifin; Ria Irawati
Jurnal Farmasi Higea Vol 7, No 2 (2015)
Publisher : STIFARM Padang

The effect of basil (Ocimum sanctum L.) leaf ethanolic extract on pH and gastric ulcers in male rats induced by ethanolic absolute 1 mL /200 g BW orally has been evaluated. The observed parameters where pH change gastric liquid and ulcer index value. The result indicated that the basil (Ocimum sanctum L.) leaf ethanolic extract at doses of 100 mg/KgBW. 300 mg/KgBW and 900 mg/KgBW significantly decreased the ulcer index with curative ratio where 45.82 %, 62.94 % and 80.65 % (for one time given extracts for two days), 49.13 %, 77.69 % and 94.62 % (for one time given extract for four days) 52.71 %, 77.67 % and 97.21 % (for one time given extract for six days) compared to the positive control. The extracts at 100 mg/KgBW, 300 mg/KgBW and 900 mg/KgBW also significantly decreased the gastric acid pH to its normal value (P<0.05).

Efek Analgetik Ekstrak Etanol Daun Kemangi (Ocimum sanctum L.) Pada Mencit Putih Jantan Erlina Rustam; Helmi Arifin
Jurnal Farmasi Higea Vol 12, No 1 (2020)
Publisher : STIFARM Padang

Telah dilakukan penelitian tentang efek analgetik dari ekstrak etanol daun kemangi (Ocimum sanctum L.) pada mencit putih jantan dengan metoda plat panas. Penelitian ini menggunakan 5 kelmpok mencit putih jantan yang tiap kelompoknya terdiri dari 5 ekor, yaitu kontrol negative (vehiculum) dan pembanding (asammefenamat 65 mg/kgBB) masing-masing satu kelompok dan tiga kelompok lainnya perlakuan terhadap 3 tingkatan dosis ekstrak yang diberikan secara oral yaitu 200mg/kgBB, 400mg/kgBB dan 800mg/kgBB. Pengamatan dilakukan setiap setengah jam selama 3 jam. Induksi nyeri secara termik menggunakan plat panas. Parameter yang di amati berupa lamanya waktu (detik) yang diperlukan mencit untuk bertahan di atas plat panas mulai dari induksi sampai mencit melompat karena merasa panas. Analisa data dilakukan dengan ANOVA. Hasil penelitian menujukkan bahwa ketiga tingkatan dosis ekstrak yang diberikan mempunyai efek yang berbeda dengan kelompok kontrol negative. Semakin besar dosis ekstrak yang diberikan semakin besar pula efekanalgetik yang diberikan oleh sampel uji.

Uji Toksisitas Akut Ekstrak Etanol Daun Kirinyuh (Chromolaenodorata (L) R.M.King & H. Rob) Pada Mencit Putih Jantan Aried Eriadi; Helmi Arifin; Nirwanto Nirwanto
Jurnal Farmasi Higea Vol 8, No 2 (2016)
Publisher : STIFARM Padang

A research on the acute toxicity of ethanol extracts of leaves kirinyuh (Chromolaena odorata (L) R.M.King & H.Rob). Parameters observed toxicity is LD50 and delayed toxic effects for 14 days of observation including changes in weight, the volume of water consumption, and the relative weight of the organs of the heart, liver, kidneys, stomach and lungs. The extract ethanol leaves kirinyuh (Chromolaena odorata (L) R.M King & H.Rob) orally at a dose of 4 g/kgBB, 8 g/kgBB and 16 g/kgBB, showed that the ethanol extract of leaves kirinyuh (Chromolaena odorata (L) R.M King & H.Rob) categorized practically non-toxic (LD50> 15 g/kgBB). Delayed toxic effects are seen from the significant differences in body weight, the volume of water, relative organ weight of lung and stomach (P<0.05). There were no significant differences in the relative organ weight of the heart, liver and kidneys (P<0.05).

Pengaruh Ekstrak Daun Jati (Tectona grandis L.f) Terhadap Fungsi Hati Dan Fungsi Ginjal Pada Mencit Putih Jantan Elisma Elisma; Novi Priyoka Putra; Helmi Arifin
Jurnal Farmasi Higea Vol 3, No 2 (2011)
Publisher : STIFARM Padang

Study about sub acute toxicity of jati leaf extract toward white male mice has been done, which consist of SGPT activity for liver function test, creatinine clearance for kidney function test and organ’s weight ratio. The extract was administered orally once a day for 15, 30 and 45 days with variable dose of 150, 300 and 600 mg per kg body weight. The result showed that there were no significant effect of jati leaf extract administration to the SGPT activity, kidney function and organ’s weight ratio (p > 0.05).

Evaluasi Kualitas Hidup Pasien Gagal Ginjal Kronik Yang Mengalami Depresi di RSUP Dr. M. Djamil Padang Havizur Rahman; Helmi Arifin; Arina Widya Murni
Jurnal Farmasi Higea Vol 10, No 2 (2018)
Publisher : STIFARM Padang

Depresi merupakan gangguan psikiatri yang menonjolkan mood sebagai masalahnya, dengan berbagai gambaran klinis yakni gangguan episode depresif, gangguan sistemik, gangguan depresif mayor dan gangguan depresif unipolar serta bipolar. Depresi merupakan penyakit yang sering muncul terutama pada pasien penyakit kronis, salah satunya gagal ginjal kronik. Pada salah satu penelitian penelitian menemukan bahwa prevalensi depresi pada pasien gagal ginjal kronik yang menjalani hemodialisis mencapai 31,1%. Kualitas hidup merupakan sesuatu yang berhubungan dengan kesehatan yang bisa diartikan sebagai respon dari emosi penderita terhadap aktivitas sosial, emosi, pekerjaan dan hubungan antar keluarga, rasa bahagia atau senang, sesuai dengan harapan maupun kenyataan yang ada, adanya kepuasan dalam melakukan fungsi fisik sosial dan emosional, juga suatu kemampuan bersosialisasi dengan orang lain. Depresi diduga merupakan salah satu penyebab terjadinya penurunan kualitas hidup pasien. Tujuan: untuk mengetahui hubungan depresi terhadap kualitas hidup pasien gagal ginjal kronik. Metode: Jenis penelitian adalah cross sectional, dengan teknik pengambilan data judgment sampling. Penilaian depresi menggunakan Beck Depression Inventory-II (BDI- II), sedangkan kualitas hidup pasien gagal ginjal kronik menggunakan Short Form Health Questionnaire (SF-36). Hasil: Nilai rata-rata kualitas hidup pasien gagal ginjal kronik pada penelitian ini adalah 61,42 yang berarti kualitas hidup rata-rata pasien baik. Dari uji korelasi menggunakan uji spearman terdapat hubungan yang cukup kuat antara tingkat kualitas hidup dengan tingkat depresi, dimana diperoleh hasil pasien non-depresi memiliki kualitas hidup yang baik, dan sebaliknya (p<0,05). Kesimpulan: Terdapat hubungan yang sangat kuat antara depresi dengan kualitas hidup, dimana kualitas hidup pasien non-depresi lebih baik dari pada depresi. Oleh karena itu perlu perhatian yang khusus terhadap pasien gagal ginjal yang mengalami depresi.

Co-Authors -, Risfaheri ., Nirwanto Agustini, Tiara Tri Akmal M. Hanif Almahdy Almahdy Ariadi, Aried Aried Ariadi Aried Eriadi Arina Widya Murni Asram Ahmad Barmitoni Barmitoni Benny Benny Bobbi Hemriyantton Candra Syuryani Dahlyanti, Rina Delladari Mayefis Deni Kurniati Deswinar Darwin Dewi Eka Putri Dian Ayu Juwita Diana Idrifa Dwisari Dillasamola Eddy Duarto Elisma Elisma Elisma Elisma Elka Elka Ella Handalia Endang Purwati RN Erlina Rustam Fajrian Aulia Putra Fathul Jannah Feni Efrianti Fitri Maya Sari Gina Sonia Harto H. Havizur Rahman Havizur Rahman Hengki Afdhal Henny Lucida Heppy Riyono Hesti Effendi Hidayat, Zoni Hidayati Hidayati Hilmarni Hilmarni Ifora Ifora Ira Oktaviani Rz Jaka Perdana Leli Sriyani Machdawaty Masri Masitah Masitah Menkher Manjas Meri Andani Meri Susilawati Merry C, Ann Murni, Yulia Nasrul Zubir Nela Andriani Nelfa Yulianti Nelwati, Nelwati Netty Suharti Nirwanto . Nirwanto Nirwanto Nofiza, Welli Novi Priyoka Putra Novika Maulina Octy Aisyahharma Rahimatul Uthia Rahimatul Uthia Rahman, Havizur Rahmi Yosmar Rahmi Yulia Nesia Randika Fransiska Raveinal Raveinal RAVEINAL RAVEINAL Raveinal Raveinal Rella Silvia Reni Trevia Ria Irawati Rina Dahlyanti Ririn Anjelin Risfaheri - Rizky Yulion Rosa Julia Wijaya Rostin Rostin Rusdi Rusdi Rusdi Saputra, Harry Saputra, Harry Satrina Chania Sinata, Novia Solly Aryza Sri Ana Setianingsih Sri Oktavia Sri Oktavia Suci Ahda Novitri Suhatri Suhatri Sumanti, Titi Sumaryati Syukur Surya Dharma Susi Handayani Tesa Inmerka Alwi Titi Sumanti Vivi Resviana Wesnawati, Wesnawati Widya Kardela Wildra Martoni Yulia Murni Yuliana Arsil Yuni Andriani Zet Rizal Zet Rizal ZK Abdurahman Baizal Zoni Hidayat

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