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All Journal Jurnal Farmanesia Journal of Innovative and Creativity Jurnal ABDIMAS MUTIARA Jurnal Medika STIKes Kesehatan Baru
Marpaung, Jon Kenedy
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PENETAPAN KADAR NATRIUM PADA BUAH PISANG EMAS (Musa acuminata Colla.) SECARA SPEKTROFOTOMETRI SERAPAN ATOM Simanjuntak, Nelson; Marpaung, Jon Kenedy; Nasution, Pandapotan; Pratiwi, Tiara
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v7i1.2759

Abstract

Bananas are the most consumed fruit by the people of Indonesia. This fruit has many health benefits including improving digestion, treating anemia, healthy bones, and improving nerve function. The nutritional content contained in bananas is carbohydrates, sugar, dietary fiber, fat, protein, vitamins, and minerals such as sodium, calcium, magnesium, phosphorus, potassium, and zinc. This study aims to determine the sodium content in golden bananas. The assay was carried out using an air-acetylene flame atomic absorption spectrophotometer. Quantitative analysis of sodium was carried out at a wavelength of 589.6 nm. The results of the study concluded that the sodium content of golden bananas was 1.8647 mg/100g. The results of the relative standard deviation test are 15% and have good precision because the results obtained for analytes with levels of parts per million are not more than 16% (Harmita, 2004).
ISOLASI DAN IDENTIFIKASI PEKTIN DARI KULIT PISANG MAS (Musa acuminata Colla) Sitorus, Panal; Supartiningsih, Supartiningsih; Marpaung, Jon Kenedy; Munthe, Bernadetta R.
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v7i1.2763

Abstract

Pectin is one of the types of carbohydrate from polysacharide compound derivatives found in plan cell walls. pectin can be used in the viscosity, stability, texture and appearance of the food. The use of pectin in pharmacy is used for diarrhea, where pectin works as absordent in the intestine and also used as wound medicine as the hemostatic agent. The purpose of this research is utilize the mas banana peel as the source of pectin. This research was conducted by using the reflux extraction method using 1N hydrochloric acid as a solvent. Pectin isolation at pH 2, temperature 70-80-C for 60 minutes. The result of the precipitate is then added ethanol into the filtrate to precipitate the pectin and the final process is drying to obtain dry pectin which is 2.2975 gr. Dried pectin is obtained in the form of a fine powder, reddish brown in color and practically insoluble in ethanol. From the result of the identification that was carried out positive for the reaction with the addition of 96% ethanol and 2N NaOH, there was a gel which when added with 3N HCI and heated it formed brownish yellow lumps and had a distinctive odor. Physical specific characterization of pectin was also carried out, including moisture content (31.37%) and ash content (38.79%). Pure pectin standard for maximum moisture content of 12%, and maximum ash content of 10%. Pectin from mas banana (Musa acuminataColla) does not meet IPPA (International Pectin Producers Association) quality standards. Keywords: Banana peel, pectin, extraction, Reflux
UJI VALIDASI METODE SPEKTROFOTOMETRI ULTRAVIOLET PADA PENETAPAN KADAR TABLET KAPTOPRIL GENERIK DAN NAMA DAGANG Marpaung, Jon Kenedy; Harun, Fatur Rahman; Girsang, Febriyantu
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v7i2.2769

Abstract

In the manufacture of drugs, checking the levels of active substances is a requirement that must be met to ensure the quality of drug preparations. Good quality drug preparations will support the achievement of the desired therapeutic effect. One of the requirements for drug quality is that the content contained must meet the level requirements as stated in the Indonesian Pharmacopoeia, which is not less than 90% and not more than 110%. This study aims to test the validation of the ultraviolet spectrophotometric method on the determination of generic captopril tablets and trade names. The sample used consisted of 3 generic tablet preparations and 2 trade names. Determination of the concentration of captopril tablets in tablet preparations was carried out by ultraviolet spectrophotometry using 0.1N NaOH solvent at a wavelength of 236.2 nm and this validation test was carried out using the standard addition method. Parameters of the method validation test include accuracy (accuracy), precision (accuracy), limit of detection (Limit of Detection), and limit of quantitation (Limit of Quantitation). This method provides good determination and accuracy, LOD (Limit Of Detection) 0.575486 mcg/ml & LOQ (Limit Of Quantitation) 1.9179 mcg/ml is declared valid. The results of the validation test, obtained an average recovery value of 100.6% with an RSD value of 1.05%. Based on the research, the levels of captopril brand A tablets were 97.47 -+ 2.3670, captopril brand B tablets were 98.08 -+ 2.4911, captopril brand C tablets were 98.03 -+ 2.4223, captopril brand D tablets were 98.93 -+ 1.5138, captopril brand E tablets of 99.57 -+ 2.3985.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN LEGUNDI (Vitextrifolia L.) TERHADAP PERTUMBUHAN Staphylococcus epidermidis Marpaung, Jon Kenedy; Sitorus, Panal; Nasution, Pandapotan; Yanti, Roma Devina
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v7i2.2770

Abstract

Legundi leaves (Vitextrifolia L.) contain flavonoid compounds, alkaloids and saponins, tannins, steroids/triterpenoidsthatact as antiseptic substancesandaid in the wound healing process. Staphylococcusepidermidis (Gram positive) is a mild skin infection-causing bacteria that accompanies the formation of abscesses. As for the purpose of this study To know the absence of antibacterial activity from concentrations of 10%, 15%, 20%, 25% legundileaf extractagainst Staphylococcus epidermid is bacteria and know the effective concentration of legunleaf extract in in hibiting the growth of Staphylococcus epidermidis bacteria. This research methoduses experimental methods and legundileaf extract with concentrations of 10%, 15%, 20%, 25%. The resultsshowedthatconcentrationsof 10%, 15%, 20%, 25% of legundileaf ethanol extract had antibacterial activity against the growth of Staphylococcus epidermidisindicated with a blockable zone diameter of 8 mm, 8.84 mm, 9.84 mm, 10.54 mm, respectively. Base dont here search that has beendone can be concluded that legundileaf extractcan inhibit the growth of bacteria Staphylococcus epidermidis, because around the discpaperthere is a clear zone that indicates the absence of bacterial growth.
ANALISA CEMARAN LOGAM MERKURI PADA IKAN AIR LAUT DAN UDANG SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA) Silalahi, Yosy Cinthya Eriwaty; Marpaung, Jon Kenedy; Supartiningsih, Supartiningsih
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v7i2.2771

Abstract

Mercury is a heavy metal that can have a toxic effect on the body so it can cause death. Mercury metal contamination in food is regulated in SNI number 7387 of 2009 regarding the Maximum Heavy Metal Limit. Some metal waste disposal ends up in rivers, lakes, or sea waters so that metal pollution can occur in the ecosystem. This study aims to determine levels of mercury metal contamination in seawater fish, including shark, mackerel, salmon, tuna, red snapper, and white shrimp. Sample preparation was carried out by wet digestion method using a microwave digestion device. Mercury analysis was carried out using the AAS (Atomic Absorption Spectrophotometry) method. The wavelength used is 253.7 nm. The results showed that mercury in sharks was 0.2045 ± 0.0099 mg/kg, mackerel 0.4184 ± 0.0297 mg/kg, salmon 0.3848 ± 0.0794 mg/kg, tuna fish 0.3706 ± 0.0674 mg/kg, snapper 0.4088 ± 0.0397 mg/kg, and shrimp 0.4289 ± 0.0813 mg/kg. The results of the analysis showed that of the six samples of seawater fish that had been tested, the maximum metal contamination limit determined by SNI 7387 the Year 2009 was 0.5 mg/kg.
PEMANFAATAN LIMBAH CAIR TAHU MENJADI Nata de Soya MENGGUNAKAN BAKTERI Acetobakter xylinum Purwandari, Vivi; Zuhairiah, Zuhairiah; Marpaung, Jon Kenedy; Silitonga, Maringan
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v7i2.2774

Abstract

Nata de Soya merupakan salah satu jenis pangan yang diperoleh dari pengolahan limbah cair tahu yang berbahan dasar kedelai. Penelitian ini bertujuan untuk memanfaatkan limbah cair tahu yang sering terabaikan dan menjadi penyebab rusaknya lingkungan perairan dekat perindustrian pembuatan tahu. Nata de Soya dibentuk oleh bakteri Acetobacter xylinum yang merupakan bakteria erob. Masing-masing perlakuan difermentasi selama 8-14 hari, parameter yang diamati yaitu berat nata, kadar air, kadar serat dan selulosa Nata de Soya selama 8-14 hari. Pada penelitian ini didapat data ketebalan Nata de Soya dengan perlakuan 1, 2, dan 3 dengan kosentrasi 5, 10, dan 20% starter bakteri yaitu, 2,4503 gr, 2,8922 gr, dan 2,9226. Pada berat nata didapat 0,21 cm, 0,82 cm, dan 1,53 cm. Kandungan kadar air pada Nata de Soya pada perlakuan 1,2 dan 3 dengan kosentrasi masing-masing 5, 10, dan 20% yaitu 82,71, 83,71%, dan 84,17%%. Kandungan kadar serat Nata de Soya pada perlakuan 1, 2, dan 3 dengan kosentrasa bakteri 5, 10 dan 20% didapat 49,90%, 50,74% dan 54,02%. Pada uji kadar selulosa menggunakan FTIR dengan sampel 0,4 g nilai tertinggi didapat sebanyak 3361,12 menunjukan adanya gugus aldehid dari selulosa acetat. Pemanfaatan limbah cair tahu menjadi Nata de Soya menggunakan bakteri acetobacter xylinum dapat menjadi alternative pengolahan limbah cair tahu.
UJI AKTIVITAS ANTIBAKTERI MADU HUTAN TERHADAP BAKTERI Bacillus cereus Maimunah, Siti; Supartiningsih, Supartiningsih; Marpaung, Jon Kenedy; Silalahi, Yosy Cinthya Eriwaty; Turnip, Icha Wahyuni
Jurnal Farmanesia Vol 8 No 1 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v8i1.2780

Abstract

Honey is a thick sweet liquid which comes from bees which can cure many diseases and is antibacterial. Antibacterial potential of honey caused by the content of active compounds, low moisture content, high osmolarity, hydrogen peroxide content, and low pH.The aim of this study was to determine the antibacterial activity of forest honey on Doloksaribu, Simalungun district on the growth of Bacillus cereus bacteria.Experiment research method includes the analysis quality of honey, includes checking moisture content, ash content, pH tested, acidity, viscosity, spesific gravityphytochemical screening, and antibacterial activity test ith disk diffusion method use blank disk with each concentration 25%, 35%, 45%, 55%, and 65%, positive control using erythromycin and negative control sterile distilled water. Organoleptic test conducted on forest honey gave results that honey reach the requirements for good quality. The result of moisture and ash content test and pH test reach of SNI 3545: 2013 about honey. Antibacterial activity test of forest honey with concentration 25%, 35%, 45%, 55%, and 65% against Bacillus cereus showed that there was an inhibitory around the blank disc, namely 10,16 mm, 13 mm, 15,6 mm, 21,6 mm, and 22,6 mm. The greatest inhibition of forest honey occurred at the highest concentration that is 65% (22,6 mm).
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN KEMANGI (Ocimumbasilicum L.) TERHADAP PERTUMBUHAN BAKTERI Staphylococcusaureus Manurung, Kesaktian; Marpaung, Jon Kenedy; Harefa, Karnerius; Mardianis, Mardianis
Jurnal Farmanesia Vol 8 No 1 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v8i1.2784

Abstract

Basil (Ocimumbasilicum L.) is one of the natural plants that is easily obtained in Asia such as Indonesia which has medicinal properties. Basil leaves contain flavonoid compounds, tannins, saponins, and steroids/triterpenoids. These compounds are known to have antibacterial activity. This study aims to determine the antibacterial activity of the ethanolic extract of basil leaves (Ocimumbasilicum L.) against Staphylococcus aureus bacteria. This research is experimental. The test was carried out through several stages including material collection, preparation of simplicia, making ethanol extract of basil leaves, and testing the inhibitory power of basil leaves against Staphylococcus aureus bacteria. The ethanol extract of basil leaves was made by the maceration method using 96% ethanol and concentrated with a rotary evaporator to obtain a thick extract from basil leaves. Antibacterial activity was tested by the agar diffusion method using disc paper. The results of the antibacterial activity test showed that the ethanolic extract of basil leaves inhibited the growth of Staphylococcus aureus bacteria at concentrations of extracts of 5%, 10%, 15%, 20%, and 25% with inhibition zone diameters of 8. 31 mm, 9. 43 mm, respectively. 9. 73 mm, 9. 91 mm, and 11. 33 mm. The ethanol extract of basil leaves has antibacterial activity against Staphylococcus aureus bacteria.
UJI AKTIVITAS ANTIBAKTERI DARI BLACK GARLIC DENGAN VARIASI WAKTU BERBEDA TERHADAP Streptococcusmutans PENYEBAB KARIES GIGI Purwandari, Vivi; Marpaung, Jon Kenedy; Suharyanisa, Suharyanisa
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v8i2.2797

Abstract

Dental cariesand gingivitis are the two mostcommon dental and oral diseases in human society. The main cause of both diseasesis a collection of bacteria bound in anorganicmatrix and firmlyattachedtothe tooth surface known as plaque. Black garlicis garlic that has been processed by fermentationat a certaintemperaturefor a long time, resulting in new compounds that have pharmacological effects showing broad antibiotic properties against gram-positiveand gram-negative bacteria, includingstrains that are multi-bacterial. Antibiotic resistance. The purpose of this study was to determine the antibacterial activity of black garlic against Streptococcus mutans bacteria and to determine the differences in the variation of the antibacterial fermentation time of blackgarlicon the antibacterial activity of Streptococcus mutans bacteria. The methodused in this study isanexperimentalmethod (experimentalresearch) to determine the effect of blackgarlic as anantibacterial against Streptococcusmutans. The resultsobtained fromthis study are blackgarlic extract containsalkal oids, flavonoids, tannins, andsaponins. Black garlic extract from variations of 7 days, 12 days, 15 days, and Chlorhexidine had an inhibitoryzone with a strong category while steriledistilled water had an inhibitionzone in the weakcategory.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK BUNGA KECOMBRANG (Etlingera elatior) TERHADAP PERTUMBUHAN BAKTERI Salmonella thypi Nasution, Pandapotan; Marpaung, Jon Kenedy; Suharyanisa, Suharyanisa; Sitanggang, Rolastri
Jurnal Farmanesia Vol 9 No 1 (2022): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v9i1.3430

Abstract

Kecombrang (Etlingera elatior) is a type of spice that has long been known and used by humans as medicine. Kecombrang flower parts contain several chemical compounds, namely: alkaloids, flavonoids, and saponins. In addition, kecombrang flowers can also inhibit the growth of Salmonella typhi bacteria. This study aims to determine the concentration of ethanolic extract of kecombrang flower (Etlingera elatior) which is effective in inhibiting the growth of Salmonella typhi bacteria. The research sample was Kecombrang Flowers purchased at the Tarutung traditional market. This research was carried out experimentally including sampling, drying simplicia, maceration using 70% ethanol solvent, making extracts made using a rotary evaporator, and testing the antibacterial activity of kecombrang flowers using the disc diffusion method. Data analysis was conducted to see the effect of kecombrang flower ethanol extract on the activity of Salmonella typhi bacteria. The results of the study found that the results of phytochemical screening showed simplicia and ethanol extract of kecombrang flower leaves contained alkaloids, flavonoids, and saponins. While the results of the antibacterial activity test of the ethanolic extract of kecombrang flower leaves have antibacterial properties against Salmonella typhi at extract concentrations of 45%, 50%, 55%, and 60% with inhibition zone diameters of 9.4 mm, 12.2 mm, 14.8 mm, respectively. , 16.3mm. The most effective concentration of ethanol extract to inhibit the growth of Salmonella typhi was at a concentration of 60% with a larger inhibition zone diameter of 16.3 mm.
Co-Authors Adiansyah Adiansyah, Adiansyah Ahmad ghazali, Ahmad Ayu, Herti Dicky Yuswardi Wiratma Eka Margareta Sinaga Eriwaty Silalahi, Yosy Cinthya Fitri, Nadiatul Ginting, Jansen Asriel Girsang, Febriyantu Harefa, Karnerius Harun, Fatur Rahman Hutajulu, Johansen Hutauruk, Dumartina Komsary, Pauline Manik, Maria Partiwi Manurung, Kesaktian Marbun, Eva Diansari Mardianis, Mardianis Marpaung, Aditiya Baginda Munthe, Bernadetta R. Musyaawarah, Yanti Nasution, Pandapotan Nelson Simanjuntak Nurmela, Nuranti Purba, Yuni Kristina Purwandari, Vivi Silitonga, Maringan Simanjuntak, Amsal Wahyu Maralus Simbolon, Lampita Putri Sinarsi, Sinarsi Sipayung, Inri Priskila Sitanggang, Rolastri Siti Maimunah Siti Nurbaya Sitorus, Carlos Salinas Sitorus, Panal Sofwan, Ahmad Gazali Suharyanisa Suhendri, Martin Supartiningsih Supartiningsih - - Syahfitri, Novita Thaib, Cut Masyithah Tiara Pratiwi, Tiara Turnip, Icha Wahyuni Vevariantina, Ayu Yanti, Roma Devina Yosy Cinthya Eriwaty Silalahi Yudhistira Yudhistira Zai, Andi Kristian Faatulo Zuhairiah Nasution, Zuhairiah