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All Journal Pharmaciana: Jurnal Kefarmasian Science and Technology Indonesia Jurnal Penelitian Sains Indonesian Journal of Chemistry Pharmacoscript Jurnal 'Aisyiyah Medika Babul Ilmi Jurnal Ilmiah Multi Science Kesehatan Jurnal Ilmiah Medicamento Jurnal Pengabdian Masyarakat Indonesia Jurnal Farmasi Sains dan Praktis Jurnal Pengabdian Pada Masyarakat Jurnal Kesehatan Farmasi Journal of Pharmaceutical and Sciences. Pharmacon: Jurnal Farmasi Indonesia
Shaum Shiyan
Program Studi Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Sriwijaya, Indralaya, Indonesia
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Revealing Phytopharmaceutical Insights into Jaras Gambo Extract from Uncaria gambir Roxb. against Breast Cancer Using Network Pharmacology and ADME/Tox Approach Viviani, Rafiqah Nur; Mahendra, Nathasya Shasykirana; Shiyan, Shaum; Pratiwi, Galih
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.12687

Abstract

Background: Breast cancer remains a leading cause of mortality in women and demands multi-target strategies that can address pathway redundancy and resistance.Objective: This study aimed to characterize the bioactive constituents of Jaras Gambo Toman extract and evaluate its potential anti-breast cancer activity through an integrated network pharmacology and molecular docking approach.Methods: Jaras Gambo (processed gambier sap mass; Uncaria gambir Roxb.) collected in Babat Toman, South Sumatra, was macerated in ethanol, and the macerate was then filtered and concentrated to obtain a crude extract. Its constituents were profiled by liquid chromatography–high-resolution mass spectrometry (LC–HRMS). Network pharmacology (target prediction, pathway enrichment, and drug-likeness/toxicity screening) was integrated with structure-based molecular docking to prioritize active constituents and predict their interactions with breast cancer–related proteins.Results: The results of the analysis show therapeutic potential through the significant binding affinity between the bioactive components of the extract and proteins in the regulation of cancer cell proliferation and apoptosis, particularly AKT1, TP53, BCL2, TNF, and EGFR. Molecular interactions are suggested by favorable binding affinity parameters accompanied by the formation of hydrogen and hydrophobic bonds at the active sites of key residues. The involvement of several signaling pathways, such as the PI3K/AKT pathway, p53 signaling pathway, and TNF signaling pathway, may represent key mechanistic pathways of bioactive compounds in targeting disease proteins. Further characterization showed that there are eight main active components, including chlorogenic acid, isoquercitrin, morin hydrate, naringenin, quercetin, eriodictyol, ribofuranoside, and scopoletin, which showed docking profiles comparable to erlotinib across selected targets.Conclusion: These results suggest the potential of Jaras Gambo Toman extract as a potential source of multi-target bioactive compounds for further breast cancer research.
OPTIMIZATION GEL OF ESSENTIAL OIL OF LEMONGRASS (Cymbopogon nardus) AS A REPELLANT AND ACTIVITY AGAINST Aedes aegypti Ramadhiani, Aninditha Rachmah; Pratiwi, Galih; Oktarina, Tri; Aulia, Faizah; Shiyan, Shaum
Jurnal Kesehatan Farmasi Vol 7 No 2 (2025): Jurnal Kesehatan Farmasi
Publisher : Jurusan Farmasi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkpharm.v7i2.2824

Abstract

Latar Belakang: demam berdarah salah satu jenis penyakit yang menular yang diakibatkan gigitan nyamuk pembawa virus dengue. Salah satu tanamaan mempunyai sifat repelan ialah minyak atsiri sereh yang mempunyai kandungan yaitu sitronelal, sitrnelol, dan geraniol. Karbopol merupakan sifat fisik sebagai pengental dan gliserin sebagai humektan. Tujuan: penelitian ini untuk mengoptimalkan gel repelan minyak atsiri sereh metode SLD, mengetahui stabilitas sifat fisik gel, dan uji aktivitas terhadap nyamuk aedes aegypti dan meliputi waktu proteksi. Metode: penelitian ini dilakukan secara eksperimental laboratorium dengan menggunakan pendekatan simplex lattice design. Menggunakan bantuan piranti lunak design expert. Parameter diuji, meliputi uji viskositas, uji daya sebar dan uji viskositas. Stabilitas fisik menggunakan metode T-test. Uji daya tolak nyamuk menggunakan SPSS diuji menggunakan metode kruskall wallis. Kesimpulan: perbandingan konsentrasi karbopol 1.007% dan gliserin 18,993% dan daya tolak pada nyamuk aedes aegypti 98,25% menghasilkan gel minyak atsiri sereh (cymbopogon nardus) dengan sifat gel yang optimum. Uji stabilitas menunjukkan tidak adanya perubahan yang signifikan pada uji organoleptis, gel minyak atsiri variasi konsentrasi carbopol dan gliserin terbukti mempunyai daya tolak nyamuk aedes aegypti sebesar 98,25%.
Co-Authors Aisyah , Jasmine Rani Alfarado, Daniel Alta, Ulik Alzuraiqi, Lutfi Muhammad Anggun Prasasty, Mas Ayu Arina, Yudi Arsela, Della Aulia, Faizah Ayu Ratna Sari Bella, Annisa Mutiara Della Arsela Dina Permata Wijaya Elmiawati Latifa Ferlinahayati Ferlinahayati Fertilita, Soilia Friska, Audia Galih Pratiwi Galih Pratiwi, Galih Hafid Syahputra Herlina . Herlina Herlina Indah Solihah Jessica Nathasia Khoirin, Khoirin Laida Neti Mulyani Latifa, Elmiawati Mahendra, Nathasya Shasykirana Mardiyanto Mardiyanto Mardiyanto Marseli, Cindy Misirti Maulidia Anis Marketama Muhammad Andry Muhammad Hendri Mutia Sari Wardana Nabilah Putri, Hadiani Najma Annuria Fithri, Najma Annuria Nalindra, Wahyu Naga Nurfitriyana Nurfitriyana Nuria , Siti Azzahra Oktarina, Tri Prasetyo, M Yosi Pratiw, Galih Puspita Rasyid, Rianasari R, Anidita Rachmah Rafifah Azzahra Ramadaini, Tiara Ramadhiani, Aninditha Rachmah Rianasari Puspita Rasyid Saputri, Mutiara Ariani Sari, Familia Maya Satrio, Fakhri D. Soilia Fertilita Solihah, Indah Suprayetno Suprayetno Suprayetno Suprayetno Tari, Mayang Trisakti, Intan Viva Starlista Viviani, Rafiqah Nur Yudi Arina