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All Journal International Journal of Public Health Science (IJPHS) E-Jurnal Medika Udayana Biology, Medicine, & Natural Product Chemistry Jurnal Pengabdian Magister Pendidikan IPA Jurnal Kedokteran: Media Informasi Ilmu Kedokteran dan Kesehatan Jurnal Pengabdian Masyarakat Sains Indonesia (Indonesian Journal Of Science Community Services) JURNAL PENELITIAN PERAWAT PROFESIONAL JPMB: Jurnal Pemberdayaan Masyarakat Berkarakter AKSONA Jurnal Pepadu Promotor: Jurnal Mahasiswa Kesehatan Masyarakat Acta Neurologica Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Zubaidi, Fitriannisa Faradina
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Journal : AKSONA

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Determinants of Executive Dysfunction: Serum NRF2 and Sociodemographic Profiles in Lombok Island’s Coastal Population Wulandari, Inayah; Nurhidayati, Nurhidayati; Hunaifi, Ilsa; Rivarti, Arina Windri; Harahap, Herpan Syafii; Saputri, Legis Octaviana; Suryani, Dini; Zubaidi, Fitriannisa Faradina; Rosyidi, Rohadi Muhammad
AKSONA Vol. 6 No. 1 (2026): JANUARY 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v6i1.74449

Abstract

Highlight: Coastal communities show high prevalence of cognitive decline. There is no correlation between NRF2 levels and executive function. Gender and education level were significantly associated with executive dysfunction.   ABSTRACT Introduction: Elderly people frequently suffer from neurodegenerative conditions that affect cognitive function. Redox homeostasis dysregulation plays a significant role in neurodegenerative diseases. Oxidative stress activates the transcription factor called nuclear factor erythroid 2-related factor 2 (NRF2), which is essential for regulating the expression of genes involved in cellular defense mechanisms. Objective: This study aimed to determine the relationship between serum NRF2 levels and executive function, as well as to identify other variables that may influence executive function among residents of coastal villages on Lombok Island. Methods: The study used a cross-sectional design with consecutive sampling. Data on sociodemographic characteristics, hypertension, diabetes mellitus, smoking status, and physical activity were collected. Statistical analyses employed Spearman's rank correlation test, Fisher's exact test, and logistic regression test. Results: A total of 39 participants were included, with an average age of 53.38 years. Most participants were female, had a low educational level, did not have hypertension or diabetes mellitus, had high physical activity levels, and were non-smokers. The average NRF2 level was 0.54 ng/mL. The correlation test showed no significant relationship between serum NRF2 levels and executive function. Fisher's exact test showed a significant relationship between gender and education with executive function. Furthermore, logistic regression analysis identified education level as a predictor of executive dysfunction. Conclusion: Serum NRF2 levels were not correlated with executive dysfunction. Educational level was identified as a predictive factor for executive dysfunction.
Co-Authors Andhera, Athalita andi, Silmi chairan Anditiarina, Dasti Annafi, Muhammad Ibnu Ardiana Ekawanti Arjita, I Putu Dedy As’ad, Suryani Ayu Anulus Ayunda, Rahmah Dara Citranggana Prajnya Dewi Dany Karmila Deasy Irawati Dini Suryani, Dini Fachrudi Hanafi Faizah, Lillah Haq, Abiyyu Didar Herpan Syafii Harahap Hilam, Muhammad Ilsa Hunaifi, Ilsa Indrayana, Yanna Indrayana, Yanna Jaya Putra, Rian Akka Kadriyan, Hamsu Khairil Pahmi Lasmi, Anjely Doni Lestari, Diayanti Tenti Lina Nurbaiti, Lina Lysa Mariam Miraditi, Ni Komang Muhammad Abdurrosyid Munadi Munadi Musyarrafah, Musyarrafah Natsir, Rosdiana Ni Nyoman Ayu, Susilawati Nurhayati, Putri Nurhidayati Nurhidayati Nurhidayati Ocktaviana Saputri, Legis Rivarti, Arina Windri Rosyidi, Rohadi Muhammad Rusdi, Yudika Ilhami Sahidu, Muhammad Ghalvan Saputri, Legis Octaviana Umar, Husaini Utami, Herdiana Nurul Wiwin Mulianingsih Wulandari, Inayah Yudha Permana