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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Kewarganegaraan Nusantara Hasana Journal
Nadia Purnama Dewi
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PROFIL PENDERITA HIPERTENSI DI RSUD PASAMAN BARAT TAHUN 2022 Abdullah, Dessy; Nadia Purnama Dewi; Divna Monaprlya; Zamsari Chan
Nusantara Hasana Journal Vol. 3 No. 11 (2024): Nusantara Hasana Journal, April 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v3i11.1112

Abstract

The prevalence of hypertension is increasing worldwide, especially in developing countries. The process by which hypertension occurs cannot be known clinically, so hypertension is often referred to as the silent killer because this disease does not show early clinical symptoms. This study aims to determine the profile of hypertension sufferers at West Pasaman Regional Hospital. This research covers the scope of Internal Medicine and Public Health Sciences. The research location is West Pasaman Regional Hospital. The research period is September 2022 to February 2023. The type of research is descriptive. The research design was cross sectional design. The population reached by outpatient hypertensive patients with a total population of 479 patients registered in the West Pasaman Regional Hospital's medical records in 2022 is 90 samples using a purposive sampling technique. Univariate data analysis is presented in the form of a frequency distribution and data processing uses the computerized SPSS program IBM version 25.0. The largest age group is pre-advanced (45-59 years), namely 42 people (46.7%), the largest gender is female, namely 48 people (53.3%), the highest status is working, namely 50 people (55.6%), The highest systolic blood pressure was grade I, namely 52 people (57.8%), the highest diastolic blood pressure was grade I, namely 60 people (66.7%), there was a relationship between age and blood pressure in hypertension sufferers at West Pasaman District Hospital. (p=0.000), there is a relationship between gender and blood pressure in hypertension sufferers at West Pasaman Regional Hospital. (p=0.021) and there is a relationship between work and blood pressure in hypertension sufferers at West Pasaman Regional Hospital. (p=0.008). It has been proven that there is a relationship between age and blood pressure in hypertension sufferers, there is a relationship between gender and blood pressure and there is a relationship between work and blood pressure in hypertension sufferers at the West Pasaman District Hospital.
PENURUNAN KADAR INTERLEUKIN-6 SETELAH PEMBERIAN ALOIN PADA TIKUS JANTAN (RATTUS NORVEGICUS) MODEL ARTRITIS REUMATOID Wafda Azizah Ilzan; Nadia Purnama Dewi; Rika Amran; Ade Teti Vani; Dessy Abdullah
Nusantara Hasana Journal Vol. 5 No. 7 (2025): Nusantara Hasana Journal, December 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i7.1920

Abstract

Rheumatoid arthritis (RA) is a chronic progressive autoimmune inflammatory disease that damages joint cartilage and synovial tissue. Inflammation in RA activates pro-inflammatory cytokines, including interleukin-6 (IL-6), whose elevated levels contribute to disease progression. Aloe vera contains aloin, an active compound with antioxidant, anti-inflammatory, and anticancer properties.This study aimed to determine the effect of aloin on IL-6 levels in male rats (Rattus norvegicus) with a rheumatoid arthritis model. This experimental study used a pretest-posttest control group design. Twenty-four rats were divided into four groups: K(-) normal control; K(+) positive control induced with CFA and treated with 50 mg Na diclofenac; P I induced with CFA and treated with 500 μg aloin; and P II induced with CFA and treated with 1000 μg aloin. IL-6 levels were measured using a Rat IL-6 ELISA kit and analyzed with an ELISA reader. Statistical analysis showed that aloin significantly reduced IL-6 levels (p<0.05). The 500 μg dose (P I) was the most effective, showing significant differences compared to other groups (p<0.05). Aloin administration reduces IL-6 levels in male rats with rheumatoid arthritis model.
POTENSI ANTIDIABETES EKSTRAK ALOIN PADA MENCIT JANTAN LANSIA OBESITAS DENGAN DIABETES MELITUS TIPE 2 Fahrezi Maulana; Nadia Purnama Dewi; Ade Teti Vani; Dessy Abdullah
Nusantara Hasana Journal Vol. 5 No. 7 (2025): Nusantara Hasana Journal, December 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i7.1921

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia resulting from impaired insulin secretion, insulin resistance, or both. Controlling blood glucose levels is the primary therapeutic goal to prevent complications. The use of medicinal plants as complementary therapy has gained increasing attention, one of which is aloe vera (Aloe vera), which contains aloin and antioxidant compounds with potential antihyperglycemic effects. This study aimed to evaluate the effect of aloin extract administration on blood glucose levels in elderly obese male mice (Mus musculus) with type II diabetes mellitus. This laboratory experimental study employed a pretest–posttest control group design. The subjects were 25-week-old male mice weighing 30–40 grams with random blood glucose levels ≥176 mg/dL. The animals were divided into treatment and control groups. Blood glucose levels were measured before treatment and on days 14 and 28. Data were analyzed using SPSS. The mean baseline blood glucose levels in the treatment and control groups were 182.69 mg/dL and 184.75 mg/dL, respectively. On day 14, the levels decreased to 127.75 mg/dL and 134.88 mg/dL, and on day 28 to 104.62 mg/dL and 121.13 mg/dL. The results demonstrated a significant reduction in blood glucose levels following aloin extract administration. Aloin extract has an effect on lowering blood glucose levels in elderly obese male mice with type II diabetes mellitus.
Co-Authors Abdullah, Dessy Ade Teti Vani Annisa Diva Dhiersa Aryaldi Zulkarnaini Aryaldy Zulkarnaini Dessy Abdullah Dita Hasni Divna Monaprlya Fadilla Marisa Fahrezi Maulana Ilham Arief Irdawati Izrul Irwan Triansyah Irwan Triansyah, Irwan Jefri Henky Jely Safitri M. Fiqran Mulyadi Melya Susanti Meta Oktora Meta Zulyati Oktora Mhd Nurhuda Muchamad Arif Al Ardha Muhammad Ivan Nasywa Yudeldi Nilas Warlem Rika Amran Riki Nova Rinita Amelia Roland Helmizar Rosmaini Rosmaini, Rosmaini Sarah Lativa Taufiqa, Zuhrah Vani, Ade Teti Wafda Azizah Ilzan Wisda Widiastuti Yanti Fitri Yasa Yuliza Birman Zamsari Chan