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All Journal International Journal of Evaluation and Research in Education (IJERE) Cakrawala Pendidikan Jurnal Penelitian Saintek Jurnal Pendidikan dan Pengajaran Jurnal Pendidikan Kimia Indonesia EDUSAINS Pharmaciana: Jurnal Kefarmasian Journal of Educational Science and Technology Jurnal Inovasi Pendidikan IPA Indonesian Journal of Science and Technology Scientiae Educatia: Jurnal Pendidikan Sains Jurnal Penelitian Pendidikan IPA (JPPIPA) Journal of Science Learning Jurnal Pendidikan Kimia (JPKim) Indonesian Journal of Chemistry Jurnal Pengabdian Masyarakat MIPA dan Pendidikan MIPA Biosaintifika: Journal of Biology & Biology Education Molekul: Jurnal Ilmiah Kimia JKPK (Jurnal Kimia dan Pendidikan Kimia) Jurnal Kependidikan: Jurnal Hasil Penelitian dan Kajian Kepustakaan di Bidang Pendidikan, Pengajaran dan Pembelajaran Indonesian Journal of Chemistry and Environment Jurnal Pemberdayaan Masyarakat Molekul: Jurnal Ilmiah Kimia Jurnal Elemen Kimia Jurnal Riset Pembelajaran Kimia
Nurfina Aznam
Universitas Negeri Yogyakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Education Engineering Environmental Science Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Journal : Molekul: Jurnal Ilmiah Kimia

 1 
Antioxidant Activity of Aloe vera and Prediction of Interaction Mechanisms on ROS1 Kinase and Collagenase Receptorsco Atun, Sri; Aznam, Nurfina; Arianingrum, Retno; Azeeza, Sabira Nurul; Sangal, Aditi
Molekul Vol 19 No 3 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.3.11427

Abstract

The Aloe vera plant has been widely used as a food ingredient, medicine and cosmetics. This research aims to test the gel and ethanol extract of Aloe vera leaves as an antioxidant and absorber of UV light in vitro, as well as predicting the interaction mechanism for ROS1 kinase and collagenase receptors in silico.The antioxidant activity test method was carried out in vitro using DPPH (1,1-Diphenyl-2-Picrylhydrazyl-Hydrazine) reagent. Activity as a UV light absorber is carried out by calculating the sun protected factor (SPF) value. The antiaging activity test was carried out by predicting the interaction mechanism of the ROS1 kinase and collagenase receptors in silico using several phenolic compounds that have been found in Aloe vera. The total phenolic content of Aloe vera ethanol extract was 379.136 ± 0.34 GAE/g sample, while that of Aloe vera gel was 0.0619 ± 0.04 GAE/g sample. Aloe vera ethanol extract showed moderate antioxidant activity with an IC50 of 101.9 µg/mL, and is able to absorb UV light at concentrations of 0.05% and 0.1% with ultra protection criteria. Several phenolic compounds found in Aloe vera plants showed high binding energy to ROS1 kinase and collagenase receptors. Isoquercitrin showed the highest binding energy to the ROS1 kinase receptor, while isovitexin showed the highest binding energy to the collagenase receptor. The conclusion of this research showed that Aloe vera leaves contain compounds that have potential as antioxidants and antiaging. Keywords: Aloe vera, antioxidant, antiaging, ROS1 kinase, collagenase
Co-Authors Adauyah, Robiatul Afifah, ST Agnesi Sekarsari Putri Agung Nugroho Catur Saputro Alya Rizkita Irwan Amaliyah, Nur Inayah Anding, Imanuel Anggi Alham Murfian Ani Nurhidayanti Arfan, Septian Arini Miftaqul Jannah Arthamena, Vegha Dwi Assari, Andra Meisantry Astuti Lestari Ayyubi, Mizzan Azeeza, Sabira Nurul Baroroh, Farida Bian Ihda An Naila Crys Fajar Partana Danik Noor Utami Defista, Chesa Dewi, Shofrina Surya Eli Rohaeti Faiz Ilham Pratama Farida Baroroh Faridah Baroroh Fau, Fazita Apritama Dewi Fazita Apritama Dewi Fau Hadaina Zulfah Hafsah, Devina Siti Handayani, Sri Hari Susanti Heru Nurcahyo Insih Wilujeng Isana Supiah Yosephine Louise Isnaini Amanah Ixora Sartika Mercuriani Jumadi Jumadi Jumadi Jumadi Kun Sri Budiasih Kusmiyati kusmiyati Latifah Kurnia Devani Magfirah Perkasa Mamluaturrahmatika, Annisa Manarisip, Alessandro Jeremi Masatake Niwa Masatake Niwab Mizzan Ayubi Munnal Hani'ah Nadiya Fitri Anisa Nafisa Rahmah Nida Qurbaniah Juhara Nindi Mediartika Novitasari, Karina Wahyu Ayu Nur Aini Purnamaningsih Nur Fitriyana Nurason, Febri Nurhidayanti, Ani Pratama, Faiz Ilham Putri, Sarmila Eka Retiyanto, Hana' Fadhilah Retno Arianingrum Riki Perdana Risky Nugraheni Purnamawati Rumahorbo, Shinta S. Senam Sangal, Aditi Senam Senam Shiddiqi, Muhammad Habib Ash Sri Atun Sri Atun Sri Atun SRI ATUN Sri Handayani Sri Handayani Sri Handayani Sri Nurestri Sri Nurestri ST Afifah St Afifah Susila Kristianingrum Suwardi Suyanta Suyanta Tanti Wulandari Vegha Dwi Arthamena Wika Rinawati Yusman Wiyatmo Zulfah, Hadaina