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All Journal International Journal of Evaluation and Research in Education (IJERE) Cakrawala Pendidikan Jurnal Penelitian Saintek Jurnal Pendidikan dan Pengajaran Jurnal Pendidikan Kimia Indonesia EDUSAINS Pharmaciana: Jurnal Kefarmasian Journal of Educational Science and Technology Jurnal Inovasi Pendidikan IPA Indonesian Journal of Science and Technology Scientiae Educatia: Jurnal Pendidikan Sains Jurnal Penelitian Pendidikan IPA (JPPIPA) Journal of Science Learning Jurnal Pendidikan Kimia (JPKim) Indonesian Journal of Chemistry Jurnal Pengabdian Masyarakat MIPA dan Pendidikan MIPA Biosaintifika: Journal of Biology & Biology Education Molekul: Jurnal Ilmiah Kimia JKPK (Jurnal Kimia dan Pendidikan Kimia) Jurnal Kependidikan: Jurnal Hasil Penelitian dan Kajian Kepustakaan di Bidang Pendidikan, Pengajaran dan Pembelajaran Indonesian Journal of Chemistry and Environment Jurnal Pemberdayaan Masyarakat Molekul: Jurnal Ilmiah Kimia Jurnal Elemen Kimia Jurnal Riset Pembelajaran Kimia
Nurfina Aznam
Universitas Negeri Yogyakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Education Engineering Environmental Science Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Journal : Indonesian Journal of Science and Technology

 1 
Antiangiogenesis Activity of Indonesian Local Black Garlic (Allium Sativum ‘Solo): Experiments and Bibliometric Analysis Retno Arianingrum; Nurfina Aznam; Sri Atun; S. Senam; Alya Rizkita Irwan; Nida Qurbaniah Juhara; Nadiya Fitri Anisa; Latifah Kurnia Devani
Indonesian Journal of Science and Technology Vol 8, No 3 (2023): (ONLINE FIRST) IJOST: December 2023
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/ijost.v8i3.63334

Abstract

Cancer is still one of the leading causes of death in the world. Angiogenesis is the formation of new blood vessels, which plays a vital role in the growth of cancer cells. As a result, inhibition of proangiogenic factors such as vascular epidermal growth factor (VEGF) could be used as a cancer treatment strategy. Black garlic (BG) is processed fresh garlic (Allium sativum L.) for several days under controlled high temperature and humidity. The research aims to investigate the effect of Indonesian local BG on antiangiogenic activity through in vivo and in silico studies. The in vivo test was carried out by observing the formation of new blood vessels using the Chorio-Allantoic Membrane Assay (CAM). The in silico study was performed by docking analysis of BG bioactive compounds on the VEGF receptor (VEGFR). The results showed that ethanol extract, ethyl acetate fraction, and n-hexane fraction of BG inhibit new vessel blood formation, with n-hexane fraction having the highest efficacy. The molecular docking assay indicated some similarities in the amino acids involved in the interaction between the BG bioactive compounds and the native ligand in binding to VEGFR. This similarity may lead to interference with VEGFR resulting in angiogenesis inhibition. The study suggests that BG has the potential to be developed as an anticancer agent, which might be through the mechanism of inhibiting the angiogenesis process
Co-Authors Adauyah, Robiatul Afifah, ST Agnesi Sekarsari Putri Agung Nugroho Catur Saputro Alya Rizkita Irwan Amaliyah, Nur Inayah Anding, Imanuel Anggi Alham Murfian Ani Nurhidayanti Arfan, Septian Arini Miftaqul Jannah Arthamena, Vegha Dwi Assari, Andra Meisantry Astuti Lestari Ayyubi, Mizzan Azeeza, Sabira Nurul Baroroh, Farida Bian Ihda An Naila Crys Fajar Partana Danik Noor Utami Defista, Chesa Dewi, Shofrina Surya Eli Rohaeti Faiz Ilham Pratama Farida Baroroh Faridah Baroroh Fau, Fazita Apritama Dewi Fazita Apritama Dewi Fau Hadaina Zulfah Hafsah, Devina Siti Handayani, Sri Hari Susanti Heru Nurcahyo Insih Wilujeng Isana Supiah Yosephine Louise Isnaini Amanah Ixora Sartika Mercuriani Jumadi Jumadi Jumadi Jumadi Kun Sri Budiasih Kusmiyati kusmiyati Latifah Kurnia Devani Magfirah Perkasa Mamluaturrahmatika, Annisa Manarisip, Alessandro Jeremi Masatake Niwa Masatake Niwab Mizzan Ayubi Munnal Hani'ah Nadiya Fitri Anisa Nafisa Rahmah Nida Qurbaniah Juhara Nindi Mediartika Novitasari, Karina Wahyu Ayu Nur Aini Purnamaningsih Nur Fitriyana Nurason, Febri Nurhidayanti, Ani Pratama, Faiz Ilham Putri, Sarmila Eka Retiyanto, Hana' Fadhilah Retno Arianingrum Riki Perdana Risky Nugraheni Purnamawati Rumahorbo, Shinta S. Senam Sangal, Aditi Senam Senam Shiddiqi, Muhammad Habib Ash Sri Atun Sri Atun Sri Atun SRI ATUN Sri Handayani Sri Handayani Sri Handayani Sri Nurestri Sri Nurestri ST Afifah St Afifah Susila Kristianingrum Suwardi Suyanta Suyanta Tanti Wulandari Vegha Dwi Arthamena Wika Rinawati Yusman Wiyatmo Zulfah, Hadaina