Article Per Year (5 Year)
p-Index From 2020 - 2025
3.957
P-Index
This Author published in this journals
All Journal CHEMISTRY PROGRESS ILMU KELAUTAN: Indonesian Journal of Marine Sciences Reaktor Saintek Perikanan : Indonesian Journal of Fisheries Science and Technology SAINS DAN MATEMATIKA JURNAL KIMIA SAINS DAN APLIKASI Jurnal Ilmu Lingkungan Jurnal Pengolahan dan Bioteknologi Hasil Perikanan Alchemy : Journal of Chemistry Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Chemical Science Akta Kimia Indonesia Al Qalam: Jurnal Ilmiah Keagamaan dan Kemasyarakatan Indonesia Journal of Halal Indonesian Journal of Chemical Analysis (IJCA) Molekul: Jurnal Ilmiah Kimia JKPK (Jurnal Kimia dan Pendidikan Kimia) Bahasa: Jurnal Keilmuan Pendidikan Bahasa dan Sastra Indonesia JATI (Jurnal Mahasiswa Teknik Informatika) International Journal Of Science, Technology & Management (IJSTM) Journal International of Lingua and Technology Prosiding Seminar Nasional Universitas Serambi Mekkah International Journal of Cell and Biomedical Science JURNAL VOKASI TEKNIK (JUVOTEK)
Bambang Cahyono
Department Of Chemistry, Faculty Of Science And Mathematics, Diponegoro University Jl. Prof. Soedarto SH. - Tembalang, Semarang (50275)
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Social Sciences Transportation Other

Published : 56 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : International Journal of Cell and Biomedical Science

 1 
Application of Bioinformatics Analysis to Identify Important Pathways and Hub Genes in Breast Cancer Affected by HER-2 Tjipta, Arya; Hermansyah, Dedy; Suzery, Meiny; Cahyono, Bambang; Amalina, Nur Dina
International Journal of Cell and Biomedical Science Vol 1 No 1 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i1.11

Abstract

Human epidermal growth factor receptor 2 (HER-2) is used as a marker for the diagnosis and prognosis of breast cancer. However, the molecular mechanisms involving HER2 in breast cancer require further study. Herein, we used the bioinformatics approaches to identify important pathways and hub genes in breast cancer affected by HER-2. The results showed that HER-2 is highly expressed in ovarian cancer and is closely related to the overall survival and progression-free survival of breast cancer. A total of 3014 downregulated genes and 4121 upregulated genes were identified under Gene Expression Omnibus (GEO) database with the GEO2R tool. Among them, the top 10 hub genes including CCNB1, KIF11, BUB1B, TOP2A, ASPM, MAD2L1, BUB1, RRM2, EGFR, and FN1 demonstrated by connectivity degree in the protein-protein interaction (PPI) network were screened out. In Kaplan–Meier plotter survival analysis, the overexpression of CCNB1, EGFR, MAD2L1, ASPM, and RRM2 were shown to be associated with an unfavourable prognosis in HER-2 positive breast cancer patients. In conclusion, we have identified important signalling pathways involving HER-2 that affect breast cancer. These findings could provide new insights outlining mechanisms involving HER-2 gene expression in breast cancer and provides a rationale for the novel treatment of breast cancer.
Co-Authors . Widayat A.A. Ketut Agung Cahyawan W Agustina L.N. Aminin Al-Baarri, Ahmad Ni’matullah Amalia Syaputri, Istifah Amalina, Nur Dina Ambaryanto Ambaryanto Andrijasa, Muhammad Farman Aninditya Artina Setiaputri Anton Topadang, Anton Ardelia Zahra, Deswita Bayu Legowo Budi Setiawan Burhan Nudin Bustomi, Tommy Christiana Suci Prihatini Christina Setyadewi M. Citra Agustina Isnaning Damar Nurwahyu Bima Dedy Hermansyah Defita Faridlotus Shalihah Degdo Suprayitno Dewi Kusrini Diana Chilmawati Dwi Hudiyanti Ely Kusniawati Farman andrijasa, M. Farman Andrijasa, Muhammad Fauzang Haniar, Alfat Fransisca Biranti Fronthea Swastawati H Hadiyanto Hartanto, Subhan Hendarko, Sriani Heru Susanto I Gusti Bagus Wiksuana Ima Wijayanti Irsandy, Wahyu Bahri Ismiyarto Ismitarto Ita Widowati Jusup Supriyanto Khairul Anami Laely Zahro Leenawaty Limantara M. Suzery Madiyono, Madiyono Magfiratun Hasanah, Mayta Meiny Suzery Meiny Suzery Merry Gultom Metandi, Farindika Muflihatul Muniroh Muhammad Diah Khoirul Huda Muhammad Fauzan Anwar, Harahap Muhammad Nur Arkham Muhammad Nursid Mukhammad Asy'ari Musmulyadin, Musmulyadin Nazli, Nazli Ngadiwiyana M.Si. S.Si. Nike Rizky Prahesti, Nike Rizky Ningsih, Alyxia Stellata Aria Palayukan, Marfan Pardede, Mahadi Parsaoran Siahaan Puspita, Dhea Putri Pratiwi Raisi Aga Oktavi Ramadaniati, Shintiya Retno Sariningsih Reyhan Awliya Sudjana, Muhammad Riky Auliawan Rinaldy Yudhistira, Muhammad Rini Budi Hastuti Sestri Bela Pratiwi Siti Khumairoh Slamet Suharto Sulistyowati Sulistyowati Supriyanto . Suradi, Agus Tari, Tari Tjipta, Arya Tri Winarni Agustini Umi Baroroh Lili Utami Veronika Adelina Hartini Widayadi, Eko Yusni Nyura, Yusni Zahroul Umami Qodri Zainal Arifin Zainul Rohman, Muchamad