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All Journal HAYATI Journal of Biosciences Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical Science and Technology MPI (Media Pharmaceutica Indonesiana) As-syifaa Jurnal Farmasi Jurnal SOLMA Jurnal Jamu Indonesia BERNAS: Jurnal Pengabdian Kepada Masyarakat J.Abdimas: Community Health Society: Jurnal Pengabdian Masyarakat Pharmaceutical Sciences and Research (PSR) Borneo Journal of Pharmacy Jurnal Pengabdian Farmasi dan Sains Indonesian Journal of Jamu
Ni Putu Ermi Hikmawanti
Departemen Biologi Farmasi, Fakultas Farmasi Dan Sains, Universitas Muhammadiyah Prof. DR. HAMKA, DKI Jakarta 13460, Indonesia
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Aktivitas Afrodisiaka Fraksi dari Ekstrak Etanol 70% Daun Katuk (Sauropus androgynus (L). Merr) Pada Tikus Putih Jantan Rusdi, Numlil Khaira; Hikmawanti, Ni Putu Ermi; Maifitrianti, Maifitrianti; Ulfah, Yuanita Sofiana; Annisa, Ayyoehan Tiara
Pharmaceutical Sciences and Research Vol. 5, No. 3
Publisher : UI Scholars Hub

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Abstract

Decreased of libido is illustrated with disinterest in sexual activity caused by erectile dysfunction, impotence, and infertility. It can be treated by aphrodisiac agents. Katuk or Sauropus androgynus (L). Merr has long been used as a medicinal plant. The aim of this research was to evaluate which fraction of katuk leaf ethanol extract that had the aphrodisiac activity with parameters of climbing, introduction and the weight of testicular and seminal vesicle of male rat. Sprague-Dawley male rats as animals model divided into five groups: the normal control group, the positive control group (X-gra®), the n-hexane, ethyl acetate and water fraction groups in which each fraction group given a dose of 11.85 mg/kg body weight. The number of climbing and introductions were calculated on 0, 1st, 3th, and 5th day. The data were tested statistically with one-way ANOVA test followed by Tukey test. The weight of testicular and seminal vesicle of male rat were observed on the 15th day. Previously, rats were anesthetized using ketamine and then performed surgery. The results showed that the n-hexane fraction (11.85 mg/kg body weight) increased libido with the average number of climbing was 16.5 times and the average number of introductions was 27.75 times. It was also able to increase the weight of testicular and seminal vesicle of male rat compare to positive control (X-gra® 51.37 mg/kg body weight). The compounds contained in n-hexane fraction are terpenoids and steroids.
The Effect of Pre-Extraction Preparation on Antioxidant Compounds of Sauropus androgynus (L.) Merr. Leaves Extracts Hikmawanti, Ni Putu Ermi; Fatmawati, Sofia; Arifin, Zainal; Cahyaningrum, Niken; Arif Fauzan, Muhammad
Pharmaceutical Sciences and Research Vol. 8, No. 3
Publisher : UI Scholars Hub

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Abstract

Sauropus androgynus (L.) Merr. (Phyllanthaceae) is a green vegetable. It is rich in natural antioxidant compounds such as phenolics and flavonoids. The pre-extraction preparation can affect the results of extracting compounds from natural materials. This study aims to determine the effect of pre-extraction procedures, including sample form (fresh/dried), drying process (oven-drying/indirect sunlight-drying/air-drying), and particle size (ground/powdered) on total phenolic and flavonoid levels of ethanolic extracts of S. androgynus leaves and their antioxidant activity against DPPH radicals. S. androgynus leaves were extracted using the cold maceration method. The total phenolic and flavonoid contents of the extract were determined by the colorimetric method using a UV-Vis spectrophotometer. Antioxidant activity was measured based on the ability of the extracts to reduce DPPH free radicals. The results showed that the pre-extraction preparation influenced the antioxidant components obtained in S. androgynus leaves. According to sample form, fresh leaves contained a higher phenolics and flavonoids (33.66 mg GAE/g and 11.61 mg QE/g, respectively) than dried leaves. Whereas according to particle size, powdered dried leaves have higher phenolics and flavonoids content (45.12 mg GAE/g and 12.54 mg QE/g, respectively) than ground dried leaves. The leaves drying method that produced the highest phenolic content was oven-drying (47.08 mg GAE/g), while the one with the highest flavonoid content was air-drying (8.87 mg QE/g). All extracts had IC50 values against DPPH radicals around 85.71-93.91 ppm. Pre-extraction preparation in optimum condition makes the extraction process more efficient and effective in obtaining the target compounds with antioxidant activities.
IDENTIFIKASI KUALITATIF FENOLIK DAN PENAPISAN AKTIVITAS PEREDAMAN RADIKAL DPPH MENGGUNAKAN KLT PADA EKSTRAK BATANG Pluchea indica L. Ni Putu Ermi Hikmawanti; Agustin Yumita; Jihan Esa Siregar
As-Syifaa Jurnal Farmasi Vol 14, No 2 (2022): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v14i2.812

Abstract

Pluchea indica L. (beluntas) from the Asteraceae is a plant known to be rich in phenolics. Studies on the phenolic content of P. indica stems have not been explored much. The purpose of this study is to qualitatively identify the presence of phenolic compounds and to screen for the radical scavenging ability of DPPH in P. indica stem extracts using the TLC method. Extraction was carried out with the ultrasonic directly and sequentially using 50% ethanol as solvent. Separation was carried out on a silica gel plate GF254 with ethyl acetate: water: formic acid: toluene (20:2:2:1) as the mobile phase. Gallic acid and chlorogenic acid were used as comparisons. Identification of the presence of phenolic using FeCl3 5% as a spray reagent, while screening for radical scavenging activity using DPPH 0.1 mM as a spray reagent. The results showed that the 50% ethanol extracts of P. indica stems, both obtained from direct and stratified extraction, indicated the presence of phenolic compounds as antioxidants. The phenolic compounds detected were identical to gallic acid and chlorogenic acid, respectively, at hRf values of 89.4 and 55.3. The development of phenolic utilization from P. indica stems as a source of antioxidants still needs to be studied.
Workshop Penentuan Parameter Spesifik dan Non Spesifik Bahan Baku Obat Tradisional pada Mahasiswa Farmasi UHAMKA Melalui PKKM agustin yumita; Ni Putu Ermi Hikmawanti; Fujianti; Novia Delita
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 1 (2023)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (419.417 KB) | DOI: 10.31949/jb.v4i1.3722

Abstract

Indonesia's abundant biodiversity provides good opportunities for developing medicines, especially traditional medicines made from plant materials. However, it is necessary to standardize the process to realize quality, safe, and efficacious traditional medicinal preparations. This standardization process is essential. This workshop aims to provide information on the standardization of raw materials for traditional medicines to have the knowledge and ability to standardize medicinal raw materials. At the initial stage, participants will be given a pretest. Furthermore, participants studied specific and non-specific parameters, and at the last stage, the participants were given a posttest. The data obtained from the pretest and posttest will then be processed using Excel and the IBM SPSS Statistics version 25.0 application. From the results of the workshop activities, the average value of the pretest results was 62.5806, smaller than the posttest results of 83.2258. This indicates a significant difference of P < 0.05 between the pretest and posttest. In this workshop, the team provided an understanding to the participants in standardizing the raw materials for traditional medicines. The statistical results also showed a significant effect on the treatment before being given training and after being given training to the workshop participants.
Phenolics and Flavonoids Content of Wijaya Kusuma Leaves Fractions using Micro-plate Based Assay Ni Putu Ermi Hikmawanti; Agustin Yumita; Muhammad Rafiq; Lusiana Lusiana
Indonesian Journal of Pharmaceutical Science and Technology Vol 10, No 1 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v10i1.35828

Abstract

Epiphyllum oxypetalum (DC.) or Wijaya Kusuma (Cactaceae) is an ornamental plant which is knownto contain polyphenol compounds. The purpose to determine the levels of total phenolic and flavonoidcompounds in the fractions of Wijaya Kusuma leaves using microplate-based assay. Each sample wasdetermined phenolic content with Folin-ciocalteu reagent and flavonoid content using AlCl3 on themicroplate. Absorption was measured using a microplate reader. Screening of DPPH radical scavengingactivity was identified using the TLC method. The results showed that the extract and fractions ofthe leaves of Wijaya Kusuma contained phenolic and flavonoid compounds. The ether fraction hadthe highest phenolic content (35,912±0,54776 mgGAE/g) and flavonoids (0,773±0,008 mgQE/g)compared to other fractions (ether>water>ethyl acetate fraction). There is one yellow spot with an Rfvalue of 0,85 in the ether fraction which is thought to be a compound capable of scavenging the DPPHradicals. The ether fraction of Wijaya Kusuma leaves has potential as a source of polyphenols withantioxidant activity. However, further research is needed to evaluate the antioxidant capacity in theether fraction of Wijaya Kusuma leaves.Keywords: Antioxidant, Epiphyllum oxypetalum (DC.) Haw, Flavonoids, Fraction, High-throughputMicroplate Assay, Phenolics.
Microscopical Evaluation and TLC Analysis of Pluchea indica (L.) Less: Leaf, Stem, and Root Ni Putu Ermi Hikmawanti; Fadlina Chany Saputri; Arry Yanuar; Ratih Asmana Ningrum; Abdul Mun'im; Hayati Hayati
HAYATI Journal of Biosciences Vol. 31 No. 1 (2024): January 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.1.71-81

Abstract

Pluchea indica (L.) Less is traditionally utilized to treat postpartum women in Indonesia. The plant has many pharmacological properties, so that it can be further developed as herbal medicine. In that development process, plant authentication is needed to ensure the quality of raw materials. A simple microscopical and thin-layer chromatography (TLC) analysis might be a way to authenticate the plant, but it has never been reported. So, this study evaluates the microscopical and TLC analysis for P. indica authentication in standardized herbal medicines production. Plant microscopic observation, fluorescence analysis, and polyphenol screening were conducted. n-Hexane, ethyl acetate, and methanol extracts of plant organs were then analyzed by TLC. Here, we reported that in microscopical analysis the simplicia of P. indica contains trichomes and tannin-containing cells. In addition, chlorogenic acid as a marker was present in TLC analysis by ethyl acetate-water-formic acid-acetic acid (8.5:1.5:1:1, v/v). The results of this evaluation might provide additional information in the identification, authentication, and quality control of P. indica as a raw material for herbal medicine.
Pharmacognosy, Phytochemical, and Pharmacology of Wijaya Kusuma (Epiphyllum oxypetalum (DC.) Haw.) – An Update Review Chandra Adam Lesmana; Ni Putu Ermi Hikmawanti; Agustin Yumita
Borneo Journal of Pharmacy Vol. 5 No. 2 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i2.3342

Abstract

In Indonesia, Epiphyllum oxypetalum (DC.) Haw. is known as Wijaya Kusuma. The plant is grown for home decorating and used widely as medicine in some areas. This narrative review discusses the pharmacognosy, phytochemical, and pharmacology aspects of E. oxypetalum. The review is limited to original articles and abstracts available in Science Direct, PubMed, and Google Scholar. The keyword used to search the articles was “Epiphyllum oxypetalum”. The plant contains proteins, amino acids, alkaloids, saponins, terpenoids, steroids, flavonoids, tannins, glycosides, and resins. The plant has pharmacological activities such as anti-inflammatory, antimicrobials, antidiabetic, and antioxidant properties. Researchers interested in developing E. oxypetalum as a medicinal plant might use this review as a reference.
Workshop Penentuan Parameter Spesifik dan Non Spesifik Bahan Baku Obat Tradisional pada Mahasiswa Farmasi UHAMKA Melalui PKKM agustin yumita; Ni Putu Ermi Hikmawanti; Fujianti; Novia Delita
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 1 (2023)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v4i1.3722

Abstract

Indonesia's abundant biodiversity provides good opportunities for developing medicines, especially traditional medicines made from plant materials. However, it is necessary to standardize the process to realize quality, safe, and efficacious traditional medicinal preparations. This standardization process is essential. This workshop aims to provide information on the standardization of raw materials for traditional medicines to have the knowledge and ability to standardize medicinal raw materials. At the initial stage, participants will be given a pretest. Furthermore, participants studied specific and non-specific parameters, and at the last stage, the participants were given a posttest. The data obtained from the pretest and posttest will then be processed using Excel and the IBM SPSS Statistics version 25.0 application. From the results of the workshop activities, the average value of the pretest results was 62.5806, smaller than the posttest results of 83.2258. This indicates a significant difference of P < 0.05 between the pretest and posttest. In this workshop, the team provided an understanding to the participants in standardizing the raw materials for traditional medicines. The statistical results also showed a significant effect on the treatment before being given training and after being given training to the workshop participants.
Peningkatan Pengetahuan Mengenai Penyakit Kardiovaskular dan Manfaat Konsumsi Sayur dan Buah Pada Masyarakat Desa Pasir Angin, Cileungsi, Jawa Barat Wiyati, Tuti; Nurhasna, Nurhasna; Hikmawantia, Ni Putu Ermi
Society : Jurnal Pengabdian Masyarakat Vol 2, No 3 (2023): Mei
Publisher : Edumedia Solution

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55824/jpm.v2i3.271

Abstract

Cardiovascular disease is still at the top cause of death in Indonesia and globally. Cardiovascular diseases include hypertension, stroke, and heart disease. Knowledge is still ignored and also an unhealthy lifestyle caused increasing worse risk of its. The aim was to educate about the knowledge of cardiovascular disease and the importance of consuming vegetables and fruits as preventive and treatment of its in community of Pasir Angin Village, Cileungsi, West Java. The implementation method started with education through explanation of cardiovascular disease followed by providing information on the content of active compounds in vegetables and fruits that is beneficial for its. The succeeded of this activity was analized by the average pre-test and post-test and feed back that actually seemed by some reacted of pasticipants on discussed session. From the results has known that the knowledge of participants before being given education was 65%, increasing to 81%. Conclusion: cardiovascular disease education is still very much needed in communities widely.
Peningkatan Pengetahuan Pangan Sehat Aman Serta Kemampuan Pembuatan Bekal Sehat Anak Pada Orang Tua Murid TK Khalifah Jakarta 1: Improving the Knowledge of Safe Healthy Food and The Ability to Make Healthy Meals for Children in Parents of Students at TK Khalifah Jakarta 1 Hikmawanti, Ni Putu Ermi; Fatmawati, Sofia; Wiyati, Tuti
J.Abdimas: Community Health Vol 5 No 1 (2024): J.Abdimas: Community Health - Mei 2024
Publisher : LPPM STIKES Guna Bangsa Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30590/jach.v5n1.662

Abstract

Children are an age group that experiences a period of rapid growth and development during this phase of life, so healthy and safe food intake is needed to support optimal growth and development. Therefore, education about healthy and safe food for parents (guardians) is expected to maintain children's health and build healthy lifestyles for them into adulthood. The aim of implementing this community service program (PPM) is to help increase the knowledge of parents (and guardians) in determining healthy and safe food for children and families. The target of delivering this PPM is to parents (and guardians) of students at TK Khalifah Jakarta 1, located around the Faculty of Pharmacy and Science Campus, UHAMKA, East Jakarta. Implementation of PPM is carried out through the socialization of healthy and safe food materials. Training on making and packaging healthy lunches is also carried out in this activity involving parents (and guardians). Evaluation of the success of this PPM activity is assessed using a questionnaire given before and after the implementation of the activity. Based on statistical analysis, the results showed that there was an increase in knowledge of healthy and safe food and the ability of parents (and guardians) of students to make healthy provisions for children by 72.2% (a=0.05).
Co-Authors Abdul Mun'im Agustin Yumita Agustin Yumita Agustin Yumita Agustin Yumita Ajeng Istiningtyas Wahyudi Putri Amalia, Halisa Annisa, Ayyoehan Tiara Arif Fauzan, Muhammad Arry Yanuar Ashfiya , Shafna Raudlatul Aulia, Cahya Aulia, Cahya Ayyoehan Tiara Annisa Az-zahra, Siti Fatimah Cahya Aulia Cahyani, Siti Rosidah Cahyaningrum, Niken Chandra Adam Lesmana Chatarina Umbul Wahyuni Daniek Viviandhari Endang Hanani Endang Hanani Fadlina Chany Saputri Faradisa, Shafira Fatmawati, Sofia Fujianti Hadi Sunaryo Hadi Sunaryo Hariyanti Hariyanti Hayati Hayati Hayati Hayati Jihan Esa Siregar Lusiana Lusiana Maharani, Shintia Maifitrianti Maifitrianti Maifitrianti Maifitrianti, Maifitrianti Mardiyanti, Rini Muhammad Rafiq Mun'im, Abdul Nora Wulandari Novia Delita Numlil Khaira Rusdi, Numlil Khaira Nurhasna, Nurhasna Nurhasnah Nurhasnah Nurhasnah Nurhidayah, Sahera Nurkamalia, Prasetyo, Rachmad Eka Prasetyo, Rachmad Eka Putri, Ajeng Istiningtyas Wahyudi Putri, Meira Amalia Rachmad Eka Prasetyo Ratih Asmana Ningrum Shintia Maharani Silvy Yulida Sofia Fatmawati Tuti Wiyati Tuti Wiyati Tuti Wiyati Ulfah, Yuanita Sofiana Vesya Putri Viransa Vindianita . Viransa, Vesya Putri Viransa, Vesya Putri Wiyati, Tuti Wiyati, Tuti Yeni Andriyani Yeni Andriyani Yuanita Sofiana Ulfah Yumita, Agustin Zainal Arifin