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All Journal HAYATI Journal of Biosciences Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical Science and Technology MPI (Media Pharmaceutica Indonesiana) As-syifaa Jurnal Farmasi Jurnal SOLMA Jurnal Jamu Indonesia BERNAS: Jurnal Pengabdian Kepada Masyarakat J.Abdimas: Community Health Society: Jurnal Pengabdian Masyarakat Pharmaceutical Sciences and Research (PSR) Borneo Journal of Pharmacy Jurnal Pengabdian Farmasi dan Sains Indonesian Journal of Jamu
Ni Putu Ermi Hikmawanti
Departemen Biologi Farmasi, Fakultas Farmasi Dan Sains, Universitas Muhammadiyah Prof. DR. HAMKA, DKI Jakarta 13460, Indonesia
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Analisis Flavonoid pada Fraksi Hasil Hidrolisat Ekstrak Daun Cordia sebestena L. Hikmawanti, Ni Putu Ermi; Hanani, Endang; Mardiyanti, Rini
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.38849

Abstract

Cordia sebestena L. (Boraginaceae) atau Cordia merupakan tanaman hias dengan kandungan flavonoid. Penelitian ini bertujuan menganalisis senyawa flavonoid pada fraksi hasil hidrolisat ekstrak etanol 70% daun Cordia. Penelitian terbagi menjadi 7 tahapan, yaitu (1) maserasi daun menggunakan etanol 70%, (2) hidrolisis asam pada ekstrak dengan HCl 2N pada 95 °C selama 2 jam, (3) fraksinasi hidrolisat dengan etil asetat, (4) penentuan kadar flavonoid total dengan kolorimetri, (5) pengujian aktivitas antiradikal terhadap 2,2’-difenil-1-pikrilhidrazil (DPPH), (6) pemisahan flavonoid menggunakan kromatografi lapis tipis (KLT), dan (7) identifikasi flavonoid menggunakan spektrofotometri UV-Vis dan infra merah. Hasil menunjukan kadar flavonoid total fraksi etil asetat sebesar 8,20 mgQE/g dengan nilai IC50 terhadap radikal DPPH sebesar 296,91 µg/mL. Kromatogram KLT menunjukkan keberadaan satu bercak senyawa pada fraksi etil asetat dengan nilai hRf adalah 85,5. Hasil spektrum UV-Vis pada bercak tersebut diperoleh serapan pada 340 nm (pita I) dan 240 nm (pita II). Sedangkan spektrum infra merah menunjukan adanya sinyal pada 3363 cm-1 (O-H ulur), 1727 cm-1 (C=O), 1459 cm-1 (cincin aromatik) dan 1060 cm-1 kuat (C-O). Dengan demikian, dapat disimpulkan bahwa fraksi etil asetat hidrolisat ekstrak etanol daun Cordia mengandung senyawa flavonoid yang mirip dengan kelompok kalkon.
Anatomi Jaringan, Identifikasi Mikroskopis, serta Kadar Polifenol Ekstrak Etanol Daun dari Tiga Jenis Jambu Genus Syzygium Hikmawanti, Ni Putu Ermi; Yumita, Agustin; Hanani, Endang; Faradisa, Shafira; Az-Zahra, Siti Fatimah; Ashfiya , Shafna Raudlatul
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 1 (2023): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i1.5311

Abstract

Tiga spesies dari genus Syzygium, seperti jambu air (Syzygium aqueum (Burm.f.) Alston), jambu bol (Syzygium malaccense (L.) Merr. & L.M. Perry), dan jambu semarang (Syzygium samarangense (Blume) Merr. & L. M. Perry), telah dimanfaatkan daunnya dalam pengobatan tradisional karena kandungan polifenolnya. Penelitian ini bertujuan untuk mempelajari anatomi jaringan, mikroskopis, kadar senyawa fenol, flavonoid, dan tanin ekstrak etanol daun dari tiga jenis jambu tersebut. Daun jambu biji (Psidium guajava) digunakan sebagai pembanding. Anatomi jaringan daun dan identifikasi mikroskopis dilakukan menggunakan mikroskop. Penentuan kadar senyawa pada ekstrak etanol 70% ditentukan dengan metode kolorimetri yang absorbansinya diukur pada spektrofotometer UV- Vis. Anatomi jaringan daun dan fragmen pengenal secara mikroskopis ada kemiripan pada ketiga jenis daun jambu genus Syzygium. Secara statistik, ada perbedaan signifikan antara kadar fenol, flavonoid, dan tanin pada ekstrak etanol 70% daun jambu air, daun jambu bol, dan daun jambu semarang dibandingkan dengan ekstrak etanol 70% daun jambu biji. Daun jambu air merupakan spesiesterpilih dari genus Syzygium yang diuji pada penelitian ini dengan kandungan polifenol yang tinggi. Leaves of three guava species of the genus Syzygium, such as water apple/jambu air (Syzygium aqueum (Burm.f.) Alston), malay apple/jambu bol (Syzygium malaccense (L.) Merr. & L.M. Perry), and wax apple/jambu Semarang (Syzygium samarangense (Blume) Merr. & L. M. Perry), have been used in traditional medicine because of its polyphenol content. This study aims to investigate the anatomy of leaf tissues, powder microscopical characteristic, and total phenolic, flavonoids, and tannins content in the ethanol extract of the leaves of the three types of selected guava species of the genus Syzygium. Guava leaves (Psidium guajava) were used as a comparison. Leaf tissue anatomy and microscopic identification were carried out using a microscope. Determination of the polyphenol content in 70% ethanol extract was determined by the colorimetric method in which the absorbance was measured on a UV-Vis spectrophotometer. Leaf tissue anatomy and microscopic recognition fragments are similar in the three types of Syzygium guava leaves. Statistically, there were significant differences between the total phenols, flavonoids, and tannins content in the 70% ethanol extract of water apple, Malay apple, and wax apple compared to the 70% ethanol extract of guava leaves. Water apple leaves are selectedspecies from the genus Syzygium tested in this study with high polyphenol content.
SOSIALISASI BAHAYA BAHAN KIMIA OBAT (BKO) DALAM JAMU DAN PELATIHAN MEMBUAT SEDUHAN HERBAL Hikmawanti, Ni Putu Ermi; Fatmawati, Sofia; Wiyati, Tuti
JURNAL PENGABDIAN FARMASI DAN SAINS Vol. 3 No. 1 (2024): Oktober 2024
Publisher : Jurusan Farmasi FMIPA Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/jpsf.2024.v3.i1.17399

Abstract

Jamu is a traditional medicine that is still popular with Indonesian people. Jamu consists of herbs or medicinal plants that are efficacious for preventing disease and maintaining body health. Generally, herbal medicine can be prepared by the community themselves. However, nowadays, herbal medicine has developed a lot and is packaged in the form of products that are ready to be consumed. Unfortunately, several herbal medicine products were found to contain prohibited medicinal chemicals (BKO). The community needs socialization of the dangers of BKO and training in making herbal infusions that are safe, easy and healthy for the body. Women from PKK RT 06 RW 05 Malaka Sari are the targets for this activity. The success achievements of the activities were evaluated with a pre-post-test by filling out a questionnaire. In the future, knowledge regarding the safe selection and method of consuming herbal medicine can be applied in the family to maintain body health and preserve the consumption of herbal medicine as Indonesia's cultural heritage.
KANDUNGAN PIPERIN DALAM EKSTRAK BUAH LADA HITAM DAN BUAH LADA PUTIH (Piper nigrum L.) YANG DIEKSTRAKSI DENGAN VARIASI KONSENTRASI ETANOL MENGGUNAKAN METODE KLT-DENSITOMETRI Hikmawanti, Ni Putu Ermi; Hariyanti, Hariyanti; Aulia, Cahya; Viransa, Vesya Putri
Media Farmasi: Jurnal Ilmu Farmasi Vol. 13 No. 2: September 2016
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v13i2.7769

Abstract

Kualitas ekstrak buah lada (Piper nigrum L.) dipengaruhi oleh komponen dan kadar senyawa didalamnya. Piperin merupakan senyawa alkaloid utama dalam buah lada.  Banyaknya piperin yang larut selama proses ekstraksi dipengaruhi oleh jenis pelarut yang digunakan. Penelitian ini didesain untuk mengetahui kadar piperin dalam ekstrak buah lada hitam dan lada putih yang diekstraksi dengan variasi konsentrasi etanol. Ekstraksi buah lada dilakukan dengan metode ekstraksi sokhlet menggunakan variasi konsentrasi etanol (60%, 70% dan 96%) dan kemudian dilanjutkan dengan teknik ekstraksi asam-basa untuk mendapatkan ekstrak alkaloidnya. Ekstrak alkaloid masing-masing dianalisis pada plat KLT silika gel 60 F254 sebagai fase diam dan campuran n-heksana:etil asetat (1:1) sebagai fase gerak. Kadar piperin ditetapkan menggunakan metode KLT-densitometri pada panjang gelombang 254 nm. Hasil menunjukkan bahwa kadar piperin tertinggi diperoleh dari ekstrak buah lada hitam menggunakan pelarut etanol 60% sebagai pelarut pengekstraksi dengan kadar 52,81±4,66 (%b/v) terhadap ekstrak alkaloidnya. Kadar piperin tertinggi diperoleh dari ekstrak buah lada putih menggunakan pelarut etanol dengan konsentrasi 96% sebagai pelarut pengekstraksi dengan kadar 38,72±8,28 (%b/v) terhadap ekstrak alkaloidnya.
Kombinasi Ekstrak Herba Andrographis Paniculata (Burm f.) Nees dan Daun Pandanus Amaryllifolius Roxb. Sebagai Antihiperglikemia Hikmawanti, Ni Putu Ermi; Sunaryo, Hadi; Prasetyo, Rachmad Eka
Media Farmasi: Jurnal Ilmu Farmasi Vol. 15 No. 1: Maret 2018
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v15i1.9696

Abstract

Herba Andrographis paniculata (Burm f.) Nees atau sambiloto dan daun Pandanus amaryllifolius (Burm f.) Nees atau pandan wangi telah diketahui khasiatnya sebagai antihiperglikemia. Penelitian bertujuan untuk mengoptimasi kombinasi ekstrak etanol 70% herba sambiloto dan daun pandan wangi sebagai antihiperglikemia pada tikus jantan galur Sprague Dawley yang diinduksi aloksan. Hewan uji dibagi menjadi 7 kelompok perlakuan, masing-masing kelompok terdiri dari 4 ekor tikus. Kelompok I adalah kelompok tanpa perlakuan; kelompok II mendapatkan glibenklamid dosis 0,26 mg/Kg BB; kelompok III mendapatkan ekstrak herba sambiloto tunggal dosis 1000 mg/Kg BB; kelompok IV mendapatkan ekstrak daun pandan wangi tunggal dosis 600 mg/Kg BB; kelompok V, VI, dan VII masing-masing mendapatkan kombinasi ekstrak herba sambiloto dan daun pandan wangi dosis berturut-turut 1000:300, 500:300, dan 500:600 mg/Kg BB. Pemeriksaan kadar gula darah menggunakan sampel serum darah tikus yang diukur dengan metode GOD-PAP dan dibaca dengan spektrofotometer klinikal mikrolab 300. Preparat jaringan pankreas diamati menggunakan mikroskop dengan perbesaran 40x untuk melihat ada tidaknya vacuolation dan nekrosis pada sel pulau Langerhans pankreas. Data persentase penurunan kadar gula darah tikus dianalisis menggunakan ANOVA satu arah dan dilanjutkan dengan uji Tukey. Gambaran histopatologi pankreas dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa kelompok yang mendapatkan kombinasi ekstrak herba sambiloto dan daun pandan wangi (500:300 mg/Kg BB) merupakan kelompok kombinasi yang lebih baik dari kelompok ekstrak tunggalnya (p<0,05) dan sebanding dengan kelompok kontrol positif glibenklamid (p>0,05) dalam menurunkan kadar gula darah. Semua kelompok kombinasi ekstrak mampu memberikan perbaikan sel pulau Langerhans pankreas tikus. 
Piperine Levels in Java Chili and Black Fruits Extracts from Regions with Different Altitude Hikmawanti, Ni Putu Ermi; Hanani, Endang; Maharani, Shintia; Putri, Ajeng Istiningtyas Wahyudi
Jurnal Jamu Indonesia Vol. 6 No. 1 (2021): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v6i1.176

Abstract

Piper retrofractum Vahl. (java chili or cabe jawa) and Piper nigrum L. (black pepper or lada hitam) are parts of the Piperaceae. One of the chemical constituents found in the fruit of the two plants is piperine, which has properties as antimicrobial, antidiabetic, anti-inflammatory, anticancer etc. This study aims to determine the piperine levels contained in 95% ethanol extract of java chili and black pepper fruits from regions with different altitude using UV-Visible spectrophotometer. Each sample were extracted by maceration method using 95% ethanol. Qualitative identification of piperine was carried out using thin layer chromatography (TLC). Determination of piperine levels was carried out with UV-Visible spectrophotometer at maximum wavelength of 253.8 nm. The results showed that the levels of piperine contained in the 95% ethanol extract of java chili fruit from low altitude (Lampung), medium altitude (Madura) and high altitude (Bogor) are 1.54&plusmn;0.02%; 1.44&plusmn;0.02%; and 1.41&plusmn;0.02% (w/v), respectively. Whereas the levels of piperine contained in the 95% ethanol extract of black pepper fruit from low altitude (East Luwu), medium altitude (Central Lampung) and high altitude (Bogor) are 5.63&plusmn;0.14%; 5.38&plusmn;0.05%; and 4.87&plusmn;0.09% (w/v), respectively.
Total Flavonoid Content in Hydro-ethanolic Extract of Sauropus androgynus (L.) Merr Leaves from Three Regions with Different Altitude Ni Putu Ermi Hikmawanti; Hayati; Yeni Andriyani
Jurnal Jamu Indonesia Vol. 6 No. 2 (2021): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v6i2.195

Abstract

Sauropus androgynus (L.) Merr (Phyllanthaceae), also known as katuk in Indonesia, is a plant that grows in tropical climates. The study aimed to determine the total flavonoid levels of hydroethanolic extract of katuk leaves from three regions with different altitudes. Dried katuk leaves were macerated using hydroethanolic (the mixture of ethanol:H2O (7:3, v/v)) as solvent extraction at room temperature. Determination of flavonoid levels was carried out by the colorimetry method using AlCl3 reagent. Quercetin was used as a reference. A UV-Visible spectrophotometer measured the absorbance at the maximum wavelength of 434.50 nm. The total flavonoids level of hydroethanolic extract of katuk leaves from a different region with low-altitude (Bogor), medium-altitude (Sleman), and high-altitude (Bandung) are 8.56±0.63 mgQE/g, 4.67±0.30 mgQE/g, and 9.72±0.24 mgQE/g, respectively. Thus, it can be concluded that there are differences in total flavonoid levels of hydroethanolic extract of katuk leaves from three regions with different altitudes.
Antioxidant Polyphenolics Extraction Techniques from Beluntas Leaves using Choline Chloride-Urea: Comparative Study with 70%-Ethanol Hikmawanti, Ni Putu Ermi; Yumita, Agustin; Amalia, Halisa; Cahyani, Siti Rosidah; Putri, Meira Amalia; Mun'im, Abdul
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 2 (2025): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i2.7627

Abstract

Pluchea indica L. (Less), known as Indian camphorweed (common name) or Beluntas (Indonesia), is an antioxidant polyphenol-rich plant. In our previous studies, choline chloride-urea (CCU) at a molar ratio of 1:2 was one type of natural deep eutectic solvents (NADES) in the extraction of P. indica leaves (PIL) polyphenolics. The present study aims to evaluate the comparison of total phenolics (TPC) and flavonoids content (TFC) and antioxidant activity of CCU (1:2) extract of PIL obtained from ultrasonic-assisted extraction (UAE) and magnetic stirrer-assisted extraction (MSAE). Ethanol was used as a comparison to conventional extraction solvents. Determination of TPC and TFC was carried out using colorimetric with a microplate reader, while the antioxidant activity test was carried out using the ferric thiocyanate (FTC) method. The UAE is more effective in terms of PIL flavonoid extraction using CCU compared to MSAE, while PIL phenolic extraction with CCU is more effective with MSAE. CCU extract of PIL from extraction with MSAE at a concentration of 1.56% has an antioxidant capacity equivalent to 500 ppm ascorbic acid in inhibiting lipid peroxidation by about 70%. Thus, CCU combined with the MSAE can be recommended in further development of phenolic antioxidants extraction from PIL.
Co-Authors Abdul Mun'im Agustin Yumita Agustin Yumita Agustin Yumita Agustin Yumita Ajeng Istiningtyas Wahyudi Putri Amalia, Halisa Annisa, Ayyoehan Tiara Arif Fauzan, Muhammad Arry Yanuar Ashfiya , Shafna Raudlatul Aulia, Cahya Aulia, Cahya Ayyoehan Tiara Annisa Az-zahra, Siti Fatimah Cahya Aulia Cahyani, Siti Rosidah Cahyaningrum, Niken Chandra Adam Lesmana Chatarina Umbul Wahyuni Daniek Viviandhari Endang Hanani Endang Hanani Fadlina Chany Saputri Faradisa, Shafira Fatmawati, Sofia Fujianti Hadi Sunaryo Hadi Sunaryo Hariyanti Hariyanti Hayati Hayati Hayati Hayati Jihan Esa Siregar Lusiana Lusiana Maharani, Shintia Maifitrianti Maifitrianti Maifitrianti Maifitrianti, Maifitrianti Mardiyanti, Rini Muhammad Rafiq Mun'im, Abdul Nora Wulandari Novia Delita Numlil Khaira Rusdi, Numlil Khaira Nurhasna, Nurhasna Nurhasnah Nurhasnah Nurhasnah Nurhidayah, Sahera Nurkamalia, Prasetyo, Rachmad Eka Prasetyo, Rachmad Eka Putri, Ajeng Istiningtyas Wahyudi Putri, Meira Amalia Rachmad Eka Prasetyo Ratih Asmana Ningrum Shintia Maharani Silvy Yulida Sofia Fatmawati Tuti Wiyati Tuti Wiyati Tuti Wiyati Ulfah, Yuanita Sofiana Vesya Putri Viransa Vindianita . Viransa, Vesya Putri Viransa, Vesya Putri Wiyati, Tuti Wiyati, Tuti Yeni Andriyani Yeni Andriyani Yuanita Sofiana Ulfah Yumita, Agustin Zainal Arifin