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All Journal Jurnal Ilmu dan Teknologi Kelautan Tropis Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Acta Pharmaceutica Indonesia Indonesian Journal of Chemistry JSKK (Jurnal Sains Keolahragaan dan Kesehatan) Marine Research in Indonesia PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JFIOnline Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASI GALENIKA Jurnal Farmagazine Narra J Pharmaceutical Sciences and Research (PSR) Molekul: Jurnal Ilmiah Kimia Jurnal Kefarmasian Indonesia Journal of Tropical Pharmacy and Chemistry Jurnal Farmasi Galenika
Sophi Damayanti
Institut Teknologi Bandung
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Optimasi Proses Pembuatan dan Karakterisasi Fisik Niosom Sinkonin Hariyanti Hariyanti; Sophi Damayanti; Sasanti Tarini
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 16 No. 02 Desember 2019
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (632.613 KB) | DOI: 10.30595/pharmacy.v16i2.5841

Abstract

Sinkonin praktis tidak larut dalam air, sedikit larut dalam kloroform dan alkohol. Hal ini berdampak pada rendahnya penetrasi transfollicular sinkonin, karena hanya bahan aktif hidrofilik yang mampu melewati hair follicle. Dengan demikian dibutuhkan satu sistem penghantaran yang mampu menurunkan hidrofobisitas sinkonin untuk meningkatkan penetrasi sinkonin ke follicle. Niosom merupakan vesikel ampifilik dengan struktur lapisan rangkap yang terbentuk dari hidrasi kombinasi surfaktan nonionik dan kolesterol yang mampu menurunkan hidrofobisitas sinkonin. Penelitian ini bertujuan untuk menentukan proses pembuatan niosom sinkonin yang optimum. Pembuatan niosom sinkonin diawali dengan menentukan temperatur gelasi (Tg) dari span 60 dengan Differential Scanning Calorimetry (DSC), kemudian dilanjutkan dengan optimasi proses meliputi: optimasi kecepatan rotavapor pembentukan film lapis tipis, temperatur hidrasi, kecepatan rotavapor hidrasi, waktu hidrasi, dan waktu sonikasi. Karakteristik vesikel niosom yang optimal meliputi: ukuran partikel dan indeks polidispersitas dengan menggunakan Particle Size Analized (PSA) serta efisiensi penjeratan sinkonin dengan menggunakan KCKT. Temperatur gelasi (Tg) span 60 45±2 oC, kecepatan rotavapor pembentukan film lapis tipis niosom 210 rpm, temperatur hidrasi 55±2 oC, kecepatan rotavapor hidrasi 210 rpm, waktu hidrasi 20 menit, waktu sonikasi suspensi niosom 1 menit. Ukuran vesikel yang diperoleh adalah 100–200 nm, indeks polidispersitas 0,2–0,4 dan efisiensi penjeratan niosom sinkonin 84,49±0,0025%. Proses pembuatan niosom sinkonin memiliki pengaruh besar terhadap hasil ukuran vesikel dan efisiensi penjeratan niosom sinkonin.
Identification of Community Knowledge on Lead Contamination and Analysis of Lead Level in Fish Nurwulan, Sita; Damayanti, Sophi; Amalia, Lia
Pharmaceutical Sciences and Research Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Poisoning is an event of human exposure to poisonous substances that are harmful to the body at certain doses. Lead is a heavy metal that can cause toxicity, including neurotoxic effects, hypertension, digestive system disorders, bone and tooth growth disorders, immune system disorders, infertility, and fetal disorders. Fish is a source of nutrients that are often consumed by people, however can also accumulate lead. This study aimed to analyze the lead level in fish and identify the community knowledge level regarding lead contamination in fish. Identification of community knowledge levels regarding lead. Identification of community knowledge levels regarding lead contamination in fish was conducted on three hundred respondents consisting of School of Pharmacy (SF) Institut Teknologi Bandung (ITB) one hundred students, one hundred community, and one hundred housewives. This study also analyzed lead levels in six fish samples using Graphite Furnace Atomic Absorption Spectroscopy (GFAAS). As the result, SF ITB students had the highest level of knowledge in the definition of lead (97%), lead poisoning (98%), fish lead accumulation (75%), the poisoning effects of lead, and sources of lead. However, all of the respondents had a low level of knowledge regarding regulations about lead levels in fish. The lead levels analysis on fish showed that three out of six samples had lead levels that exceeded the limit of lead contamination (>0.2 g/kg). The study indicated that respondents’ knowledge regarding lead contamination in fish is still low and lead-contaminated fish is still being sold on the market.
A Deep Overview of Anticoagulant Drugs: Recent Synthesis and Their Activity Assay Engrid Juni Astuti; Slamet Ibrahim; Muhammad Ali Zulfikar; Sophi Damayanti
Indonesian Journal of Chemistry Vol 24, No 2 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.87252

Abstract

During the unprecedented COVID-19 pandemic, anticoagulant drugs have emerged as a crucial component of treatment alongside antivirus medications. Patients with severe COVID-19 frequently have critical conditions marked by blood clot development, necessitating the administration of anticoagulants. This review aims to provide a comprehensive overview of various anticoagulant drugs, their synthesis methods, and assays employed to predict their anticoagulant activity. Notable anticoagulant categories frequently utilized include oral anticoagulants heparin, non-vitamin K antagonists, and vitamin K antagonists. In recent years, the development of new anticoagulants has seen a shift towards a multifaceted approach that combines in silico prediction with in vitro and in vivo assays. In silico prediction techniques play a pivotal role in the initial screening process. This integrated approach has yielded promising results, paving the way for the synthesis of novel anticoagulant candidates, as substantiated by a battery of in vitro, in vivo, and ex-vivo tests.
Synthesis and Characterization Molecularly Imprinted Polymers for Analysis of Dimethylamylamine Using Acrylamide as Monomer Functional Amin, Saeful; Damayanti, Sophi; Ibrahim, Slamet
Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 2, AGUSTUS 2018
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v8i2.330

Abstract

A selective separation techniques with Molecularly Imprinted Polymer (MIP) for High-Performance Liquid Chromatography (HPLC) has been developed for the assay of Dimethylamylamine (DMAA) doping compounds. Molecular imprinted polymer (MIP) is a technique to produce a polymer having the cavity due to the disposal of the templates, in which the cavity serves to recognize the molecules of the same size, structure, chemical and physical properties. The selectivity and affinity of the templates itself will increase, while the concentration value is increasing. MIP is made by DMAA as template, acrylamide as functional monomer, ethylene glycol dimethacrylate (EGDMA) as cross linking, azobisisobutyronitrile (AIBN) as the initiator and chloroform as a porogen solvent; using bulk method. The aim of research are conduct the MIP for the DMAA compound analysis, then the formed MIP is characterized by using Fourier Transform Infra Red (FTIR) and Scanning Electron Microscopy (SEM) to find out the polymer complexes formed and the morphological form of the MIP. The MIP formed then was analyzed by using High-Performance Liquid Chromatography (HPLC) to know the amount of the DMAA, the adsorption capacity, and the adsorption condition found in the MIP. The result of analysis on the content of DMAA in the MIP by using UV-Vis Spectrophotometer is 1.957 mg. Scanning Electron Microscopy (SEM) shows that the MIP has irregular and rough morphological structure; while the NIP has irregular morphology structures and smooth surfaces shape
Evaluasi Formula Krim Minyak Biji Delima (Punica granatum L.) dan Uji Aktivitas Antioksidan dengan Metode β-Carotene Bleaching Nur Mita; Sasanti Tarini D.; Sophi Damayanti
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 2 (2015): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v3i2.97

Abstract

Minyak biji delima memiliki aktivitas antioksidan kuat, sehingga berpotensi untuk diformulasi menjadi sediaan antioksidan topikal. Tujuan penelitian ini adalah untuk mengevaluasi formula sediaan krim minyak biji delima dan menguji aktivitas antioksidan dari sediaan tersebut. Krim a/m diformulasi menggunakan emulgator Tween 80- Span 80. Evaluasi sediaan meliputi pemeriksaan pH dan viskositas sediaan yang disimpan selama 4 minggu pada suhu kamar, stabilitas fisik dengan metode Freeze Thaw sebanyak 4 siklus dimana 1 siklus terdiri dari 48 jam pada suhu 4°C dan 48 jam pada suhu 40°C. Potensi antioksidan diuji dengan metode β-Carotene Bleaching. Formula krim yang mengandung minyak biji delima 1% stabil secara fisik. Hasil uji efek antioksidan menunjukkan persen penghambatan minyak biji delima murni dan minyak biji delima dalam bentuk krim terhadap penurunan warna β-Carotene berturut-turut adalah 73,41% dan 52,80%. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa aktivitas antioksidan minyak biji delima dalam bentuk krim mengalami penurunan 0,3 kali.Kata kunci: krim, minyak biji delima, antioksidan, β-Carotene BleachingABSTRACTPomegranate seed oil has a potent antioxidant activity that is potential to be formulate into topical antioxidant dosage form. The purpose of this study is to formulate cream of pomegranate seed oil that physically stable, however have antioxidant activity. Cream w/o was formulated using Tween 80 - Span 80 as emulsifier. Evaluation of cream products includes determining pH and viscosity of the preparations stored for 4 weeks at room temperature, physical stability test by Freeze Thaw method which was carried out for 4 cycles in where 1 cycle consists of 48 hours at 4°C and 48 hours at 40°C. Antioxidant activity was tested by β-carotene bleaching method. The results of the research showed that all cream formulas containing pomegranate seed oil 1% were physically stable and can increase the comfortness in use on the skin. The antioxidant test results showed antioxidant activity of pure pomegranate seed oil and pomegranate seed oil as formulated in creams have antioxidant capacity with inhibition percentage of 73.41% and 52.80%, respectively. Based on these results it can be concluded that the antioxidant activity of pomegranate seed oil in cream decreased 0,3 times.Keywords: cream, pomegranate seed oil, antioxidant, β-Carotene Bleaching
Reseptor P2Y G-Protein Couple Receptors (GPCRs): Target Menarik Pengembangan Obat Baru Sophi Damayanti
JURNAL FARMASI GALENIKA Vol 2 No 01 (2015): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v2i01.23

Abstract

P2Y purinergik reseptor adalah bagian dari G-protein couple receptor (GPCRs), group reseptor yang merupakan target utama pada berbagai pengobatan. Hingga kini, delapan subtipe reseptor P2Y telahdiidentifikasi. Kelompok pertama dari P2Yadalah reseptor P2Y1, P2Y2, P2Y4, P2Y6, dan P2Y11. Reseptor P2Yditemukan di berbagai lokasi di dalam tubuh seperti otak, limfosit, paru-paru, sel darah dan lain-lain. Salah satu reseptor yaitu reseptor P2Y12 memainkan peran utama dalam aktivasi trombosit. Reseptor ini dilaporkan untuk mengambil bagian dalam amplifikasi dan penyelesaian aktivasi platelet dan agregasi antagonis reseptor P2Y12 yang telah dikenal untuk pengobatan adalah clopidogrel dan ticlopidin. Berdasarkan lokasi dan peran P2Y reseptor dalam berbagai fungsi tubuh, dapat disimpulkan bahwa P2Y reseptor merupakan salah satu reseptor yang dapat dijadikan pengembangan obat secara rasional berdasarkan target.
Toxicity assessment and bioimaging potential of carbon dots synthesized from banana peel in zebrafish model Wijayanti, Ni PAD.; Permatasari, Fitri A.; Damayanti, Sophi; Anggadiredja, Kusnandar; Iskandar, Fery; Wibowo, Indra; Rachmawati, Heni
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1228

Abstract

Zebrafish serve as a pivotal model for bioimaging and toxicity assessments; however, the toxicity of banana peel-derived carbon dots in zebrafish has not been previously reported. The aim of this study was to assess the toxicity of carbon dots derived from banana peel in zebrafish, focusing on two types prepared through hydrothermal and pyrolysis methods. Banana peels were synthesized using hydrothermal and pyrolysis techniques and then compared for characteristics, bioimaging ability, and toxicity in zebrafish as an animal model. Pyrolysis-derived banana peel and hydrothermal-derived banana peel showed blue emission under ultraviolet light, indicating excitation-dependent behavior. To test their potential application for bioimaging, a soaking method was used using zebrafish that showed fluorescence intensity in the eyes, abdomen, and tail of zebrafish. Toxicity comparison showed that pyrolysis-derived banana peel had lower toxicity with 50% lethal concentrations (LC50) of 1707.3 ppm than hydrothermal-derived banana peel (LC50 993 ppm) in zebrafish. Both types of carbon dots showed significant differences (p<0.05) in hatching rates at 96 and 120 hours of exposure. Of the two methods for carbon dot synthesis from banana peel, the pyrolysis method had a higher toxicity threshold than the hydrothermal method, as indicated by the LC50 value and the number of zebrafish embryos that died, hatched delayed, and experienced malformation during their development.
EVALUASI PENGETAHUAN MAHASISWA FARMASI DAN MASYARAKAT UMUM TERKAIT PENGGUNAAN SUPLEMEN PADA COVID-19 Reyaan, Irianti Bahana Maulida; Dwiyanti, Jessica; Damayanti, Sophi
Acta Pharmaceutica Indonesia Vol. 49 No. 01 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v49i01.23613

Abstract

COVID-19 adalah penyakit yang disebabkan oleh virus SARS-CoV-2. Selain obat, banyak penelitian yang juga dilakukan untuk menentukan efikasi serta keamanan suplemen untuk COVID-19, misalnya vitamin C, vitamin D, dan zink yang memiliki peran bagi sistem kekebalan tubuh termasuk potensiasi efek antivirus. Pengetahuan dan penggunaan suplemen yang tepat dapat menjadi salah satu upaya untuk menunjang pengobatan COVID-19. Survei dengan menggunakan kuesioner merupakan metode yang dapat dipilih untuk mendapatkan gambaran pengetahuan mahasiswa farmasi dan masyarakat umum terkait hal tersebut. Tujuan penelitian ini adalah menentukan tingkat pengetahuan mahasiswa farmasi dan masyarakat umum terkait suplemen dan penggunaannya dalam kondisi COVID-19. Survei dilakukan pada 412 responden yang terdiri dari mahasiswa farmasi dan masyarakat umum pada bulan Januari 2021-April 2021. Hasil survei dari 412 responden menunjukkan bahwa pengetahuan mahasiswa farmasi dan masyarakat umum terkait suplemen dan penggunaannya untuk COVID-19 masih kurang dengan 18,4% mahasiswa farmasi dan 4,5% masyarakat umum berada pada kategori pengetahuan tinggi. Berdasarkan analisis, tingkat pengetahuan mahasiswa farmasi lebih baik dari masyarakat umum terkait penyakit COVID-19, penggunaan suplemen secara umum, dan penggunaan suplemen untuk COVID-19 (p<0,001).
STUDI KOMPARATIF PREDIKSI PROFIL ADMET OBAT SINTETIS DENGAN SENYAWA AKTIF TANAMAN HERBAL ANTIMALARIA MELALUI PENDEKATAN IN SILICO Rima Rasida; Pinanga, Yangie Dwi Marga; Anjar Hermadi Saputro; Damayanti, Sophi
Acta Pharmaceutica Indonesia Vol. 49 No. 2 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

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Abstract

Resistance to antimalarial drugs has become a global challenge in achieving the target of malaria eradication. To address this issue, effective and safe alternative treatments are urgently needed. This study compares the ADMET profiles (absorption, distribution, metabolism, excretion, and toxicity) of synthetic antimalarial drugs with active compounds derived from herbal sources using an in-silico approach. The analyzed herbal compounds, including piperine, kaempferol, berberine, quassin, and limonin, demonstrated high intestinal absorption (>30%), good water solubility, and sufficient skin permeability. In the distribution analysis, kaempferol exhibited high volume distribution due to its lipophilic interactions with body tissues, although most compounds were unable to penetrate the blood-brain barrier. The herbal compounds piperine and kaempferol inhibited metabolic enzymes CYP2C19 and CYP1A2, whereas synthetic drugs tended to act as substrates. Regarding excretion, piperine served as a renal OCT2 substrate, while pyrimethamine exhibited low clearance. Toxicity assessments revealed that herbal compounds generally exhibited better toxicity profiles compared to synthetic drugs, with limonin showing the lowest acute and chronic toxicity. These findings suggest that herbal active compounds hold significant potential for development as alternative antimalarial agents, particularly in addressing drug resistance. This study highlights the importance of further developing herbal-based drugs through in silico approaches to enhance the efficacy and safety of malaria therapy. Keyword : malaria drug resistance, active herbal compounds, ADMET, In silico
Development and Validation of Analytical Method for Piperine in Phytopharmaceutical Product Containing Cabe Jawa Fructus by HPLC Galih, Wening; Permana, Benny; Damayanti, Sophi
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.46348

Abstract

Cabe Jawa fruit (Retrofractii fructus) has empirically known to have effects such as anti-inflammatory and analgesic due to the presence of piperine. The maximum daily dose for piperine is 0.300–0.540 mg/kg/person/day. A reliable analytical method is required to ensure that phytopharmaceutical preparation is safe. This study developed and validated a piperine analysis method using phytopharmaceutical samples containing Cabe Jawa. A Shimadzu prominence HPLC SIL-20A Prominence autosampler and an X-Bridge C18 column (5 m x 250 mm x 4.6 mm) were used in the research devices. The OFAT method optimised the mobile phase, instrument systems, and sample preparation. The instrument system was optimized for acetonitrile:1% glacial acetic acid (48:52), 40°C, and a 1 mL/min flow rate. Each solid and liquid sample was prepared using the multilevel methanol dilution and water-dichloromethane liquid-liquid extraction (LLE) method. The results of validating the analytical procedures for solid and liquid samples were LOD and LOQ of 1.290 g/mL and 4.300 g/mL, 1.310 g/mL and 4 g/mL, respectively. Precision: 0.157% and 1.174%. Accuracy for three different concentrations were 94.232±1.050%, 95.387%±0.176%, and 96.272±1.043%; 88.801±0.428%, 89.473 ±0.252%, and 89.338 ±0.052% respectively. The analysis of the sample's piperine revealed that this method met the criteria for the validation parameters.
Co-Authors Adi Suwandi Adi Suwandi Ahsogan, Kanaka L. Aluicia Anita Artarini Anjar Hermadi Saputro Bambang Gunawan Choong Chie Weng Daryono H Tjahjono Dian Ayu Eka Pitaloka Dina Pratiwi S.Si, M.Si Dwiyanti, Jessica Eko Prayitno Elin Yulinah Sukandar Engrid Juni Astuti Farel Fahrizal Fathurohman, Mochamad Fitria Muharini Framesti Frisma Sriarumtias Galih, Wening Gunawan, Bambang Hadi, Daryono Hariyanti Hariyanti HENI RACHMAWATI Indra Maulana` Indra Maulana Indra Topik Maulana Indra Wibowo Indra Wibowo Irma M. Puspitasari Irma M. Puspitasari, Irma M. Iskandar, Fery Julianti, Elin Julianti, Elin Kanaka L. Ahsogan Kartasasmita, Rahmana Emran Khonsa Khonsa Kurnia Firman Kusnandar Anggadiredja LIA AMALIA Mardiana Mardiana Mardiana, Mardiana Marlia Singgih Marlia Singgih Masdiana Tahir Muhammad Ali Zulfikar Muhammad Insanu Muharini, Fitria Nadiyah Athifah Salim Martak Nur Mita Nurwulan, Sita Permana, Benny Permana, Benny Permatasari, Fitri A. Pinanga, Yangie Dwi Marga Rahmana Emran Kartasasmita Rahmana Emran Kartasasmita Rasida, Rima Reyaan, Irianti Bahana Maulida Rika Hartati Saeful Amin Saeful Amin, Saeful Samuel Gunadi Tanusondjaja Sasanti Tarini Darijono Slamet Ibrahim Slamet Ibrahim - Sriarumtias, Framesti Frisma Sukrasno Sukrasno Sukraso Sukraso Tasia Amelia Tjahyono Tjahyono Triantri Kartika Putri Vita Yuanita Wanti Megawati Weng, Choong Chie Wibowo, Indra Wijayanti, Ni PAD. Yuanita, Vita