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All Journal Jurnal Ilmu Pertanian Indonesia Jurnal Teknologi Dan Industri Pangan Jurnal Sain Veteriner Indonesian Journal of Tropical and Infectious Disease Indonesian Journal of Biotechnology UNEJ e-Proceeding SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Biosaintifika: Journal of Biology & Biology Education Jurnal Pengabdian Masyarakat Kesehatan Amerta Nutrition Journal of Aquaculture and Fish Health Indian Journal of Forensic Medicine & Toxicology Berkala Penelitian Hayati Exact Paper In Compilation (EPIC) Jurnal Kedokteran Hewan Borneo Journal of Pharmacy Journal of Fisheries & Marine
Win Darmanto
Departement Of Biology, Faculty Of Science And Technology, Airlangga University, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Evaluation of Clove Volatile Extract Vaporizer Mats for Mosquito Control Against Aedes aegypti: Bioassay and Computational Analysis Mochammad Aqilah Herdiansyah; Rifaid Nur Arsad; Rosalia Nuril Qolbi; Inge Permatasari; Etik Ainun Rohmah; Sri Subekti; Siti Fatimatuz Zahra; Kris Cahyo Mulyatno; Intan Ayu Pratiwi; Zubaidah Ya’cob; Win Darmanto
Borneo Journal of Pharmacy Vol. 9 No. 2 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i2.11189

Abstract

Syzygium aromaticum contains bioactive compounds that may serve as natural alternatives to synthetic mosquito control agents. This study aimed to evaluate the mosquitocidal activity of stem, leaf, and bud extracts of S. aromaticum, formulated as vaporizer mats, against Aedes aegypti and to identify potential molecular targets of the major compounds in these extracts through computational analysis. Volatile extracts from stems, leaves, and buds were prepared by ethanol maceration and formulated into vaporizer mats at concentrations of 0.5% and 1%. A total of 525 adult A. aegypti (F330 strain) were exposed under controlled laboratory conditions in accordance with WHO guidelines. Mortality, LT50, and LT90 values were recorded after exposure. Molecular docking was performed against odorant-binding protein AaegOBP1 and pyruvate kinase (PK1), followed by molecular dynamics simulation. Among all treatments, bud extract at 1% produced the highest mortality (33%), compared with 2% in the negative control. LT50 and LT90 values for this treatment were 1.468 minutes and 50.543 minutes, respectively, indicating prolonged biological activity. Docking analysis showed that β-caryophyllene had the strongest affinity toward AaegOBP1 (-8.4 kcal/mol), while chavicol showed the strongest interaction with PK1 (-6.5 kcal/mol). Molecular dynamics simulation confirmed stable ligand-receptor interactions with RMSF values below 3 Å. These findings indicate that S. aromaticum bud extract has moderate mosquitocidal potential in vaporizer mat formulation and may act through olfactory disruption and metabolic interference in A. aegypti.
Bioconversion of Microalga Chlorella sp. as an Alternative Energy for Biofuel in Fishery Waste Media Endah Rochmatika; Ahmad Shofy Mubarak; Win Darmanto
Jurnal Ilmu Pertanian Indonesia Vol. 30 No. 2 (2025): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18343/jipi.30.2.416

Abstract

Carbon dioxide emissions from burning fuel oil have been increasing, resulting in increasingly severe climate change. The use of microalgae as raw materials for biofuel production is an environmentally friendly alternative. Microalgae Chlorella sp. can be sustainably converted into alternative biofuels. Fishery liquid waste, such as that resulting from fish farming and fish processing, can be used as a nutrient medium for microalgae. This study aimed to analyze biomass production from Chlorella sp. using fishery waste in an algae reactor. The working principle of fisheries wastewater processing is related to microalgae in the reactor. The surface of the media forms a biological layer that breaks down organic compounds in the air, thereby reducing the organic content. The compounds resulting from metabolic processes are in the form of solids and gases. The results show that the bioethanol produced from the thermostat Chlorella sp. with fishery waste media can produce 20,000 L/ha. Microalgae contain approximately 20-50% dry weight of carbohydrates, which can be converted into bioethanol. Chlorella sp. can reduce chemical oxygen demand and ammonia by up to 70% by converting carbon dioxide into carbohydrates, fats, and proteins. The application of bioconversion to all companies in the fisheries sector will provide benefits and help the government reduce fossil fuel subsidies. Keywords: bioconversion, biofuel, fisheries, microalgae, waste
Potensi Ekstrak Ganoderma applanatum Terhadap Kadar MDA dan Bax pada Mencit (Mus musculus) yang Terinduksi Diethylnitrosamine Siti Rahayu; Win Darmanto; Sri Puji Astuti Wahyuningsih
Exact Papers in Compilation (EPiC) Vol. 7 No. 2 (2025): Mei 2025
Publisher : Lembaga Penelitian Pengabdian Masyarakat Universitas KH. A. Wahab Hasbullah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32764/epic.v7i2.1514

Abstract

Polisakarida Ganoderma applanatum memiliki sifat antioksidan sebagai respon biologis yang kuat untuk terapi kanker. Penelitian ini menguji potensi ekstrak polisakarida G. applanatum terhadap kadar MDA dan Bax pada tikus (Mus musculus) yang diinduksi DEN. Tikus betina galur DDY dibagi secara acak menjadi 4 kelompok (n=6). DEN diberikan secara intraperitoneal dua kali seminggu, kemudian doxorubicin sebagai kontrol positif dan ekstrak polisakarida sebagai perlakuan selama satu bulan secara oral. Metode penelitian dilakukan dengan membandingkan KN yang diberi air; K- yang diberi DEN 100 mg/kg BB; K+ yang diberi DEN 100 mg/kg BB dan doksorubisin 10 mg/kg BB; dan P yang diberi DEN 100 mg/kg BB dan ekstrak polisakarida G. applanatum 150 mg/kg BB. Dari analisis statistik uji ANOVA yang dilanjutkan dengan uji Duncan, diperoleh bahwa pemberian ekstrak polisakarida G. applanatum dibandingkan dengan K- tidak menunjukkan perbedaan bermakna kadar MDA dan Bax. Data hasil percobaan sebagai berikut: KN menunjukkan kadar MDA sebesar 1,62±0,28 nmol/mL dan Bax 4,41±2,14 ng/mL. Kadar MDA K- sebesar 1,58±0,11 nmol/m dan Bax 3,91±1,84 ng/mL. Kadar MDA K+ sebesar 1,75±0,21 nmol/mL dan Bax 4,30±1,61 ng/mL. Kadar MDA P sebesar 1,74±0,29 nmol/mL dan Bax 2,28±1,27 ng/mL.
Co-Authors A, Aulanniam Agoes Soegianto Agus Abadi Agus Heri Setyo Wahyudi Ahmad Shofy Mubarak Alifah Hayati Andita Ayu Mandasari Aulanni'am, Aulanni'am Bambang Poernomo Betti Lukiati Betti Lukiati Binti Yunaida Djoko Agus P. Dwi Winarni Eko Prihiyantoro Eko Prihiyantoro Endah Rochmatika Endah Rochmatika Endang Dewi Masithah Evy Diah Woelansari farach Firli Rohmah Primula Dewi Harianto Notopuro Herdiansyah, Mochammad Aqilah I Gede Widhiantara I.B. Rai Pidada Inge Permatasari Intan Ayu Pratiwi Intan Permata Putri Intan Permata Putri Is Yuniar Juliana Christyaningsih Khambali Khambali Kris Cahyo Mulyatno Kusala, Muhammad Khaliim Jati Kusala Lailatul Lutfiyah, Lailatul Listijani Suhargo, Listijani Mammed Sagi Manikya Pramudya Mochammad Amin Alamsjah Mochammad Aqilah Herdiansyah Mufasirin Mutiarawati, Diah Titik Nadyatul Ilma Indah Savira Nanik Siti Aminah Natalia Tri Astuti Nunuk Dyah Retno Lastuti Nurmalasari Darsono Nurmalasari Darsono P Kumaladewi Panjaitan, Novaria Sari Dewi Panjaitan Permatasari, Anak Agung Ayu Putri Pieter Kakisina Pujiastuti Wahyuningsih , Sri Puspita Sari, Evi Putri Andreyna Saragi Putu Angga Wiradana Ramadhana Ramadhana Retnosari Apriasti Ria Harmonis Rifaid Nur Arsad Rohmah, Etik Ainun Rosalia Nuril Qolbi Rr. Juni Triastuti Samekto Wibowo Sapto Andriyono Sari, Ni Kadek Yunita Sari Siti Fatimatuz Zahra Siti Rahayu Sri Kadarsih Soedjono Sri Puji Astuti Sri Puji Astuti Wahyuningsih, Sri Puji Astuti Sri Subekti Sugiharto Suhendra Agung Wibowo Sukardiman Susanto, Awaluddin Susilowati, Rina Priastini Suvia Widyaningrum Teguh Hari Sucipto, Teguh Hari Tri Dewanti W. Victorin Mega Putri Wiartini, Ni Wayan Ayu Wiartini Widhi Dyah Sawitri YULIA IRNIDAYANTI Yuni Kilawati Zubaidah Ya’cob