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All Journal HAYATI Journal of Biosciences Jurnal Pendidikan dan Pembelajaran Khatulistiwa (JPPK) BIOTROPIA - The Southeast Asian Journal of Tropical Biology Indonesian Journal of Biotechnology Jurnal Teknologi Laboratorium BIOEDUSCIENCE Biosaintifika: Journal of Biology & Biology Education Jurnal Labora Medika Gorontalo Journal of Public Health Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Borneo Journal of Medical Laboratory Technology Narra J Quality : Jurnal Kesehatan Sureq: Jurnal Pengabdian Masyarakat Berbasis Seni dan Desain Prosiding University Research Colloquium Jurnal Kefarmasian Indonesia
Sri Darmawati
Muhammadiyah Semarang University
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Optimization and Evaluation of the Accuracy of the C-Reactive Protein Detection Range in a Rapid Test Based on Lateral Flow Immunoassay with Two Clinical Cut-Offs Rukmi, Ai; Darmawati, Sri; Alisjahbana, Bachti; Depamede, Sulaiman Ngongu; Pambudi, Sabar; Yuwita, Anita
BIOEDUSCIENCE Vol 10 No 2 (2026): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/20220

Abstract

Background: C-Reactive Protein (CRP) is an important biomarker for infection and inflammation; however, quantitative assessment using ECLIA is costly and requires adequate laboratory facilities and trained personnel. This study aims to optimize antibody concentration and conjugate volume, and to evaluate the accuracy of the detection range of an LFIA-based CRP rapid test at two clinical cut-offs (10 and 40 mg/L). Methods: Experimental research was conducted by optimizing antibody concentrations on the T1 and T2 lines, optimizing CGC volume, and testing sensitivity, specificity, and the correlation between color intensity and Image. Results: The optimal antibody concentrations were obtained at T1 of 0.075 mg/mL and T2 of 0.025 mg/mL with a CGC volume of 2 µL. Sensitivity and specificity were 95.7% and 100% at T1, and 83.3% and 95.5% at T2. Conclusions: The developed CRP rapid test has adequate diagnostic performance as a semi-quantitative screening tool in primary healthcare facilities.
Co-Authors A.A. Ketut Agung Cahyawan W Afriansyah, M. Ardi Afriansyah, Muhammad Ardi Ainutajriani, Ainutajriani Al Ansyari, Mas’ud Uqbah Al Hidayani Ana Hidayati Mukaromah Anak Agung Wiradewi Lestari Aprilia Indra Kartika, Aprilia Indra Bachti Alisjahbana Batara, Murni Budi Santosa Budi Santosa BUDI SETIADI DARYONO Cahyaningrum, Dea Galuh Daryono, Budi S. Dewi Seswita Zilda Edward Kurnia Setiawan Limijadi, Edward Kurnia Setiawan Endang Tri Wahyuni Maharani Ernanto, Aditya Rahman Ethica, Stalis N. Faisal Faisal Fandhi Adi Wardoyo Felim, Jethro Fitria Hariati Ramdhani Fuad, Hayatun Hariutami, Desi Hikmah, Annisa Nurul Jannah, Erni M Joharlinda, Joharlinda La’lang, Marselaonety LANGKAH SEMBIRING Listiyanti, Apriliya Manufandu, Anjar Richardo Mardiyah Hayati Masashi Kawaichi, Masashi Maulida, Gita Rossa NANIK RAHMANI Nasruddin, N Nur Hidayah Palimbongan, Junita Rensa Permana, Atna Prastiyanto, Muhammad E. Prastiyanto, Muhammad Evy Prastiyanto, Muhammad Evy Putri, Desty Ratna Ragil Saptaningtyas, Ragil Retnaningrum, Endah Rinaldi, Muhamad Rizqi Rosnita . Rukmi, Ai Rustiyarso . Sabar Pambudi Salsabila, Nia Setianingsih, Erna Silvestre, Richard David Sri Sinto Dewi Stalis Norma Ethica Sulaiman Ngongu Depamede Sulistyaningtyas, Ayu Rahmawati Susanti, A.Meryam Syaiful Anwar Trianes, Juwy Tulus Ariyadi Wayan T. Artama Wayan T. Artama Widya Asmara Wilson, Wildiani Windya Nazmatur Rahmah Yuwita, Anita Zilda, Dewi S. Zuraida Zuraida