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All Journal International Journal of Public Health Science (IJPHS) Pharmacon Jurnal Kebidanan Dan Kesehatan Tradisional Journal Of Nursing Practice Journal of Pharmacopolium Chemistry Indonesian Journal of Chemical Research JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Pharmacoscript Jurnal Ilmiah Farmako Bahari Borneo Journal Of Pharmascientech Journal of Pharmaceutical and Health Research Jurnal Kesehatan: Jurnal Ilmu- Ilmu Keperawatan, Kebidanan, Farmasi dan Analis Kesehatan Pelita Abdi Masyarakat Pharmacy Reports Jurnal Ilmiah Farmasi Akademi Farmasi Jember Kolaborasi Jurnal Pengabdian Masyarakat Jurnal Farmasi Sains dan Praktis Pharmacy Genius SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT Jurnal Farmasi Indonesia Journal of Pharmaceutical and Sciences. Jurnal Ilmiah Farmasi Simplisia
Ikhwan Yuda Kusuma
Program Studi Farmasi, Universitas Harapan Bangsa Purwokerto
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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Revolutionizing the fight against antimicrobial resistance with artificial intelligence Kusuma, Ikhwan Yuda
Pharmacy Reports Vol. 3 No. 1 (2023): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.53

Abstract

Antimicrobial resistance (AMR) is a major public health threat, responsible for millions of deaths annually. Current efforts to combat AMR include antibiotic stewardship programs, infection prevention and control measures, and the development of new antimicrobial agents. However, traditional laboratory techniques used to identify antibiotic-resistant genes are inadequate. Artificial intelligence (AI) has emerged as a promising tool to combat AMR, potentially facilitating rapid diagnosis, predicting antibiotic resistance patterns, and identifying new treatments. AI can analyze large amounts of data from various sources and identify patterns and correlations that humans may miss. However, there are potential challenges and risks associated with implementing AI in the fight against AMR, including ethical concerns and data quality issues.
Social anxiety disorder: prevalence and dominant factor among adolescents in urban and rural school Priasmoro, Dian Pitaloka; Kusuma, Ikhwan Yuda; Asri, Yuni
International Journal of Public Health Science (IJPHS) Vol 13, No 2: June 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i2.23610

Abstract

In the age range of 16-18 years, commonly known as adolescence, individuals undergo a period of self-discovery in their socio-emotional development. Failures during this process can lead to individuals experiencing anxiety in social interactions, which can have a negative impact on their mental health. The Indonesia National Adolescent Mental Health Survey (I-NAMHS), findings also indicate that the most prevalent mental disorder among adolescents is anxiety disorder (a combination of social phobia and generalized anxiety disorder), is equivalent to 15.5 million. The widespread use of the internet and social media, on one hand, has led to a high dependency on smartphones among teenagers, causing them to spend more time interacting in the virtual world. Over an extended period, this condition can lead to social anxiety due to the fear of failure and lack of success. The objective of this research is to explore whether there is a difference in social anxiety among teenagers living in rural or urban areas, related to factors such as the duration of smartphone usage, school activities, and so on. The results of this research are crucial for providing feedback to high schools, especially for early detection of potential anxiety symptoms from the beginning, in order to prevent and provide appropriate treatment for social anxiety, thus not affecting students' academic achievements. It is recommended that schools conduct early detection measures.
Solid Dispersion of Acetosal Using Polyvinyl Pyrrolidone (PVP) K-30 in Tablets with Direct Compressing Method Khasanah, Khuswatun; Nawangsari, Desy; Kusuma, Ikhwan Yuda
Indonesian Journal of Chemical Research Vol 10 No 3 (2023): Edition for January 2023
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598//ijcr.2023.10-kha

Abstract

Acetosal is classified in the Biopharmaceutical Classification System (BCS) class II (low solubility, high permeability). Low solubility causes a decreased dissolution rate. Polyvinyl pyrrolidone (PVP) K-30 is an inert carrier easily soluble in water and can influence the solubility of a drug substance. Efforts to increase the solubility of acetosal make a solid dispersion system. This study aims to determine the effect of the solid dispersion system of acetosal: PVP K-30 on dissolution rate, the ratio of the solid dispersion with the best dissolution rate, and the physical properties of acetosal tablets formed in the dispersion system. Solid dispersions using the dissolving method with variations in the concentration of acetosal: PVP K-30 1:1, 1:3, and 1:5. The results of the dissolution test of acetosal in solid dispersion powder, i.e., PVP Formula 1:5, which has the highest dissolution percentage compared to formula 1:1 and 1:3 with the concentration this formula was 140.96 mg, dissolution percentage was 28.19±0,63% in 30 minutes. Statistical results by ANOVA test show a significant difference of 0.044 (p<0.05). The physical properties of tablets with a dispersion system show higher addition of PVP K-30. This result is related to slower disintegration time and lower friability.
PENGARUH EFEK PEMBERIAN EKSTRAK EKSOKARP SEMANGKA (Citrullus lanatus(thunb)) TERHADAP KADAR LAKTAT DAN GLUKOSA PADA TIKUS SETELAH AKTIVITAS PADA SWIMMING TEST Kusuma, Ikhwan Yuda
JURNAL KESEHATAN STIKes MUHAMMADIYAH CIAMIS Vol. 8 No. 1 (2021): Jurnal Kesehatan (April 2021)
Publisher : LPPM STIKes Muhammadiyah Ciamis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52221/jurkes.v8i1.689

Abstract

Fatigue is a condition that occurs after a strong and prolonged muscle contraction, where the muscle is no longer able to contract for a certain period of time. Activities that are too long can cause muscle fatigue. The purpose of this study was to determine the effect of watermelon exocarp extract on glucose and lactate levels in rats after swimming activity. This research method was carried out experimentally for 7 days; the data was analyzed using the paired t test method to find out the significant differences between groups I, II, and III. The results of this study indicate that blood sugar levels and blood lactic acid levels were measured before and after treatment. Data analysis using the Fairy test gave significant results if P was less than 0.05. The results of this study showed that administration of exocarp extract 500 mg per kg orally gave a significant effect. significant on blood glucose levels and lactic acid levels in rats. In conclusion, in this study, administration of watermelon exocarp extract (Citrullus lanatus (thunb)) had an effect on reducing blood glucose and lactate levels in rats, the fastest decreasing at a dose of exocarp extract at a dose of 500 mg/kg bw blood glucose was 72.75 while at a lactate level of 2.75 mmol/L.
KOMBINASI EKSTRAK EKSOKARP BUAH SEMANGKA (Citrullus Lanatus (Thunb.)) DAN EKSTRAK DAUN SALAM (Syzygium Polyanthum) SEBAGAI ANTIKOLESTEROL POTENSIAL PADA MENCIT JANTAN GALUR Balb/C Kusuma, Ikhwan Yuda
JURNAL KESEHATAN STIKes MUHAMMADIYAH CIAMIS Vol. 8 No. 1 (2021): Jurnal Kesehatan (April 2021)
Publisher : LPPM STIKes Muhammadiyah Ciamis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52221/jurkes.v8i1.690

Abstract

Dyslipidemia is a condition of abnormal lipid profile in the blood such as an increase in total cholesterol, triglycerides (TG), Low-Density Lipoprotein (LDL), and a decrease in High-Density Lipoprotein (HDL) cholesterol. This study aims to compare the effects of watermelon exocarp extract (Citrullus lanatus (Thunb.)) and bay leaf extract (Syzygium polyanthum) and the combination of the two in lowering blood cholesterol levels. This research method was carried out experimentally for 7 days, the data were analyzed using the Paired T-Test, One Way ANOVA (Analysis of Variant), and LSD Post Hoc Test methods with sig = 0.05 to determine the significant difference between the 6 groups. The results of this study indicate the normality test results of cholesterol levels show the value of sig. > 0.05, it can be concluded that the data is normally distributed. In the one-way ANOVA test, it shows sig. <0.05 so it can be concluded that the average of the six test groups differed significantly. The LSD test showed that the treatment of the control group was positive with bay leaf extract, the watermelon fruit exocarp extract group with a combination of bay leaf extract and watermelon exocarp extract which had a sig value. > 0.05 which means there is no significant difference, while the other groups have sig values. <0.05 which means there is a significant difference. The conclusion on the LSD test obtained the value of Sig. > 0.05 which indicates that there is no difference. The greatest decrease in cholesterol levels occurred in the combination group compared to the single group.
Efektivitas Leaflet dalam Meningkatkan Pengetahuan Hipertensi pada Lansia di Desa Gandatapa Kusuma, Ikhwan Yuda; Nawangsari, Desi; Prabandari, Rani; Kurniasih, Khamdiyah Indah; Fauziah, Fauziah; Abely, Nastasya Anis; Safitri, Cindy Ade
Kolaborasi: Jurnal Pengabdian Masyarakat Vol 4 No 5 (2024): Kolaborasi: Jurnal Pengabdian Masyarakat
Publisher : Yayasan Inspirasi El Burhani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/kolaborasi.v4i5.437

Abstract

Introduction:  Hypertension is a significant global health issue that often presents without symptoms, leaving many individuals unaware of their condition. Effective management and prevention of hypertension require increased awareness and education, particularly among the elderly population, who are at higher risk. Objective: This study aims to evaluate the effectiveness of health counseling using leaflets in improving hypertension knowledge among the elderly at Integrated service post (Posyandu) community association (RW) 4 Gandatapa. Method: This descriptive quantitative study employed a pre-post design. Health counseling was conducted using leaflets at  Integrated service post  (Posyandu) community association (RW) 4 Gandatapa on July 16, 2024, involving 44 elderly participants aged 65-70 years. Knowledge levels were assessed using pre-test and post-test questionnaires. The intervention included distributing leaflets and conducting a discussion session to reinforce the information provided. Result:The study observed a significant increase in participants' knowledge about hypertension, with average knowledge scores rising from 43% in the pre-test to 63% in the post-test. Conclusion: The findings suggest that health counseling using leaflets is an effective method for improving hypertension knowledge among the elderly. However, to optimize the impact, future interventions should consider additional support methods, especially for those with limited literacy or visual impairments.
Analisis Minimalisasi Biaya (AMiB) Antihipertensi Irbesartan dengan Candesartan pada Pasien Hipertensi Rawat Jalan Nurlaela, Nurlaela; Fauziah, Fauziah; K, Khamdiyah Indah; Kusuma, Ikhwan Yuda
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.5599

Abstract

Cost minimization of antihypertensive therapy is very essential to optimize patient care and allocation of hospital resources. This study aimed to compare the most cost-minimized cost of irbesartan and candesartan therapy treatment in hypertensive patients at Goeteng Taroenadibrata Purbalingga in the periods January to December 2023. The research method used quantitative with a retrospective approach. Data were analyzed using normality kormogorov smirnov test and continued by mann whitney test. population in this were hypertensive patients at Goeteng Taroenadibrata Purbalingga with a sample of 100 hypertensive patients.The results showed that out of 100 samples, 37 samples used irbesartan and 63 candesartan samples with an average total direct medical cost of antihypertensive treatment, laboratory costs and consultation costs required by patients using irbesartan therapy Rp. 158,665, and candesartan Rp. 116,874. Statistical analysis has a p-value that shows a significant difference between irbesartan treatment and candesartan treatment. the conclusion in this study is that the most cost-minimizing antihypertensive therapy is the candesartan group compared to the irbesartan group. Further research is needed to analyze a broader CMA of blood pressure control and comorbid diseases.
Antibiotic Use for Genitourinary Infections in an Indonesian Hospital During COVID-19: A Retrospective Study Abely, Nastasya Anis; Fauziah, Fauziah; Kurniasih, Khamdiyah Indah; Nurkholis, Fiqih; Kusuma, Ikhwan Yuda
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 3 (2024): J Sains Farm Klin 11(3), December 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.3.153-160.2024

Abstract

The management of genitourinary infections presents a growing challenge due to antimicrobial resistance, shifting regional patterns, and evolving etiologies. This study aimed to elucidate antibiotic utilization trends and patterns for genitourinary system diseases at an Indonesian teaching hospital during the COVID-19 pandemic. This retrospective, cross-sectional study analyzed antibiotic use in an Indonesian teaching hospital's inpatient department in 2021. Data on systemic antibiotics (ATC: J01) for genitourinary diseases (ICD-10: N00-N99) were extracted from electronic records. Prescription patterns were evaluated by patient characteristics, disease profiles, administration routes, and WHO AWaRe classification. Among the 47,696 hospitalized patients who received antibiotics, 1,752 were treated with J01 antibiotics for genitourinary disorders, mostly in elderly men with prostatic hyperplasia and obstructive uropathy. Cephalosporins, especially ceftriaxone (724 prescriptions) and cefazolin (294 prescriptions), were the most commonly prescribed, while amoxicillin/beta-lactamase inhibitors were the least prescribed. Parenteral administration was more common than oral, and "Watch" category antibiotics were prescribed twice as often as "Access" antibiotics in adults and the elderly. Genitourinary disorders like prostatic hyperplasia and obstructive uropathy significantly impact elderly men. This study reveals a trend of high broad-spectrum antibiotic use, such as ceftriaxone and cefazolin injections, in hospitalized patients with these conditions.
Monitoring of Medication Compliance in Type 2 Diabetes Mellitus Patients with Media Adherence Pill Box Unit Daily Dose Tresnowati, Gulita Indah; Kusuma, Ikhwan Yuda; Sunarti, Sunarti
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 2 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (843.245 KB) | DOI: 10.35617/jfionline.v14i2.23

Abstract

Diabetes melitus (DM) merupakan suatu kelompok penyakit metabolik dengan karakteristik hiperglikemia yang terjadi karena kelainan sekresi affront, kerja affront atau kedua-duanya. Manajemen dan tatalaksana DM merupakan bagian dari asuhan kefarmasian untuk mengurangi penyebab ketidakpatuhan pasien dalam minum obat yang berakibat komplikasi. Salah satu cara untuk mencegah ketidakpatuhan adalah dengan menyediakan alat bantu berupa Adherence Pill Box Unit Every day Measurements. Tujuan dari penelitian ini adalah mengetahui pengaruh media Adherence Pill Box Unit Daily Dose dalam meningkatkan kepatuhan pengobatan pasien DM tipe 2. Penelitian ini menggunakan metode eksperimental dengan tipe one gather pre-post test plan. Information dianalisis menggunakan Wilcoxon rank test dari kuesioner MMAS- 8 mengenai kepatuhan pengobatan serta kadar gula darah sewaktu sebelum dan setelah diberikan Adherence Pill Box Unit Daily Dose. Hasil penelitian ini menunjukkan nilai skor MMAS – 8 nilai sig. 0.002 < 0.05, Kesimpulan dari penelitian ini adalah adanya pengaruh media Adherence Pill Box Unit Daily Dose dalam meningkatkan kepatuhan pengobatan pada pasien yang berpengaruh pada penurunan kadar glukosa darah sewaktu pasien DM tipe 2.
Tingkat Penggunaan Antibiotik dan Pola Peresepannya Pada Infeksi Saluran Pernapasan (ICD-10: J00-J99) di Indonesia Selama Pandemi COVID-19 Misworo, Misworo; Kusuma, Ikhwan Yuda; Kurniasih, Khamdiyah Indah; Nurkholis, Fiqih; Fauziah , Fauziah
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.849

Abstract

Introduction: Respiratory tract infections (RTIs) contribute substantially to global antibiotic consumption, raising concerns about antimicrobial resistance (AMR). This study aimed to analyze antibiotic prescribing patterns for respiratory disorders in an Indonesian teaching hospital during the COVID-19 pandemic. Methods: This retrospective, cross-sectional study examined systemic antibiotic prescriptions based on the Anatomical Therapeutic Classification (ATC: J01) for respiratory diseases (ICD-10: J00-J99) at Cilacap Government Teaching Hospital between January and December 2021. Data were extracted from electronic medical records (e-MR), including patient demographics (i.e. age and sex), ICD codes and name of antibiotics. We analyzed WHO AWaRe classifications, administration routes, and seasonal patterns based on patient’s entry and antibiotic use. Results: The study included 2,395 patients with antibiotic prescriptions for respiratory disorders. The Watch group antibiotics accounted for 85.6% of prescriptions, with the highest use among adults (86.2%). Parenteral administration (71.5%) was more common than oral administration (28.5%). Pneumonia (38.2%) and chronic obstructive pulmonary disease (27%) were the most common indications. Antibiotic use peaked in December (n=529) and was lowest in July (n=84). Ceftriaxone (n=838), azithromycin (n=270), cefixime (n=262), levofloxacin (n=216), and meropenem (n=56) were among the top prescribed antibiotics. Conclusion: The study highlights the predominant use of broad-spectrum and parenteral antibiotics for respiratory disorders, raising concerns about AMR. Factors such as seasonality, disease patterns, and diagnostic challenges may have influenced prescribing practices. Implementing antimicrobial stewardship programs, promoting evidence-based guidelines, and addressing modifiable risk factors are crucial to combat AMR and optimize patient outcomes during and beyond the COVID-19 pandemic.
Co-Authors Abely, Nastasya Anis Afifah, Maulina Nurul Afnida Dwi Lestari Almas Amalul Fasha Alvin Ulinnuha Amalia, Najwa Nurul Amelia Damayanti Annima Alfi Fauqina Apriliansa, Elza Puspita Arrina Sabilahaq Awang Pardigantara Azizah Azizah Bella Aisya Fitri Cecep Darwis Muttaqin Destiannesvi, Anggie Desy Nawangsari Dian Pitaloka Priasmoro, Dian Pitaloka dina febrina DM, Peppy Oktaviani Elza Puspita Apriliansa Fajar Rinawati Fasha, Almas Amalul Fauziah , Fauziah Fauziah Fauziah Fina Rudiyanti Galih Samodra Galih Samodra Gita Fitriyani Halimatu Sa'diah Halimatu Sa’diah Hikmanti, Arlyana Hilmi, Nahla Habibah Ike Mardiati Agustin Irmawan Andri Izati, Fina Karunia K, Khamdiyah Indah Khasanah, Khuswatun Khosyi, Nathania Elsa Kurniasih, Khamdiyah Indah Kusnandar Anggadiredja Lauale, Evangelina Natali Theresya Linda Sukiatno Mailatunnazza, Nova Maryanti, Nelly Misworo, Misworo Nadia Ramadhani Nafi'ah, Inti Kalun nawangsari, desi Nawangsari, Desy Nida Nuridayah Noryana Novia Wulandari Nuari, Doni Anshar Nufus, Ayatun Nur Islamiah Nurkholis, Fiqih NURLAELA NURLAELA Nurrahma, Alfiya Hana Peppy Octaviani Peppy Octaviani Peppy Octaviani Dian Megasari Prabandari, Rani Pratiwi, Amelia Candra Putri, Melisa Mareta Putri, Renanda Nabila Rani Prabandari Rani Prabandari Safitri, Cindy Ade Samodra, Galih Saputri, Abelia Sari, Destika Ambar Satyadewi, Putu Ratna Hari Sita Nur Faradila Sita Sri Haryanti Sunarti Sunarti Sunarti Suryo Ediyono Susanto, Kharisma Evelyne Eka Susilo Rini Tresnowati, Gulita Indah umi sangadah Veronica, Laila Wibawa, Navyzhah Aulia Aulia Putri Wilis Sukmaningtyas Yuli Yuli Maesaroh YUNI ASRI, YUNI Yutia Ihza Komala Yuyun Pujiarti