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Leni Sri Mulyani
Instititut Pendidikan Indonesia Garut
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The Effect of Sacha Inchi Leaf Extract (Plukenetia volubilis) with Different Doses on Reducing Uric Acid Levels in Mice (Mus musculus) Mulyani, Leni Sri; Mulyaningsih, Sri; Alya, Rahma; Taufik, De Budi Irwan
Journal Of Biology Education Research (JBER) Vol. 6 No. 2 (2025): JBER (Journal Of Biology Education Research), Vol.6 No.2 (2025)
Publisher : Program Studi Pendidikan Biologi FKIP Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55215/jber.v6i2.47

Abstract

Sacha inchi (Plukenetia volubilis) is an ancestral plant native to the Amazon rainforest that has been adopted as a food source due to its high nutritional value, which has gradually been recognized for its potential health benefits for humans. One of its benefits is as a natural agent for lowering uric acid levels, due to its antioxidant content and active compounds such as flavonoids, which function as anti-inflammatory and cell protective agents. Although P. volubilis seeds have been extensively studied, the potential of its leaves as an alternative treatment for hyperuricemia remains largely unexplored. This study aims to determine the effect of sacha inchi (P. volubilis) leaf extract at different doses 0.35 mL/mouse, 0.40 mL/mouse, and 0.45 mL/mouse on reducing uric acid levels in mice (Mus musculus) and to identify the most effective dose for reducing uric acid levels in mice. This study used 24 male mice aged 3–4 months with a body weight not exceeding 25 g. The study design used a Randomized Block Design (RBD) with four treatments and six replicates. The treatments consisted of control (without extract), doses of 0.35 mL, 0.40 mL, and 0.45 mL of P. volubilis leaf extract. The P. volubilis leaf extract was administered orally via a mouth tube. The extract was obtained from the leaves of the P. volubilis using the maceration method. The mice were first induced with hyperuricemia using 1 mL of chicken liver juice per mouse. Uric acid levels were measured before and after treatment using a GCU test strip. Data were analyzed using a one way ANOVA test followed by a Duncan test at a significance level of 5%. The results showed significant differences between treatments (p = 0.001 < 0.05). The 0.45 mL dose was the most effective in lowering uric acid levels, from an average of 4.7 mg/dL to 3.4 mg/dL, and was significantly different from other doses based on Duncan's test. This study concluded that sacha inchi leaf extract has the potential to be used as a natural alternative for lowering blood uric acid levels.  
Co-Authors Aceng Ahmad Rodian Susila Ai Intan Alya, Rahma Anggia Suci Pratiwi Asep Rohayat Asep Rohayat Bonita Yunpayani bonita yunpayani Chevi Ardiana Chevi Ardiana Chevi Ardiana De Budi Irwan Taofik De Budi Irwan Taufik Desri Mulyati Diah Ika Putri Euis Erlin Fadilla, Rahma Fathoni, Shalsabila Destyari Fitriyani, Wina Hani Rubiani, Hani Hudiana Hernawan Hudiana Hernawan Ijang Ikbal Nawawi Indra Dodo Saputra Lida Amalia Melisa Nursuciani Melisa Nursuciani Mohammad Fahmi Nugraha, Mohammad Fahmi Muhammad Taufiq Munawar, Muhamad Jamiul Mustofa Jamil muthmainnah, rifaatul Novi Nurul Awaliyah Novie achdiani Nurkamilah, Milah Nurwalifah , Wini Asiyah Qurotaaini, Salsabila Restu Febriyanto Rifaatul Muthmainah Rifaatul Muthmainnah Rohayat, Asep Saputra , Indra Dodo Sentia, Nova Siti Nurkamilah Solihah, Siti Sri Mulyaningsih Sri Mulyaningsih Sri Mulyaningsih Sri Mulyaningsih Sri Mulynaingsih Sriwahjuningsih TATI KRISTIANTI Taufik, De Budi Irwan Wawan Kurniawan Wawan Kurniawan Wida Silfia Wina Fitriyani Wina Fitriyani Yopa Taufik Saleh, Yopa Taufik Yuli Sumiati yuli sumiati