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Journal : Narra J

Titer disparity of anti-Spike receptor binding domain SARS-CoV-2 antibody between vaccinated and naturally infected individuals Surawan, Dewa P.; Sumohadi, Duwi; Budhitresna, Anak AG.; Lestari, Putri P.; Dewi, Kartika; Wikananda, Wasudewa; Suwari, Retenra P.; Islam, Md. Rabiul; Te, Haypheng; Rabaan, Ali A.; Masyeni, Sri
Narra J Vol. 2 No. 1 (2022): April 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i1.71

Abstract

In conjunction with other health promotion strategies, vaccination of coronavirus disease 2019 (COVID-19) is a strategy to alleviate the burden of infection. The aim of this study was to determine the differences in antibody response strength between individuals who received COVID-19 vaccination and those who had a natural infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A cross-sectional study was conducted among post-natural confirmed COVID-19 infection and immunized people in Bali, Indonesia. The vaccination was using Sinovac-CoronaVac with two-weeks interval between the two vaccine doses. To measure the level of anti-Spike receptor binding domain (SRBD) of SARS-CoV-2 antibody, we used Roche electro-chemiluminescence immunoassay (ECLIA) platform. Blood samples were obtained before and 28 days after first immunization in the vaccinated group, as well as two weeks after hospital discharge in the confirmed COVID-19 patients based on real-time reverse transcription polymerase chain reaction (RT-PCR). A total of 58 confirmed COVID-19 patients and 60 vaccinated individuals were included. On the 28th day after the initial vaccination, the seroconversion rate among vaccinated individuals was 91.67%. The mean titer of anti-SRBD SARS-CoV-2 antibody among vaccinated participants was 63.62±82.57 IU/mL (ranged between 0 IU/mL and 250 IU/mL). The mean titer among naturally infected group was 188.47±94.57 IU/mL (ranged between 4.25 IU/mL to 250 IU/mL) regardless the severity of COVID-19. Our data suggested that the titer of anti-SRBD SARS-CoV-2 antibody was significantly higher in naturally infected individuals compared to those who received COVID-19 vaccination (p<0.001). These data suggest that not all individuals vaccinated with Sinovac COVID-19 had protective level of anti-SRBD SARS-CoV-2 antibody and booster dose of heterologous vaccine maybe required.
Co-Authors Abdawiyah, Mutiara Jati Adi Prasetyo Agustin, Cantika Ellycia Agustina, Ninik Akhmad Solihin Al-Anshory, Moh. Aep Irfan Amanah, Siti Khusniatul Aminah, Nur Angga Fitriyono Anita, Rif’atul Anton Karta Surya, Anton Karta Ariesta L, Nur Ilmi Ary Giri Dwi Kartika Asakawa, Mitsuhiko Ashari Wicaksono Asih, Eka Nurhema Ning Asih, Eka Nurrahema Ning Asmarani, Agil Silva Azulva, Naula Taufiqi Bachri, Abdul Rozak Budhitresna, Anak AG. Budjiastuti, Widowati Cesare, Jeannery Cindytia Prastari Dameria. H, Yohana Aprillia Daspi, Ivi Dewi Ayu Lestari Dewi M. Prawiradilaga, Dewi M. Dharma Aryani Dian Aswita, Dian Durinda Puspasari Endang Purwaningsih Fadholi, Bahri Fadilah, Iqbal Riza Fauzi, Shindy Ayu Fitri, Dewi Anugrah Fitriana, Dianita Aryani Fitriana, Yuli S. Galuh Tresnani Harliana Harliana Hideo Hasegawa Indah Suryawati Indudewi, Febe Yuanita Ratna Insafitri, I Iskandar, Muhamad Dandi Iqbal Kazuto Kawakami, Kazuto Lefrysa, Dhiva Lestari, Graffiera Widya Lestari, Putri P. Lestnando, Georgius Christofano Bagus Limbong, Monika Tiodina Ulina Madani, Nurul Maghfira, Riska Maghfuroh, Hanik Maiharani, Windi Tri Makhfud Efendy, Makhfud Malikthun Badriyah, siti Masyeni, Sri Md. Rabiul Islam Mersiana Setiarini Mohammad Irham Mukarromah, Safitri Nana Supriatna Nazira, Alfiodhea NEVIATY PUTRI ZAMANI Novi Indriyawati Nurul Himmah Nuzula, Nike Ika Oktapiani, Septi Prabowo, Tito Qurbaniah, Mahwar Rabaan, Ali A. Rafiqi, Muhammad Rahmat Siauwijaya, Rahmat Ramadhanti, Annisa Riandi Riandi Riyanto, Awal Riyanto, Awal Rizki Tri Prasetio, Rizki Tri Rohmah, Khilda Firdausiyah Rusdian Yusron, Rizki Darma Safitri, Seliya Safitri, Seliya Fuji Salma, Amanda Nadiva Samsuci, Samsuci Sandi Destian Pratama Sanggaria, Evita Putri Saputri, Ferza Ayu Selamet Joko Utomo, Selamet Joko Setiyariski, Ramdani Sopa Martina, Sopa SRI ASTUTIK Sri Wahyuni Sriningsih Sumohadi, Duwi Sunita Dasman Surawan, Dewa P. Suwari, Retenra P. Suyadi Suyadi Syarifuddin , Didin Ta.by, Fery Te, Haypheng Ulfa, Fenny Vadia Wennyta, Wennyta Widyaningsih, Dhea Wikananda, Wasudewa Willma Fauzzia winata, Dimas Chandra Wulansari, Destin Retno Yosef Abdul Ghani Yuliadi Zamroni Yuliana Pinaringsih Kristiutami Yuni Apriyanti, Yuni