Articles
Distribusi frekuensi missing teeth pada anak sindroma DownMissing teeth frequency distribution of Down syndrome children
Nadiya Mujaheda Alwafa;
Yetty Herdiyati;
Inne Suherna Sasmita;
Williyanti Suwondo
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 31, No 1 (2019): April 2019
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran
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DOI: 10.24198/jkg.v31i1.21466
Pendahuluan: Missing teeth adalah suatu keadaan berupa hilangnya gigi karena adanya kegagalan perkembangan gigi yang dapat menyebabkan berkurangnya fungsi pengunyahan, fonetik, estetika, serta munculnya masalah pada jaringan keras dan lunak di sekitarnya. Gejala missing teeth ditemukan pada anak sindroma Down, yaitu anak yang memiliki kromosom berlebih (trisomi 21), yang mengakibatkan kelainan dan keterlambatan pertumbuhan dan perkembangan baik fisik dan mental. Tujuan penelitian adalah untuk mengetahui distribusi frekuensi missing teeth pada anak sindroma Down di Yayasan POTADS. Metode: Jenis penelitian adalah deskriptif dengan teknik survei. Populasi pada penelitian ini adalah penderita sindroma Down anggota Yayasan Persatuan Orang Tua Anak dengan Down Syndrome (POTADS) dan diperiksa di Rumah Sakit Gigi dan Mulut (RSGM) Universitas Padjadjaran (Unpad). Pengambilan sampel dilakukan dengan teknik total sampling sebanyak 25 orang. Anak dengan sindroma Down berusia lebih dari 5 tahun didapatkan berdasarkan data yang diperoleh dari POTADS. Analisis data dilakukan dengan distribusi frekuensi relatif. Hasil: Sebanyak 48,07% anak sindroma Down yang diperiksa mengalami missing teeth dengan tipe hipodonsia sebesar 88%. Simpulan: Distribusi frekuensi missing teeth terjadi pada hampir setengah populasi anak sindroma Down di Yayasan POTADS.Kata kunci: Missing teeth, hipodonsia, sindroma Down. ABSTRACTIntroduction: Missing teeth is a condition of tooth loss due to developmental failure which can reduce the function of mastication, phonetics, aesthetics, and the problems in the surrounding hard and soft tissues. Missing teeth symptoms are found in Down syndrome children, which is children with excessive chromosomes (trisomy 21), resulting in abnormalities and delays in growth and development both physically and mentally. This study was aimed to determine the missing teeth frequency distribution of Down syndrome children at POTADS Foundation. Methods: The research was descriptive with survey technique. Population in this study were Down syndrome patients who were members of the Association of Parents with Down Syndrome Children (POTADS) Foundation and were examined at Universitas Padjadjaran (Unpad) Dental Hospital (RSGM). Sampling technique was a total sampling resulting 25 people. Children with Down syndrome more than 5 years old were based on data obtained from POTADS Foundation. Data analysis was carried out by relative frequency distribution. Results: A total of 48.07% of Down syndrome children examined had missing teeth with the type of hypodontia by 88%. Conclusion: Missing teeth occur in almost half the population of children with Down syndrome at POTADS Foundation.Keywords: Missing teeth, hypodontia, Down Syndrome.
Electro-gene therapy followed by intratumoral injection of pcDNA3.1-p27Kip1 wild type in human tongue base cancer cells SP-C3 xenograft
S. Supriatno;
Inne Suherna Sasmita
Padjadjaran Journal of Dentistry Vol 21, No 3 (2009): November 2009
Publisher : Faculty of Dentistry Universitas Padjadjaran
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DOI: 10.24198/pjd.vol21no3.14106
Human tongue base cancers are characterized by a high degree of local invasion and metastasis to the regional lymph nodes and included a disease with difficult treatment. A novel method for high-efficiency and region-controlled in vivo gene transfer was developed by combining electro-gene therapy and plasmid (pcDNA). The aims of the study were to examine the efficiency of transfection of p27Kip1 gene by electro-gene therapy and to evaluate p27Kip1 gene therapy in Supri’s clone-3 (SP-C3) xenografts using pcDNA3.1-p27Kip1 wild-type (wt) and pcDNA3.1 empty vector (neo) with electro-gene therapy. To investigate gene transfer method, the enhanced green fluorescence protein (EGFP) gene was transfected into xenografts by electro-gene therapy. The efficiency of p27Kip1 gene transfection at protein level was confirmed by Western blotting. To estimate the reduction in tumour size in Wistar Balb/c mice after electro-gene therapy with p27Kip1 wt gene was examined by tumorigenesis assay. To evaluate the induction of apoptosis was carried out by colourimetric assay. The result, the growth of tumours was markedly suppressed by p27Kip1 wt gene transfection. Up-regulation of p27Kip1 protein was detected in pcDNA3.1-p27Kip1 wt. Apoptosis induction through the activity of caspase -3 and -9 was significantly increased in p27Kip1 wt-transfected tumours. These results suggest that it is possible to transfer p27Kip1 wt into tongue base cancer cell xenografts using electro-gene therapy. p27Kip1 wt had a high-potential to suppress the growth of tumours. Conclusion, electro-gene therapy followed by intratumoral injection of pcDNA3.1-p27Kip1 wt had a high-potential to suppress the growth of a human tongue base cancer cell xenograft.
Deksripsi kesesuaian usia kronologis dan usia dentalis melalui estimasi pertumbuhan ujung akar gigi premolar
Inne Suherna Sasmita;
Lusi Epsilawati;
Fadhlil Ulum Abdul Rahman
Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Vol 4 No 1 (2020): Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI)
Publisher : Ikatan Radiologi Kedokteran Gigi Indonesia
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DOI: 10.32793/jrdi.v4i1.476
Objectives: The purpose of this study was to find out the description of chronological age and dental age suitability through estimation of root growth of maxillary and mandibular premolar teeth. Material and Methods: This study was a descriptive study with cross-sectional approach performed on the maxillary and mandibular first and second premolars. Data was taken from 50 panoramic radiographs contained in the 2015-2016 RSGM Unpad archives. Analyzes were performed based on age predictions from the Demirjian table compared to chronological ages in several age groups. The data is then presented in tabular form. Results: This study shows that there is a high degree of concordance between chronological age and dental age through premolars 1 and 2, both upper and lower jaws of the Demirjian table in the initial phase of tooth root formation at 8 years chronological age and at the final phase of root apex closure at 12-13 years chronological age through the assessment of panoramic radiograph. Conclusion: Chronological age and dental age depend on the precise assessment of root growth of premolar 1 and 2 teeth in the maxillary and mandibular regions having a high degree of suitability in the early and final phases of tooth root formation which are seen more radiographically.
Role of P27kip1 Protein, P45skp2 Coactivator, and P38jab1 Coactivator in Preventing Rhabdomyosarcoma (RMS) in Oral Cavity of Children
Inne Suherna Sasmita;
Ratna Indriyanti;
Willyanti Soewondo
Majalah Kedokteran Bandung Vol 54, No 2 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran
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DOI: 10.15395/mkb.v54n2.259
Rhabdomyosarcoma is a rare malignant tumor that attacks the differentiation of skeletal muscle and usually affects children, contributing to about 60% of all soft tissue sarcomas. The purpose of this study was to examine the relationship between p27Kip1 immunoexpression and p45Skp2 and p38Jab1 coactivators, as well as the relationship between p27Kip1 immunoexpression and p45Skp2 and p38Jab1 coactivators on stages and prognosis of oral RMS in children. This was a restrospective study on the immunoexpression of p27Kip1 and p45Skp2 and p38Jab1 coactivators on RMS cells. The RMS stage was determined according to the American Joint Committee of Cancer/AJCC of stages 1–4, and were divided into group I (stages 1 and 2) and group II (3 and 4). Samples were retrieved fromt he paraffin blocks of patients with embryonal RMS. Each paraffin block was cut, and 6 samples with 5 µm thickness from each block were examined using p27Kip1, p45Skp2, and p38Jab1 proteins. The analysis was performed using a linear regression test on the relationship between p27Kip1 and p45Skp2 and p38Jab1, resulting in a p-value of 0.000 (<0.05) and a coefficient value of b -1.36. Meanwhile, the stage was analyzed using the Wald test of 8.0688, resulting in a p-value of 0.0045 with a significant negative correlation. Analysis on the relationship between p45Skp2 and p38Jab1 and the RMS stage was performed using the Gamma test, resulting in a significant positive correlation (p<0.05).
Modifikasi Restorasi Stainless Steel Crown Pada Kasus Severe Early Childhood Caries
Yoana Yoana;
Inne Suherna Sasmita
Jurnal Material Kedokteran Gigi Vol 8 No 2 (2019): JMKG Vol 8 No 2 September 2019
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)
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DOI: 10.32793/jmkg.v8i2.432
Early Childhood Caries (ECC) is a form of dental caries that occur rapidly. ECC is a common chronic disease in children that could harm self-esteem, nutrition, oral cavity development, also quality of life, then veer to malocclusions and psychological problems. In children with severe early childhood caries (SECC), losing vertical dimension of occlusion were also reported to occur 2.5 times more. Restoration of deciduous teeth with severe damage offers great challenge for pediatric dentists. This case reported clinical management of patients suffering from SECC using stainless steel crown to restore masticatory function and vertical dimensions. A 5-year-old boy escorted by his parents came to pedodontic dentistry Clinic at Universitas Padjadjaran Dental and Oral Hospital, with complaints of many tooth were damage. On clinical examination, it was shown that all primary teeth have caries, except for the two mandibular lateral incisor, teeth 16 and 26 were partial eruption, with deep bite in the anterior region. Therefore the diagnosis was deep bite in the anterior region because of SECC. Correction then had done by modifying metal crown restorations on posterior teeth. Modification of stainless steel crown restoration can correct vertical dimension of occlusion so as to prevent malocclusion.
Penilaian keberhasilan pemberian Dental Health Education (DHE) menggunakan media video-modeling pada individu Gangguan Spektrum Autisme (GSA) pada masa pandemi COVID-19Dental Health Education delivering using Video-Modeling in Children with Autism Spectrum Disorder during Pandemic COVID-19
Fa``Iqoh Zulfal Majidah;
Risti Saptarini Primarti;
Inne Suherna Sasmita
Padjadjaran Journal of Dental Researchers and Students Vol 6, No 3 (2022): Oktober 2022
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran
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DOI: 10.24198/pjdrs.v6i3.34306
ABSTRAKPendahuluan: Tantangan tenaga kesehatan dalam memberikan Dental Health Education (DHE) pada anak dan individu berkebutuhan khusus, salah satunya adalah penderita Gangguan Spektrum Autisme (GSA) yang memiliki gejala atau tanda berupa masalah perilaku, kesulitan dalam berkomunikasi, dan keterbelakangan kognitif. Individu GSA memiliki berbagai masalah medis yang menyertai (komorbiditas) termasuk masalah kesehatan di mulut. Kondisi rongga mulut Individu GSA oral seperti oral hygiene yang buruk, karies, dan penyakit periodontal. Tujuan penelitian adalah menilai keberhasilan pemberian Dental Health Education (DHE) menggunakan media Video-modeling (VM). Metode: Jenis penelitian deskriptif dengan teknik cross sectional. Pengambilan sampel secara total sampling dengan jumlah responden sebanyak 13 Individu GSA di Lembaga Pendidikan Autisma Prananda Kota Bandung. Kriteria penilaian keberhasilan pemberian DHE (video animasi cara menyikat gigi) menggunakan Object Retrieval Through Observational Learning Rating Criteria dengan skor 0 : subyek gagal mengikuti instruksi yang diberikan; skor 1 : subyek hamper tidak dapat mengikuti instruksi yang diberikan; skor 2: subyek hampir dapat mengikuti instruksi, walaupun tidak berurutan seperti instruksi; Skor 3 : responden mengikuti seluruh instruksi yang diberikan dengan urutan yang benar. Hasil: Sebanyak 12 responden mendapat skor 2 dan 1 responden mendapat skor 1. Simpulan: Keberhasilan pemberian DHE dengan video modelling. pada masa pandemi COVID-19 pada Individu GSA adalah dapat mengikuti instruksi cara menyikat gigi.Kata kunci: dental health education; anak gangguan spektrum autisme; video-modeling ABSTRACTIntroduction The challenges of health workers in providing Dental Health Education (DHE) to children and individuals with special needs, one of which is children with autism spectrum disorders (ASD) who have symptoms or signs in the form of behavioral problems, difficulty in communicating, and cognitive retardation. Children with ASD have various accompanying medical problems (comorbidities) including oral health problems. Oral conditions in children with ASD include poor oral hygiene, caries, and periodontal disease. The purpose of the study was to analyzed Dental Health Education (DHE) delivering using Video-modeling (VM) media. Methods: This research was a descriptive with cross sectional technique. Sampling with the number of respondents as many as 13 GSA children at the Pranada Autism Educational Institution, Bandung City. The criteria for assessing the success of giving DHE (animated video on how to brush teeth) using the Object Retrieval Through Observational Learning Rating Criteria with a score of 0: the subject failed to follow the instructions given; score 1: the subject can barely follow the instructions given; score 2: the subject can almost follow the instructions, although not sequentially like the instructions; Score 3: respondents follow all instructions given in the correct order. Results: A total of 12 respondents got a score of 2 and 1 respondent got a score of 1. Conclusion: Children with ASD are able to follow instructions on how to brush their teeth after being given DHE with video modeling. during the COVID-19 pandemic at the Prananda Autism Education Institute, Bandung City.Keywords: dental health education; autism spectrum disorder; video-modeling
Gambaran risiko karies anak gangguan spektrum autisme (GSA) di Yayasan Prananda pada masa pandemi COVID-19Description Caries Risk of Children with Autism Disorders (ASD) at Prananda Institution During Pandemic COVID-19
Bani Gidel;
Sri Susilawati;
Inne Suherna Sasmita
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 34, No 2 (2022): Agustus 2022
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran
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DOI: 10.24198/jkg.v34i2.34272
ABSTRAKPendahuluan: Anak dengan gangguan spektrum autisme (GSA) termasuk ke dalam kelompok berisiko terjadinya penyakit karies gigi karena kesulitan menjaga kebersihan gigi dan mulut sendiri. Karies gigi merupakan penyakit infeksi yang disebabkan oleh demineralisasi email dan dentin yang erat hubungannya dengan konsumsi makanan yang kariogenik Salah satu upaya yang dapat dilakukan dalam menanggulangi masalah karies yaitu dengan penilaian risiko karies. Tujuan penelitian adalah untuk mengetahui risiko karies anak GSA pada masa pandemi COVID-19 agar dapat melakukan perawatan dan pencegahan dini. Metode: Jenis penelitian deskriptif dengan teknik survei. Sampel sebanyak 16 anak GSA dengan teknik pengambilan sampel dengan cara total sampling dan menggunakan kuesioner risiko karies dari The American Academy of Pediatric Dentistry (AAPD). Data diolah dengan distribusi frekuensi dan disajikan dalam bentuk tabel. Penelitian dilakukan pada anak usia 6-12 tahun di Yayasan Prananda Kota Bandung dengan menggunakan kuesioner. Hasil: Terdapat 16 responden pada anak GSA usia 6-12 tahun menunjukkan bahwa risiko karies anak pada masa pandemi COVID-19 yaitu 25 % risiko tinggi, 18,75% risiko sedang, 56,25% risiko rendah. Simpulan: Sebagian besar risiko karies anak GSA usia 6-12 tahun pada masa pandemi COVID-19 berisiko karies rendah.Kata kunci: penilaian risiko karies; anak; gangguan spektrum autism; usia 6-12 tahunABSTRACT Introduction: Children with autism spectrum disorders (ASD) are at risk for caries because it is difficult to maintain their own oral and dental hygiene. Dental caries is an infectious disease caused by the demineralization of enamel and dentin, which is closely related to the consumption of cariogenic foods. One of the efforts that can be done to overcome the problem of caries is caries risk assessment. This study aimed to determine the risk of caries for ASD children during the COVID-19 pandemic so early treatment and prevention can be carried out. Methods: This research method is descriptive with survey techniques. The sample was 16 children with ASD (Autistic Syndrome Disorder) with a sampling technique or total sampling using the caries risk questionnaire from Permenkes 89 of 2015. The data was processed with frequency distribution and presented in table form. The research was conducted on children aged 6-12 years at the Prananda Institution in Bandung using a questionnaire. Results: The study showed that 16 respondents with ASD children aged 6-12 years showed that the risk of caries in children during the COVID-19 pandemic was 25 % high, 18.75 % moderate, and 56.25 % low. Conclusion: The risk of caries for ASD children aged 6-12 years n during the COVID-19 pandemic has low risk of caries.Keywords: caries risk assessment; children; autism disorder; aged 6-12 year
IMPROVING ORAL HYGIENE STATUS IN CHILDREN WITH AUTISM SPECTRUM DISORDER IN BANDUNG THROUGH EDUCATION USING “TOOTH BRUSHING VISUAL PEDAGOGY” FLIPCHART
Josevinda Ayu Pramesti;
Sri Susilawati;
Inne Suherna Sasmita
Jurnal Health Sains Vol. 4 No. 7 (2023): Journal Health Sains
Publisher : Syntax Corporation Indonesia
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DOI: 10.46799/jhs.v4i7.1025
Background: Autism Spectrum Disorder (ASD) is characterized by social communication deficits and restricted interests. Children with ASD face challenges in oral health, necessitating education. Education with visual pedagogy using “Tooth Brushing Visual Pedagogy” flipchart can be used to improve dental health in ASD children. Purpose: This study examined the effectiveness of the "Tooth Brushing Visual Pedagogy" flipchart in improving oral hygiene among children with ASD at Biruku Indonesia Foundation. Methods: A quasi-experimental study with 14 participants measured the Patient Hygiene Performance (PHP) plaque index pre- and post-education. The flipchart was used, followed by a toothbrushing session Results: A significant improvement (p < 0.05) was observed (p-value = 0.000071). Before education, plaque index varied from excellent (0.0%) to poor (21.42%). After education, excellent and good oral hygiene increased (0.0% and 71.42%, respectively), while fair and poor levels decreased (28.57% and 0.0%, respectively). Conclusion: The "Tooth Brushing Visual Pedagogy" flipchart effectively improved oral hygiene among children with ASD.
Prevalensi kebiasaan buruk bruksisme pada anak dengan gangguan spektrum autisme: studi cross sectional
Kholid, Ittaqi Tafuzi;
elih, Elih;
Sasmita, Inne Suherna;
Hasyimi, Ananto Ali
Padjadjaran Journal of Dental Researchers and Students Vol 7, No 2 (2023): Juni 2023
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran
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DOI: 10.24198/pjdrs.v7i2.34330
ABSTRAKPendahuluan: Gangguan Spektrum Autisme (GSA) merupakan masalah serius pada bidang psikiatri anak. Bruksisme merupakan gangguan tidur atau parasomnia yang lebih sering terjadi pada anak GSA dibandingkan sleepwalking dan mimpi buruk. American Academy of Sleep Medicine mendeskripsikan bruksisme sebagai aktivitas otot rahang berulang yang ditandai dengan mengepalkan atau menggiling gigi dan/atau mendorong mandibula. Dampak kebiasaan buruk yang dilakukan terus menerus adalah gigi menjadi sensitif dikarenakan terjadi pengikisan email, nyeri otot dan nyeri TMJ. Hal tersebut tentunya akan berdampak buruk untuk Kesehatan gigi dan mulut Anak GSA. Tujuan penelitian mengetahui prevalensi kebiasaan buruk bruksisme pada anak dengan gangguan spektrum autisme. Metode: Jenis penelitian deskriptif cross sectional. Teknik pengambilan sampel penelitian menggunakan metode total sampling sebanyak 24 orang, Pengumpulan data menggunakan kuesioner bruksisme melalui online form. Data diolah dan dianalisis menggunakan 3 kategori bruksisme dan disajikan dalam bentuk tabel. Hasil: Tidak ada responden yang masuk dalam kategori 1 yakni responden mengalami seluruh gejala bruksisme. Sebanyak 9 orang termasuk dalam kategori 2 yakni anak tersebut mengalami beberapa gejala bruksisme dan perlu dilakukan pemeriksaan klinis lebih lanjut dan 15 anak masuk dalam kategori 3 yang artinya ke-15 anak tersebut tidak mengalami tanda-tanda bruksisme. Simpulan: Sebagian besar anak GSA Yayasan Biruku Kota Bandung tidak menunjukkan gejala bruksisme.KATA KUNCI: bruksisme, gangguan spektrum, autisme, anak, prevalensiPrevalence of bruxism in children with autism spectrum disorder at the biruku foundation in bandung city: descriptive researchABSTRACTIntroduction: Autism Spectrum Disorder (ASD) is a serious problem in the field of child psychiatry. Bruxism is a sleep disorder or parasomnia that is more common than sleepwalking and nightmares in ASD children. The American Academy of Sleep Medicine describes bruxism as repetitive jaw muscle activity characterized by clenching or grinding of the teeth and/or pushing of the mandible. The impact of bruxism that are carried out continuously are sensitive teeth due to enamel erosion, muscle pain and TMJ pain. Which negatively affect the dental and oral health of ASD Children. The purpose of this study was to describe the prevalence of bruxism in order to be able to carry out early treatment and prevention. Methods: This study was cross sectional descriptive, and used a total sampling method with 24 respondents, each of whom would later fill out a bruxism questionnaire via online form. Data were processed and analyzed using 3 categories of bruxism and presented in tabular form. Results: There was no Category 1 respondent - who experienced all of the bruxism symptoms. The results showed that 9 respondents were Category 2 which means they had several bruxism symptoms and needed further clinical examination, while 15 respondents were Category 3 which means they did not show any symptoms of bruxism. Conclusions: Most of the children of the Biruku Foundation GSA Bandung City did not show symptoms of bruxism.KEY WORDS: bruxism, autism, spectrum disorder, child, prevalence
KONSELING ORANG TUA TERHADAP KUALITAS HIDUP ANAK DENGAN GANGGUAN SPEKTRUM AUTISME (GSA)
Sasmita, Inne Suherna;
Susilawati, Sri;
Damayanti, Lisda;
Suwargiani, Anne Agustina;
Setiawan, Asty S
DHARMAKARYA: Jurnal Aplikasi Ipteks untuk Masyarakat Vol 12, No 4 (2023): Desember, 2023
Publisher : Universitas Padjadjaran
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DOI: 10.24198/dharmakarya.v12i4.45982
Autisme merupakan salah satu gangguan yang disebut Gangguan Spektrum Autisme (GSA). GSA sendiri adalah suatu gangguan pada perkembangan sistem saraf pusat yang sifatnya heterogen dan diturunkan secara polygenik atau melibatkan banyak gen yang berbeda. Gangguan ini akan terus ada seumur hidup penderita, umumnya penderita akan didiagnosis pada usia sekitar 2 tahun, sehingga banyak dari penderita yang memerlukan “bantuan” sepanjang hidupnya. Dalam menghadapi kondisi dan perilaku anak dengan GSA, orang tua, guru, pengasuh membutuhkan banyak waktu, upaya dan kesabaran. Konseling dapat bergerak di bidang mana saja, baik di sekolah maupun di masyarakat yang lebih luas, termasuk lingkungan keluarga. Kerjasama antara keluarga dan sekolah dalam membantu anak autisme mengoptimalkan kemampuannya sangatlah penting.