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All Journal Majalah Kedokteran Bandung Dentika Dental Journal Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Padjadjaran Journal of Dental Researchers and Students Jurnal Material Kedokteran Gigi Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Jurnal Health Sains

Inne Suherna Sasmita

Universitas Padjadjaran

Author-ID : 2541115

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Energy Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Distribusi frekuensi missing teeth pada anak sindroma DownMissing teeth frequency distribution of Down syndrome children Nadiya Mujaheda Alwafa; Yetty Herdiyati; Inne Suherna Sasmita; Williyanti Suwondo
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 31, No 1 (2019): April 2019
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Pendahuluan: Missing teeth adalah suatu keadaan berupa hilangnya gigi karena adanya kegagalan perkembangan gigi yang dapat menyebabkan berkurangnya fungsi pengunyahan, fonetik, estetika, serta munculnya masalah pada jaringan keras dan lunak di sekitarnya. Gejala missing teeth ditemukan pada anak sindroma Down, yaitu anak yang memiliki kromosom berlebih (trisomi 21), yang mengakibatkan kelainan dan keterlambatan pertumbuhan dan perkembangan baik fisik dan mental. Tujuan penelitian adalah untuk mengetahui distribusi frekuensi missing teeth pada anak sindroma Down di Yayasan POTADS. Metode: Jenis penelitian adalah deskriptif dengan teknik survei. Populasi pada penelitian ini adalah penderita sindroma Down anggota Yayasan Persatuan Orang Tua Anak dengan Down Syndrome (POTADS) dan diperiksa di Rumah Sakit Gigi dan Mulut (RSGM) Universitas Padjadjaran (Unpad). Pengambilan sampel dilakukan dengan teknik total sampling sebanyak 25 orang. Anak dengan sindroma Down berusia lebih dari 5 tahun didapatkan berdasarkan data yang diperoleh dari POTADS. Analisis data dilakukan dengan distribusi frekuensi relatif. Hasil: Sebanyak 48,07% anak sindroma Down yang diperiksa mengalami missing teeth dengan tipe hipodonsia sebesar 88%. Simpulan: Distribusi frekuensi missing teeth terjadi pada hampir setengah populasi anak sindroma Down di Yayasan POTADS.Kata kunci: Missing teeth, hipodonsia, sindroma Down. ABSTRACTIntroduction: Missing teeth is a condition of tooth loss due to developmental failure which can reduce the function of mastication, phonetics, aesthetics, and the problems in the surrounding hard and soft tissues. Missing teeth symptoms are found in Down syndrome children, which is children with excessive chromosomes (trisomy 21), resulting in abnormalities and delays in growth and development both physically and mentally. This study was aimed to determine the missing teeth frequency distribution of Down syndrome children at POTADS Foundation. Methods: The research was descriptive with survey technique. Population in this study were Down syndrome patients who were members of the Association of Parents with Down Syndrome Children (POTADS) Foundation and were examined at Universitas Padjadjaran (Unpad) Dental Hospital (RSGM). Sampling technique was a total sampling resulting 25 people. Children with Down syndrome more than 5 years old were based on data obtained from POTADS Foundation. Data analysis was carried out by relative frequency distribution. Results: A total of 48.07% of Down syndrome children examined had missing teeth with the type of hypodontia by 88%. Conclusion: Missing teeth occur in almost half the population of children with Down syndrome at POTADS Foundation.Keywords: Missing teeth, hypodontia, Down Syndrome.

Craniofacial growth and development of Turner syndrome children Inne Suherna Sasmita; Arlette Suzy Puspa Pertiwi; M Harun Achmad
Padjadjaran Journal of Dentistry Vol 21, No 2 (2009): July 2009
Publisher : Faculty of Dentistry Universitas Padjadjaran

Turner syndrome is a genetic disorder which characterized by specific physical appearance and the lost of one of sex chromosome in females. The most frequent chromosome constitution in Turner syndrome is 45X. This disorder may cause an interruption of growth and development in the whole body as well as in the craniofacial region. The oral manifestations of Turner syndrome are micrognathia, high palate, malocclusion, and the premature eruption of first permanent molars. This paper will discuss the oral manifestations associated with the craniofacial growth and development of Turner syndrome.

Role of Streptococcus Anginosus on the formation of dental caries Yetty Herdiyati Nonong; Mieke Hemiawati Satari; Inne Suherna Sasmita
Padjadjaran Journal of Dentistry Vol 23, No 3 (2011): November 2011
Publisher : Faculty of Dentistry Universitas Padjadjaran

Generally, the etiology of dental caries is the cariogenic properties of bacteria, these are always associated with Streptococcus mutans. Glucosyltransferase fragment (Gtf) are also in other strains of Streptococcus such as Streptococcus anginosus, Streptococcus milleri which includes beta hemolysis. Genotypically B Streptococcus anginosus has genetic characteristics that are similar to Streptococcus mutans. The research objective was to determine the existence of Gtf B/C gene as a cause of caries in Streptococcus anginosus. The study was conducted in experimental laboratories with PCR technique by taking a sample of 20 children who had caries. The results showed there was the amplification of Streptococcus anginosus with a level of homology 96%, 97%, and 99%. The results of the Gtf genes amplification fragment B/C provided 600 pb ribbon. The conclusion was Streptococcus anginosus classified as cariogenic bacteria because they had Gtf B/C genes.

Electro-gene therapy followed by intratumoral injection of pcDNA3.1-p27Kip1 wild type in human tongue base cancer cells SP-C3 xenograft S. Supriatno; Inne Suherna Sasmita
Padjadjaran Journal of Dentistry Vol 21, No 3 (2009): November 2009
Publisher : Faculty of Dentistry Universitas Padjadjaran

Human tongue base cancers are characterized by a high degree of local invasion and metastasis to the regional lymph nodes and included a disease with difficult treatment. A novel method for high-efficiency and region-controlled in vivo gene transfer was developed by combining electro-gene therapy and plasmid (pcDNA). The aims of the study were to examine the efficiency of transfection of p27Kip1 gene by electro-gene therapy and to evaluate p27Kip1 gene therapy in Supri’s clone-3 (SP-C3) xenografts using pcDNA3.1-p27Kip1 wild-type (wt) and pcDNA3.1 empty vector (neo) with electro-gene therapy. To investigate gene transfer method, the enhanced green fluorescence protein (EGFP) gene was transfected into xenografts by electro-gene therapy. The efficiency of p27Kip1 gene transfection at protein level was confirmed by Western blotting. To estimate the reduction in tumour size in Wistar Balb/c mice after electro-gene therapy with p27Kip1 wt gene was examined by tumorigenesis assay. To evaluate the induction of apoptosis was carried out by colourimetric assay. The result, the growth of tumours was markedly suppressed by p27Kip1 wt gene transfection. Up-regulation of p27Kip1 protein was detected in pcDNA3.1-p27Kip1 wt. Apoptosis induction through the activity of caspase -3 and -9 was significantly increased in p27Kip1 wt-transfected tumours. These results suggest that it is possible to transfer p27Kip1 wt into tongue base cancer cell xenografts using electro-gene therapy. p27Kip1 wt had a high-potential to suppress the growth of tumours. Conclusion, electro-gene therapy followed by intratumoral injection of pcDNA3.1-p27Kip1 wt had a high-potential to suppress the growth of a human tongue base cancer cell xenograft.

The differences of caries prevalence and caries index of children in primary school with UKGS and without UKGS in Kota Batam Ratna Ayu Alia Zulkarnain; Eriska Riyanti; Inne Suherna Sasmita
Padjadjaran Journal of Dentistry Vol 21, No 1 (2009): March 2009
Publisher : Faculty of Dentistry Universitas Padjadjaran

The purposes of this research were to describe the caries prevalence and caries index of children in primary school with UKGS (SD Kartini I) and without UKGS (SD 009 Bulang) in Kota Batam. Total samples of this research were 193 persons, it is consist of 107 persons from SD Kartini I and 86 persons from SD 009 Bulang. The Chi-Square Test and U Mann-Whitney Test were conducted in this research. The statistical analysis was significant for caries prevalence between children in primary school with UKGS and without UKGS with χ2table = 2.71 and χ2calculate = 3.73, whereas def-t index between children in primary school with UKGS and without UKGS was significant with - Ztable = - 1.96 and Zcalculate = - 2.91 with α = 0.05. The DMF-T index between children in primary school with UKGS and without UKGS was significant with Ztable = 1.96 and Zcalculate = 6.32 with α = 0,05. The conclusions of this study indicate that there were differences of caries prevalence and caries index between children in primary school with UKGS and without UKGS.

Ethanol extract of mangosteen (Garcinia Mangostana Linn) peel effect in inhibiting the growth of human tongue cancer cells Supri’s Clone 1, invitro Edi Suanto; Roosje Rosita Oewen; Inne Suherna Sasmita; S. Supriatno; Unang Supratman
Padjadjaran Journal of Dentistry Vol 23, No 2 (2011): July 2011
Publisher : Faculty of Dentistry Universitas Padjadjaran

The incidence of tongue cancer in Indonesia reached 1.01% of all cancers and 42% of oral cavity cancer. Tongue cancer therapies including chemotherapy, radiotherapy, surgery, and all three combined therapy. Search for anti-cancer drugs currently switched on herbal plants, one of which is the mangosteen. Has the properties of mangosteen peel extract inhibited the growth of cancer cells. The purpose of the study, obtain IC50 of ethanol extract of mangosteen peel in inhibiting the growth of human tongue cancer cells SP-C1. Research carried out on 96 preparations of human tongue cancer SP-C1 were incubated with ethanol extract of mangosteen peel, preparations were classified in two groups of incubation time (24 hours and 48 hours) and each group will be given preferential treatment over 6 randomly different concentrations: 0 (control), 62.5 μg/mL, 125 μg/mL, 250 μg/mL, 500 μg/mL and 1000 μg/mL. Model experiments were 2 x 6 factorial experiment with eight replication for each cell. Test results with ANAVA, incubation (24 and 48 hour) SP-tongue cancer cells with various concentrations of C1 ethanol extract of mangosteen peel gives a highly significant, indicating differences cancer cell growth inhibition. Incubation time factor showed the long incubation effect on cancer cell growth inhibition. Furthermore, by Newman Keuls test, showed 500μg/mL concentrations of 24-hour incubation had the best effect. Conclusion of the study of ethanol extract of mangosteen peel could achieve with IC50 values of cell growth resistance 50.3% at a concentration of 500 μg/mL and an incubation time of 24 hours.

Prevalence of caries in intellectually impaired children at Sekolah Semangat Maju, Taiping, Perak, Malaysia Sanjit Singh; Inne Suherna Sasmita
Padjadjaran Journal of Dentistry Vol 21, No 2 (2009): July 2009
Publisher : Faculty of Dentistry Universitas Padjadjaran

Dental caries also known as tooth decay is a disease where a bacterial process damages the hard tooth structure. The aim of conducting this research was to obtain the prevalence of caries in the intellectually impaired children in Sekolah Semangat Maju, Taiping, Perak, Malaysia. The research was a descriptive research that utilized the survey technique. The population of the research was the students aged 7-17 years old from class 1 to class 5. The total sample for this research was 56 students. The students were examined for the presence of caries and the results were used to obtain the prevalence of caries in these subjects. The results from this study showed that the prevalence of caries based on the student’s medical diagnose was 68.42% for autism students, 57.14% for cerebral palsy students, 91.67% for Down’s syndrome students, 100.00% for mental retardation students and 42.86% for slow learner students. The conclusion from this research was that the overall prevalence of caries in intellectually impaired children at Sekolah Semangat Maju Taiping, Perak, Malaysia is 67.89%.

Oral manifestations and their management in children undergoing haemodialysis treatment Arlette Suzy Puspa Pertiwi; Inne Suherna Sasmita; Meirina Gartika
Padjadjaran Journal of Dentistry Vol 19, No 3 (2007): November 2007
Publisher : Faculty of Dentistry Universitas Padjadjaran

Haemodialysis is a medical procedure that artificially filters blood. This procedure is carried out to treat children with end-stage renal disease (ESRD). Although haemodialysis is a lifesaving treatment, it also raises many severe oral manifestations associated with ESDR. Among these are increased hypoplasia, enamel opacities, uremic stomatitis, oral bleeding, increased periodontal disease, reduced salivary flow, xerostomia, and an increased tendency of calculus deposition. This paper will discuss the oral manifestations associated with ESRD and their management in children undergoing haemodialysis treatment.

Deksripsi kesesuaian usia kronologis dan usia dentalis melalui estimasi pertumbuhan ujung akar gigi premolar Inne Suherna Sasmita; Lusi Epsilawati; Fadhlil Ulum Abdul Rahman
Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Vol 4 No 1 (2020): Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI)
Publisher : Ikatan Radiologi Kedokteran Gigi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jrdi.v4i1.476

Objectives: The purpose of this study was to find out the description of chronological age and dental age suitability through estimation of root growth of maxillary and mandibular premolar teeth. Material and Methods: This study was a descriptive study with cross-sectional approach performed on the maxillary and mandibular first and second premolars. Data was taken from 50 panoramic radiographs contained in the 2015-2016 RSGM Unpad archives. Analyzes were performed based on age predictions from the Demirjian table compared to chronological ages in several age groups. The data is then presented in tabular form. Results: This study shows that there is a high degree of concordance between chronological age and dental age through premolars 1 and 2, both upper and lower jaws of the Demirjian table in the initial phase of tooth root formation at 8 years chronological age and at the final phase of root apex closure at 12-13 years chronological age through the assessment of panoramic radiograph. Conclusion: Chronological age and dental age depend on the precise assessment of root growth of premolar 1 and 2 teeth in the maxillary and mandibular regions having a high degree of suitability in the early and final phases of tooth root formation which are seen more radiographically.

Role of P27kip1 Protein, P45skp2 Coactivator, and P38jab1 Coactivator in Preventing Rhabdomyosarcoma (RMS) in Oral Cavity of Children Inne Suherna Sasmita; Ratna Indriyanti; Willyanti Soewondo
Majalah Kedokteran Bandung Vol 54, No 2 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n2.259

Rhabdomyosarcoma is a rare malignant tumor that attacks the differentiation of skeletal muscle and usually affects children, contributing to about 60% of all soft tissue sarcomas. The purpose of this study was to examine the relationship between p27Kip1 immunoexpression and p45Skp2 and p38Jab1 coactivators, as well as the relationship between p27Kip1 immunoexpression and p45Skp2 and p38Jab1 coactivators on stages and prognosis of oral RMS in children. This was a restrospective study on the immunoexpression of p27Kip1 and p45Skp2 and p38Jab1 coactivators on RMS cells. The RMS stage was determined according to the American Joint Committee of Cancer/AJCC of stages 1–4, and were divided into group I (stages 1 and 2) and group II (3 and 4). Samples were retrieved fromt he paraffin blocks of patients with embryonal RMS. Each paraffin block was cut, and 6 samples with 5 µm thickness from each block were examined using p27Kip1, p45Skp2, and p38Jab1 proteins. The analysis was performed using a linear regression test on the relationship between p27Kip1 and p45Skp2 and p38Jab1, resulting in a p-value of 0.000 (<0.05) and a coefficient value of b -1.36. Meanwhile, the stage was analyzed using the Wald test of 8.0688, resulting in a p-value of 0.0045 with a significant negative correlation. Analysis on the relationship between p45Skp2 and p38Jab1 and the RMS stage was performed using the Gamma test, resulting in a significant positive correlation (p<0.05).

Co-Authors Anie Apriani Anissa Maya Kania Anissa Maya Kania Anne Agustina Suwargiani Arlette Suzy Puspa Pertiwi Asty Samiaty Setiawan, Asty Samiaty Bani Gidel Dela Armilda Dewi, Chita Sintya Dhia Thifal Malihah Dianegianty, Rine Dudi Aripin Edi Suanto Edi Suanto, Edi elih, Elih Eriska Riyanti Fadhlil Ulum Abdul Rahman Fahmi Oscandar, Fahmi Fa``Iqoh Zulfal Majidah Georgiana Marsya, Georgiana Harun Achmad Hasyimi, Ananto Ali Hidayat, Septian Rahmat Hilnia Zidnia Iwan Ahmad Musnamirwan Josevinda Ayu Pramesti Kholid, Ittaqi Tafuzi Kirana Lina Gunawan Kirana Lina Gunawan Lisda Damayanti Lusi Epsilawati M Harun Achmad, M Harun Meirina Gartika Mieke Hemiawati Satari Mieke Hemiawati Satari Miryasandra, Astari Murnisari Dardjan, Murnisari Nadiya Mujaheda Alwafa Nani Murniati Nurwahidah, Sinta Putri, Tarisya Permata Ratna Ayu Alia Zulkarnain Ratna Ayu Alia Zulkarnain, Ratna Ayu Alia Ratna Indriyanti Risti Saptarini Primarti Roosje Rosita Oewen Roosje Rosita Oewen, Roosje Rosita S. Supriatno Sandy Dwiputra Sanjit Singh Sanjit Singh, Sanjit Setiawan, Asty S Setiawan, Editha Meydiana Sinta Nurwahidah Soekamto, Debrina Mayasari Sri Susilawati Sukmasari, Susi Supriatno Suwondo, Willyanti Syarief Hidayat Unang Supratman Wibowo, Kyle Raditya Williyanti Suwondo Willyanti Soewondo Willyanti Suwondo Yetty Herdiati Nonong Yetty Herdiyati Yetty Herdiyati Nonong Yetty Herdiyati Nonong, Yetty Herdiyati Yoana Yoana Yonathan, Heidy Stefanie Yurika Ambar Lita Yuti Malinda

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