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All Journal Pharmaciana: Jurnal Kefarmasian Pharmacon IDJP (Indonesian Journal of Pharmaceutics) Jurnal Fitofarmaka Indonesia FITOFARMAKA: Jurnal Ilmiah Farmasi EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Molekul: Jurnal Ilmiah Kimia JFIOnline Jurnal Abdimas Madani dan Lestari (JAMALI) Jurnal Pusat Studi Pendidikan Rakyat (PUSDIKRA) JURNAL AGROINDUSTRI HALAL Pharmaceutical Sciences and Research (PSR) Jurnal Sosial dan Sains Kenduri: Jurnal Pengabdian Dan Pemberdayaan Masyarakat Journal of Tropical Pharmacy and Chemistry Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research) Jurnal Pengabdian Masyarakat Inovatif Jurnal Pengabdian Masyarakat Inovatif
Sri Wardatun
Program Studi Farmasi Universitas Pakuan
Agriculture, Biological Sciences & Forestry Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Removal of Mimosine from Leucaena leucocephala (Lam.) de Wit Seeds to Increase Their Benefits as Nutraceuticals Wardatun, Sri; Harahap, Yahdiana; Mun'im, Abdul; Saputri, Fadlina Chany, Dr.; Sutandyo, Noorwati
Pharmaceutical Sciences and Research Vol. 7, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The Leucaena leucocephala (Lam.) de Wit tree contains pharmacologically active compounds and can easily be found in abundant quantities. The utilization of this tree as a source of nutraceuticals would increase its value. The extraction yields show the number of compounds that have been extracted by solvent. However, Leucaena leucocephala (Lam.) de Wit seeds also contain mimosine, which can cause hair loss. The present study investigated the process of removing mimosine from the seeds. Three treatments were applied to these seeds: treatment without soaking, soaking with distilled water for 24 hours, and splitting the seeds in half and then soaking with distilled water for 24 hours. The seeds were dried, ground, and then extracted with different concentrations of ethanol solvent. The mimosine levels of the extracts were measured with a JascoV-730 spectrophotometer using ferry chloride as a reagent. The results showed that the soaking process and the concentration of ethanol had significant effects on the extract yields and mimosine levels. The unsoaked seeds, extracted with 70% ethanol, produced the highest ratio of extract yield to mimosine level. Therefore, 70% ethanol can be used as a solvent to utilize unsoaked seeds as nutraceuticals.
Perbandingan Kadar Flavonoid Serbuk Instan Kunyit Putih (Curcuma Zedoaria Rosc.) Yang Beredar Di Pasaran Dengan Metode Spektrofotometri UV-VIS Trirakhma Sofihidayati; Sri Wardatun; Alvia Suraya
Jurnal sosial dan sains Vol. 1 No. 12 (2021): Jurnal Sosial dan Sains
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1775.907 KB) | DOI: 10.59188/jurnalsosains.v1i12.278

Abstract

Latar belakang: Minuman herbal siap saji merupakan produk bahan minuman berbentuk serbuk atau granula yang biasa dibuat dari gula dan rempah-rempah yang dicampur menjadi satu dengan atau tanpa penambahan bahan makanan lain. Metode: Penelitian ini bertujuan untuk menentukan perbandingan kadar Flavonoid dari berbagai serbuk instan kunyit putih yang beredar di pasaran dengan merek (I), (II), (III), (IV) dan (V) dengan 2 Batch yang berbeda pada setiap merek dilakukan menggunakan metode spektrofotometri UV-Vis. Hasil: Hasil kadar flavonoid dari serbuk instan kunyit putih berbagai merek yang beredar di pasaran yaitu kadar flavonoid yang paling tinggi terdapat pada sampel merek (I)pada (batch A) dengan kadar sebanyak 5,366% dan (II) pada (batch B) dengan kadar sebanyak 5,423%. Kesimpulan: kadar flavonoid terendah terdapat pada merek (IV) 2,851% (batch B) dan 3,024% (batch A).
AKTIFITAS BERBAGAI SEDIAAN BUAH SIRSAK (Annona muricata Linn) DALAM PENURUNAN KADAR ASAM URAT TIKUS PUTIH Sprague-Dawley - Prasetyorini; - Moerfiah; Sri Wardatun; - Affandi
Ekologia: Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Vol 14, No 2 (2014): Ekologia : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/ekol.v14i2.215

Abstract

Research potential of juice, extract ethanol, ethyl acetate extracts with different doses of soursop fruit as down as the asamurat has been performed. The treatment given these supplies juice with doses of 930 mg, 1870 2810 mg and mg: 96% ethanol extract with a dose of 26.79 g/100 ml, 53.58 g/100 ml and 80.37 g/100 ml; and extract with ethyl acetate dose 2.58 g/100 ml, 5.16 g/100 ml and 7.74 g/100 ml. The making of extracts is done with methods of maceration of fruit juice, and squeeze the flesh of the fruit directly with Batiste. The results of qualitative testing all positive preparations contain a flavanoid, alkaloids, tannins, saponins and polyphenols. The content of polyphenols  100 g ingredients for fruit juice, extract 96% ethanol and ethyl acetate extracts of consecutive 0.473 g SAG: SAG 0.324 g; and 0.194 mg SAG. Vitamin C 100 g of ingredients for fruit juice, extract 96% ethanol and ethyl acetate extracts of consecutive 38.24 mg; 30.56 mg; 35.66 mg. for 100 g K Content material to juice, extract the ethanol 96% ethyl acetate extracts and a row of 0.39 g; 0.26 g; 0.22 g. Content of 100 g each Na ingredients for fruit juice, extract the ethanol 96% ethyl acetate extracts and a row of 0.0269 g; 0.0416 g; 0.0436 g. The results showed the treatment given the very real effect of lowering uric acid levels of rats, a third dose of juice lowers blood uric acid levels up to 40%, 96% ethanol extract Dosage dose 53.58 g/100 ml and 80.37 g/100mlserta ethyl acetate extract dosage 7.74 g/100 ml can also lower blood uric acid levels exceed the positive control. Key words:   Uric acid, fruit juice, ethanol and ethyl acetate extract fruit soursop (Annona muricata Linn),
ANALISIS KANDUNGAN TIMBAL, TEMBAGA DAN ARSEN PADA DAUN KANGKUNG (Ipomoea aquatica) YANG DIJUAL DI TEMPAT YANG BERBEDA DENGAN METODE SPEKTROFOTOMETRI SERAPAN ATOM - Prasetyorini; Sri Wardatun
Ekologia: Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Vol 11, No 2 (2011): Ekologia : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/ekol.v11i2.258

Abstract

Kangkung merupakan sumber gizi yang murah harganya dan mudah untuk mendapatkannya. Kangkung yang ditanam dan disiram dengan air yang tercemar kemungkinan besar akan mengandung logam pencemar tersebut. Penelitian ini menganalisis kandungan logam pencemar pada kangkung yang dijual di pasaran dengan metode spektrofotometri serapan atom (AAS). Hasil menunjukkan bahwa kangkung yang dijual di pasaran mengandung logam timbal, arsen dan tembaga dengan kadar  di bawah kisaran maksimum  yang diijinkan dalam pangan.  Kata kunci : Kangkung, logam berat, AAS
POTENSI SARI BUAH SEMANGKA MERAH (Citrullus vulgaris rubrum) DAN SARI BUAH SEMANGKA KUNING (Citrullus vulgaris flavum) SEBAGAI PELURUH BATU GINJAL KALSIUM OKSALAT SECARA IN VITRO E. Mulyati Effendi; Sri Wardatun
Ekologia: Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Vol 12, No 1 (2012): Ekologia : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/ekol.v12i1.249

Abstract

Buah semangka merah (Citrullus vulgaris rubrum) dan buah semangka kuning (Citrullus vulgaris flavum) merupakan tanaman obat yang berkhasiat sebagai peluruh air seni dan digunakan untuk melarutkan batu ginjal. Telah dilakukan pengujian potensi sari buah semangka merah dan sari buah semangka kuning sebagai peluruh batu ginjal kalsium oksalat secara in vitro. Pengujian dilakukan dengan merendam batu ginjal kalsium oksalat dan menganalisis kadar kalium serta kalsium oksalat yang larut secara Spektrofotometer Serapan Atom. Hasil penelitian menunjukkan bahwa sari buah semangka merah dan sari buah semangka kuning dapat melarutkan batu ginjal kalsium oksalat. Kelarutan batu ginjal kalsium oksalat tertinggi dalam sari buah semangka kuning pada konsentrasi 100% sebesar 16,25 x 10-5 mol/L sedangkan pada sari buah semangka merah pada konsentrasi 100% sebesar 10,83 x 10-5 mol/L. Kadar kalium diduga menjadi faktor yang mempengaruhi kelarutan batu ginjal kalsium oksalat. Kandungan kalium semangka kuning sebesar 0,02454% lebih tinggi dibandingkan dalam semangka merah sebesar 0,02093%. Kata kunci  : Semangka merah (Citrullus vulgaris rubrum), Semangka kuning (Citrullus vulgaris flavum), Kalsium oksalat, Batu ginjal
Comparison of Maceration and Ultrasound-Assisted Extraction Method in Determining Quercetin Content of Clitoria ternatea L. Flowers Wardatun, Sri; Ahyar, Akmal Zainul; Nining, Euis
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 14, No 1 (2024): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v14i1.10043

Abstract

Butterfly pea flowers (Clitoria ternatea L.) contain the compound quercetin which has been studied extensively. Butterfly pea flowers have shown various pharmacological activities. The extraction method has an impact on the amount of active compound extracted. The aim of this research was to determine the effect of different extraction methods on quercetin content of C. ternatea L flowers using the High-Performance Liquid Chromatography (HPLC).  The HPLC system uses an ODS-3 column stationary phase; a mobile phase mixture of 0.1 % orthophosphoric acid and methanol (36:64); a flow rate of 1.2 mL/min; and a PDA-UV detector. The extraction methods used were maceration, and ultrasound-assisted extraction (UAE) using methanol as a solvent. The results showed that the quercetin content of C. ternatea L flower extract with maceration method results was 1.0669 ± 0.0283 mg/g and with UAE method was 1.3915 ± 0.1789 mg/g. Statistical test results showed that differences in both extraction method did not have a significant effect on quercetin content. However, the UAE method is considered more efficient in terms of extraction time, so the UAE method can be used as an alternative for extracting quercetin from C. ternatea L. flowers.
Optimization of Temperature and Drying Time on Flavonoids Levels of Anjasmoro Variety Soybean (Glycine Max) Extract Using Response Surface Methodology Wardatun, Sri; Indah Puspita Dewi, Anggy; Amalina, Dhaifa Ghaisani Rizkia
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 13, No 2 (2023): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v13i2.9273

Abstract

Soybeans (Glycine max) contain a number of nutritional and health-supporting compounds, such as protein, fibers, phytosterols, and isoflavones. The pharmacological activities of soybeans include improving the immune system, acting as an antioxidant, inhibiting carcinogenesis, and reducing cholesterol levels. Anjasmoro variety is one of the superior varieties of large-seeded soybeans and is in great demand by farmers. The temperature and drying time of soybeans can have an effect on the level of compounds extracted. The aim of this research was to optimize flavonoid extraction from soybeans based on temperature and drying time using the response surface methodology (RSM). The results show that the optimal temperature and drying time of soybeans was obtained at 60.027 °C and 6.036 hours, with optimal flavonoid levels of 21.9707 mg QE/g. The verification results based on laboratory test confirmed that the level of flavonoids at optimal condition was 20.6461 mg QE/g, with a deviation of 6.03 % from prediction value and accuracy results of 93.97 %. The optimal drying temperature and drying time of soybeans can be used to obtain the highest flavonoid levels.
Sosialisasi dan Pelatihan Deteksi Dini Kanker Payudara di Lingkungan Dosen dan Karyawan Universitas Pakuan Nhestricia, Nhadira; Wardatun, Sri; Herlina, Nina
KENDURI : Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 3 No. 3 (2023): Desember
Publisher : Yayasan Darussalam Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62159/kenduri.v3i3.1012

Abstract

Kanker payudara (KPD) merupakan keganasan pada jaringan payudara yang dapat berasal dari epitel duktus maupun lobulusnya. Kanker payudara merupakan salah satu jenis kanker terbanyak di Indonesia. Lebih 80% kasus ditemukan berada pada stadium yang lanjut, dimana upaya pengobatan sulit dilakukan. Pemahaman masyarakat terutama yang berada di lingkungan dosen dan karyawan Universitas Pakuan yang menganggap dirinya sehat, seringkali melupakan bahwa kanker payudara sewaktu-waktu juga dapat menyerang dirinya. Hal ini yang menyebabkan tingkat kesadaran masyarakat untuk memeriksa payudara sendiri secara rutin juga rendah, sehingga jika segala sesuatunya sudah terjadi maka semuanya serba terlambat. Oleh karena itu perlu adanya upaya pencegahan, diagnosis dini, pengobatan kuratif maupun paliatif serta upaya rehabilitasi yang baik, agar pelayanan pada penderita dapat dilakukan secara optimal. Kegiatan pencegahan atau prevensi terdiri dari pencegahan primer dan sekunder. Pencegahan primer merupakan usaha agar tidak terkena kanker payudara dengan mengurangi atau meniadakan faktor-faktor risiko yang diduga sangat erat kaitannya dengan peningkatan insiden kanker payudara. Pencegahan primer atau supaya tidak terjadinya kanker secara sederhana adalah mengetahui faktor -faktor risiko kanker payudara, seperti yang telah disebutkan di atas, dan berusaha menghindarinya. Kegiatan sosialisasi dan pelatihan deteksi dini di lingkungan Universitas Pakuan merupakan kegiatan pengabdian untuk mendeteksi secara dini terjadinya kanker payudara. Kegiatan ini dilakukan bekerjasama dengan dengan Yayasan Love pink. Love pink merupakan Organisasi nirlaba yang berfokus pada kegiatan sosialisasi deteksi dini dengan cara SADARI (Periksa Payudara Sendiri), SADANIS (Periksa Payudara Secara Klinis), dan pendampingan bagi sesama perempuan dengan kanker payudara. Lovepink bergerak dengan basis komunitas survivors yang bekerja secara sukarela untuk mendukung visi dan misi organisasi. Diharapkan kegiatan ini dapat menurunkan resiko kejadian kanker payudara..
Ethanol-based solvent system for recovery antioxidant activity Centella asiatica L. Urban and its application in sleep-deprived Rats Wardatun, Sri; Sofihidayati, Trirakhma; Afifah, Nida; Juhroh, Juju
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.27277

Abstract

Antioxidants have the ability to eliminate free radicals by donating electrons to oxidants. Preclinical and clinical studies show that Centella asiatica L. Urban has antioxidant activity. Ethanol was the best solvent for extracted antioxidant compounds from Centella asiatica L. Urban. The concentration of ethanol solvents effect to the compounds extracted and its antioxidant activities. The objective of study to determine ethanol based solvent systems for best recovery of antioxidant activities and in vivo antioxidant activity of the most active extract using stress induced sleep-deprived rats with glutathione (GSH) concentration parameters. Ethanol based solvent system show different recovery antioxidant activity of Centella asiatica L. Urban. Ethanol 70% had the highest recovery of antioxidant activity with an IC50 value of 76.76 ppm. Ethanol 70% Centella asiatica L. Urban extract given in sleep-deprived rats at 300 mg/kg were not significantly different in glutathione levels from those group rats that received the positive control solution (ascorbic acid). The 70% ethanol extract of C. asiatica L. Urban has the potential to ameliorate the stress induced by sleep deprivation.
Antioxidant Activity and Total Flavonoid Propolis Stingless Bee Hasan, Akhmad Endang Zainal; Safira, Ukhradiya Maharaniq; Purnamasari, Anita; Wardatun, Sri
JURNAL AGROINDUSTRI HALAL Vol. 9 No. 2 (2023): Jurnal Agroindustri Halal 9(2)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/jah.v9i2.6818

Abstract

Propolis from Indonesia contains secondary metabolites which include flavonoids and other organic compounds. The ethanol extract of 70% propolis Trigona spp from Pandeglang can be used as an antibacterial compound. The purpose of this study was to examine the toxicity of the propolis and nanopropolis with an LC50 value, test the antioxidant activity with an IC50 value, and determine the total flavonoid content. LC50 was determined by the BSLT method on Artemia salina Leach larvae. The antioxidant activity was tested using the DPPH method (1,1 diphenyl-2-picrylhydrazil), and the determination of flavonoid content was carried out with aluminum chloride. The results showed that the LC50 value of propolis was 16.010 ppm, and for 20% nanopropolis was 18.689 ppm. Antioxidant activity obtained IC50 value for propolis is 95.54593 ppm, for 20% nanopropolis is 527.7939 ppm. The total flavonoid content of the propolis was 2.1123%, and the total flavonoid content for the nanopropolis equivalent extract was 1.5293%.
Co-Authors - Affandi - Moerfiah - Prasetyorini Achmad Noerkhaerin Putra Aditya Aprizayansyah Afifah, Nida Agustin, VIna Ahyar, Akmal Zainul Akhmad Endang Zainal Hasan Almunawaroh, Zahra Alvia Suraya Amalina, Dhaifa Ghaisani Rizkia Andi Fauzi Aprizayansyah, Aditya Asri Wulandari Aulia Fitriani Bina Lohita Sari D Prasetyorini E Mulyati Effendi, E Mulyati Erni Rustiani Fadlina Chany Saputri fauzi, andi Fitri Atika suri Herman Suryadi Ike Yulia Indah Puspita Dewi, Anggy Ismail Nasution Juhroh, Juju Lakum, Lakum Lia Puspita Sari Mahyuni, Siti Malatabu, Shapira Mera Mardiamah, Suci Marpaung, Juwita Rosvenia Mira Miranti MOERFIAH . Moerfiah Moerfiah Mun'im, Abdul Nhestricia, Nhadira Nina Herlina Nining, Euis Noorlaela, Ella Noorwati Sutandyo Novi Fajar Utami Oom Komala Opi Damahyanti Padhilah, Prasti Restu Prasetyorini Prasetyorini Purnamasari, Anita Putra Setiawan Randiansyah, Randiansyah Safira, Ukhradiya Maharaniq Sofihidayat, Trirakhma Sofihidayati, Trirakhma Sofihidayati, Trirakhma Sunarya, M. Rustan suri, Fitri Atika Trirakhma Sofihidayati Wildan Aristyo Yahdiana Harahap Yulia, Ike Zaldy Rusli Zaldy Rusli