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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya As-syifaa Jurnal Farmasi Dinamisia: Jurnal Pengabdian Kepada Masyarakat JMM (Jurnal Masyarakat Mandiri) Window of Health : Jurnal Kesehatan Jurnal Masyarakat Merdeka (JMM) Journal of Pharmaceutical and Medicinal Sciences Jurnal Mandala Pharmacon Indonesia Jurnal Ilmiah Farmasi Farmasyifa Jurnal Insan Farmasi Indonesia Current Research on Biosciences and Biotechnology Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Praktis Lansau: Jurnal Ilmu Kefarmasian Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Indonesian Journal of Community Empowerment Jurnal Pengabdian Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Informatika dan Kesehatan Jurnal Farmasi Galenika Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu Jurnal Analis Kesehatan Kendari
Nirwati Rusli
Politeknik Bina Husada Kendari, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Anti-hyperuricemia Activity of Ethanol Extract of Bajakah Stem (Spatholobus litoralis Haask) on In Vivo Model: Analysis of Uric Acid and Cyclooxygenase-2 Levels Muhammad Ilyas Y.; Apriyanto; Adriatman Rasak; Nirwati Rusli; Asriullah Jabbar; Ufu Rindang; Fadhliyah Malik
Window of Health : Jurnal Kesehatan Vol 9 No 2 (April 2026)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/woh.vi.1517

Abstract

Investigation of bajakah (Spatholobus littoralis Hassk), a typical plant of the island of Borneo, as an anti-hyperuricemia and anti-inflammatory agent through the cyclooxygenase-2 (COX-2) inhibition pathway is important to reveal. This is supported by previous research indicating that bajakah has strong anti-inflammatory and antioxidant effects, with a higher flavonoid content. Evidence-based studies were conducted to determine whether the bajakah stem extract can reduce uric acid levels and inhibit COX-2 as an anti-hyperuricemia therapy. This study was conducted in vivo on mice with a hyperuricemia model induced by potassium oxonate. The treatment consisted of a normal control group, a negative control (Na-CMC, 0.5%), a positive control (allopurinol), and a dose-variation group of Bajakah stem ethanol extract at 100, 200, and 300 mg/kg BW. Uric acid levels were determined at hours 1, 2, and 3 by lateral chromatography and COX-2 levels by the sandwich ELISA method. The study results showed that bajakah stem ethanol extract in the 300 mg/kg body weight dose group was effective in reducing uric acid levels at the 3rd hour from 3.60 ± 0.25 mg/dL to 2.33 ± 0.35 mg/dL, with the greatest reduction of 0.33 ± 0.06 mg/dL, equivalent to 92%, and reduced COX-2 levels by 1.14 ± 0.02 ng/mL, which was significantly different from the negative control (p<0.05), and there was a positive correlation between the reduction in uric acid levels and COX-2 inhibition in hyperuricemic animal models. The conclusion of this study is that administration of bajakah wood can increase uric acid levels while simultaneously inhibiting inflammation, making it a potential candidate for development as an antihyperuricemic and anti-inflammatory drug.
Immunomodulatory potential of galing (Cayratia trifolia L. Domin) plant on IgM antibody and monocytes in Salmonella typhi-infected rats Muhammad Ilyas Y.; Nirwati Rusli; Wahyuni; Asriullah Jabbar; Asniar Pascayantri; Lukman La Basy
Current Research on Biosciences and Biotechnology Vol. 8 No. 1 (2026)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2026.8.1/VIGAR0LA

Abstract

Typhoid fever remains a health problem that requires support from both humoral and cellular immune responses. Therefore, the search for natural immunomodulators is important. Galing plant (Cayratia trifolia L. Domin) contains bioactive compounds such as flavonoids, alkaloids, and saponins, which are thought to have the potential to enhance immune responses. This study aimed to evaluate the immunomodulatory effects of ethanol extracts of galing leaves and stems on immunoglobulin M (IgM) levels and monocyte counts in male white rats induced with Salmonella typhi. The research hypothesis was that ethanol extract of galing plant could increase IgM levels and monocyte counts. This study used a randomized posttest-only control group design with seven treatment groups: normal control, negative control, positive control, leaf extract at doses of 400 and 500 mg/kg BW, and stem extract at doses of 400 and 500 mg/kg BW. IgM levels were measured using the ELISA method, while monocyte counts were analyzed using a hematology analyzer. The results showed that administration of ethanol extract of galing plant significantly increased IgM levels and monocyte counts compared with the negative control (p<0.05). The leaf extract group at a dose of 500 mg/kg BW showed the highest IgM level of 22.94 ± 2.00 ng/mL and the highest monocyte count of 8.44 ± 0.11%. A positive correlation was found between IgM levels and monocyte counts (p<0.05). Ethanol extract of galing plant has the potential to be developed as a natural immunomodulator to enhance immune responses against infection.
Co-Authors Ado, Moldefya Wahid Adriatman Rasak Agung Wibawa Mahatva Yodha Akib, Nur Illyyin Angriani Fusvita Anisa Arfan Aprilia, Sitti Aisyah Apriyanto Apriyanto Arfan Arfan Asniar Pascayantri Asniar Pascayantri Asnita Hafsani Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Audina, Fina Badia, Esti Bonni Rubak Chatarina Umbul Wahyuni Daud, Nur Saadah Dian Munasari Solo Elma Winarti Elviyanti Yusdin Eny Nur Hikma Eny Nurhikma Erika Erika Evi Nur Indah Sari Fadhliyah Malik Fadhliyah Malik Fadhliyah Malik Fatmawati Fatmawati Fauziah, Yulianti Firdayanti Firdayanti Firman Oktivendra Halik Halik, Halik Ilyas Y., Muhammad Ilyas Y., Muhammad - Imran, Shintia Agrifa Ali Isna Dwi Wulandari Jabbar, Asriullah Karmilah, Karmilah Lilis Yusriani Lukman La Basy Lukman La Basy Malaka, Muhammad Hajrul Marlin, Nova Marningsih, Elfi Masempo, Mustawakal Mega Fatimah Rosana Miftahul Jannah Mubarak Mubarak Mubarak Mubarak Mubarak Muh. Ilyas Yusuf Muhammad Ilyas Y Muhammad Ilyas Y Muhammad Ilyas Y. Muhammad Ilyas Y. Muhammad Syaiful Saehu Murtafia Murtafia Musdalipah Nabila, Putri Nasrudin Nasrudin Nasrudin Niluh Yeniati Nur Aisyah Abdullah Nur Hikmawati Nur Salma Nuralifah Nurhikma Nurhikma Nurhikma Nurhikma Nurhikma Nurhikma, Nurhikma Nursaadah Daud Parawansah Parawansah Pascayantri, Asniar Pratiwi, Afryanti Reymon, Reymon Rifcha Selviana Puput Riswanti Ruslan Sahidin Sahidin Selfyana Austin Tee Sernita Setiawan, Muhammad Azdar Siti Hardiyanti Liasambu Solo, Dian Munasari Suhikma Sofyan Sulsiah Sulsiah Sulsiah, Sulsiah syamsu Alam Syamsu Alam Titin Syafiransyah Ufu Rindang Wa Ode Salma Wahyuni wahyuni wahyuni Wisnianti, Dwi Wulaisfan, Randa Y, Muhammad Ilyas Yolanda Wirayani Rante Rerung Yulianti, Sri Samrina Yuqqabad, Yuqqabad Yusuf, Muh. Ilyas