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PENYULUHAN TENTANG KUALITAS LAYANAN FARMASI DI RUMAH SAKIT GRANMED LUBUK PAKAM Nerdy Nerdy; Nurul Aini Siagian; Saiful Batubara; Silmi Hayati
Jurnal Pengabdian Masyarakat Putri Hijau Vol 1 No 3 (2021): Jurnal Pengabdian Masyarakat Putri Hijau
Publisher : INSTITUT KESEHATAN DELI HUSADA

The hospital is one of the health facilities where health efforts are carried out. Health efforts are every activity to maintain and improve health, aiming to realize optimal health degrees for the community. Pharmaceutical services as one element of the main services in hospitals, are an inseparable part of the service system in hospitals that are oriented to patient care, providing quality drugs, including affordable clinical pharmacy services for all levels of society. The practice of pharmacy services is an integrated activity, with the aim of identifying, preventing and solving problems related to drugs and health. Hospital pharmacy services are one of the activities in hospitals that support quality health services. This is explained in the Decree of the Minister of Health Number 1333/Menkes/SK/XII/1999 concerning Hospital Service Standards, which states that hospital pharmacy services are an inseparable part of the hospital health service system that is oriented to patient care, drug provision. quality, including clinical pharmacy services, which are affordable for all levels of society. Currently, pharmacists who work at the Granmed Lubuk Pakam Hospital are required to be able to provide patient-oriented clinical pharmacy services. The aim is to improve patient safety. Pharmacists are required to play a role in improving patient safety, especially for drug-related problems.

Tablet Formulation with Galactomannan Binding Agent and Acute Toxicity Test from Terminalia catappa L. Nilsya Febrika Zebua; Tandra Alexandro; Virda Widya Pratiwi; Syarifah Nadia; Supran Hidayat; Muflihah Fujiko; Muharni Saputri; Tedy Kurniawan Bakri; Nerdy
Science and Technology Indonesia Vol. 8 No. 1 (2023): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2023.8.1.129-136

Ketapang is one of the many medicinal plant species that grow in Indonesia and is used to treat various diseases. Ketapang leaves contain flavonoids, tannins, saponins, and terpenoids that have anti-inflammatory, antioxidant, antiviral, and antimicrobial properties. This study aimed to determine the LD50 and histopathology of Liver and kidney damage before the formulation of tablets containing galactomannan-binding agents. The toxicity determination method was carried out in vivo in experimental animals at doses of 4g/kg BW, 8g/kg BW and 16g/kg BW, and Liver and kidney histopathology was carried out before formulation into tablet preparations using the wet granulation method with various concentrations of binders and disintegrants, namely F1(8:0), F2(0:8), F3(4:4), F4(2:6), and F5(6:2). The results of the toxicity test showed an LD50 of 15.9959, liver damage at a dose of 4 g/kg BW hepatocyte karyorrhexis cells, central vein constriction, sinusoidal dilatation, a dose of 8 g/kg BW hepatocyte karyorrhexis, significant venous congestion, sinusoidal dilatation, a dose of 16 g/kg BW hepatocyte cells, karyolysis, dilated central veins, and dilated sinusoids. The results of the tablet mass preformulation test meet the requirements: the flow time test was 1.48-2.14 g/second, the angle of repose test was 24.60°-30.60°, and the tab index test was 5.33%-9.33%. The results of the tablet evaluation test were as follows: the tablet hardness test was 3.8-8.6 kg, the tablet friability test was 0.167-0.64%, and the tablet disintegration time test was 29.06-107.51 minutes.

VALIDATION OF ULTRAVIOLET SPECTROPHOTOMETRY METHOD FOR DETERMINATION OF MEFENAMIC ACID LEVEL IN SUSPENSION DOSAGE FORMS Nerdy Nerdy
Jurnal Natural Volume 17, Number 1, March 2017
Publisher : Universitas Syiah Kuala

Abstract. Mefenamic Acid is one type of nonsteroidal antiinflammatory drug that works to relieve pain by blocking an enzyme that produces prostaglandins. The quality requirements that must be met by pharmaceutical preparations are levels contained must meet the level requirement as listed in the Indonesian Pharmacopoeia or other standard books. The purpose of this study was to conduct a validation test of ultraviolet spectrophotometry methods for determination of the Mefenamic Acid level in the suspension preparation. The sample consisted of three suspensions preparation under the trade name obtained from a pharmacy in the Medan city. The solvent used is sodium hydroxide (NaOH) 0,1 N solution and the measurement was done at a wavelength of 286 nm. Validation parameters determined were Accuracy, Precision, Linearity, Range, Limit of Detection and Limit of Quantitation. The results of the determination of the Mefenamic Acid suspension preparation under the trade name Pondex® was 100,39±0,21%, trade name Omestan® was 99,98±0,33% and trade name Novastan® was 103,21±0,83%. All the suspension preparations were determined meet the general level requirement, that contain not less than 90,0% and not more than 110,0% of the amount stated on the label. The results meet the requirements of the validation test of analysis methods with the parameter percent recovery 100,08% for accuracy, relative standard deviation 0,04% for precision, the correlation coefficient 1,0000 for linearity, range 8 μg/mL to 12 μg/mL, limit of detection limit 0,0118 μg/mL, limit of quantitation 0,0356 μg/mL. Keywords: Validation, Spectrophotometry, Determination, Suspension, Mefenamic Acid

Development of Fourier transform infrared spectrophotometric method for identification and determination of marketed metamizole tablet preparation NERDY NERDY; EFFENDY DE LUX PUTRA; NILSYA FEBRIKA ZEBUA; CHRISTICA ILSANNA SURBAKTI; JIHAN SAFIRA
Jurnal Natural Volume 21 Number 1, February 2021
Publisher : Universitas Syiah Kuala

Metamizole is a nonsteroidal antiinflammatory drug (NSAID) that functions as an analgesic, antipyretic, and antiinflammatory. Examination of active substance contents is a requirement that must be met to ensure the quality of drug preparations. The aims of this study were to develop and validate the Fourier Transform Infrared spectrophotometric method for the quantitation of metamizole content in marketed tablet preparation. Identification and determination of metamizole contents by Fourier Transform Infrared spectrophotometric method used methanol solvent in the wavenumber range 4000 cm–1 to 650 cm–1. The results showed that the specific wavenumbers of metamizole were 1649.3 cm–1; 1623.3 cm–1; and 1589.7 cm–1; and the contents metamizole in marketed tablet preparation ranged from (97.954 ± 0.121)% to (104.541 ± 0.257)%. From the validation method, the recovery result is 100.129%; the relative standard deviation is 0.057%; the limit of detection is 2.09526 mg/mL; the limit of quantitation is 6.34928 mg/mL; and the range 40 mg/mL to 60 mg/mL. The quantitation of metamizole contents can be carried out by Fourier Transform Infrared spectrophotometric method with accurate and precise quantitation results.

DETERMINATION OF VITAMIN C IN SEVERAL VARIETIES OF MELON FRUITS BY TITRATION METHOD Nerdy Nerdy
Jurnal Natural Volume 17, Number 2, September 2017
Publisher : Universitas Syiah Kuala

Abstract. Vitamin C (ascorbic acid) is micronutrient that is water soluble and indispensable for the body's metabolism, also plays a role in immune function. Vitamin C are easy to be absorbed actively. One of the fruits that contain vitamin C is melon fruit. Many varieties of melon fruit affect the vitamin C levels. The levels of vitamin C can be determined by 2,6-dichloroindophenol titration method using 2,6-dichloroindophenol solution. The advantages of the 2,6-dichloroindophenol titration method in the determination of vitamin C levels is reductor substances other than vitamin C are not oxidized by 2,6-dichloroindophenol. The examination begins with the determination of equivalence of 2,6-dichloroindophenol solution to vitamin C and followed by determination of vitamin C levels in several varieties of melon fruit. Equivalence of 2,6-dichloroindophenol solution to vitamin C was obtained 0,1347 mg vitamin C per 1 mL 2,6-dichloroindophenol solution. Levels of vitamin C in various varieties of melon fruit obtained that the highest levels was in Golden Melon variety (9,209 mg vitamin C per 100 g of Golden Melon) while the lowest levels was in Langkawi Melon variety (0,335 mg of vitamin C per 100 g of Langkawi Melon). It can be concluded that vitamin C levels contained in melon fruit vary and depend on melon fruit varieties.Keywords: Vitamin C, Ascorbic Acid, Melon Fruits, Varieties, Titration MethodREFERENCE S. Almatsier, 2001, Prinsip Dasar Ilmu Gizi, Gramedia Pustaka Utama, Jakarta, 152-153, 185-186.F. Prajnanta, 2003, Melon: Pemeliharaan secara Intensif dan Kiat Sukses Beragribisnis. Penebar Swadaya, Jakarta, 3, 30.R. Rukmana, 2007, Melon Hibrida, Kanisius, Yogyakarta, 11, 13-15, 16.B. Samadi, 2007, Melon: Usaha Tani dan Penanganan Pascapanen, Kanisius, Yogyakarta, 19, 23, 25-28, 31.P.M. Wijoyo, 2009, Panduan Praktis Budi Daya Melon, Bee Media Indonesia, Jakarta, 14-17, 55.I.G. Gandjar, dan A. Rohman, 2007, Kimia Farmasi Analisis, Pustaka Pelajar, Yogyakarta, 249.N. Andarwulan, dan S. Koswara, 1992, Kimia Vitamin, Rajawali Press, Bogor, 14-20, 32-35, 235.Direktorat Jenderal Pengawasan Obat dan Makanan Departemen Kesehatan Republik Indonesia, 1995, Farmakope Indonesia, Edisi Ke-4, Departemen Kesehatan Republik Indonesia, Jakarta, 1215-1216.W. Horwitz, 2002, Official Methods of Analysis of Association Offical Analytical Chemist Internasional, Edisi Ke-42, Association Offical Analytical Chemist International Suite, Maryland, 16-17.10. J.N. Counsell, and D.H. Hornig, 1981, Vitamin C, Applied Science Publisher, London, 123-124.11. R.M. Astrid, 2016, Cara Cerdas Berkebun Emas Dengan Menanam Melon, Villam Media, Depok, 67.

EFFECT OF HESPERETIN TREATMENT ON BLOOD GLUCOSE LEVEL, SPERMATOZOA QUALITY, AND SPERMATOZOA QUANTITY IN ALLOXAN-INDUCED DIABETIC MICE Nerdy Nerdy; Linta Meliala; Bunga Rimta Barus; Puji Lestari; Selamat Ginting; Peny Ariani; Vriezka Mierza; Tedy Kurniawan Bakri
Jurnal Kedokteran Hewan Vol 15, No 1 (2021): March
Publisher : Universitas Syiah Kuala

Male infertility has occurred rapidly in the last few decades, primarily in developing countries. An antioxidant, hesperetin is a flavonoid that is found in abundance in orange peels. The aims of this research were to determine the effect of hesperetin on blood sugar levels, spermatozoaquality, and spermatozoa quantity. The research structure included induction of diabetes mellitus and treatment for 8 weeks, followed bydetermination of blood sugar levels, spermatozoa quality, and spermatozoa quantity. Hesperetin has the ability to restore blood sugar levels, spermatozoa quantity, seminiferous tubules diameter, and testicular weight, volume, and germinal epithelial layer thickness with significant difference from the normal control group. Hesperetin did not fully restore spermatozoa motility, viability, and morphology with significant difference from the normal control group, nor from the positive control group. However, overall, hesperetin decreased blood glucose levels, increased spermatozoa quantity, and improved the spermatozoa quality in alloxan-induced diabetes mellitus mice. Dose-dependent activity was observed with the optimum dose at 200 mg/kg body weight.

MUCOLYTIC ACTIVITY OF ROSELLE (Hibiscus sabdariffa L.) CALYCES EXTRACT ON COW INTESTINAL MUCUS Nerdy Nerdy; Kesaktian Manurung
Jurnal Kedokteran Hewan Vol 12, No 2 (2018): June
Publisher : Universitas Syiah Kuala

This study aimed to examine the mucolytic activity of roselle calyces extract on cow intestinal mucus in vitro. The extraction of rosellecalyces was performed by the subsequence maceration method using different polarity solvent (n-hexane, ethyl acetate, and methanol). Mucolyticactivity of each extract was evaluated by measuring the viscosity of mixture of cow intestinal mucus and phosphate buffer pH 7 compared toacetylcysteine as the standard mucolytic drug. The result showed that the decreasing of cow intestinal mucus and phosphate buffer pH 7 mixturesviscosity was indicated the increasing of mucolytic activity. The n-hexane, ethyl acetate, and methanol extract of roselle calyces exhibit dosedependentmucolytic activity. Mucolytic activity of roselle calyces ethyl acetate extract with dose of 0.8% and roselle calyces methanol extractwith dose of 0.6% showed no significant difference to mucolytic activity from acetylcysteine with dose of 0.1% (positive control). An increaseddose of roselle calyces extract will decrease the viscosity of cow intestinal mucus and phosphate buffer pH 7 mixtures, indicating an increase inmucolytic activity.

Penerapan Serta Validasi Metode Spektrofotometri Inframerah Pada Penetapan Kadar Ibuprofen Dalam Sediaan Tablet Zuhairiah Nst; Nerdy Nerdy; Rifoni Simbolon
Herbal Medicine Journal Vol 3 No 2 (2020): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (670.007 KB)

Ibuprofen is one of drugs, which was used in medication rematic and arthritis, The purpose of this research was used to determination ibuprofen in the tablet, which circulates in the general whether it fulfilled requirement of drug quality, or not so that it will give the therapeutic effect. The determining of ibuprofen in tablet was done by Infrared Spectrophotometry using Methanol as a solvent at wavenumber 1709,0 cm-1 and tested it validity based on parameter accuracy using standard addition method, precision, limit of detection and limit of quantitation. Based on quantitative determination of ibuprofen in generic tablet ; Ibuprofen Sampel A was 98,36% ± 0,15%. Ibuprofen Sampel B was 102,38%± 0,21% and branded name, Sampel C, D, E in succession was 97,10% ± 0,18%; 99,34% ± 0,24%; was 103,33% ± 0,19%. The result of research indicate that determining ibuprofen in the generic tablet and branded name was fullfilled requirement of the Farmakope Indonesia Edisi IV (1995), not less than 90,0% and not more than 110,0% of the labelled amount.

Development and Validation of Fast and Simple Fourier Transform Infrared Spectrophotometric Method for Analysis of Thiamphenicol in Capsule Dosage Form Nerdy Nerdy; Linda Margata; Nilsya Febrika Zebua; Puji Lestari; Tedy Kurniawan Bakri; Faisal Yusuf; Vonna Aulianshah
Science and Technology Indonesia Vol. 8 No. 3 (2023): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2023.8.3.344-352

The development of a method for identification and determination of thiamphenicol by Fourier Transform Infrared will provide convenience to developers because it is fast and easy for analysis. The research was carried out by utilizing the solubility of thiamphenicol in methanol with three stages, namely method development, sample analysis, and method validation. The method development stage showed that the specific peak of thiamphenicol was at a peak with a wavenumber of 1694.1 cm−1; this specific peak of thiamphenicol was used for qualitative analysis and quantitative analysis of thiamphenicol in the capsule dosage form. The sample analysis showed that all analyzed thiamphenicol in capsule dosage form showed good results both qualitatively and quantitatively. Qualitatively all the samples analyzed showed a specific peak at specific positions and specific wavenumbers. These results meet the requirements for containing thiamphenicol in the dosage form. Quantitatively all the samples analyzed ranged from 97.97% to 102.24% by peak height and peak area. These results meet the requirements for active substance levels in general preparations within 90.0% to 110.0%. The method validation for peak height and peak area showed that the accuracy parameter had a recovery percentage of 100.28% and 100.41% (between 98.0% to 102.0%), the precision parameter with a relative standard deviation of 0.31% and 0.37% (not more than 2.0%), and the linearity parameter with a correlation coefficient of 0.9999 and 0.9997 (not less than 0.99). The limit of detection value was 0.2971 mg/mL and 0.5338 mg/mL, the limit of quantitation value was 0.9004 mg/mL and 1.6176 mg/mL, the range for both was 80% to 120%, and the specificity for both met the requirement. The Fourier Transform Infrared method has been successfully developed, applied, and validated for qualitative analysis and quantitative analysis of thiamphenicol in capsule dosage form.

DETERMINATION OF VITAMIN C IN SEVERAL VARIETIES OF MELON FRUITS BY TITRATION METHOD Nerdy Nerdy
Jurnal Natural Volume 17, Number 2, September 2017
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v17i2.8255

Abstract. Vitamin C (ascorbic acid) is micronutrient that is water soluble and indispensable for the body's metabolism, also plays a role in immune function. Vitamin C are easy to be absorbed actively. One of the fruits that contain vitamin C is melon fruit. Many varieties of melon fruit affect the vitamin C levels. The levels of vitamin C can be determined by 2,6-dichloroindophenol titration method using 2,6-dichloroindophenol solution. The advantages of the 2,6-dichloroindophenol titration method in the determination of vitamin C levels is reductor substances other than vitamin C are not oxidized by 2,6-dichloroindophenol. The examination begins with the determination of equivalence of 2,6-dichloroindophenol solution to vitamin C and followed by determination of vitamin C levels in several varieties of melon fruit. Equivalence of 2,6-dichloroindophenol solution to vitamin C was obtained 0,1347 mg vitamin C per 1 mL 2,6-dichloroindophenol solution. Levels of vitamin C in various varieties of melon fruit obtained that the highest levels was in Golden Melon variety (9,209 mg vitamin C per 100 g of Golden Melon) while the lowest levels was in Langkawi Melon variety (0,335 mg of vitamin C per 100 g of Langkawi Melon). It can be concluded that vitamin C levels contained in melon fruit vary and depend on melon fruit varieties.Keywords: Vitamin C, Ascorbic Acid, Melon Fruits, Varieties, Titration MethodREFERENCE S. Almatsier, 2001, Prinsip Dasar Ilmu Gizi, Gramedia Pustaka Utama, Jakarta, 152-153, 185-186.F. Prajnanta, 2003, Melon: Pemeliharaan secara Intensif dan Kiat Sukses Beragribisnis. Penebar Swadaya, Jakarta, 3, 30.R. Rukmana, 2007, Melon Hibrida, Kanisius, Yogyakarta, 11, 13-15, 16.B. Samadi, 2007, Melon: Usaha Tani dan Penanganan Pascapanen, Kanisius, Yogyakarta, 19, 23, 25-28, 31.P.M. Wijoyo, 2009, Panduan Praktis Budi Daya Melon, Bee Media Indonesia, Jakarta, 14-17, 55.I.G. Gandjar, dan A. Rohman, 2007, Kimia Farmasi Analisis, Pustaka Pelajar, Yogyakarta, 249.N. Andarwulan, dan S. Koswara, 1992, Kimia Vitamin, Rajawali Press, Bogor, 14-20, 32-35, 235.Direktorat Jenderal Pengawasan Obat dan Makanan Departemen Kesehatan Republik Indonesia, 1995, Farmakope Indonesia, Edisi Ke-4, Departemen Kesehatan Republik Indonesia, Jakarta, 1215-1216.W. Horwitz, 2002, Official Methods of Analysis of Association Offical Analytical Chemist Internasional, Edisi Ke-42, Association Offical Analytical Chemist International Suite, Maryland, 16-17.10. J.N. Counsell, and D.H. Hornig, 1981, Vitamin C, Applied Science Publisher, London, 123-124.11. R.M. Astrid, 2016, Cara Cerdas Berkebun Emas Dengan Menanam Melon, Villam Media, Depok, 67.

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