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All Journal VALENSI Science and Technology Indonesia ALCHEMY Jurnal Penelitian Kimia JURNAL PENDIDIKAN TAMBUSAI Journal of Midwifery and Nursing Jurnal Penelitian Farmasi dan Herbal JURNAL INOVASI KESEHTAN MASYARAKAT Jurnal Farmanesia Jurnal Pengabdian Masyarakat Putri Hijau Jurnal Pengabdian Masyarakat Tjut Nyak Dhien Jurnal Natural Jurnal Kedokteran Hewan Herbal Medicine Journal Journal of Pharmaceutical and Sciences. Molekul: Jurnal Ilmiah Kimia
Nerdy, Nerdy
Universitas Tjut Nyak Dhien
Religion Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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EFFECT OF HESPERETIN TREATMENT ON BLOOD GLUCOSE LEVEL, SPERMATOZOA QUALITY, AND SPERMATOZOA QUANTITY IN ALLOXAN-INDUCED DIABETIC MICE Nerdy, Nerdy; Meliala, Linta; Barus, Bunga Rimta; Lestari, Puji; Ginting, Selamat; Ariani, Peny; Mierza, Vriezka; Bakri, Tedy Kurniawan
Jurnal Kedokteran Hewan Vol 15, No 1 (2021): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v15i1.18406

Abstract

Male infertility has occurred rapidly in the last few decades, primarily in developing countries. An antioxidant, hesperetin is a flavonoid that is found in abundance in orange peels. The aims of this research were to determine the effect of hesperetin on blood sugar levels, spermatozoaquality, and spermatozoa quantity. The research structure included induction of diabetes mellitus and treatment for 8 weeks, followed bydetermination of blood sugar levels, spermatozoa quality, and spermatozoa quantity. Hesperetin has the ability to restore blood sugar levels, spermatozoa quantity, seminiferous tubules diameter, and testicular weight, volume, and germinal epithelial layer thickness with significant difference from the normal control group. Hesperetin did not fully restore spermatozoa motility, viability, and morphology with significant difference from the normal control group, nor from the positive control group. However, overall, hesperetin decreased blood glucose levels, increased spermatozoa quantity, and improved the spermatozoa quality in alloxan-induced diabetes mellitus mice. Dose-dependent activity was observed with the optimum dose at 200 mg/kg body weight.
MUCOLYTIC ACTIVITY OF ROSELLE (Hibiscus sabdariffa L.) CALYCES EXTRACT ON COW INTESTINAL MUCUS Nerdy, Nerdy; Manurung, Kesaktian
Jurnal Kedokteran Hewan Vol 12, No 2 (2018): June
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v12i2.9621

Abstract

This study aimed to examine the mucolytic activity of roselle calyces extract on cow intestinal mucus in vitro. The extraction of rosellecalyces was performed by the subsequence maceration method using different polarity solvent (n-hexane, ethyl acetate, and methanol). Mucolyticactivity of each extract was evaluated by measuring the viscosity of mixture of cow intestinal mucus and phosphate buffer pH 7 compared toacetylcysteine as the standard mucolytic drug. The result showed that the decreasing of cow intestinal mucus and phosphate buffer pH 7 mixturesviscosity was indicated the increasing of mucolytic activity. The n-hexane, ethyl acetate, and methanol extract of roselle calyces exhibit dosedependentmucolytic activity. Mucolytic activity of roselle calyces ethyl acetate extract with dose of 0.8% and roselle calyces methanol extractwith dose of 0.6% showed no significant difference to mucolytic activity from acetylcysteine with dose of 0.1% (positive control). An increaseddose of roselle calyces extract will decrease the viscosity of cow intestinal mucus and phosphate buffer pH 7 mixtures, indicating an increase inmucolytic activity.
Formulasi dan Evaluasi Tablet dengan Bahan Tambahan Tongkol Jagung (Zea mays L.) sebagai pengganti HPMC yang digunakan untuk Anti Diabetes Surbakti, Christica Ilsanna; Suryani , Monica; Nerdy, Nerdy
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.779

Abstract

Corn (Zea mays L) is a food crop that is known and cultivated in developing countries. So far, corn cobs have not been widely used as a value-added product. Corn cobs have 35.5% crude fiber, 2.5% protein, 0.12% calcium, 0.04% phosphorus and the remaining 38.16% of other substances. Corn cobs, which are biomass, contain phenolic phytochemicals which are very likely to be used as active antioxidant ingredients. The choice of method for making tablets is adjusted to the characteristics of the active substance used. In this research, the method used in making metformin HCl tablets was wet granulation. Wet granulation is the process of adding liquid to a powder or powder mixture in a container equipped with stirring which will produce agglomeration or granules. The evaluation results of corn cob additive granules as a substitute for HPMC showed the results of the flow time test (F1 1.5 seconds, F2 1.4 seconds F3 1.63 seconds), F1 angle of repose test (34.96 o, F2 41, 43 o, F3 41.92 o), humidity test (F1 1.794 %, F2 1.999 %, F3 2.331 %) and compressibility test (F1 11 %, F2 15%, F3 8%).  The results of the evaluation of antalgin tablets using corn cobs as a substitute for HPMC showed visual test results where the tablets were round and white in color, the weight uniformity test showed results (F1 A (5%) 708.7-783.3 and column B (10% ) 671.4-820.6, F2 A (5%) 562.775– 705.75 and column B (10%) 571.05-698.6, F3 688.75– 761.25 and column B (10%) 625.5-797.5), size uniformity test shows results (F1 diameter 1.3545 and thickness 0.4705, F2 diameter 1.359 and thickness 0.468, F3 diameter 1.36 and thickness 0.471), fragility test shows results (F1 0 .06978367 %, F2 0.53272451 %, F3 0.06978367 %) and tablet hardness showed results (F1 6.764, F2 4.984, F3 7.89) and disintegration time test showed results (F1 2 minutes, F2 2 minutes, F3 2 minute).
Determination of Vitamin C in Various Colours of Bell Pepper (Capsicum annuum L.) by Titration Method Nerdy Nerdy
ALCHEMY Jurnal Penelitian Kimia Vol 14, No 1 (2018): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.14.1.15738.164-178

Abstract

Vitamin C is needed by human body to improve the immune system and can be obtained from the bell pepper. Bell pepper has a different color according to the level of maturity, ranging from green, yellow, orange, and red. Differences in color also make possible differences in vitamin C content. The purpose of this study was to determine vitamin C levels in various colors of bell fruit. Measurement of vitamin C was done by titration method with metaphosphoric acid as the solvent and 2,6 dichloroindophenol as the standardized solution. The samples used were green bell pepper, yellow bell pepper, orange bell pepper, and red bell pepper taken from Gundaling, Berastagi, Karo, Sumatera Utara, 22152, Indonesia. The results show that vitamin C level in various colors of bell pepper respectively, for green bell pepper 16.52 mg vitamin C per 100 g green bell pepper; yellow bell pepper 159.61 vitamin C per 100 g yellow bell pepper; orange bell pepper 121.38 vitamin C per 100g orange bell pepper; red bell pepper 81.19 vitamin C per 100 g red bell pepper. These results indicate that different levels of bell pepper maturity have different vitamin C content.
Co-Authors Abdi Wira Septama Ariani, Peny Atika Mulyati Bahtera Bin David Purba BAKRI, TEDY KURNIAWAN Barus, Bunga Rimta Bunga Mari Sembiring Bunga Rimta Barus Christivo Tambusai Dachi, Kanne Dhita Millenia Br. Tarigan Dian Ika Perbina Meliala Effendy De Lux Putra, Effendy De Lux Elysa Elysa Evalina Manurung FAHDI, FIRDAUS Faisal Yusuf Faisal, Yusuf Febia, Ananda Dwina Ferry Handika Firdaus, Fahdi Fitri, Rizka Ramadhani Fujiko, Muflihah GINTING, SELAMAT Hulu, Titi Kurniawati Ika Julianti Tambunan JIHAN SAFIRA Kanne Dachi Kesaktian Manurung Linda Margata Linda Margata Linda Margatha Linta Meliala Linta Meliala Manurung, Kesaktian MAYA KUSUMA Meliala, Linta Mierza, Vriezka Muflihah Fujiko Muflihah Fujiko Muharni Saputri Nadia, Syarifah NILSYA FEBRIKA ZEBUA Nilsya Febrika Zebua, Nilsya Febrika Ningrum, Adelia Puspita Retno Ningrum, Siti Rahmi Nurfazillah, Nurfazillah Nurul karima Oppie Meisya Tanjung Palas Tarigan Pravil Mistriyanto PUJI LESTARI Puji Lestari Puji Lestari Puji, Lestari RANI FARAH BUTSAINAH TANJUNG Razali Razali Razali, Mariany Refi Bahrainur Rifoni Simbolon Rusdi Andreas Sembiring Saiful Batubara SATRIYAS ILYAS Selamat Ginting Siagian, Nurul Siagian, Nurul Aini Silmi Hayati Siti Nurmalisa Siti Rahmi Ningrum Sitohang, Nikasia Gabriela Supran Hidayat SURBAKTI, CHRISTICA ILSANNA Suryani , Monica Syarifah Nadia Tandra Alexandro Tedy Kurniawan Bakri Tedy Kurniawan Bakri Tedy Kurniawan Bakri Tedy Kurniawan Bakri TJUT XENA Virda Widya Pratiwi Vivi Sofia Vonna Aulianshah Vriezka Mierza Zuhairiah Nasution, Zuhairiah