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Acute Toxicity of Self-Nanoemulsifying Drug Delivery System of Ipomoea reptans Poir Leaves Extract on Female Wistar Rats Cynthia Astiti Putri; Farida Hayati; Lutfi Chabib; Muhammad Iqbal Pangestu
Borneo Journal of Pharmacy Vol. 6 No. 1 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i1.2099

Abstract

Ipomoea reptans Poir has many health benefits, such as decreasing blood glucose and as an antioxidant. Self-nano emulsifying drug delivery systems (SNEDDS) are an innovation in pharmaceutical technology that minimizes drug molecules and maximizes surface area, thus increasing drug absorption. This study aimed to investigate SNEDDS of I. reptans acute toxicity in female Wistar rats. An acute toxicity test was done using a limit test of OECD 423. Female Wistar rats were divided into control and treatment groups, with three animals for each group being used per step. No animals died after they were given SNEDDS of I. reptans leaves extract at a dose of 2000 mg/kg. No toxic effect was detected at clinical examination and histopathology of the organ. SNEDDS of I. reptans leaves extract had an LD50 cut-off value of 5000 mg/kg.
Peningkatan kenyamanan dan early mobilization pada ibu post SC melalui efflurage back massage Widayati, Dhina; Hayati, Farida; Fajarotin, Dwi Rori
Jurnal Riset Kebidanan Indonesia Vol 7, No 1 (2023): Juni
Publisher : AIPKEMA (Asosiasi Institusi Pendidikan Kebidanan Muhammadiyah-'Aisyiyah Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32536/jrki.v7i1.212

Abstract

Latar belakang: Ibu Post Sectio Cesaria (SC) mempunyai permasalahan nyeri akibat luka post SC yang dapat menggangu kenyamanan dan mobilisasi. Mobilisasi dini pada ibu nifas dapat meningkatkan proses penyembuhan luka.  Masase merupakan salah satu upaya menurunkan nyeri sehingga kenyamanan meningkat dan diharapakan dapat mempercepat mobilisasi dini. Tujuan penelitian: Untuk mengetahui pengaruh efflurage back massage  terhadap tingkat kenyamanan dan early mobilization pada ibu post sc di Rumah Sakit Amelia Pare Kediri. Metode: Penelitian ini menggunakan desain quasi eksperimental yang melibatkan 40 responden melalui total sampling. Efflurage back massage sebgaai variabel independen, kenyamanan dan eraly mobilitation sebagai variabel dependen. Data kenyamanan diukur menggunakan kuesioner dan early mobilization dengan lembar observasi.  Data dianalisa dengan paired T-Test  dengan α 0.05.   Hasil: rata – rata early mobilisation kelompok kontrol 6,4 dan peningkatan kenyamanan (mean = 3,85) sedangkan pada kelompok perlakuan rata - rata early mobilisation 11,65 dan peningkatan kenyamanan (mean = 5,32). Nilai P = 0,000 (p0,05) menunjukkan effleurage back massage berpengaruh terhadap kenyamanann dan early mobilisation. Simpulan: massage pada punggung klien dapat menstimulasi release hormon endhorphin yang dapat menurunkan nyeri, kenyamanan  meningkat dan responden dapat lebih cepat melakukan mobilisasi. Intervensi effleurage back massage dapat digunakan salah satu intervensi untuk meningkatkan kenyamanan dan early mobilization yang berguna untuk mempercepat kesembuhan luka.
PERAN MEDIA MASSA DALAM PENANGANAN STUNTING DI JAKARTA Indriani, Indriani; Hayati, Farida; Ariefaldy, Muhammad Ilhan; Satrio, Rezky Metra
Media Bahasa, Sastra, dan Budaya Wahana Vol 30, No 1 (2024): Volume 30 Nomor 1 Tahun 2024
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/wahana.v30i1.10218

Abstract

Stunting has become a major problem in various developing countries, including Indonesia. A report from the Indonesian Nutrition Status Survey (SSGI) in 2022 stated that the prevalence of stunting in Indonesia was 21.6%. Meanwhile, the prevalence of stunting in DKI Jakarta is 14.8%. Handling stunting cannot only be done through one sector, because stunting is also caused by many factors. In handling stunting, mass communication has an important role in changing people's behavior. The research was conducted using a qualitative method to find out how the process carried out by the mass media in reporting related to stunting handling, especially in DKI Jakarta. From the results of the study, it is known that the issue of stunting has not been considered attractive to the mainstream media and the packaging of news about stunting tends to be monotonous so that it is considered less interesting for the public to read it. Efforts are needed to optimize social media so that the message of stunting prevention and handling can reach the community. Keywords: behavior, handling stunting, media, journalist.
Senyawa Non-aromatik Herba Centella asiatica menggunakan Metode Baru melalui Karbon Aktif, dan Analisis Farmakologi Jejaring pada Luka Bakar Awaluddin, Rizki; Mustaqim, Rafli Mulkan; Arbain, Dayar; Hayati, Farida; Khaerunnisa, Siti
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.50623

Abstract

Prevalensi luka bakar masih menjadi perhatian kaitannya dengan perubahan fisik pasca luka bakar yakni contractures, hypertrophic scar dan keloid yang menurunkan fungsi, kualitas hidup dan estetika kulit. Herba pegagan (Centella asiatica) melalui senyawa triterpen telah dikenal untuk mempercepat luka bakar. Namun, sifat senyawa triterpen yang polar identik dengan keberadaan klorofil dan senyawa lainnya yang sulit dipisahkan. Masih adanya kontroversi terkait protein yang berperan dalam kesembuhan luka bakar membutuhkan kajian untuk menentukan protein potensial. Penelitian ini bertujuan untuk mengeksplorasi metode baru pada ekstraksi herba pegagan menggunakan karbon aktif serja kajian farmakologi jejaring untuk menentukan protein potensial. Herba pegagan diekstraksi menggunakan metode maserasi pada pelarut metanol dan dilanjutkan dengan penambahan karbon aktif. Hasil purifikasi diidentifikasi menggunakan KLT dengan fase gerak kloroform: asam asetat glasial: metanol: akuades (60:32:12:8 v/v) dan pereaksi semprot anisaldehid-asam sulfat. Kajian farmakologi jejaring dilakukan secara in silico untuk mengkaji interaksi protein-protein dan senyawa-protein berkaitan dengan luka bakar. Hasil skrining fitokimia menunjukkan keberadaan asaticoside pada ekstrak terpurifikasi dan maserat dengan nilai Rf yang relatif identik. Senyawa non aromatik berperan dalam mempercepat kesembuhan luka bakar dengan mempengaruhi protein IL1β, IL6, MAPK8, PTGS2, NOX4, IFN-γ, NFKB1, TGFβ1, MMP13, dan TNF.
Narrative Review: Potential of Flavonoids from Moringa (Moringa oleifera Lam.) Leaves as Immunomodulators: Tinjauan Naratif: Potensi Flavonoid dari Daun Kelor (Moringa oleifera Lamk.) sebagai Imunomodulator Poluan, Jesica Carine; Zubair, Muhammad Sulaiman; Ramadani, Arba Pramundita; Hayati, Farida
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 9 No. 2 (2023): (October 2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2023.v9.i2.16265

Abstract

Background: Moringa leaves (Moringa oleifera Lamk.) are plants from the Moringaceae family that have many properties and are often used empirically as traditional medicine. One of the benefits of M. oleifera leaves is immunomodulator, which functions to modulate the human immune system in both immunostimulants and immunosuppressants. Objectives: To provide information on the potential of flavonoids in M. oleifera leaves as immunomudulators developed as alternative therapies. Methods: Review of articles using original articles from national and international journals with the keywords "immunomodulator," "immunostimulant," "immunosuppressant," "Flavonoids," and "Moringa oleifera leaf or leaves". Results: Based on a search of various literature studies, M. oleifera leaf extract is proven as an immunomodulator with the most compounds found, namely flavonoids such as quercetin and kaempferol. This content can affect the immune response to trigger or inhibit the proliferation and activation of immune cells in the process of increasing or decreasing the immune system in the body. Conclusions: Moringa leaves have activity as immunomodulators that can help maintain the immune system in the body.
PEMBERDAYAAN KADER DALAM PERTOLONGAN PERTAMA STROKE DENGAN DETEKSI DINI FAST (FACE, ARM, SPEECH, TIME) PADA AGREGAT DEWASA DI DESA PELEM hayati, farida
Prosiding SPIKesNas : Seminar Publikasi Ilmiah Kesehatan Nasional Vol 3 No 4 (2024): SPIKesNas - November 2024
Publisher : STIKES dan AKZI Karya Husada Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Empowerment is a process to give or support to weaker organizations and reduce support to stronger organizations so that balance occurs. The goal of mass empowerment is to create a more favorable environment for people to live in, which will also contribute to a more favorable quality of life for people. This exercise is carried out using a material demonstration method with a sample size of 20 people. The results of the activities before the educational intervention was carried out found an average score of 73,50 and after the educational intervention was given an average score of 79,50. As a result, based on the results of the preliminary research conducted before and after the first stroke patient was treated with the FAST (Face, Arm, Speech, Time) detection method, it was determined that public awareness of the first stroke patient had increased. Detecting FAST is one method for detecting strokes that patients experience by looking at their wajah, elbow, and leg muscles, as well as their bicara sensitivity. It also involves quickly referring patients to the closest RS so they don't miss the golden period of stroke.  
LOW BACK PAIN (LBP) PADA PETANI DI DESA RINGINSARI KANDAT KEDIRI setyorini, dwi; Hayati, Farida; Septian Pradana, Dimas
Prosiding SPIKesNas : Seminar Publikasi Ilmiah Kesehatan Nasional Vol 3 No 4 (2024): SPIKesNas - November 2024
Publisher : STIKES dan AKZI Karya Husada Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Low back pain (LBP) is a common complaint in farmers due to agricultural work such as bending, standing, squatting, lifting and carrying loads, and the back as the main support. These activities have a high level of tension and involve many repetitive movements causing the spinal muscles to be continuously overloaded resulting in low back pain. The aim of this study was to determine the level of low back pain in farmers in the Ringinsari Kandat Village farmer group, Kediri. This study used a descriptive design. The population in this study were 60 members of the farmer group with a purposive sampling technique, a sample of 18 respondents was obtained. Data collection used a questionnaire sheet, data analysis used a percentage. The results of the study showed that most of the respondents (55.6%) had low back pain on a scale of 5, with an average value of 4.44. Agricultural work has a high level of tension and involves many repetitive movements. This causes the spinal muscles to be overloaded due to work that is done continuously without time to relax, resulting in pain in the farmers' lower backs. Respondents are advised to minimize continuous static loads and pay attention to ergonomics at work to prevent and reduce the level of Low Back Pain.  
Pengaruh E-Powerme Berbasis Aplikasi Terhadap Citra Diri Pada Remaja Acne Vulgaris Laviana Nita Ludyanti; Farida Hayati; Muhammad Agus Firmansyah Ramadhani
Jurnal Keperawatan Mandira Cendikia Vol. 3 No. 2 (2024)
Publisher : YAYASAN PENDIDIKAN MANDIRA CENDIKIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70570/jkmc.v3i2.1566

Abstract

Remaja menghadapi banyak tantangan dan perubahan dalam kehidupan mereka yang mempengaruhi fisik, emosional, sosial, dan kognitif mereka. Ini termasuk transformasi fisik yang ditandai oleh pubertas dan munculnya masalah kulit seperti acne vulgaris,Salah satu cara penanganan citra diri yang buruk adalah dengan edukasi. e-PowerMe adalah aplikasi yang dirancang untuk membantu remaja memahami dan memperkuat citra diri. Tujuan dari penelitian ini untuk mengetahui pengaruh e-PowerMe berbasis aplikasi terhadap citra diri pada remaja acne vulgaris di SMAN 1 Kandangan Kelas 11. Desain penelitian Pra Experimental dengan pendekatan one grup pretest – posttest design. Teknik pengambilan sampel dengan random sampling didapatkan 60 responden dari 300 populasi. Variabel citra diri diukur dengan lembar kuesioner dan hasilnya dianalisis dengan uji paired t test. Analisis didapatkan hasil α 0,05 hasil penelitian sebelum diberikan seluruhnya (100%) responden (mean 10,9) mengalami citra diri kurang. Setelah diberikan intervensi hampir seluruhnya (95%) mengalami citra diri cukup dan sebagian (5%) mengalami citra diri baik. Didapatkan ρ-value = 0,000 (<α), artinya e-PowerMe berbasis aplikasi dapat meningkatkan citra diri pada remaja acne vulgaris. e-PowerMe dapat menjadi salah satu cara untuk meningkatkan citra diri remaja dengan meningkatkan kesadaran remaja akan kekuatan dirinya. Penggunaan aplikasi yang masih terdapat bug yang menyebabkan kecepatan pengoprasian aplikasi cenderung lambat.
Determination of Total Flavonoid Content and Characterization of Nanoparticles of Kecombrang Leaf Extract (Etlingera elatior (Jack) R.M.Sm.) Hayati, Farida; Sofi Nurmay Stiani; Renditya Ismiyati
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 6, ISSUE 1, April 2025
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol6.iss1.art4

Abstract

Kecombrang (Etlingera elatior (Jack) R.M.Sm.) is one of Indonesia's potential plants that contain such bioactive compounds as polyphenols, alkaloids, flavonoids, steroids, saponins, and essential oils. This study aims to determine the total flavonoid content of kecombrang leaf extract. It also defines the characteristics of the nanoparticles of kecombrang leaf extract. Kecombrang leaves were extracted through maceration. The determination of the total flavonoid content by spectrophotometry used quercetin as a comparison. The synthesis of nanoparticles used ionic gelation with 0.1% sodium alginate and 0.01% calcium chloride crosslinkers. The characteristic parameters of the nanoparticles of kecombrang leaf extract included the visual, transmittance, adsorption efficiency, particle size distribution, polydispersity index, and zeta potential. The yield value was 46.55%. The total flavonoid content was 88.11 mgQE/g with a regression standard curve Y = 0.1022x + 0.0745 and correlation coefficient (r) = 0.9922. The nanoparticle solution provided a clear visual with a particle size and PI of 108.2 nm and 0.311, a transmittance and adsorption efficiency of 94.76% and 93.76%, and a zeta potential of -36 mV. The total flavonoid content was 88.11 mgQE/g. The nanoparticle solution of kecombrang leaf extract has the characteristics that qualify as a nanoparticle preparation.
Modeling the Prevalence of Stunting in Indonesia Using Quantile Regression Hayati, Farida; Nurlaily, Diana; Hasanah, Primadian
Enthusiastic : International Journal of Applied Statistics and Data Science Volume 5 Issue 1, April 2025
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/enthusiastic.vol5.iss1.art1

Abstract

Stunting is a condition where a child’s height is under the average height of their age. Stunting will have an impact on the quality of human resources. The 2022 Indonesian Nutrition Status Survey reported that the prevalence of stunting in Indonesia reached 21.6%. This number decreased compared to the previous year. However, it remains below the government’s planned target of 14%. Therefore, appropriate methods are needed to model and identify the factors with the most significant impact on the data for each region studied. This research modeled the stunting problem using quantile regression. Quantile regression has several advantages, including the fact that it can be used on data with an inhomogeneous distribution and is not affected by outliers. The results showed that variables that had a significant effect on the prevalence of stunting using 0.95 quantile regression included babies receiving exclusive breast milk, percentage of family planning participants, percentage of households with access to adequate sanitation, low birth weight (LBW) babies, and percentage of toddlers who have Maternal and Child Health (MCH) books. It is hoped that this research can be utilized to carry out appropriate interventions to reduce the prevalence of stunting that occurs in Indonesia.
Co-Authors . PRAPTIWI Agung Giri Samudra Amalinda Setya Kartika Arba Pramundita Ramadani Arde Toga Nugraha Ari Wibowo Arief Rahman Hakim Ariefaldy, Muhammad Ilhan Awaluddin, Rizki Cynthia Astiti Putri DAYAR ARBAIN Desyandri Desyandri Dhina Widayati Dhina Widayati, Dhina DIAN AMALIA Dian Sukma Dimas Adhi Pradana Dimas Adhi Pradhana Dina Zakiyyatul Fuadah, Dina Zakiyyatul Diny Lidya Djoko Wahyono Djoko Wahyono Djoko Wahyono Dwi Brilyani Sandy Dwi Setyorini Elok Atiqoh Fajarotin, Dwi Rori Firnanda, Muhammad Erick Fitriani, Hannie Gina Nadia Hastarin Ginna Zabrina Girianto, Pria Wahyu Romadhon Gusti Rizaldi Hakim, Lukman Hasanah, Primadian Helmina Wati Herianto Pandapotan, Herianto Indriani Indriani Ishariani, Linda Islamiyah Neda Rahayu Khaerunnisa, Siti Laviana Nita Ludyanti Lian Widi Astutik Ludyanti, Laviana Lutfi Chabib, Lutfi M.Pd S.T. S.Pd. I Gde Wawan Sudatha . Mae Sri Hartati Wahyuningsih Maulaya, Ikvini Muh Iqbal Pangestu Muhammad Agus Firmansyah Ramadhani Muhammad Iqbal Pangestu Muhammad Sulaiman Zubair Mustaqim, Rafli Mulkan Nina Salamah Nurlaily, Diana Nurul Laili Pinus Jumariyatno Pinus Jumaryatno Poluan, Jesica Carine Puspita, Arum Dwi Putri Widi Rahmi Muthia Renditya Ismiyati Retno Murwanti Riptasari, Rhatna Dewi Rizsanti Meirina Satar Samad, Ayu Wandari Sandi, Dita Ayulia Dwi Sandi, Dita Ayulia Dwi Satrio, Rezky Metra Selvi Amadia Septian Pradana, Dimas Sitarina Widyarini Stiani, Sofi Nurmay Sugiyanto . Sugiyanto Sugiyanto Taukhid, Muhammad Tri Alfiana, Yolanda Velincia Tanriono, Levana Wahyu Utaminingrum Yandi Syukri Yundari, Yundari Yusmein Uyun