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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Media Bahasa, Sastra, dan Budaya Wahana JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Surya Enthusiastic : International Journal of Applied Statistics and Data Science Journal of Applied Nursing and Health Kolaborasi Jurnal Pengabdian Masyarakat Khazanah: Jurnal Mahasiswa Jurnal Riset Kebidanan Indonesia JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Abdi Kesehatan dan Kedokteran SPIKESNAS Media Farmasi Borneo Journal of Pharmacy Jurnal Keperawatan Mandira Cendikia (JKMC) Journal of Pharmascience
Hayati, Farida
Prodi Farmasi, Fakultas MIPA, Universitas Islam Indonesia, Yogyakarta Prodi Profesi Apoteker, Fakultas MIPA, Universitas Islam Indonesia, Yogyakarta
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EFEK ANTIHIPERGLIKEMIA INFUSA KANGKUNG DARAT (Ipomoea reptans Poir) TERHADAP KADAR GLUKOSA DARAH MENC1T JANTAN YANG DIINDUKSI STREPTOZOTOCIN Farida Hayati; Sitarina Widyarini; Helminawati Helminawati
Jurnal Ilmiah Farmasi Vol. 7 No. 1 (2010)
Publisher : Universitas Islam Indonesia

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Abstract

Penelitian ini dilakukan untuk mengetahui efek antihiperglikemia infusa kangkung darat (Ipomoea reptans P.j pada mencit Swiss jantan yang diinduksi streptozotocin (STZ) dengan parameter pengukuran kadar glukosa darah puasa (KGDP) dan berat badan. Sebanyak 30 ekor mencit Swiss janlan berat 20 - 30 g dibagi menjadi 6 kelompok (N=5). Kelompok I (kontrol normal) yang tidak diberi perlakuan. Kelompok II (kontrol negatif) diberi STZ dosis 40mg/kgbb secara intra peritoneal selama 5 hari berturut-turut. Keiompok III (kontrol positif) diberi metformin 3,9 mg/20gBB. Kelompok IV;V:VI diberi infusa kangkung darat dosis 44,64mg/20gBB; 89,28mg/20gBB; 178,56mg/20gBB. Kangkung darat diberikan secara p.o selama 7 hari berturut-turut yaitu pada hari ke-13 sampai hari ke-19 seEelah pemberian STZ. Pengukuran KGDP pada hari ke-0 (sebelum pemberian STZ), hari ke-13, hari ke-20 dengan cara diarnbi darah secukupnya melalui ekor mencit Swiss jantan yang sudah dipuasakan sebelumnya dan diukur menggunakan glukotest . Data dianalisis dengan analysis of covarian (ANCOVA) dan analysis of varian (ANOVA) (p=0:05). Hasil penelitian menunjukkan bahwa berat badan mencit diabetes rata-rata mengalami kenaikan dibandingkan kelompok kontrol normal sebesar 0,2g/hari dan mencit Swiss jantan mengalami penurunan KGDP setelah diberikan infusa kangkung darat (Ipomea reptans P.) dosis 44,64mg/20gBB; 89,28rng/20gBB; 178,56mg/20gBB sebesar 21,27%; 34,44%: 31,18%.
PENGARUH PRAPERLAKUAN PREDNISON TERHADAP BIOAVAILABILITAS TEOFILIN PADA TIKUS WISTAR JANTAN Dimas Adhi Pradhana; Farida Hayati; Elok Atiqoh
Jurnal Ilmiah Farmasi Vol. 10 No. 2 (2013): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol10.iss2.art1

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh pra-perlakuan prednison terhadap profil bioavailabilitas teofilin. Hewan coba yang dipergunakan dalam penelitian ini adalah tikus Wistar jantan yang dibagi dalam 2 kelompok yaitu kelompok kontrol dan perlakuan dimana setiap kelompok terdiri atas 5 ekor tikus. Kelompok kontrol diberikan teofilin dosis 45 mg/kg BB tikus sedangkan kelompok perlakuan diberikan prednison dosis 3,6mg/kg BB tikus sekali sehari selama 7 hari dan pada hari ke-8 diberikan prednisolon. Cuplikan darah diambil sebanyak 0,25 ml dari vena lateral ekor. Penetapan kadar fenitoin dilakukan dengan metode HPLC. Berdasarkan data kadar obat dalam darah lawan waktu dilakukan perhitungan parameter bioavalabilitas teofilin yang meliputi Cpmax, tmax and AUC0-∞,. Hasil penelitian menunjukkan pemberian pra perlakuan prednison menurunkan secara signifikan nilai tmax dari teofilin sampai dengan 51,19% (p<0,05).
Effect Of Curcumin And Honey To Pharmacokinetics Of Paracetamol In Male Wistar Rats Dimas Adhi Pradana; Farida Hayati; Agung Giri Samudra; Amalinda Setya Kartika
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 12, ISSUE 1, February 2011
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

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Abstract

Honey and curcumin is widely consumed by children as food supplements. Honey is useful as an antioxidant and antibacterial, while curcumin  is useful as an antioxidant, antiinflammatory,  antibacterial,  antiviral. Both  health  supplements  are  not  infrequently used in conjunction with drugs, especially paracetamol. This study aims to determine the effect of curcumin and honey on the pharmacokinetic parameters of paracetamol in male rats.  In  this  study,  test  animals  were  divided  into  3  groups:  control,  treatment  I  and treatment  II.  In  the  control  group  mice  were  given  paracetamol  150mg  /  KgBW, treatment  group  I  rats  were  given  curcumin  18  mg  /  KgBW,  1  hour  and  then  given paracetamol 150mg  / KgBW whereas  the  treatment group  II  rats given a dose of honey 7.65 mL / KgBW along with giving paracetamol 150mg KgBB . The results showed that administration of curcumin on the pharmacokinetics of paracetamol in mice can decrease the  primary  parameters  of  the  elimination  phase  of  CLT  for  68.25%,  increasing  the secondary parameter t 1 / 2 at 193.72%, thus increasing the derivative parameters AUC0-inf for 88.36%, and MRT of 155.17% (p
EFEK ANTIANGIOGENIK EKSTRAK METANOL AKAR PASAK BUMI (Eurycoma longifolia, Jack) PADA MEMBRAN KORIO ALANTOIS (CAM) EMBRIO AYAM YANG TERINDUKSI bFGF Nina Salamah; Sugiyanto Sugiyanto; Mae Sri Hartati; Farida Hayati
Majalah Obat Tradisional Vol 15, No 1 (2010)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (618.799 KB) | DOI: 10.22146/tradmedj.8062

Abstract

Angiogenesis is a neovascularization process which its function is to supply nutrient and oxygen for cell survival. Pasak bumi is one of the Indonesian original plants having anti cancer activity. Extract of methanol, buthanol, kloroform, and water akar pasak bumi was proved to have cytotoxic effect on cancer cell culture. This research aim to know activity of antiangiogenic extract of metanol akar pasak bumi at chorioallantoic membrane of chicken embryo. Antiangiogenic activity test conducted by divide 8-9 days old egg embrio into 8 groups. Group I as paper disc control, group II as bFGF control, group III as bFGF control + DMSO 0.8% solvent, group IV, V, VI, VII, and VIII as  groups of treatment. Each groups of treatment were gave by bFGF 1ng/µL extract of metanol akar pasak bumi respectively with concentration 20, 40, 60, 80 and 100 µg/mL concentration. After 3 days incubation, then the chorioallantoic membrane macroscopic and microcospically analized. The antiangiogenic activity extract of metanol akar pasak bumi at chorioallantoic membrane bFGF induce at used concentration, that is start from 40 µg/mL concentration. The increases of the concentration also increase the prohibition activity to angiogenesis. 
Isolation and identification of eurycomanone from akar pasak bumi (Eurycoma longifolia, Jack) and its antiangiogenic activity Sugiyanto .; Nina Salamah; Mae Sri Hartati; Farida Hayati; Pinus Jumariyatno
Indonesian Journal of Pharmacy Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (371.242 KB) | DOI: 10.14499/indonesianjpharm0iss0pp118-126

Abstract

Pasak bumi is one of the Indonesian original plants having anti cancer activity. One compound of akar pasak bumi, i.e eurycomanone was proven to have cytotoxic effect on cancer cell culture by apoptosis induction on HeLa cells. Therefore, this study was aimed to isolate and identify euycomanone from akar pasak bumi and to look at the anti angiogenic activity of the compounds on corio alantois membrane (CAM) of chicken embryo induced by bFGF.The akar pasak bumi was ground and was macerated with methanol. The macerate was fractioned by mean of VLC. Six fractions was obtained. The second fraction exhibited two spots on a TLC system, one spot was cochromatographed with eurycomanone as the reference standart and another spot exhibited blue fluorecence at 254 nm. This second fraction, then, was chromatographed on a preparative scale TLC to separate isolate A. Anti angiogenic test was performed for Isolate A at concentration series of 5, 10, 15, 20, 40 μg/mL respectively. Egg embrio (8-9 days) were divided into 8 groups. The first group was implanted paper disc only, the second group were given bFGF on Tris HCl buffer and the third group were given bFGF (on Tris HCl buffer) + 0,8 % DMSO. The fourth to eighth group were induced by 10 ng bFGF and the test preparation at the respective concentration. After incubation at 39 °C for 3 days, each egg was opened, the content of each was aspired and discarded, the CAM sticked to its shell was examined macroscopically and microscopically for the formation of new blood vessels.Based on spectral data of UV, IR, 1H NMR, 13C NMR and MS of isolate A and comparison with the spectral data of the standart, the isolate A was eurycomanone. Eurycomanone inhibited angiogenesis at concentration of 10 μg/mL.Key words: antiangiogenic, angiogenesis, E.longifolia, eurycomanone,CAM.
Standardization of the Extract of Cultivated Ipomoea reptans Poir. Leaves from Sardonoharjo, Sleman and Its Potency as Antioxidant FARIDA HAYATI; ARI WIBOWO; PINUS JUMARYATNO; ARDE TOGA NUGROHO; DIAN AMALIA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Telah dilakukan penelitian untuk mengetahui nilai parameter spesifik dan nonspesifik standardisasi ekstrak kangkung darat hasil budidaya di wilayah Sardonoharjo, Sleman serta potensinya sebagai antioksidan. Sampel yang digunakan dipanen pada saat usia kangkung darat ±25-30 hari setelah penanaman. Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol 96%. Parameter spesifik terdiri dari uji organoleptik, pola kromatografi, kadar senyawa marker dan parameter nonspesifik terdiri dari uji bobot jenis,uji kadar air, uji kadar abu total, uji kadar abu tidak larut asam, uji cemaran logam, uji cemaran mikroba, uji cemaran kapang dan khamir, perkiraan angka koliform, dan uji sisa pelarut etanol. Hasil standardisasi ekstrak menunjukkan nilai pengukuran berturut-turut untuk parameter kadar air 16,45±0,05%, bobot jenis ekstrak 3,26±3,37x10-3 g/mL, kadar abu total 4,52± 0,77%. Tidak terdapat sisa pelarut etanol di dalam ekstrak, serta angka cemaran mikroba, angka kapang dan khamir, angka koliform, serta cemaran logam timbal (Pb) dan kadmium (Cd), di dalam ekstrak di bawah standar batas maksimal yang ditetapkan BPOM. Hasil pengukuran dengan KLT densitometri menunjukkan nilai kadar β-karoten di dalam ekstrak sebesar 5,7% (b/b). Hasil Uji aktivitas antioksidan dengan menggunakan 2,2-diphenyl-1- picrylhydrazyl (DPPH) menunjukkan nilai IC50 ekstrak daun kangkung sebesar 178,3 μg/ mL.
THE PHARMACOKINETIC PROFILE OF BUPIVACAINE IN NORMOTENSIVE PREGNANT PATIENT DURING CAESAREAN SECTION Dita Ayulia Dwi Sandi; Djoko Wahyono; Farida Hayati; Yusmein Uyun
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 3, No 2
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.105

Abstract

Bupivacaine is used as a local anesthetic with Epidural Lumbal Anasthesia (ELA) for Caesarean Section (CS) in Indonesia. During pregnancy, there are changes in pharmacokinetic parameter values, as a result of changes in the physiology of the body. This study was designed to determine the pharmacokinetic parameters of isobaric bupivacaine 0.5% with non-compartment model and to monitor its effectiveness. The study was conducted on 7 normotensive pregnant patients who treated with 0.5% bupivacaine doses 75 mg at Integrated Central Surgery Building in Dr. Sardjito Hospital. Blood samples (3 mL) from each patients were drawn at the following intervals: 0, 15, 20, 25, 30, 45, 60, 75 and 90 minutes, then the plasma bupivacaine consentration were measured using HPLC and pharmacokinetic parameters were calculated with non-compartment models, i.e. AUC(0-~), AUMC(0-~) and the MRT. Monitoring the effectiveness was conducted by Pinprick test. Relationship of AUC(0-~) with maximum sensory block was analyzed by Pearson correlation. The results of pharmacokinetic parameters of isobaric bupivacaine 0.5% for 7 normotensive pregnant patients with non-compartment model were AUC(0-~) 101,25 ± 15,07 μg.mL-1.min; AUMC(0-~) 6.431,92 ± 2.212,96 μg.mL-1.min2 and MRT 63,74 ± 20,52 minutes. Bupivacaine 0,5% doses 75 mg as an anesthetic for CS with ELA in 7 normotensive pregnant patients was effective for pain blockade, with maximum sensory block was T6. There was no correlation between AUC(0-~) and sensory block (p>0,05).Keywords: Bupivacaine 0.5%, Sectio Caesarea, Pharmacokinetics, Sensory bloc
PHARMACOKINETIC PROFILE OF LUMBAR EPIDURAL BUPIVACAINE INJECTION IN PREECLAMPSIA PATIENTS DURING CESAREAN SECTION: CASE STUDY IN DR. SARDJITO HOSPITAL YOGYAKARTA Helmina Wati; Djoko Wahyono; Farida Hayati; Yusmein Uyun
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 3, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.102

Abstract

Preeclamsia patient experienced deterioration of glomerolus filtration and plasma protein concentration. Bupivakain is bound strongly with the plasma protein that is 95%. This research was aimed to know the pharmacokinetics profiles of isobaric bupivacaine with the noncompartemen model in preeclampsia patients who underwent Sectio Caesarea (SC) with lumbar epidural technique in RSUP Dr. Sardjito and to know correlation between protein levels and pharmacokinetics profiles of isobaric bupivacaine in preeclampsia patients. Firstly, albumin concentration of patients was checked in the laboratory and then isobaric bupivacaine 0.5% in 15ml (75mg) was given by lumbar epidural technique. The samples of blood were taken through veins vessels at 0; 15; 20; 25; 30; 45; 60 and 90 minutes. The concentration of 0.5% isobaric bupivacaine in those samples of blood was determined with High Performance Liquid Chromatography (HPLC) methods. Furthermore, pinprick test was taken to measure block sensoric effect in T10-T6 areas. Pharmacokinetics parameters of bupivacaine (AUC, AUMC, MRT) were calculated based on data of bupivakain concentration in the blood versus time. The results of this research showed that the AUC0-∞ (total AUC) was 116±37,6 (μg/ml) minutes; AUMC0-∞ (total AUMC) was 9187,5 (μg/ml) minutes2; and MRT0-∞ was 102,5 minutes. Average block sensoric effect was at T8. There was no linear correlation between the protein levels and pharmacokinetics profiles of bupivacaine (p>0,05). The conclusion was that there was no linear correlation between the protein levels and pharmacokinetics profiles of bupivacaine that was given by lumbar epidural in preeclampsia patientswho underwent section caesarea.Keywords : bupivakaine, pharmacokinetic profile, lumbar epidural, section caesarea.
PENINGKATAN DERAJAT KESEHATAN MELALUI PROMOSI KESEHATAN POLA HIDUP BERSIH DAN SEHAT (PHBS) DI DUSUN SAWAHAN DESA PENDOWOHARJO, KECAMATAN SEWON, KABUPATEN BANTUL Rizsanti Meirina Satar; Diny Lidya; Putri Widi; Gina Nadia Hastarin; Farida Hayati
Khazanah: Jurnal Mahasiswa Vol. VI, No. 1, Juni 2013
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/khazanah.vol6.iss1.art3

Abstract

Telah dilakukan penelitian mengenai peningkatan derajat kesehatan melalui promosi kesehatan Pola Hidup Bersih Sehat (PHBS) di Dusun Sawahan Desa Pendowoharjo, Kecamatan Sewon, Kabupaten Bantul dengan metode penyuluhan dan pemantauan serta pengamatan tanpa sepengetahuan subjek uji. Penelitian ini bertujuan untuk mengetahui pengaruh dari pelaksanaan promosi kesehatan Pola Hidup Bersih Sehat (PHBS) terhadap kesehatan masyarakat Dukuh Sawahan. Hasil penelitian menunjukkan bahwa frekuensi penyuluhan dan pemantauan Pola Hidup Bersih dan Sehat (PHBS) terhadap warga dusun Sawahan menunjukkan korelasi yakni meningkatnya indikator Pola Hidup Bersih dan Sehat (PHBS) yang tercapai. Tercapainya indikator Pola Hidup Bersih dan Sehat (PHBS) menunjukkan peningkatan kesadaran warga akan pentingnya lingkungan sehat dan perilaku sehat sehingga meningkatkan derajat kesehatan warga Dusun Sawahan.
METODE QUANTUM LEARNING DALAM MENINGKATKAN SELF AWARENESS DAN MOTIVASI SADARI PADA REMAJA Dhina Widayati; Farida Hayati
Prosiding SPIKesNas : Seminar Publikasi Ilmiah Kesehatan Nasional Vol. 1 No. 01 (2022): SPIKesNas - Agustus 2022
Publisher : STIKES dan AKZI Karya Husada Kediri

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Abstract

Breast cancer is at risk at all ages including teenagers as well. However, adolescents are not yet aware of the need for early detection of breast cancer, so it requires mehods to increase awareness of importance of early detection measures. The purpose of this research is to know the influence of Quantum learning methods on Self awareness and the motivation to check breasts themselves on class XI students in MA Al Fatah Badas. The design of this research is Pre experimental design with One Group pretest-posttest Design. research plan. The population of all XI class students in MA Al Fatah Badas, sample 27 respondents, taken with a total sampling technique. Analyze pre and post interventions on self awareness and motivation variables. This research variable data was tested with the Wilcoxon statistical test with a -value signification of 0.00 (α = 0.05). The results of the self Awareness variable study showed the rate of self awareness of respondents prior to almost all interventions (88.89%) with low categories and after almost all interventions (92.59%) with good category. While the results of the motivation variable study showed the motivation level of respondents before the intervention almost all (88.89%) with the low category and after total intervention (100%) with high category. There is an influence on the quantum learning method of self awareness and the motivation to examine the breasts themselves with the value of -value self awareness of 0.00 (α = 0.05) while the value of the -value motivation is 0.00 (α = 0.05). The quantum learning method is a fun and interesting learning model so that the material can be well absorbed. This learning method invites students to participate actively in learning activities so as to allow them to explore their curiosity. Based on this research, learners are advised to use quantum learning methods to increase interest in classroom learning.
Co-Authors . PRAPTIWI Agung Giri Samudra Amalinda Setya Kartika Arba Pramundita Ramadani Arde Toga Nugraha Ari Wibowo Arief Rahman Hakim Ariefaldy, Muhammad Ilhan Awaluddin, Rizki Cynthia Astiti Putri DAYAR ARBAIN Desyandri Desyandri Dhina Widayati Dhina Widayati, Dhina DIAN AMALIA Dian Sukma Dimas Adhi Pradana Dimas Adhi Pradhana Dina Zakiyyatul Fuadah, Dina Zakiyyatul Diny Lidya Djoko Wahyono Djoko Wahyono Djoko Wahyono Dwi Brilyani Sandy Dwi Setyorini Elok Atiqoh Fajarotin, Dwi Rori Firnanda, Muhammad Erick Fitriani, Hannie Gina Nadia Hastarin Ginna Zabrina Girianto, Pria Wahyu Romadhon Gusti Rizaldi Hakim, Lukman Hasanah, Primadian Helmina Wati Herianto Pandapotan, Herianto Indriani Indriani Ishariani, Linda Islamiyah Neda Rahayu Khaerunnisa, Siti Laviana Nita Ludyanti Lian Widi Astutik Ludyanti, Laviana Lutfi Chabib, Lutfi M.Pd S.T. S.Pd. I Gde Wawan Sudatha . Mae Sri Hartati Wahyuningsih Maulaya, Ikvini Muh Iqbal Pangestu Muhammad Agus Firmansyah Ramadhani Muhammad Iqbal Pangestu Muhammad Sulaiman Zubair Mustaqim, Rafli Mulkan Nina Salamah Nurlaily, Diana Nurul Laili Pinus Jumariyatno Pinus Jumaryatno Poluan, Jesica Carine Puspita, Arum Dwi Putri Widi Rahmi Muthia Renditya Ismiyati Retno Murwanti Riptasari, Rhatna Dewi Rizsanti Meirina Satar Samad, Ayu Wandari Sandi, Dita Ayulia Dwi Sandi, Dita Ayulia Dwi Satrio, Rezky Metra Selvi Amadia Septian Pradana, Dimas Sitarina Widyarini Stiani, Sofi Nurmay Sugiyanto . Sugiyanto Sugiyanto Taukhid, Muhammad Tri Alfiana, Yolanda Velincia Tanriono, Levana Wahyu Utaminingrum Yandi Syukri Yundari, Yundari Yusmein Uyun