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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY QUANTUM: Jurnal Inovasi Pendidikan Sains Pharmascience Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Media Bahasa, Sastra, dan Budaya Wahana JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Surya Enthusiastic : International Journal of Applied Statistics and Data Science Journal of Applied Nursing and Health Khazanah: Jurnal Mahasiswa Jurnal Riset Kebidanan Indonesia JKKI : Jurnal Kedokteran dan Kesehatan Indonesia SPIKESNAS Media Farmasi Borneo Journal of Pharmacy Jurnal Keperawatan Mandira Cendikia (JKMC)
Hayati, Farida
Prodi Farmasi, Fakultas MIPA, Universitas Islam Indonesia, Yogyakarta Prodi Profesi Apoteker, Fakultas MIPA, Universitas Islam Indonesia, Yogyakarta
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Determination of Total Flavonoid Content and Characterization of Nanoparticles of Kecombrang Leaf Extract (Etlingera elatior (Jack) R.M.Sm.) Hayati, Farida; Sofi Nurmay Stiani; Renditya Ismiyati
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 6, ISSUE 1, April 2025
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol6.iss1.art4

Abstract

Kecombrang (Etlingera elatior (Jack) R.M.Sm.) is one of Indonesia's potential plants that contain such bioactive compounds as polyphenols, alkaloids, flavonoids, steroids, saponins, and essential oils. This study aims to determine the total flavonoid content of kecombrang leaf extract. It also defines the characteristics of the nanoparticles of kecombrang leaf extract. Kecombrang leaves were extracted through maceration. The determination of the total flavonoid content by spectrophotometry used quercetin as a comparison. The synthesis of nanoparticles used ionic gelation with 0.1% sodium alginate and 0.01% calcium chloride crosslinkers. The characteristic parameters of the nanoparticles of kecombrang leaf extract included the visual, transmittance, adsorption efficiency, particle size distribution, polydispersity index, and zeta potential. The yield value was 46.55%. The total flavonoid content was 88.11 mgQE/g with a regression standard curve Y = 0.1022x + 0.0745 and correlation coefficient (r) = 0.9922. The nanoparticle solution provided a clear visual with a particle size and PI of 108.2 nm and 0.311, a transmittance and adsorption efficiency of 94.76% and 93.76%, and a zeta potential of -36 mV. The total flavonoid content was 88.11 mgQE/g. The nanoparticle solution of kecombrang leaf extract has the characteristics that qualify as a nanoparticle preparation.
Modeling the Prevalence of Stunting in Indonesia Using Quantile Regression Hayati, Farida; Nurlaily, Diana; Hasanah, Primadian
Enthusiastic : International Journal of Applied Statistics and Data Science Volume 5 Issue 1, April 2025
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/enthusiastic.vol5.iss1.art1

Abstract

Stunting is a condition where a child’s height is under the average height of their age. Stunting will have an impact on the quality of human resources. The 2022 Indonesian Nutrition Status Survey reported that the prevalence of stunting in Indonesia reached 21.6%. This number decreased compared to the previous year. However, it remains below the government’s planned target of 14%. Therefore, appropriate methods are needed to model and identify the factors with the most significant impact on the data for each region studied. This research modeled the stunting problem using quantile regression. Quantile regression has several advantages, including the fact that it can be used on data with an inhomogeneous distribution and is not affected by outliers. The results showed that variables that had a significant effect on the prevalence of stunting using 0.95 quantile regression included babies receiving exclusive breast milk, percentage of family planning participants, percentage of households with access to adequate sanitation, low birth weight (LBW) babies, and percentage of toddlers who have Maternal and Child Health (MCH) books. It is hoped that this research can be utilized to carry out appropriate interventions to reduce the prevalence of stunting that occurs in Indonesia.
A Systematic Narrative Review : Kajian Farmakologi dan Toksikologi Meniran (Phyllanthus niruri L.): A Systematic Narrative Review : Pharmacology and Toxicology Study of Meniran (Phyllanthus niruri L.) Pandapotan, Herianto; Fitriani, Hannie; Hayati, Farida; Syukri, Yandi
Media Farmasi Vol 21 No 1 (2025): Media Farmasi Edisi April 2025
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v21i1.1317

Abstract

Background: Meniran (Phyllanthus niruri L.) is a traditional medicinal plant widely utilized in various countries due to its pharmacological potential. Objective: This study aims to explore the biological activity by summarizing scientific findings regarding the pharmacological effects and toxicological profile of meniran, as well as highlighting the understanding related to safe therapeutic doses. Methods: This review was conducted using a systematic narrative approach, utilizing literature from journal articles, scientific reports, reference books, and publication data from databases such as PubMed, Scopus, and Google Scholar. Inclusion criteria comprised peer-reviewed studies published in the last 10 years, while exclusion criteria eliminated non-scientific articles and those not relevant to pharmacology or toxicology. Results: A total of 200 articles were identified, resulting in 34 articles selected for review after applying inclusion and exclusion criteria. From the four journals/studies reviewed, it was found that bioactive compounds in meniran, such as flavonoids and lignans, play a crucial role in therapeutic effects including antioxidant activity, hepatoprotection, antimicrobial effects, and anti-inflammatory properties. Additionally, two journals/studies indicated that long-term use of meniran may have toxic effects. Conclusion: Meniran exhibits pharmacological activities such as antioxidant effects, hepatoprotection, antimicrobial effects, and anti-inflammatory effects; however, it may have toxic effects on the kidneys and liver when used in high doses. Further research is necessary to ensure the safety and effectiveness of its use in medical therapy.
PENGARUH PRAPERLAKUAN JUS PISANG AMBON ( Musa paradisiaca L. ) TERHADAP BIOAVAILABILITAS SULFAMEZATIN PADA TIKUS PUTIH JANTAN Hayati, Farida; Hakim, Arief Rahman; Riptasari, Rhatna Dewi
Jurnal Ilmiah Farmasi Vol. 1 No. 1 (2004)
Publisher : Universitas Islam Indonesia

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Abstract

The influence of ambon banana’s fruit ( Musa paradisiaca L. ) juice on the bioavailability of sulfamezathin on the rat that aim to know there are interaction result from their consumption together has been studied. The study was using experiment’s animal is white rats Wistar’s spesies that have age around 3-4 months and their weight 200-300 g. This experimental was used completely randomized design with three group’s test, each group’s test is contain seven rats. The first group is pretreatment single dose sulfamezathin (60 mg/kg ww; peroral ), second is sullfamezathin and banana ( 12,6 g/kg ww; peroral ) together and third group is sulfamezathin after one hour dose banana like second group. Respectively blood samples take up from tail vein of rat at 15, 30, 45, 60, 90, 120, 150, 180, 240, 360, 480 and 600 minutes. Consentrations of Sulfamezatin were measured use Bratton Marshall methode with spektrofotometer instrument at 545 mn wavelength. Consentrations of sulfamezathin versus times by software of Stripe used to calculate pharmacokinetics parameters in each group’s test and the value parameters of pharmacokinetics have statistic analysis by ANOVA and if there are difference’s significant ( p < 0,05 ) from calculated value, statistic analysis continued by Tukey test. The results from experimental banana at second and third groups in compare with control at the first group can increased significant ( p < 0,05 ) parameters C maks, t maks, AUC0- .Bioavailability, Sulfamezathin, Ambon banana, Musa paradisiaca L.
Toxicity of activated-charcoal purified Centella asiatica (L.) Urb. methanolic extract on zebrafish embryos Maulaya, Ikvini; Hayati, Farida; Awaluddin, Rizki
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 2, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss2.art4

Abstract

Background: Purification of Centella asiatica methanolic extract using activated charcoal (ACP-CME) to isolate its non-aromatic compounds is a novel method that requires rigorous foundational safety data for the next validation stage.Objectives: The study aimed to determine the LC50 and identify toxicity signs of activated charcoal-purified Centella asiatica methanolic extract (ACP-CME) on zebrafish embryos.Methods: Fish Embryo Acute Toxicity (FET) was conducted following the 2013 standardized guidelines from OECD number 236. The zebrafish embryos were divided into eight groups (n=20/group), with an additional internal control in each group (n=4), namely 5 ACP-CME groups (ACP-CME at concentrations of 15.625, 31.25, 62.5, 125, and 250 ppm), a negative control group (distilled water), a positive control group (3,4-dichloroaniline), and a solvent control group (DMSO 0.2%). The observation was performed every 24 hours for 96 hours on four lethality parameters (coagulation, somite formation, tail-bud detachment, and visible heartbeat). The lethal concentration 50 (LC50) was calculated using Microsoft Excel 2019 to determine the signs and levels of toxicity of the extract based on the observational data. Results: ACP-CME exhibited concentration-dependent lethality caused by coagulation and absence of heartbeat, with 100% mortality at 250 ppm. Some abnormalities caused by ACP-CME exposure were spotted at concentrations of 31.25 and 125 ppm, with the occurrence of 15% and 10%, respectively.Conclusion: The LC50 of ACP-CME was 39.56 ppm. Malformation effects included lordosis, kyphosis, delayed tail-bud detachment, abnormal fin, somite formation failure, hatching failure, and yolk sac edema.
The Relationship between Adolescent Attitudes and Compliance in Implementing COVID-19 Prevention Health Protocols Girianto, Pria Wahyu Romadhon; Hayati, Farida; Puspita, Arum Dwi
Jurnal Surya Vol 14 No 1 (2022): VOL 14 NO 01 APRIL 2022
Publisher : Universitas Muhammadiyah Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38040/js.v14i1.410

Abstract

Introduction: Indonesia is being hit by the COVID-19 pandemic at the moment. The government established a disaster emergency status to prevent the spread of this virus by making a COVID-19 health protocol. The success of the COVID-19 health protocol depends on the attitude of the teenager and their level of compliance. This study aimed to analyze the correlation between attitude and compliance with the implementation of health protocols during the COVID-19 pandemic.Methods: Research design was correlated with a cross- sectional approach. There were 55 teenagers aged 17-20 years by purposive sampling. The instrument used for collecting attitude and compliance data was a questionnaire. The data analysis used Spearman rank.Results: The results showed that almost half of the respondents, 49.1%, had a moderate attitude and most of the respondents, 56.4%, had moderate compliance. Analysis with the Spearman rank statistical test obtained a p-value of 0.012 and an error rate of =0.05 (0.0120.05). It means that there was a correlation between attitude and compliance with implementing health protocols in teenagers aged 17–20 years, with a positive correlation and weak power category (r = 0.335).Conclusion: Attitude is sufficient to cause moderate compliance in teenagers aged 17–20 years when implementing health protocols. For this reason, hopefully the health worker will add information about COVID-19 to the community by conducting socialization about COVID-19 and health protocols.
Begonia medicinalis: a review of Phytochemistry and Pharmacology Velincia Tanriono, Levana; Hayati, Farida; Zubair, Muhammad Sulaiman
Jurnal Ilmiah Farmasi Vol. 20 No. 1 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss1.art3

Abstract

Background: Begonia medicinalis, often referred to as benalu batu, is a plant belonging to the Begoniaceae family. It is renowned for its wide range of pharmacological activities and its extensive application in the treatment of many diseases. Saponins, tannins, flavonoids, phenolics, steroids, alkaloids, and triterpenoids are some of the chemical compounds in this plant responsible for its pharmacological activity.Objective: The aim of this review is to provide information about the phytochemical and pharmacological properties of B. medicinalis.Method: This narrative review was performed by conducting literature searches on various relevant reputable online databases, and there were 17 articles that discussed the phytochemistry and pharmacology activity of B. medicinalis. Results: People have long used B. medicinalis as a test treatment for a variety of diseases. Flavanols, 2-O-β-glucopyranosyl cucurbitan D, β-sitosterol-3-O-β-D-glucopyranoside, and 9(11)α,16(17)α-dioxirane-20,25-dihydroxy-β-sitosterol-3-O-β-glucopyranoside are among the compounds found in the plant. Studies have demonstrated the immunomodulatory, anticancer, antiviral, and antioxidant activity of this plant. In vitro toxicity tests revealed that this plant is toxic and has anticancer potential. The in vivo toxicity test revealed that this plant has mild toxicity.Conclusion: This study suggests that B. medicinalis has strong potential for future development into herbal medicine.Keywords: Begonia medicinalis; Begonia sp.; pharmacological; phytochemical
Students' First-Aid Ability in Earthquake Disasters Significantly Improved Through an Online Role-Playing Method Taukhid, Muhammad; Hayati, Farida; Tri Alfiana, Yolanda
Journal of Applied Nursing and Health Vol. 3 No. 2 (2021): Journal of Applied Nursing and Health
Publisher : Chakra Brahmanda Lentera Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (250.403 KB) | DOI: 10.55018/janh.v3i2.10

Abstract

Background: The earthquake brought about unprecedented societal changes, particularly among schoolchildren. Thus, in the educational setting, a lack of disaster readiness is caused by a lack of knowledge of hazards, which leads to a lack of preparedness in the event of a disaster. This study aims to see how the role-playing method in the network affects adolescent red cross students' abilities to provide first aid in an earthquake emergency. Methods: The research design used a pre-experimental design with a one-group pre-test post-test design approach to 20 PMR student respondents utilizing the Total Sampling technique, with the intervention of delivering earthquake first aid education, given twice for one week for a total of 60 minutes. An observation sheet was employed as the data-gathering equipment. The data was analyzed. T-Test with paired samples. Results: The results revealed that all respondents with a percentage (100.0 percent) had a 50 percent ability score in the pre-test and practically all of them with a percentage (90.0 percent) had a score of 75 percent-100 percent in the post-test. The mean pre-test = 8.70% and the mean post-test = 27.30% in obtaining value 0,000 = 0.05, indicating that there is an Effect of Method Role Playing In First Aid Network Capability Against Earthquake In PMR students in SMPN 1 Kalidawir Tulungagung. Conclusion: The network's role-playing strategy has an impact on motivation, and motivation is vital in the effectiveness of disaster awareness learning so that the community is more prepared and resilient in the event of a disaster.
The Family Support in Strengthening Fine Motor Ability for Children 3-4 Years Old Ludyanti, Laviana; Hayati, Farida; Fuadah, Dina Zakiyyatul
Journal of Applied Nursing and Health Vol. 5 No. 2 (2023): Journal of Applied Nursing and Health
Publisher : Chakra Brahmanda Lentera Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55018/janh.v5i2.147

Abstract

Background: Family was the first school for children to support their growth and development. Fine motor development of children 3-4 years old can develop optimally if they get optimal family support through good and correct stimulation.  This research to determine the relationship between family support and fine motoric skills in children aged 3-4 years at the Smart Kids Preschool. Methods: The design of this study was correlational with a cross sectional approach using a questionnaire. The independent variable is family support and the dependent variable is fine motoric skills in children aged 3-4 years, with a population and sample consisting of 35 respondents using total sampling. The research data were analyzed using the Spearman Rank Test. Results: The results of the family support study showed that almost all respondents (82.9%) were in good criteria, in the fine motoric skills of children aged 3-4 years, almost all of them (85.7%) were in the appropriate criteria. The results of data analysis showed p-value = 0.000 (α = 0.05) with a correlation level of 0.703 which means there is a strong relationship between family support and fine motoric skills of children aged 3-4 years. This is influenced by many factors, one of which is internal factors and external factors such as motivation to practice, health, motivation or attributes that distinguish a person from others, then parental knowledge, parental education, parental attitudes, socio-economic family, socio-cultural, environment, and parenting.  Conclusion: Based on the result of this study, it is suggested that mothers can provide stimulation so that the potential of children can develop optimally by providing optimal support for children.
Pengaruh Hipnotherapy Terhadap Kepercayaan Diri Pada Remaja Korban Bullying Verbal Di SMK PSM 1 Kedunggalar, Ngawi Farida Hayati; Laviana Nita Ludyanti; Lian Widi Astutik
Jurnal Keperawatan Mandira Cendikia Vol. 3 No. 1 (2024)
Publisher : YAYASAN PENDIDIKAN MANDIRA CENDIKIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70570/jkmc.v3i1.1245

Abstract

Kepercayaan diri pada remaja sangat penting yang harus dimiliki dan dapat menunjang berbagai aktivitas dalam berinteraksi dengan orang lain. Bullying verbal akan memberikan dampak luar biasa terhadap kepercayaan diri pada seseorang yang menjadi korban. Metode yang dapat mengatasi masalah kepercayaan diri salah satunya adalah hipnotherapy dengan cara pemberian sugesti positif. Tujuan dari penelitian ini untuk mengetahui pengaruh hipnotherapy terhadap kepercayaan diri pada remaja korban bullying verbal di SMK PSM 1 Kedunggalar, Ngawi. Desain penelitian Pre Experimental dengan pendekatan one grup pretest-postest design. Teknik pengambilan sampel dengan purposive sampling didapatkan 41 responden dari 46 populasi. Variabel kepercayaan diri diukur dengan lembar kuesioner dan hasilnya di analisa dengan uji paired T test dengan α 0,05. Hasil penelitian sebelum diberikan intervensi (mean 47,10) seluruhnya (100%) responden mengalami kepercayaan diri rendah. Setelah diberikan intervensi (mean 101,78) hampir seluruhnya (82,9%) responden mengalami percaya diri dan sebagian kecil (17,1%) responden mengalami kepercayaan diri tinggi. Di dapatkan ρ-value = 0,000 (<α), artinya hipnotherapy dapat mengatasi masalah kepercayaan diri pada remaja korban bullying verbal. Hipnotherapy membimbing untuk memasuki kondisi trance yang dapat meningkatkan hormone melatonin, cathecolamine dan arginine vasopressin (AVP) yang membuat pikiran tenang dan rileks sehingga mudah menerima sugesti positif. Hipnotherapy dapat menjadi upaya non farmakologi untuk mengatasi masalah kepercayaan diri pada remaja.
Co-Authors . PRAPTIWI Agung Giri Samudra Amalinda Setya Kartika Arba Pramundita Ramadani Arde Toga Nugraha Ari Wibowo Arief Rahman Hakim Ariefaldy, Muhammad Ilhan Awaluddin, Rizki Cynthia Astiti Putri DAYAR ARBAIN Desyandri Desyandri Dhina Widayati Dhina Widayati, Dhina DIAN AMALIA Dian Sukma Dimas Adhi Pradana Dimas Adhi Pradhana Dina Zakiyyatul Fuadah, Dina Zakiyyatul Diny Lidya Djoko Wahyono Djoko Wahyono Djoko Wahyono Dwi Brilyani Sandy Dwi Setyorini Elok Atiqoh Fajarotin, Dwi Rori Febrianti, Shabrina Adzhani Fitriani, Hannie Gina Nadia Hastarin Ginna Zabrina Girianto, Pria Wahyu Romadhon Hakim, Lukman Hasanah, Primadian Helmina Wati Herianto Pandapotan, Herianto Indriani Indriani Islamiyah Neda Rahayu Khaerunnisa, Siti Laviana Nita Ludyanti Leny Leny, Leny Lian Widi Astutik Ludyanti, Laviana Lutfi Chabib, Lutfi M.Pd S.T. S.Pd. I Gde Wawan Sudatha . Mae Sri Hartati Wahyuningsih Maulaya, Ikvini Muh Iqbal Pangestu Muhammad Agus Firmansyah Ramadhani Muhammad Iqbal Pangestu Muhammad Sulaiman Zubair Mustaqim, Rafli Mulkan Mustarianti, Lila Nina Salamah Nurlaily, Diana Parham Saadi, Parham Pinus Jumariyatno Pinus Jumaryatno Poluan, Jesica Carine Puspita, Arum Dwi Putri Widi Renditya Ismiyati Retno Murwanti Rilia Iriani Riptasari, Rhatna Dewi Rizki Awaluddin Rizsanti Meirina Satar Sandi, Dita Ayulia Dwi Sandi, Dita Ayulia Dwi Satrio, Rezky Metra Septian Pradana, Dimas Sitarina Widyarini Stiani, Sofi Nurmay Sugiyanto . Sugiyanto Sugiyanto Syahmani Syahmani Taukhid, Muhammad Tri Alfiana, Yolanda Velincia Tanriono, Levana Wahyu Utaminingrum Yandi Syukri Yogo Dwi Prasetyo Yundari, Yundari Yusmein Uyun