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All Journal Jurnal Kimia Mulawarman The Indonesian Biomedical Journal Majalah Kesehatan FKUB Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Ilmiah Manuntung Jurnal Abdimas Mandiri Jurnal Kebidanan Mutiara Mahakam Buletin LOUPE (Laporan Umum Penelitian) Jurnal Kesehatan Pasak Bumi Kalimantan Jurnal Kedokteran Mulawarman International Journal of Multidisciplinary: Applied Business and Education Research Jurnal Medika: Karya Ilmiah Kesehatan Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Pharmacology and Therapy Proceeding Mulawarman International Conference on Tropical Public Health
Nataniel Tandirogang
Universitas Mulawarman
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Aktivitas Antimikroba Ekstrak Daun Karamunting (Melastoma malabathricum L.) Terhadap Bakteri Penyebab Diare Nataniel Tandirogang; Swandari Paramita; Yadi Yasir; Yuniati Yuniati; Meiliati Aminyoto; Evi Fitriany
Jurnal Sains dan Kesehatan Vol. 1 No. 7 (2017): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v1i7.54

Abstract

Diare hingga kini masih merupakan masalah kesehatan utama di Indonesia. Pemberian antibiotik merupakan salah satu upaya penatalaksanaan diare, namun belakangan terkendala masalah adanya resistensi terhadap antibiotik. Berdasarkan hal tersebut, maka upaya pencarian sumber antimikroba baru berbasis tumbuhan obat perlu dilakukan. Penelitian ini dilakukan untuk menguji potensi ekstrak daun karamunting (Melastoma malabathricum L.) yang secara tradisional digunakan etnis Dayak sebagai obat diare. Aktivitas antimikroba ekstrak tumbuhan diuji terhadap 5 bakteri standar; Escherichia coli ATCC 35128, Shigella sonnei ATCC 25931, Campylobacter jejuni ATCC 33291, Pseudomonas aeruginosa ATCC 15442, dan Enterobacter cloacae ATCC13047. Pengukuran aktivitas antimikroba dilakukan dengan disc diffusion method (Kirby-Bauer) dan pengukuran minimum inhibitory concentration (MIC). Hasil penelitian menunjukkan ekstrak daun M. malabathricum dapat menghambat pertumbuhan seluruh bakteri uji, dengan diameter zona hambat sebesar 12,3-16 mm dan MIC sebesar 2,3-13,3 mg/ml. Kesimpulan penelitian ini adalah ekstrak daun M. malabathricum berpotensi sebagai antidiare berdasarkan aktivitas antimikrobanya.
Gambaran Pasien Papil Atropi Di RSUD Abdul Wahab Sjahranie Samarinda Tahun 2015-2020: Overview of Optic Atrophy Patients at Abdul Wahab Sjahranie Hospital, Samarinda in 2015-2020 Budi Santoso Nong Ulir; Nur Khoma Fatmawati; Nataniel Tandirogang
Jurnal Sains dan Kesehatan Vol. 5 No. 1 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i1.1742

Abstract

Optic atrophy is the end process of a disease that causes degeneration of axons along the pathway to the lateral retinogeniculate bodies. Previous studies regarding the optic atrophy have had different results. This study was conducted to determine the description of optic atrophy patients at Abdul Wahab Sjahranie Hospital Samarinda in 2015-2020. This retrospective descriptive study was conducted in February 2021. Data were obtained from 64 patients who were taken by purposive sampling technique at Abdul Wahab Sjahranie Hospital, Samarinda. This study used a medical record sheet as a research source. This study found that the most common types of optic atrophy were secondary optic atrophy with 20 patients (83,3%). The highest age group of patients with optic atrophy was the 45-55 years group with 17 patients (26.6%). The most prevalent gender was male as many as 37 patients (57.8%). Eyes affected by optic atrophy were bilateral or both eyes with 34 patients (53,1%). Most of the patients with optic atrophy had visual acuity below 3/60 or experienced blindness with 44 eyes (67.7%). Eye disease was the most comorbid group with a total of 26 patients (35,1%). The most comorbidities were retrobulbar neuritis with 11 patients (14,9%). Keywords: optic atrophy, description, age, eyes Abstrak Papil atropi adalah proses akhir dari suatu penyakit yang menyebabkan degenerasi akson pada sepanjang jalur menuju badan retinogenikulatum lateralis. Penelitian sebelumnya mengenai gambaran papil atropi memiliki hasil yang berbeda. Penelitian ini dilakukan untuk mengetahui gambaran pasien papil atropi di RSUD Abdul Wahab Sjahranie Samarinda tahun 2015-2020. Penelitian ini bersifat desktiptif retrospektif yang dilakukan pada bulan Februari 2021. Data diperoleh dari 64 pasien yang diambil dengan teknik purposive sampling di RSUD Abdul Wahab Sjahranie Samarinda. Penelitian ini menggunakan lembar rekam medik sebagai sumber penelitian. Penelitian ini mendapatkan jenis papil atropi terbanyak adalah jenis papil atropi sekunder sebanyak 20 pasien (83,3%). Kelompok usia pasien papil atropi tertinggi adalah kelompok usia kelompok 45-55 tahun sebanyak 17 pasien (26,6%). Jenis kelamin terbanyak adalah laki-laki sebanyak 37 pasien (57,8%). Mata yang terkena papil atropi terbanyak adalah bilateral atau kedua mata sebanyak 34 pasien (53,1%). Tajam penglihatan pasien papil atropi terbanyak adalah tajam penglihatan dibawah 3/60 atau mengalami kebutaan sebanyak 44 mata (67,7%). Penyakit mata adalah kelompok penyakit penyerta terbanyak dengan jumlah sebanyak 26 pasien (35,1%). Penyakit penyerta terbanyak adalah neuritis retrobulbar sebanyak 11 pasien (14,9%). Kata Kunci: papil atropi, gambaran, usia, mata
Use of The Heat Treatment Method as An Alternative to Commercial Kit-Based Nucleic Acid Extraction Method for Detecting SARS-CoV-2 Using RT-qPCR Technique under Reagent Limited Conditions Alhawaris, Alhawaris; Yadi, Yadi; Tandirogang, Nataniel
Jurnal Kesehatan Pasak Bumi Kalimantan Vol 7, No 2 (2024): JKPBK Desember 2024
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/j.kes.pasmi.kal.v7i2.15797

Abstract

The increase in the number of COVID-19 cases could cause disruptions to the global supply chain of commercial kits for the extraction of SARS-CoV-2 nucleic acid so that the COVID-19 screening process has the potential to be hampered. Another alternative method that can be used is the heat-treatment (HT) method. This study aims to assess the quality of the results of the RT-qPCR examination for the detection of SARS-CoV-2 using the HT nucleic acid extraction method. The samples were nasopharyngeal and oropharyngeal swabs and then underwent nucleic acid extraction using the magnetic beads extraction (MBE) / commercial kit and the HT method on the same day (less than 6 hours). The nucleic acid extraction results from both methods were then amplified using the RT-qPCR technique, then compared and analyzed the results. The results showed that qualitatively there was a very significant difference in the interpretation of the results between the two nucleic acid extraction methods (McNemar test, p = 0; p < 0.01). Qualitative comparative analysis also showed that there were very significant differences in ct (cycle threshold) values in the SARS-CoV-2 genes detected between the two nucleic acid extraction methods (McNemar test, p = 0; p < 0.01). While the value of ct in human gene between the two methods of nucleic acid extraction qualitatively there was no significant difference (McNemar test, p = 1; p > 0.05). The use of HT method for extraction will be more effective on cells or microorganisms that have genetic material in the form of DNA than RNA. The HT method is not recommended for use in the diagnosis of COVID-19. The use of this method as a screening in moderate to severe symptomatic populations under conditions of limited extraction reagents may be considered.Keywords:  SARS-CoV-2, COVID-19, Heat-Treatment Method, Nucleic Acid Extraction, RT-qPCR
UJI FITOKIMIA DAN ANTIOKSIDAN EKSTRAK ETANOL PROPOLIS LEBAH KELULUT (Tetragonula iridipennis) DARI SAMARINDA KALIMANTAN TIMUR Binti Khairunnisa; Enih Rosamah; Harlinda Kuspradini; Irawan Wijaya Kusuma; Sukemi Sukemi; Nataniel Tandirogang; Enos Tangke Arung
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.309

Abstract

The study aims to identify the secondary metabolite compounds contained in the ethanol extract Propolis Tetragonula Iridipennis and determine the antioxidant activity. Propolis is extracted from the beehive of Kelulut (Tetragonula Iridipennis) with a method of maceration of ethanol 96% produce a yield of 66.73%. Propolis extract contains alkaloid compounds, flavonoids, triterpenoids, tannins and carbohydrates. Propolis extract tested its antioxidant activity using the DPPH method (1.1-diphenyl-2-picrylhydrazyl) with a wavelength of 514 nm. Results showed a percentage of propolis extract free radicals 59% in concentrations of 100 ppm with IC50 33.74 ppm so that propolis extract is potentially as an antioxidant.
The effects of Curcuma xanthorrhiza rhizome simplicia and Camellia sinensis green tea in a patient with chronic hepatitis B infection: a case report Sjarif Ismail; Ika Fikriah; Nataniel Tandirogang; Khemasili Kosala
Indonesian Journal of Pharmacology and Therapy Vol 3 No 3 (2022)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.4567

Abstract

The hepatitis B virus (HBV) causes acute and chronic liver infections which can be treated by using interferon and antiviral. However, the treatment is relatively expensive. We reported here a case of a patient with chronic hepatitis B who had negative seroconversion without interferon (IFN) and antiviral treatment after herbal consumption. A retrospective investigation showed that the patient consumed Curcuma xanthorrhiza rhizome and Camelia sinensis green tea. These herbs were widely both in vitro and in vivo studied for their effects against HBV infection, although the clinical studies are limited. This case reported the effect of C. xanthorrhiza rhizome and C. sinensis green tea consumption in a patient with chronic hepatitis B. A female patient with chronic hepatisis B infection at the age of 32 y.o. had been taking neuro vitamins regularly for a year before infection detected. She was an asymptomatic patient with normal limits liver function, positive HBsAg and negative anti-Hbs. At the age of 45, she started taking C. xanthorrhiza rhizome simplicia equivalent to 5mg of curcumin twice daily and drinking C. sinensis green tea regularly. Six years later, HBsAg was not detected and her liver function remained within normal limits and Anti-HBs were detected 5 years later. In conclusion, the consumption of C. xanthorrhiza rhizome and C. sinensis green tea can against chronic hepatisis B infection by eliminate HBV dan induce anti-HBs.
Environmentally Friendly Larvicides: A Post-Test Only Experimental Comparison of Eleutherine palmifolia and Allium sativum Extracts (0.6–1.8%) on Aedes aegypti Larval Mortality Nuryanto, Muhammad Khairul; Nurkhalisa, Nina; Rasendriya , Fauzan Firjatullah; Saputra, Rudi; Fitriany, Evi; Duma, Krispinus; Tandirogang, Nataniel
International Journal of Multidisciplinary: Applied Business and Education Research Vol. 6 No. 6 (2025): International Journal of Multidisciplinary: Applied Business and Education Rese
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ijmaber.06.06.03

Abstract

This study aims to identify the larvicidal potential of Eleutherine palmifolia (Dayak onion) and Allium sativum (garlic), which are rich in flavonoids and known to possess insecticidal properties. The study used a pure experimental design with a post-test control group. Aedes aegypti larvae were tested with Eleutherine palmifolia and Allium sativum extracts at concentrations of 0.6%, 1.2%, and 1.8%, respectively, along with abate as a positive control. Larval mortality was monitored for 24 hours with four replicates. The results showed that Allium sativum was highly effective at all concentrations (99–100% mortality), even at the 0.6% concentration. In contrast, Eleutherine palmifolia exhibited varying effectiveness, with mortality rates of 67%, 67%, and 84% at concentrations of 0.6%, 1.2%, and 1.8%, respectively. These findings confirm that Allium sativum has superior, consistent, and stable larvicidal effectiveness even at low doses, making it a promising alternative for mosquito control and dengue prevention.
Analysis of Water Quality of the Senibung River in the Oil Palm Plantation PT Telen East Kutai Suwadi; Nataniel Tandirogang; Adi Susanto; Rudito; Edy Wibowo Kurniawan
Jurnal Loupe Vol 21 No 01 (2025): Juni 2025
Publisher : Jurusan Pertanian Politeknik Pertanian Negeri Samarinda Kampus Sei Keledang Jalan Samratulangi, Kotak Pos 192 Samarinda 75123

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51967/buletinloupe.v21i01.3238

Abstract

This study aims to analyze the water quality of the Senibung River flowing through the oil palm plantation of PT Telen, East Kutai. This analysis is very important to ensure that the water used as domestic water and the water used in palm oil processing is in good condition and not contaminated. The methods used are STORET and biological analysis with plankton abundance as an indicator of water quality. Sampling was conducted at the upstream (inlet) and downstream (outlet) sections of the river in March, June, September, and December 2024. The results indicate that the water quality is classified as good; however, several parameters such as TDS, BOD, nitrite, and ammonia exceed the threshold of water quality standards. The plankton diversity index in the downstream section is higher than in the upstream section, with values of H’ 1.47 and 1.17, respectively. Water discharge shows a significant positive relationship with TSS, BOD, COD, and the H' index, with the H' index having the strongest influence (R² = 0.711). The conclusion of this study is that the water quality in the downstream section is better than in the upstream section, and water discharge significantly affects water quality.
Program Intervensi 1000 Hari Pertama Kehidupan di Desa Senoni, Kecamatan Sebulu, Kabupaten Kutai Kartanegara Anggraini, Fitria; Tandirogang, Nataniel; Yadi; Bakhtiar, Rahmat; Pramulia Yudia, Riries Choiru
Jurnal Abdimas Mandiri Vol. 9 No. 2
Publisher : UNIVERSITAS INDO GLOBAL MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36982/jam.v9i2.5749

Abstract

Stunting merupakan masalah gizi kronis yang memerlukan intervensi pada periode 1000 Hari Pertama Kehidupan (HPK) sebagai golden age tumbuh kembang anak. Indonesia menempati urutan kelima dunia dengan prevalensi stunting 37% atau hampir 9 juta balita. Program intervensi 1000 HPK dilaksanakan di Desa Senoni, Kecamatan Sebulu, Kabupaten Kutai Kartanegara pada 24 Mei 2025 sebagai upaya pencegahan stunting berbasis masyarakat. Kegiatan ini merupakan kolaborasi Fakultas Kedokteran Universitas Mulawarman dengan masyarakat setempat menggunakan pendekatan edukatif dan partisipatif untuk meningkatkan keterlibatan program. Metode pelaksanaan meliputi sesi edukasi oleh dr. Setya Wardana, Sp.OG dengan materi "Risiko Stunting Periode Kehamilan" dan dr. Magdalena Rusady Goey, MRes, Sp.A dengan materi "Deteksi Gangguan Tumbuh Kembang Anak", talkshow interaktif, pelayanan kesehatan komprehensif, dan evaluasi program. Hasil menunjukkan partisipasi masyarakat tinggi dengan kehadiran mencapai target 50 orang. Sesi edukasi berhasil meningkatkan pemahaman tentang pentingnya asupan gizi adekuat selama kehamilan dan deteksi dini gangguan tumbuh kembang, dibuktikan melalui wawancara 12 peserta yang menyatakan paham dan puas dengan jawaban yang diberikan. Tingginya antusiasme terlihat dari banyaknya peserta yang hadir dan mengajukan pertanyaan pada sesi talkshow interaktif. Pelayanan kesehatan komprehensif memberikan manfaat langsung melalui pemeriksaan antropometri, konsultasi medis, dan pelayanan caregiver. Pelaksanaan kegiatan mencapai dua tujuan utama: pencegahan stunting tingkat desa melalui edukasi 1000 HPK dan menciptakan model replikatif untuk wilayah lain. Program ini relevan karena merupakan inisiatif perdana pencegahan stunting yang menargetkan periode 1000 HPK di wilayah tersebut.
Environmentally Friendly Larvicides: Comparison of Eleutherine bulbosa and Allium sativum Extracts against Aedes aegypti mosquito larvae Nuryanto, Muhammad Khairul; Duma, Krispinus; Fitriany, Evi; Tandirogang, Nataniel; Yulianti, Martina; Nurkhalisa, Nina; Rasendriya, Fauzan Firjatullah
Mulawarman International Conference on Tropical Public Health Vol. 1 No. 1 (2025): The 3th MICTOPH
Publisher : Faculty of Public Health Mulawarman University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background : Research has identified several plants that have potential larvicidal properties, notably Eleutherine bulbosa (Dayak onion) and Allium sativum (garlic), both of which are rich in flavonoids. Flavonoids are known insecticides, thus making these plants promising candidates to control mosquito populations and reduce the risk of dengue transmission. Objective : This study aims to evaluate the larvicidal efficacy of extracts from Dayak onion and garlic in lethal ovitraps. Research Methods/ Implementation Methods : This study used a true experimental design with a post-test only control group. The samples used were Aedes aegypti larvae. The independent variables were larvicidal concentrations of dayak onion and garlic (0.6%, 1.2%, 1.8%) and abate as positive control. The dependent variable was mosquito larvae mortality rate. The experiment was replicated four times. Mosquito larvae were monitored and examined at intervals of 10 minutes, 20 minutes, 30 minutes, 1 hour, and 24 hours. Results : The average mortality of Aedes mosquito larvae on exposure to Dayak onion is not better than exposure to garlic, with an average mortality of Dayak onion 0.6% (71%), 1.2% (87%) and 1.8% (75%). Meanwhile, the effectiveness of garlic was almost the same in the three concentrations tested, which was around 99-100%. Conclusion/Lesson Learned : The garlic used was highly effective in killing mosquito larvae, even at the lowest concentration (0.6%). These results show that garlic has the potential to be a stable and consistent larvicidal agent, effective at low doses without requiring an increase in concentration to increase effectiveness.
POTENSI PEMANFAATAN LIMBAH ORGANIK RUMAH TANGGA MENJADI PUPUK ORGANIK CAIR MELALUI PROSES FERMENTASI MENGGUNAKAN BIOAKTIVATOR EM4 Sormin, Hendro Jatmiko; Daniel, Daniel; Tandirogang, Nataniel
JURNAL KIMIA MULAWARMAN Vol 22 No 2 (2025)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v22i2.1212

Abstract

Desa Girimukti is a village of East Kalimantan, Penajam Paser Utara. According to data for 2021, a privately owned area of around 16,000 ha will have a population of 6,730 persons and 1,908 occupied homes. The rising creation of garbage, especially home organic waste, is being caused by a sizable population. If handled improperly, it will contaminate the environment. Utilizing fermentation to transform trash into liquid organic fertilizer is one solution that is possible. Study In order to produce liquid organic fertilizer, it is necessary to know the ideal ratio of organic waste to bioactivator as well as the best fermentation time to obtain the highest nutritional content. In this research, EM4, water, and sugar are added to a reactor that already has household organic waste present in the form of vegetables. In order to test the macronutrient content, which includes C-organic, N, P, K, and pH, samples were taken on days 5, 10, and 15 of the 15-day fermentation process. In this study, the addition ratio of EM4 to vegetable waste was 30:100, with a lengthy fermentation period of 10 days. This provided the finest liquid organic fertilizer. The best pH, C-organic content, N, P, and K contents are 11.99%, 4.45%, 5.54%, 4.8200%, and 6.82, respectively. The produced liquid organic fertilizer satisfies the requirements for quality of MOA 70 of 2011.
Co-Authors Abdullah, Yenny Adi Susanto Alhawaris, Alhawaris Anggraini, Fitria Dewi Puspita Arfian Deny Prakoso Azkiah, Wa Ode Nurul Bakhtiar, Rahmat Bilqis Faiqotun Nabilah Dilan Binti Khairunnisa Budi Santoso Nong Ulir Danial Danial Daniel Daniel Edy Wibowo Kurniawan Enih Rosamah Enjelina Febri Adi Melinia Enos Tangke Arung, Enos Tangke Evi Fitriany Fadilla, Shella Fikriah, Ika Harlinda Kuspradini Hary Nugroho Irawan Wijaya Kusuma, Irawan Wijaya Ivan Joalsen Mangara Tua Khairunnisa, Binti Khemasili Kosala Krispinus Duma Magdaleni Agustina Rahayu Marihot Pasaribu Meiliati Aminyoto Miftahul Jannah Moerad, Emil Bachtiar Ningrum, Yuliana Kartika Nur Khoma Fatmawati Nurkhalisa, Nina Nursaci Mardania Nurul Fatimah Nurul Khumaida Nuryanto, Muhammad Khairul Pramulia Yudia, Riries Choiru Rahmat Bakhtiar Rasendriya , Fauzan Firjatullah Rasendriya, Fauzan Firjatullah Rosamah, Enih Rudito Sapta Rahayuning Ratri Saputra, Rudi Septa Ariany Silvia Anitasari Sjarif Ismail Sormin, Hendro Jatmiko Sukemi Sukemi Suwadi Swandari Paramita Yadi Yadi Yadi Yadi Yasir Yadi, Yadi Yuliana Kartika Ningrum Yulianti, Martina Yundari, Yundari Yung Kang Shen Yuniati Yuniati