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All Journal Biospecies CHEMISTRY PROGRESS Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan Komunikasi Fisika Indonesia Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia Jurnal Geosaintek CHEMPUBLISH JOURNAL JOURNAL ONLINE OF PHYSICS Jurnal Geocelebes Eksakta : Berkala Ilmiah Bidang MIPA JURNAL METEOROLOGI DAN GEOFISIKA Jurnal Abdimas Mahakam Jurnal Bio-Geo Material Dan Energi Jurnal Riset Teknik Pertambangan Prosiding Seminar Nasional Pengabdian Kepada Masyarakat Jurnal Karya Abdi Masyarakat Jurnal Indonesia Sosial Teknologi Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA) Journal of The Indonesian Society of Integrated Chemistry Prosiding Seminar Nasional Unimus Jurnal Meteorologi dan Geofisika al Kimiya : Jurnal Ilmu Kimia dan Terapan Jurnal Geosaintek
Faizar Farid
Program Studi Kimia, Fakultas Sains Dan Teknologi , Universitas Jambi, Jl. Jambi – Muara Bulian Km. 15 36361, Jambi
Religion Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Nursing Physics Public Health Social Sciences Other

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Journal : Journal of The Indonesian Society of Integrated Chemistry

 1 
In Silico Study of Bioactive Compounds of Putat Leaf Extract (Planchonia valida) as Anti-Cancer Against the VEGFR2 Receptor Bela, Anisa; Farid, Faizar; Nelson; Dewi, Tribuana Tungga; Prabawa, Satria; Khatib, Alfi; Yusnaidar, Yusnaidar; Latief, Madyawati; Tarigan, Indra Lasmana
Journal of The Indonesian Society of Integrated Chemistry Vol. 16 No. 1 (2024): Journal of The Indonesian Society of Integrated Chemistry
Publisher : Pendidikan Kimia FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jisic.v16i1.32049

Abstract

Cancer is the process of forming new tissue that is abnormal and malignant. Efforts to discover anti-cancer drug compounds continue to be made to minimize the toxic effects of chemotherapy, so it is necessary to look for other alternatives to treat cancer. This research aims to determine the anti-cancer activity of putat plant bioactive compounds through identification of receptor targets and interaction studies using the molecular docking method against the VEGFR2 (Vascular endothelial growth factor receptor-2) receptor. The results showed that in the test of eight putat plant bioactive compounds the best results were obtained for the compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with a binding free energy value of -9.86 kcal-mol-1 with an inhibition constant value of 1.47 Micromolar. The best docking result has an inhibition constant value that is higher than the native ligand and has a binding free energy that is almost close to the binding free energy of the native ligand with an inhibition constant value of 42.38 Micromolar and a binding free energy value of 10.06 kcal-mol-1. Therefore, the results of the docking of the bioactive compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with the VEGFR-2 receptor are considered capable of being an alternative as a candidate for anti-cancer drugs.
Co-Authors -, Maison Afrianto, Muhammad Ficky Agnes Vionita Yohana Agus Syarif Alfi Khatib, Alfi Ali Nurdin Hidayat Arsa, Daniel Azira, Ayu Azril Bela, Anisa Br Sembiring, Vera Lorensya Daryati, Daryati Defia Indah Permatasari Denny Prabawa, Aditya Dewi, Tribuana Tungga Dhian Eka Wijaya Diah Riski Gusti Dwi Tata Damayanti Edwin Permana Edwin Permana Eka Nurshafni Erna Yustika Hutasoit Fandi Oktasendra Gusti, Diah Rizki Havizur Rahman Helga Dwi Fahyuan Helga Dwi Fahyuan Heriyanti Heriyanti Iful Amri Indra Lasmana Tarigan Intan Lestari Intan Lestari ira kusuma dewi Istiqomah Malinda Jesi Pebralia Juventa, Juventa Larasati, Nurrani Linda Handayani Madyawati Latief Mahraja, Mahra Mardian Peslinof Megakusuma, Yosha Mia Aina Muhammad Ikhsan Muhammad Ikrar Lagowa Nadea Arie Saragih Nelson Nelson Nelson Ngatijo Ngatijo Novianti Novianti Nurhidayah Nurhidayah Nurrani Larasati Oky Dwi Syaputra Prabawa, Satria Puspitasari, Ratih Dyah Putri Maya Sari Putri Maya Sari Putri, Silvi Ayudiah Rahman, Havizur Rahmat Basuki Ramadhan, Ilham Ifandi Resta, Ichy Lucya Restina Bemis Revis Asra Revis Asra Rikaldo Pratama Rikaldo Pratama Rustan Sampe Napitupulu Sampe Napitupulu Sampe Napitupulu, Sampe Samsidar Samsidar Samsidar Samsidar Samsidar Samsidar Samsidar Samsidar Samsidar Samsidar Samsidar Samsidar Saputra, Muhammad Furqon Novryan Sarinah Pakpahan Silaban, Desy Vania Sukor, Mohd Zaki Suwarni Suwarni Suwarni Suwarni Uce Lestari Uce Lestari Usna, Sri Rahayu Alfitri Wahyudi, Abdi Wahyudi, Lutfi Wibowo, Yudha Gusti Wiratama, Jarot Wiwid Joni Yohana, Agnes Vionita Yoza Fendriani Yuliawati Yusnaidar, Yusnaidar Zahar, Wahyudi