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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran Syiah Kuala Jurnal Kesehatan Andalas Berkala Ilmu Kesehatan Kulit dan Kelamin Buletin Ilmiah Nagari Membangun Jurnal Ners Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Bioscientia Medicina : Journal of Biomedicine and Translational Research Scientific Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) International Journal of Health and Pharmaceutical (IJHP) Jurnal Kesehatan Masyarakat Indonesia (JKMI) Prosiding Seminar Nasional Unimus Seroja Husada: Jurnal Kesehatan Masyarakat International Journal of Health and Medicine
Rina Gustia
Universitas Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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The 15-Year Shadow: Borderline Lepromatous Leprosy with Erythema Nodosum Leprosum Following Prolonged Treatment Default Rendra Darmasatria; Tutty Ariani; Yosse Rizal; Rina Gustia; Irdawaty Izrul
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1405

Abstract

Background: Leprosy, caused by Mycobacterium leprae, persists as a global health issue where the primary challenges are not merely microbial but are deeply rooted in delayed diagnosis and poor treatment adherence. These delays, often driven by profound social stigma, lead to progressive, irreversible disability and sustain community transmission. Erythema Nodosum Leprosum (ENL), an acute immunological complication, further devastates patients' quality of life and complicates management. Case presentation: A 53-year-old Indonesian farmer presented with a 15-year history of untreated leprosy, a journey of neglect initiated by fear of treatment side effects and community ostracism. Clinical examination revealed advanced borderline lepromatous (BL) leprosy with diffuse skin infiltration, multiple anesthetic plaques, and thickened, tender peripheral nerves. He had established WHO Grade 1 disability, characterized by significant sensory loss in his hands and feet and early intrinsic muscle atrophy. A slit-skin smear confirmed a bacteriological index of +3 with a morphological index of 5%, indicating a high load of viable bacilli. Histopathology confirmed BL leprosy with a concurrent mild ENL reaction. A comprehensive, patient-centered management plan was initiated, including a 12-month course of multidrug therapy (MDT-MB), adjunctive care, and intensive counseling. Conclusion: This case powerfully illustrates the "shadow effect" of leprosy—how years of untreated disease, fueled by psychosocial barriers, culminate in a complex nexus of advanced infection, immunological reaction, and permanent neurological impairment. The patient's successful re-engagement with the health system underscores that eradicating the burden of leprosy requires a paradigm shift from a purely pharmacological approach to a deeply humanistic one. Effective control hinges on building compassionate health systems that actively dismantle stigma, empower patients with knowledge, and deliver holistic, multidisciplinary care to prevent the profound human cost of neglect.
Nummular Dermatitis Masquerading as Recalcitrant Tinea Corporis: A Diagnostic Pitfall Resolved by Dermoscopy and Histopathology Rina Gustia; Deasy Archika Alvares; Mutia Sari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1406

Abstract

Background: The morphological mimicry between nummular dermatitis (ND) and tinea corporis represents a significant source of diagnostic error in clinical practice. This convergence on a similar clinical phenotype—the annular plaque—often leads to inappropriate antifungal therapy and a protracted, debilitating course for the patient, as powerfully illustrated in this case. Case presentation: We present the case of a 22-year-old female with a five-year history of chronic, recalcitrant, and intensely pruritic annular plaques on her lower legs, with a baseline pruritus score of 8/10 on a Visual Analog Scale (VAS). Previous treatments based on presumptive diagnoses, including potent topical corticosteroids and systemic antifungals, had failed. This report demonstrates a pivot from a morphology-based assessment to a multimodal diagnostic algorithm. The cornerstone of this shift was dermoscopy, which revealed patchy, irregularly distributed red dotted vessels—a classic signature of an eczematous process—and a notable absence of features suggestive of a dermatophyte infection. The diagnosis was confirmed by histopathology. A strong correlation between disease flares and psychosocial stressors was identified, and a holistic management plan targeting the cutaneous inflammation, the compromised skin barrier, and the neurogenic triggers led to a rapid and substantial improvement in her clinical status and quality of life, with the Dermatology Life Quality Index (DLQI) score decreasing from 9 to 3 and the pruritus VAS score dropping to 1/10. Conclusion: This case argues for a revised diagnostic paradigm for chronic annular lesions, one that de-emphasizes ambiguous morphology and prioritizes the integration of a detailed psychodermatological history with in-vivo microscopic analysis via dermoscopy. This approach not only prevents therapeutic futility but also underscores that successful, long-term management of ND is contingent upon a patient-centered strategy that addresses the interconnectedness of the skin barrier, the immune system, and the psycho-neuro-cutaneous axis.
Deciphering Activity in Early Facial Vitiligo: A Case Report Integrating Clinical, Wood's Lamp, and Dermoscopic Findings Rina Gustia; Mutia Sari; Afifah Alfyanita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1408

Abstract

Background: The management of non-segmental vitiligo hinges on accurately assessing disease activity to guide appropriate therapy. A clinical challenge arises in patients presenting with a low vitiligo area scoring index (VASI), suggesting limited disease, which may be discordant with underlying inflammatory activity, potentially leading to therapeutic inertia. Case presentation: A 34-year-old woman with Fitzpatrick skin type III presented with a two-month history of rapidly progressing facial vitiligo, preceded by an erythematous phase. Despite a low VASI score of 1, the patient-reported vitiligo disease activity (VIDA) score was +4. Dermoscopy was instrumental, revealing definitive in-vivo evidence of inflammation and instability, including a pinkish background, telangiectasias, and a reversed pigment network. Based on this discordance between disease extent and activity, a multi-modal therapeutic regimen was initiated. A six-month follow-up demonstrated disease stabilization and significant perifollicular repigmentation, with resolution of the inflammatory dermoscopic signs. Conclusion: This case report illustrates the critical importance of an integrated diagnostic approach that moves beyond area-based assessment. It highlights how dermoscopy, when used to resolve the clinical paradox of low-extent but high-activity disease, can serve as an objective biomarker to justify timely and robust immunomodulatory intervention. This approach is crucial for altering the disease trajectory and optimizing patient outcomes.
Hubungan Pola Penggunaan Hand Sanitizer dengan Kejadian Dermatitis Tangan Pada Mahasiswa Program Studi Kedokteran Fakultas Kedokteran Universitas Andalas Zafira, Qory; Akhyar, Gardenia; Rustam, Erlina; Julizar, Julizar; Gustia, Rina; Afdal, Afdal
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 1 (2024): Maret 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i1.1046

Abstract

Latar Belakang: Pandemi Covid-19 membuat masyarakat menjalankan pola hidup baru dengan menerapkan protokol kesehatan dengan membersihkan tangan menggunakan hand sanitizer. Hand sanitizer diformulasikan untuk dapat menghambat dan membunuh mikroorganisme dengan cara mendenaturasi lipid, namun efek dari cara kerjanya ini dapat meningkatkan risiko terjadinya dermatitis tangan. Objektif: Penelitian ini bertujuan untuk mengetahui hubungan pola penggunaan hand sanitizer dengan kejadian dermatitis tangan. Metode: Penelitian ini merupakan penelitian analitik observasional dengan metode cross-sectional study dengan teknik simple random sampling pada mahasiswa Program Studi Kedokteran Fakultas Kedokteran Universitas Andalas Angkatan 2021 dengan jumlah sampel sebanyak 80 orang. Data responden diperoleh dari kuesioner dan dianalisis menggunakan uji chi square. Hasil: Hasil penelitian ini didapatkan sebagian besar mahasiswa menggunakan hand sanitizer lebih dari 6 bulan (82,5%) dengan frekuensi 1 sampai 5 kali dalam sehari (86,3%). Lebih dari setengah mahasiswa menggosok tangan kurang dari 10 detik setiap menggunakan hand sanitizer (75%), dan tidak menggunakan pelembab (57,5%). Sebagian besar mahasiswa tidak mengalami dermatitis tangan (77,5%) dan tidak memiliki riwayat atopi (80%). Tidak terdapat hubungan yang signifikan antara durasi penggunaan, frekuensi penggunaan, durasi scrubbing penggunaan hand sanitizer dan penggunaan pelembab dengan kejadian dermatitis tangan dengan nilai p=0.599 untuk durasi penggunaan, p=0.086 untuk frekuensi penggunaan, p=1.00 untuk durasi scrubbing, dan p=0.316 untuk penggunaan pelembab. Terdapat hubungan antara riwayat atopi dengan kejadian dermatitis tangan dengan nilai p=0,000. Simpulan: Tidak terdapat hubungan yang signifikan antara pola penggunaan hand sanitizer dengan kejadian dermatitis tangan khususnya durasi penggunaan, frekuensi, dan durasi scrubbing dan penggunaan pelembab, namun terdapat hubungan antara riwayat atopi dengan kejadian dermatitis tangan. Kata kunci: Pola penggunaan hand sanitizer, dermatitis tangan
Correlation Between C-Reactive Protein Level and Outcome In Coronavirus Disease 2019 Patients At COVID Intensive Care Unit RSUP. Dr. M. Djamil Padang Putri Ariani; Dedy Kurnia; Malinda Meinapuri; Rudy Afriant; Rina Gustia; Rikarni; Rinal Effendi
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 11 No. 3 (2023): Jambi Medical Journal: Jurnal Kedokteran dan Kesehatan Special Issues: Jambi M
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v11i3.25078

Abstract

Background: Coronavirus Disease 2019 (COVID-19) is a respiratory system disease transmitted to humans and has infected humans in almost every country. Plasma cytokine levels, such as C-reactive protein (CRP), are elevated inflammatory markers in most COVID-19 patients and are routinely examined, especially in the intensive care Unit (ICU). Elevated CRP levels are associated with higher rates of severity and death. Objective: This study aimed to determine the correlation between CRP levels and outcomes in COVID-19 patients at COVID ICU RSUP. Dr. M. Djamil Padang Period July – December 2021. Method: This research was conducted using by analytic observational method with a retrospective cohort design. Secondary data was collected from the medical records of COVID-19 patients treated in the ICU COVID RSUP. Dr. M. Djamil Padang from July – December 2021, using total sampling as a technique, 107 samples met the inclusion criteria. Data analysis was carried out using univariate and bivariate methods. Result: The result shows more male patients (51.4%) than women (48.6%). From the age range, most age was found in the range > 59 years (54.2%). The most common type of comorbid disease was diabetes (32.7%). The highest CRP level at the initial ICU admission was >160 mg/L (70.1%), and the highest ferritin level was >434 ng/mL (86.0%). The most common patient outcome was death (65.4%). There is a relationship between CRP levels (p = 0.029) and the outcome of COVID-19 patients in the COVID ICU. Conclusion: This study concludes that there is a correlation between C-Reactive Protein (CRP) levels and Outcomes in COVID-19 patients at COVID ICU RSUP. Dr. M. Djamil Padang Period July – December 2021. Keywords : COVID-19, CRP, Patient Outcome, ICU
Advantages of Using an Air Purifier for the Control of Atopic Dermatitis Nagara, Adianto Jaya; Rina Gustia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 4 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i4.961

Abstract

Numerous studies have been carried out to ascertain the detrimental impact of air pollution on allergy conditions such as asthma, allergic rhinitis, and atopic dermatitis. Substandard indoor air quality exacerbates atopic dermatitis, which can be attributed to several reasons. Proper air circulation is crucial in households, especially in areas with high foot activity, since it can lead to elevated amounts of air contaminants entering the space. Indoor air pollutants, such as house dust mites, volatile chemical compounds, particle matter, and indoor mold, can aggravate atopic dermatitis. An air purifier effectively enhances the quality of indoor air. This gadget offers significant advantages for those with atopic dermatitis by effectively mitigating the frequency and intensity of disease relapses.
The Impact of COVID-19 Pandemic on Vitiligo Patient Visits in Tertiary Hospital: A Retrospective Study Rina Gustia; Utama, Redha Cipta
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 5 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i5.992

Abstract

Background: Vitiligo, a common depigmenting skin disorder, has an estimated prevalence of 0.5–2% of the population worldwide. The COVID-19 pandemic lockdown measures significantly affected the readiness of vitiligo patients to contact dermatologists. The aim of this study is to describe vitiligo patient visits during a pandemic situation. Methods: A retrospective descriptive study, using secondary data obtained from Dr. M. Djamil General Hospital Padang medical records during the period of 2019–2021. Results: During the pandemic (2020-2021), a total of 7 in 2020 and 19 in 2021 new vitiligo patient have been consulted. The ratio of male/female for two years was 16/10. The age of group 26-24 years had more frequently visited. A total 6 patients had segmental vitiligo and 16 patients had non segmental vitiligo. A total 4 patient had unstable vitiligo. During the pandemic, there were various vitiligo therapy such as oral and topical corticosteroid, topical immunomodulator, phototherapy, and punch grafting surgery. Compare to before the pandemic situation in 2019, a total 25 new vitiligo patient have been consulted in our outpatient clinic. Compared to 2019, the number of visits decrease significantly 72% in 2020 and 24% in 2021. Conclusion: The pandemic COVID-19 had an unprecedented impact on number of vitiligo patient visits to the tertiary hospitals. This condition may affect visits and patient compliance. There were significant reductions in the number of outpatient visits due to pandemic COVID-19.
A Multidisciplinary Approach to Managing Multiple Tuberous Xanthomas in a Pediatric Patient with Familial Hypercholesterolemia Type II: A Rare Case Clarissa Maharani Putri; Rina Gustia; Ennesta Asri; Mutia Sari; Indah Indria Sari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 3 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i3.1214

Abstract

Background: Familial hypercholesterolemia (FH) is a rare inherited disorder characterized by high cholesterol levels, primarily high levels of low-density lipoprotein cholesterol (LDL-C). This condition can lead to premature cardiovascular disease. A less recognized but significant manifestation of FH is the development of multiple tuberous xanthomas, which are exogenous masses or fatty deposits on the skin. Case presentation: This report describes the case of a 4-year-old female child who presented to the Dermatology, Venereology, and Aesthetics Department of Dr. M. Djamil General Hospital Padang with multiple yellowish, painless, and non-itchy lumps on her body. These lumps were located on her knuckles, hands, elbows, buttocks, knees, back of knees, ankles, and feet. The lumps had been progressively increasing in size over the past month. Her medical history revealed that she first developed a yellowish lump on her right ankle two years prior, which gradually spread to other areas of her body. A dermoscopic examination showed a yellow-brown structureless area, and laboratory tests confirmed hypercholesterolemia with elevated LDL levels. Her triglycerides were normal, and both of her parents also had hypercholesterolemia. A histopathology examination confirmed the diagnosis of xanthoma. The patient was diagnosed with tuberous xanthomas and treated with simvastatin 1x10 mg, along with surgical excision of the xanthomas and flap reconstruction under general anesthesia. Conclusion: This case highlights the importance of a multidisciplinary approach in managing multiple tuberous xanthomas in a child with FH. While surgical excision can effectively remove the lesions, ongoing lipid-lowering therapy is crucial to prevent recurrence and reduce cardiovascular risks associated with FH. Collaboration among dermatologists, pediatric cardiologists, and pediatric nutritionists is vital to ensure comprehensive care and enhance the patient's overall quality of life.
Early-Onset Urticaria Pigmentosa in a 7-Month-Old Infant: A Case Report Nellia Fonna; Mutia Sari; Rina Gustia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 3 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i3.1218

Abstract

Background: Urticaria pigmentosa (UP) is the most common form of cutaneous mastocytosis in children, accounting for 70-90% of cases. UP typically presents in infancy or early childhood with characteristic skin lesions that vary in appearance. The hallmark of UP is the presence of reddish-brown macules or papules that urticate or blister upon rubbing, a phenomenon known as Darier's sign. Histopathological examination of a skin biopsy is confirmatory, demonstrating an increased number of mast cells in the dermis. Case presentation: We report a case of early-onset UP in a 7-month-old infant boy who presented with multiple hyperpigmented macules all over his body. The lesions were pruritic and had progressively increased in size and number over the past two weeks. Dermatological examination revealed multiple erythematous macules on the face, hyperpigmented macules on the chest, abdomen, and extremities, hyperpigmented plaques on the legs, and a nodule on the back. The lesions exhibited a positive Darier's sign, characterized by swelling and redness upon rubbing. Systemic examination was unremarkable, with no evidence of hepatomegaly, splenomegaly, or lymphadenopathy. Dermoscopy of the lesions revealed a central pigment network and a light brownish peripheral structure, suggestive of UP. Histopathological examination of a skin biopsy confirmed the diagnosis of UP, demonstrating an increased number of mast cells in the dermis. The patient was treated with oral antihistamines (cetirizine) and topical corticosteroids (hydrocortisone) for four weeks, resulting in significant regression of the lesions. Conclusion: This case highlights the importance of recognizing the clinical features of UP in infants. Early diagnosis and appropriate management can help alleviate symptoms and improve the quality of life for affected children.
Role Essential Oils In Hair Growth Cherry Chalik; Rina Gustia
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.40822

Abstract

The use of essential oils has begus to be in great demand in the community, both for health purposes and in cosmetic ingredients. Essential oils are natural active ingredients containing various growt hcomplex chemical components and unique compounds. Several studies have begun to research the benefits of the bioactive ingredients in essential oils on hair growth. The benefits of essential oils that have begun researched are the stimulating effect of the hair growth. The existence of various components and active ingredients in essential oils requires further studies regarding the mechanism of action and how essential works in growing hair.
Co-Authors Abdiana Abdiana, Abdiana Afdal Afdal, Afdal Afifah Alfyanita Afifah Alfyanita Afriwardi Afriwardi Agusti Nala Sari Agustin Vira Agustin Vira Aisyah Elliyanti Alfaridzi, Yudi Fadil Alifya Rafifah Tarwandi Amelia Rahayu Andrini Ariesti Andrini Ariesti Anisa Persia Anum, Qaira Ariani, Tutty Arina Widya Murni Ashal, Taufik Ashar, Miranda Asri, Ennesta Asri, Rizkia Chairani Astria Rima Rara Yuswir Astria Rima Rara Yuswir Aswiyanti Asri Avit Suchitra Azaria Ramadhani Zulkifli Cherry Chalik Clarissa Maharani Putri Deasy Archika Alvares Deasy Archika Alvares Dedy Kurnia Dia Rofinda, Zelly Dia Dian Pertiwi Dina Arfiani Rusjdi Dwi Sabtika Julia Dwitya Elvira Dzakiyyah, Adzristi Zahrah Edison Edison Eliza Anas Elizabeth Bahar Ellyza Nasrul Elmatris Sy Ennesta Asri Ennesta Asri Ennesta Asri Erlina Rustam Fadila Esmeralda Ilmi Farhanah, Nindya Fesdia Sari Firdawati Firdawati Gardenia Akhyar Habib El Binampiy Busnia Hafizah Putri Tasyah Hendriati, Hendriati Herman, Deddy Hersa Firda Kartika Hifzil Husni Ilahi, Fitratul Imaduddin, Ummul Khair Indah Indria Sari Indah Indria Sari Intan, Shinta Ayu Irdawati Izrul Irdawaty Izrul Irdawaty Izrul Jefrizal Wirman Jefrizal Wirman Jessica Herlianez Saiful Julita Julita Julita Julita Julizar Julizar Julizar Julizar Kemala Sayuti Laras Surakusuma Linosefa Linosefa Malinda Meinapuri Mardhiati Mardhiati Miftah Irrahmah Millenia Calista Muchyar, Mutia Sari Muflihati Nurzain Mutia Sari Mutia Sari Mutia Sari Mutia Sari Mutia Sari Nagara, Adianto Jaya Nellia Fonna Nolanda Trikanti Novian Novian Novian Novian Novita Ariani Oktora, Meta Zulyati Putra, M Firas Riselo Putri Ariani Putri Sabila Hidayat Rahmatini . Rauza Sukma Rita Rendra Darma Satria Rendra Darma Satria Rendra Darmasatria Rendra Darmasatria Reza , Mohamad Rika Desviorita Rika Desviorita Rikarni Rinal Effendi Rini Gusya Liza, Rini Gusya Riri Prima Yolanda Rizki Dwayana Rizki Dwayana Rudy Afriant Russilawati, Russilawati Sari Yunita M Sari, Indah Indria sari, Mutia Satya Wydya Yenni Satya Wydya Yenny Sigya Octari Sri Lestari Taria, Sari Almira Tisa Hamzany Tofrizal Tutty Ariani Tutty Ariani Utama, Redha Cipta Vitresia, Havriza Yenni Raflis Yevri Zulfiqar Yola Fadilla Yosse Rizal Yosse Rizal Yossy, Vesri Yufaz Aidi Mahesa Yulistini, Yulistini Yusticia Katar Zafira, Qory