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All Journal HAYATI Journal of Biosciences Medical Journal of Indonesia Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Oceana Biomedicina Journal Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Griya Journal of Mathematics Education and Application Narra J

Usman Hadi

Dept. Of Internal Medicine School Of Medicine Airlangga University/Dr. Soetomo Hospital

Author-ID : 272288

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Effector function and neutrophil cell death in the severity of sepsis with diabetes mellitus Margalin, Brilliant; Arfijanto, Muhammad V.; Hadi, Usman
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.532

Sepsis, a life-threatening condition resulting from immune dysregulation, is typically triggered by bacterial infections and commonly coexists with diabetes mellitus. Neutrophils are the first responders to infection and require regulated activation to control pathogen and damage-associated molecular patterns. Dysregulation of neutrophil activation leads to uncontrolled inflammatory responses, often observed in both sepsis and diabetes patients. Neutrophil dysregulation, characterized by effector dysfunction and inadequate cell death processes, can serve as a biomarker for assessing sepsis severity, particularly in diabetic patients. This review article provides information on the relationship between effector function, neutrophil cell death, and the severity of sepsis in individuals with diabetes mellitus, aiming to shed light on the mechanisms underlying sepsis progression. Topics covered in the review include an overview of effector function of neutrophil cells, mechanisms of neutrophil cell death, and dysregulation of effectors and neutrophil cell death processes in sepsis severity with diabetes mellitus.

Association Between Neopterin Levels and Outcome in 30 Day HIV/AIDS Naive Patients Juanita, Lydia; Hadi, Usman; Arfijanto, Vitanata
Biomolecular and Health Science Journal Vol. 2 No. 2 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: HIV/AIDS is still a major problem throughout the world even in Indonesia. Some markers can provide information regarding the description of immune activity in HIV/AIDS. Neopterin produced by macrophages as a catabolic result of Guanosine Triphosphate (GTP) is one of them. Neopterin has been widely studied as a prognostic indicator of the course in HIV/AIDS. Until now there have been no studies examine the association between neopterin levels and outcomes in 30 days of HIV/AIDS patients.Methods: A prospective longitudinal analytic study involved 56 samples of HIV/AIDS naive patients from January to April 2019. Serum neopterin levels were measured by the Enzyme Linked Immunosorbent Assay (ELISA) method. Outcome is a living condition or death within the first 30 days of the patient being treated. Discriminant function analysis was used to determine the association between variable and controlling confounding factors using the "R" program. Outputs of p value was significant if <0.05.Results: The average age of the study subjects was 39.7 ± 11 years old with predominantly male gender (71.4%). The median serum neopterin level of the study subjects was 168.13 nmol/L with the lowest levels of 11.78 nmol/L and the highest level of 196.95 nmol/L. Outcomes were grouped live and died, each group at 50%. There was a significant positive association between serum neopterin levels and outcomes in 30 days (p=0.02)Conclusion: Role of neopterin levels still need to be proven as a prognostic factor by evaluating other factors that influence the outcome of HIV/AIDS patients.

Correlation of Population and Environmental Behavior with Rat Density Rate in Plague Disease-Focus, Threatened and Safe Areas in Tutur District, Pasuruan Regency, 2016 Lestari, Evi Noerista; Andajani, Susilowati; Hadi, Usman
Folia Medica Indonesiana Vol. 55 No. 4 (2019): December
Publisher : Universitas Airlangga

Plague disease remains a public health problem in the world. According to the International Health Regulations (IHR), an outbreak is an infectious disease that has the potential to cause an outbreak. The purpose of this study was to analyze a significant relationship between human behavior and the environment with the density of the number of rats in the focus, threatened and outbreak-safe areas in Tutur Regency, Pasuruan Regency, in 2016. This was an observational analytic study with cross correlation sectional where the research variables are population behavior, environment, and the number of rat densities observed once at a time. The results showed that there was no significant relationship between the behavior (knowledge, attitude, and practice) of the population with the density of rats in the focus area of the Surorowo hamlet outbreak, in the endangered outbreaks of the Ngaro hamlet, and in the outbreak-safe area of the North Ngandong hamlet in Tutur District. Whereas, there is a significant relationship between environmental conditions and the amount of rat density in the focus area of the outbreak of the Surorowo hamlet (p: 0.047 or p <0.05), the threatened area of the Ngaro hamlet (p: 0.036 or p <0.05), and at outbreak-safe areas in Andong Utara hamlet (p: 0.047 or p <0.05). Conclusion: Environmental conditions are associated with the amount of rat density either in the outbreak, in focus, threatened, or in safe areas. That it is necessary to control environmental risk factors to reduce the amount of rat density.

Quantity of Antibiotic Use and Resistance Pattern of Gut Normal Flora Escherichia coli at Intensive Care Unit and Tropic Infection Ward, Dr Soetomo Hospital, Surabaya, Indonesia Sholeh, Mohammad Akbaruddin; Kuntaman, Kuntaman; Hadi, Usman
Folia Medica Indonesiana Vol. 56 No. 3 (2020): September
Publisher : Universitas Airlangga

Resistance to antibiotics is increasing worldwide, including in Indonesia. The use of antibiotics is the most common cause of microorganism resistance. Individuals who received antibiotic therapy impacton changes of normal micro-flora resistance through selective pressure. This study aims to analyze the relationship of the quantity of antibiotic use with the pattern of resistance of gut normal flora Escherichia coliamong patients in Intensive Care Unit (ICU) and Tropic Infection Ward, Dr. Soetomo Hospital, Surabaya. This study was cross-sectional design with 64 samples (32 the ICU and 32 in Tropic Infection Ward). The total sample were collected for three Months. Identification of intestinal microflora was done with McConkey differential selective medium, followed by IMViC biochemical test, and sensitivity test by antibiotic disc diffusion method. Data were analyzed with Chi square test and Fisher'sExact test. There was no significant difference (p=0.441) in the quantity of antibiotic use between ICU and Tropic Infection Ward. There was no significant difference (p>0.05) in normal intestinal flora Escherichia coli resistance pattern between Tropic Infection Ward and ICU against12 types of antibiotics. Ceftriaxone was the most widely used antibiotic in the Tropic Infection Ward of 54 DDD and ICU of 100 DDD. The highest percentage of intestinal flora Escherichia coli resistance at the ICU was ceftriaxone as manyas 18 (56.3%) and at Tropic Infection Ward on ciprofloxacin and levofloxacin 20 (62.5%). The other study in Primary Health center, showed that theresistance rates of both wards were significantly different as compared to intestinal flora of patients in primary health center (p <0.001), in whichthe use of antibiotics in primary health center was also lower (1.6 DDD). There was no significant difference (p>0.05) The pattern of bacterial resistance between patient with and without antibiotic use at Tropic Infection Ward and ICU Conclusion: the quantity of antibiotic use was not significantly different against resistnt gut flora between patients in ICU and Tropic Infection ward. The pattern of bacterial resistance between patient with and without antibiotic use was also not significantly different.

Pengaruh Model Pembelajaran Kooperatif Tipe TGT berbantuan Quizizz Terhadap Kemampuan Literasi Matematis Siswa Hadi, Usman; Hayati, Laila; Novitasari, Dwi; Sripatmi, Sripatmi
Griya Journal of Mathematics Education and Application Vol. 5 No. 2 (2025): Juni 2025
Publisher : Pendidikan Matematika FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/griya.v5i2.615

This study aims to determine the effect of the cooperative learning model, specifically the Teams Games Tournaments (TGT) type assisted by Quizizz, on the mathematical literacy skills of 11th-grade students at MAN 1 Mataram in the academic year 2024/2025. This research is a quasi-experimental study using a posttest-only control group design. The population consisted of three 11th-grade science classes with a total of 118 students, and the sample included two classes: XI IPA 1 as the control group, which received direct instruction, and XI IPA 2 as the experimental group, which received the TGT model assisted by Quizizz. The sampling technique used was cluster random sampling. Data were collected through a mathematical literacy skills test administered after the intervention and were analyzed using normality and homogeneity tests. Based on the results, a non-parametric test chi-square test was employed along with the calculation of the effect size. The findings showed a difference in the average scores between the control group (49) and the experimental group (78), indicating the influence of the TGT model assisted by Quizizz on students' mathematical literacy. The effect size value of d = 0.465 falls within the medium category, suggesting a moderate impact. Therefore, the TGT cooperative learning model assisted by Quizizz contributes positively to enhancing students' mathematical literacy, particularly in function-related topics such as trigonometry, logarithms, and algebra. Future studies are recommended to further explore the implementation of this model across different educational levels, subject matter, and broader learning contexts.

Co-Authors Agung Dwi Wahyu Widodo Agus Santosa Agus Santosa Agustinus Vincent Arfijanto, Muhammad V. Arfijanto, Vitanata Aryati , Aryati Aryati Aryati Aryati Aryati Benediktus Yohan Bramantono Bramantono, Bramantono Didik Hasmono Djazuly Chalidyanto Dwi Novitasari Eddy Soewandojo Eko Budi Koendhori, Eko Budi Erni J. Nelwan, Erni J. Erni Juwita Nelwan, Erni Juwita Erwin Astha Triyono Florentina Sustini Gondo Mastutik Hardiono Hardiono, Hardiono Hari Paraton Haryo N. Yahya Hidajat, Boerhan Insani Budiningsih Iqhrammullah, Muhammad Ismi Masyithah Jaap M. Middeldorp Juanita, Lydia Kuntaman Kuntaman Laila Hayati, Laila Lestari, Evi Noerista Margalin, Brilliant Margyaningsih, Nur Ita Marinda Dwi Puspitarini Mariyatul Qiptiyah, Mariyatul Masyeni, Sri Muchlis AU Sofro Muhammad Miftahussurur Muhammad Vitanata Arifijanto Nenci Siagian Nurul Ma'rifah P. Fans Pathak, Yashwant Prihartini Prihartini Purnomo, Windu R. Tedjo Sasmono Ronald Pratama Adiwinoto Sasmono, R. Tedjo Sholeh, Mohammad Akbaruddin Sofro, Muchlis AU Sofro, Muchlis AU. Sri Masyeni, Dewa Ayu Putri Sripatmi Sripatmi, Sripatmi Suci Andriani Sugiyatmi, Tri A. Suharto Suharto Susilowati Andajani, Susilowati Wahyu Setyarini Windu Purnomo Yoes Prijatna Dachlan Yohan, Benediktus

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