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All Journal HAYATI Journal of Biosciences Indonesian Journal of Tropical and Infectious Disease Sari Pediatri Jesya (Jurnal Ekonomi dan Ekonomi Syariah) Oceana Biomedicina Journal Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Griya Journal of Mathematics Education and Application Narra J Folia Medica Indonesiana
Usman Hadi
Dept. Of Internal Medicine School Of Medicine Airlangga University/Dr. Soetomo Hospital
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health

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Influence of Employee Relationship Unit on Team Intention:A Case Study in Implementation of Patient Safety Program Heru Suswojo; Usman Hadi; Widodo Jatim Pudjirahardjo; Fendy Suhariadi; Agung Dwi Laksono
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15792

Abstract

Incidencesregarding patient safety still occur,and not all are reported to the Hospital Patient SafetyCommittee. The aim studyto analyze the employee relationship influences the work unit staff’s intention inimplementingthe patient safety program—the study was conducted bythe quantitative design of observationalanalytics and through a cross-sectional staff approach. The research sites includedSidoarjo Regional Hospital,Anwar Medika Sidoarjo Hospital, and Ahmad Yani Surabaya Islamic Hospital. The research collects dataduring May–July 2019. The variables consist of employee relationship as the independent variable andintention as the dependent variable. The results show that the development stage’s employee relationshipwas broadly establishing (46.51%), whereas, for the relationship stage, it was a majority of trusts (72.09%).The source intention stage was mostly personal intention(62.79%), and at the intention level, most of thedistal intention was 84.88%. The leadership type affects theworking unit staff’s discretionto implementpatient safety programs in hospitals, with employee relationships as a variable mediator.The study concludedthat the employee relationships had a significant influence on the working unit staff’s intention in hospitalsto carry out patient safety programs. However,employee relationships affect the work unit staff’s intentionto carry out the patient safety program.
A Patient with AIDS and Embolic Stroke: A Case Report Troy Fonda; Usman Hadi
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15828

Abstract

Human immunodeficiency virus (HIV) infection is a global concern. Globally, 36.7 million people areliving with HIV and 1 million people died at the end of 2016. There is an association between humanimmunodeficiency virus (HIV) infection with neurological manifestations. Between 1% and 5% of patientswith HIV develop stroke. The pathogenesis of AIDS with stroke is still controversial. A 37-year-old malepatient with AIDS had an embolic stroke. The diagnosis of the patient was based on clinical condition andthe CT scan results of the head with contrast. The stroke-causing mechanism in patients is HIV-associatedvasculopathy that results from accelerated atherosclerosis. After administration of antiplatelet and statin, thepatient’s condition improves.
Penurunan Penggunaan Antibiotik pada Pasien Anak dengan Demam M.M. Hapsari; Helmia Farida; Monique Keuter; P.J,van den Broek; Usman Hadi; Herawati Y; Anggoro DB Sachro
Sari Pediatri Vol 8, No 1 (2006)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (108.575 KB) | DOI: 10.14238/sp8.1.2006.16-24

Abstract

Latar belakang. Resistensi antibiotik saat ini menjadi problem dunia yang mencemaskan.Penggunaan antibotik secara berlebihan dan tidak rasional merupakan kontributor utamaterjadinya resistensi antibiotik. Upaya mengubah pola peresepan antibiotik menjadi lebihrasional merupakan hal yang tidak mudah.Tujuan. Memperbaiki kuantitas dan kualitas penggunaan antibiotik pada pasien yangdirawat dengan demam, serta mengevaluasi dampak terhadap morbiditas dan mortalitas.Metoda. Penelitian prospektif intervensi di bangsal anak RS Dr Kariadi, Juli 2003 -Desember 2004, dibagi menjadi 4 periode yaitu periode awal, penyusunan pedoman,pelatihan, dan umpan balik. Pada periode awal dilakukan pengambilan data dasar. Padaperiode penyusunan pedoman dilakukan konsensus untuk menyusun pedoman penggunaanantibiotik pada anak dengan demam. Periode pelatihan adalah sosialisasi dan pelatihankepada dokter. Pada periode pascapelatihan dilakukan umpan balik terhadap pesertapelatihan. Subyek penelitian adalah semua pasien usia >1 bulan yang dirawat dengandemam> 38ºC (rektal) dalam 24 jam pertama perawatan, kecuali yang diketahui menderitaHIV/AIDS atau neutropeni karena kemoterapi. Data penggunaan antibiotik diambil daricatatan medik, diamati selama 6 hari pertama perawatan. Data morbiditas dan mortalitasdiamati sampai pasien keluar dari rumah sakit. Uji statistik menggunakan X 2 dan Anova.Hasil. Terdapat penurunan kuantitas penggunaan antibiotik dan peningkatan kualitaspenggunaan antibiotik secara bermakna (p=0.000 dan p=0,000). Penurunan kuantitasantibiotiok terutama disebabkan pengurangan penggunaan antibiotik yang tidakdiperlukan. Tidak terdapat perbedaan lama rawat dan lama demam (p=0.96 dan p=0.32)dan tidak terdapat perbedaan kematian selama periode pengamatan.Kesimpulan. Dengan pedoman yang baik, penggunaan jumlah antibiotik dapatditurunkan tanpa meningkatkan risiko morbiditas dan mortalitas.
Ventilator-Associated Pneumonia in Dr. Soetomo General Hospital Surabaya Ismi Masyithah; Usman Hadi; Eko Budi Koendhori
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 12 No. 2 (2021): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V12I22021.57-60

Abstract

Introduction: Ventilator-associated pneumonia (VAP) is one of the most common nosocomial infections in the intensive care unit (ICU). Mechanically, ventilated patients have a higher risk of VAP. VAP can increase morbidity, mortality, and treatment costs. However, Indonesia lacks data about VAP. The objective of this study was to find out the characteristics of VAP in Dr. Soetomo General Hospital, Surabaya, in the period of August 2017 until August 2018.Methods: This was a cross-sectional study by assessing medical records of the patients in ICU. The variables observed in this study were age, gender, outcome, length of stay in the ICU (LOSICU), and primary diagnosis. The inclusion criteria were the patients who have been using mechanical ventilation at least 2 x 24 hours in the ICU and confirmed VAP. The data were analyzed descriptively by using Microsoft Excel 2016.Results: A total of 18 VAP patients were diagnosed. VAP patients were dominated male (55.6%). The mean of LOSICU was 22.83 ± 11.24 days, and the mortality rate of VAP patients was high (55.6%). 30% of VAP patients had Guillain-Barre Syndrome (GBS) as the primary diagnosis, and 16.65% had Congenital Heart Disease (CHD).Conclusion: Most VAP patients were male and had prolonged stays. The mortality rate of VAP patients was still high. GBS was the most frequent of primary diagnoses in patients with VAP and also CHD.
ANALYSIS OF DENGUE SPECIFIC IMMUNE RESPONSE BASED ON SEROTYPE, TYPE AND SEVERITY OF DENGUE INFECTION Ade Rochaeni; Aryati Aryati; Puspa Wardhani; Usman Hadi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 3 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i3.1199

Abstract

Infeksi Virus Dengue (IVD) menimbulkan derajat klinis beragam dari DD hingga DBD/SSD. Respons imun spesifik dengue berupaIgM dan IgG anti dengue masih merupakan perdebatan untuk patogenesis DBD di samping faktor virulensi virus dan jenis infeksi.Penelitian ini bertujuan untuk menganalisis respons imun spesifik dengue terhadap serotipe, jenis dan derajat IVD di Surabaya. Subjekadalah pasien IVD yang dirawat di Ruang Tropik Infeksi Penyakit Dalam RSUD Dr. Soetomo dengan hasil penyaringan uji cepat NS1 (SDBioline Dengue Duo) dan/atau PCR (Simplexa Dengue) positif. Pemeriksaan IgM dan IgG anti dengue kuantitatif dengan metode ELISA(Panbio Dengue Duo IgM and IgG Capture). Penelitian dilakukan Maret–Agustus 2016 dan didapatkan 61 pasien dengan hasil NSI dan/atau PCR dengue positif. Identifikasi serotipe didominasi DEN-3, namun serotipe yang lebih virulen ditunjukkan DEN-1 yaitu semuapasien bermanifestasi sebagai infeksi sekunder dan DBD. Jenis infeksi primer sebanyak 19 (31,1%) dan infeksi sekunder 42 (68,9%).Derajat IVD meliputi DD 10 (16,4%), DBD 47 (77%) dan SSD 4 (6,56%). Nilai indeks rerata IgM dan IgG anti dengue di kelompokinfeksi serotipe DEN-1 (5,140 dan 5,774), DEN-2 (2,971 dan 2,222), DEN-3 (1,863 dan 2,792); kelompok jenis infeksi primer (1,478 dan0,746), sekunder (4,028 dan 4,864) dan kelompok derajat DD (1,170 dan 1,492), DBD I (3,370 dan 3,651), DBD II (3,924 dan 4,439)dan DBD III (4,164 dan 4,243). Sebagai simpulan respons imun spesifik dengue didapatkan lebih tinggi bermakna di kelompok infeksiserotipe DEN-1, kelompok jenis infeksi sekunder dan kelompok DBD/SSD.
IDENTIFICATION OF DENGUE VIRUS SEROTYPES AT THE DR. SOETOMO HOSPITAL SURABAYA IN 2016 AND ITS CORRELATION WITH NS1 ANTIGEN DETECTION Jeine Stela Akualing; Aryati Aryati; Puspa Wardhani; Usman Hadi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 2 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i2.1138

Abstract

Serotipe virus dengue yang beredar terus mengalami perubahan dan berbeda di setiap daerah. Pergeseran serotipe maupun genotipedi dalamnya, mempengaruhi terjadinya wabah dengue di berbagai negara. Perbedaan serotipe diduga bernasab dengan deteksi antigen(Ag) non-structural 1 (NS1), namun belum banyak penelitian yang mendukung hal tersebut. Penelitian potong lintang dikerjakan sejakFebruari-Agustus 2016 dan didapatkan 60 subjek infeksi virus dengue (IVD) dan 25 non-IVD. Ribonucleic acid (RNA) virus denguediperiksa di semua subjek menggunakan Simplexa Dengue Real-Time Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR)termasuk identifikasi serotipe virus dengue dan pemeriksaan NS1 menggunakan uji cepat NS1 Panbio. Perbedaan perbandingan variabelkategorikal dianalisis dengan uji Fisher Exact. Kenasaban antara serotipe dengan deteksi Ag NS1 dianalisis dengan Chi-Kuadrat. RNAvirus dengue terdeteksi di 43 dari 60 subjek IVD (71,7%). Serotipe terbanyak adalah DENV-3 (62,8%). Pergeseran dominasi serotipetelah terjadi di Surabaya, sebelumnya dari DENV-2 ke DENV-1 dan sekarang DENV-3, kemungkinan akibat mobilitas pejamu, transporvirus dan faktor geografis. Kepekaan uji cepat NS1 75% dan kekhasan 100%. Persentase deteksi NS1 antar serotipe berbeda bermakna(p=0,002). Deteksi NS1 lebih rendah pada DENV-1 dibandingkan DENV-2 (p=0,007) ataupun DENV-3 (p=0,003). Serotipe virusdengue bernasab dengan deteksi NS1 (p=0,005). Ciri serotipe maupun genotipe virus dengue kemungkinan mempengaruhi sekresiNS1. Telah terjadi pergeseran serotipe virus dengue di pasien IVD di Surabaya sehingga diperlukan surveillance berkesinambunganuntuk memperkirakan terjadinya wabah. Serotipe bernasab dengan deteksi NS1. Salah satu penyebab hasil negatif palsu NS1 adalahperbedaan serotipe.
CORRELATION OF DENGUE VIRUS SEROTYPE AND DVI SEVERITY IN ADULT PATIENTS Suci Andriani; Aryati Aryati; Usman Hadi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 2 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i2.1322

Abstract

The clinical manifestation of dengue virus infection is often not clear, varies widely from mild to severe. Exposure of dengue virus which serotype is different from a previous infection is a risk factor for the severe manifestation of dengue virus infection. Dengue hemorrhagic fever is classified into four degrees of severity based on clinical manifestations and laboratory results. Real-time RT-PCR Dengue can detect dengue virus serotype in early dengue virus infection. The aimed of this study was to prove the correlation between dengue virus serotype and degree of severity in adult patients. This study was a cross-sectional observational design done in February until July 2016. Subjects consisted of 100 dengue virus infection patients. Serum of the patients was examined using Real-time RT-PCR Dengue (Simplexa™ Dengue). It was shown that from 46 patients with DENV-3 serotype was 63%, DENV-2 serotype 17.4%, DENV-1 serotypes 17.4% and mixed infection of DENV-1 and DENV-3 serotype 2.2%. There was not any DENV-4 serotype. Dengue Hemorrhagic Fever (DHF) stage I was 47.8%, DHF stage II was 30.4%, DHF stage III was 10.9% and Dengue Fever was 10.9%. There was not any DHF stage IV. There was not enough evidence that DENV-3 correlated with the degree of severity (p= 0.510). Based on this research, DENV-3 serotype was the dominant serotype prevalent at the Dr. Soetomo Hospital. There was no correlation between viral dengue serotype and severity in dengue adult patients in this study. 
ANTI DENGUE IGG/IGM RATIO FOR SECONDARY ADULT DENGUE INFECTION IN SURABAYA Aryati Aryati; Puspa Wardhani; Ade Rochaeni; Jeine Stela Akualing; Usman Hadi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 1 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i1.1161

Abstract

Infeksi Virus Dengue (IVD) dibedakan menjadi infeksi primer dan sekunder berdasarkan respons antibodi yang dihasilkan. Infeksisekunder perlu dibedakan dari infeksi primer karena umumnya menimbulkan manifestasi klinis yang berat. Uji hemaglutinasi inhibisisebagai baku emas untuk menentukan infeksi primer atau sekunder dirasa tidak praktis karena membutuhkan sepasang sera denganselang waktu waktu yang cukup lama. Penelitian ini bertujuan mengetahui cut-off rasio IgG/IgM anti dengue untuk infeksi denguesekunder dewasa di Surabaya. Subjek adalah pasien IVD dengan hasil NS1 dan/atau PCR dengue positif. Rasio IgG/IgM anti-denguediperoleh dari pembagian nilai indeks IgG dan IgM metode ELISA. Nilai cut-off rasio ditentukan berdasarkan kurva ROC. Berdasarkanpola reaktivitas IgM dan IgG ELISA, 19 (31,1%) pasien dikelompokkan sebagai infeksi primer dan 42 (68,9%) infeksi sekunder. HasilPCR didominasi DEN-3. Nilai cut-off optimal rasio IgG/IgM ≥0,927 sebagai peramal infeksi sekunder memiliki kepekaan 66,7% dankekhasan 63,2%. Dianalisis pula nilai cut-off optimal IgM dan IgG anti dengue, yaitu IgM ≥1,515 dan IgG ≥2,034 sebagai peramalinfeksi sekunder memiliki kepekaan dan kekhasans masing-masing 85,7% dan 84,2%; 100% dan 100%. Disimpulkan bahwa rasioIgG/IgM ≥0,927 tidak dapat digunakan sebagai tolok ukur tunggal peramal infeksi sekunder sedangkan cut-off IgG ≥2,034 dapatdipertimbangkan sebagai peramal infeksi sekunder.
Tuberculous Lymphadenitis coexists with Non-Hodgkin Lymphoma Nenci Siagian; Bramantono Bramantono; Usman Hadi
Current Internal Medicine Research and Practice Surabaya Journal Vol. 1 No. 2 (2020): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE JOURNAL SURABAYA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v1i2.21458

Abstract

Tuberculous Lymphadenitis (TBLN) is most common extrapulmonary tuberculosis. The common symptom of TBLN is cervical lymphadenopathy which is known to mimic numerous pathological conditions like NHL. Coexistency TBLN and lymphoma is  a rare. A woman, 56 years old, had chief complaint of cervical masses since 2 months ago. She had history of weight loss, fever and night sweats but no history of chronic cough. From physical examination and supporting examination, the patient was diagnosed with TBLN coexists with NHL. She got antituberculosis drug (ATD) for 2 weeks before chemotherapy. The patient died of septic shock 9 days later after chemotherapy. From HPE examination, TBLN and NHL may show simillar feature so Zhiel-Neelsen staining and Immunohistochemical are important to confirm each disease. ATD was given to supress the mycobacterium activity before chemotherapy. However the patient had febrile neutropenia after chemotherapy and died of septic shock. Both TBLN and NHL may occur with simillar sign and symptom and HPE. Further examinations have to be done to confirm the diagnosis of both disesases. Although ATD had given to prevent Tb infection progresivity. On 7 days after chemotherapy she had febrile neutropenia and lead to death due to septic shock.
Diagnostic and management problems of chylous effusion in a patient with newly-diagnosed tuberculosis Dicky Febrianto; Usman Hadi
Current Internal Medicine Research and Practice Surabaya Journal Vol. 2 No. 2 (2021): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v2i2.28701

Abstract

Tuberculosis (TB) remains a major cause of morbidity and mortality globally. Although TB most commonly affects the lungs, any organ or tissue can be involved. Extra-pulmonary forms of TB are commonly unrecognized or late diagnosed. Chylous effusion, i.e. chylothorax and chylous ascites, which is characterized by the presence of chyle in the pleural and peritoneal cavities, is an uncommon manifestation of extra-pulmonary TB. A 22-year-old male, referred to Dr. Soetomo Hospital with complaints of dyspnea, fever, and abdominal distension. Chest X-ray showed pleural effusion. Analysis of fluid obtained from thoracentesis and paracentesis showed chylothorax and chylous ascites. M. tuberculosis had been found in sputum smear examination. ADA (adenosine deaminase) test was performed on ascites fluid and a positive result was obtained. Chylous effusion in this patient were concluded to be related to TB. Patient was then treated with anti-TB drugs and somatostatin. Chylothorax and chylous ascites improved after treatment with somatostatin for 1 week. Administration of anti-TB drugs was planned to be continued for 9 months. The most common causes of non-traumatic chylous effusion in developing countries are infection of TB and filariasis. Chylous effusion is caused by obstruction or disruption of the lymphatic system. ADA test is a new biomedical method that begins to expand its use in body fluids to diagnose extra-pulmonary TB. Fasting, together with total parenteral nutrition, can decrease the lymph flow and balance metabolic impairment. Somatostatin has been used in the treatment of chylous effusion as it diminishes peristalsis and intestinal absorption of fats as well as decreases portal pressure.
Co-Authors Ade Rochaeni Agung Dwi Laksono Agung Dwi Wahyu Widodo Agus Santosa Agus Santosa Agustinus Vincent Anggoro DB Sachro Arfijanto, Muhammad V. Arfijanto, Vitanata Aryati , Aryati Aryati Aryati Aryati Aryati Aryati Aryati Aryati Aryati Asmarawati, Tri Pudy Baehaqi Benediktus Yohan Benediktus Yohan Bramanton Bramantono Bramantono, Bramantono Brian Eka Rahman Dicky Febrianto Didik Hasmono Djazuly Chalidyanto Eddy Soewandojo Eko Budi Koendhori, Eko Budi Erika Marfiani Erni J. Nelwan Erni J. Nelwan, Erni J. Erni Juwita Nelwan, Erni Juwita Erwin Astha Triyono Fendy Suhariadi Florentina Sustini Gondo Mastutik Hardiono Hardiono, Hardiono Hari Paraton Haryo N. Yahya Helmia Farida Hening Laswati Putra Herawati Y Heru Suswojo Hidajat, Boerhan Insani Budiningsih Iqhrammullah, Muhammad Isidro Lumanpauw Ismi Masyithah Jaap M. Middeldorp Jeine Stela Akualing Juanita, Lydia Kuntaman Kuntaman Kuntaman Kuntaman Laila Hayati, Laila Lestari, Evi Noerista M Vitanata M.M. Hapsari Ma'rifah, Nurul Margalin, Brilliant Margyaningsih, Nur Ita Marinda Dwi Puspitarini Mariyatul Qiptiyah, Mariyatul Mei Wulan, Sri Mardjiati Monique Keuter Muchlis AU Sofro Muchlis AU. Sofro Muhammad Iqhrammullah Muhammad Miftahussurur Muhammad Vitanata Arfijanto, Muhammad Vitanata Muhammad Vitanata Arifijanto Musofa Rusli Nasronudin Nasronudin Nenci Siagian Nurul Ma'rifah P. Fans P.J,van den Broek Pathak, Yashwant Prihartini Prihartini Purnomo, Windu Puspa Wardhani Puspa Wardhani Puspitarini, Marinda Dwi R. Tedjo Sasmono R. Tedjo Sasmono Rachmad Suhanda Rachman, Brian Eka Ronald Pratama Adiwinoto Sasmono, R. Tedjo Setyarini, Wahyu Sholeh, Mohammad Akbaruddin Sofro, Muchlis AU Sofro, Muchlis AU. Sri Masyeni, Dewa Ayu Putri Sripatmi Sripatmi, Sripatmi Suci Andriani Sugiyatmi, Tri A. Suharto Suharto Susilowati Andajani, Susilowati Tenta Hartian Hendyatama Tripudi Asmarawati Troy Fonda Wahyu Setyarini Widodo J. Pudjirahardjo Widodo Jatim Pudjirahardjo Windu Purnomo Yoes Prijatna Dachlan Yohan, Benediktus