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All Journal International Journal of Public Health Science (IJPHS) SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Riset Kesehatan Jurnal Surya Medika Jurnal Labora Medika JURNAL ANALIS LABORATORIUM MEDIK Jaringan Laboratorium Medis ARTERI : Jurnal Ilmu Kesehatan Borneo Journal of Medical Laboratory Technology Abdimasku : Jurnal Pengabdian Masyarakat Jurnal Health Sains Jurnal Abdi Masyarakat Indonesia Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Aurelia: Jurnal Penelitian dan Pengabdian Masyarakat Indonesia Jurnal Pengabdian Pada Masyarakat Gema Lingkungan Kesehatan Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan Jurnal Dunia Ilmu Kesehatan Jurnal Laboratorium Khatulistiwa Poltekita: Jurnal Ilmu Kesehatan Jurnal Sains dan Kesehatan
Eko Naning Sofyanita
Department Of Medical Laboratory Technology, Poltekkes Kemenkes Semarang, Semarang, Central Java, Indonesia
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Gambaran Nilai Index Trombosit pada Pasien Tuberulosis Paru yang Mengonsumsi Obat Anti Tuberkulosis Widiyanto, S.Y. Didik; Qomariyah, Nurul; Sofyanita, Eko Naning
Jaringan Laboratorium Medis Vol. 5 No. 2 (2023): November 2023
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v5i2.9646

Abstract

Tuberculosis (TB) is a disease caused by the bacterium Mycobacterium tuberculosis which mostly attacks the lungs. Based on several studies, it is stated that tuberculosis sufferers who take OAT for healing experience side effects in the form of lowering the platelet index due to reactions from drugs that lyse platelets. This research is a descriptive study with a cross sectional design. Research was conducted on 30 respondents who consumed OAT. The results of this study obtained results of more than 50% on one of the platelet indices, namely the PWD value, which was obtained with low results with a total of 19 patients (63.3%), while for other indices such as platelet counts there were 21 patients (70%) , MPV in 28 patients (93%) and PCT in 23 patients (77%) had normal results. The conclusion of this study is that platelet index examinations in TB patients tend to be low in MPV and PDW, while they show high results in PLT and PCT examinations.
Mentoring and Empowerment Diploma Three Student in Blood Bank Technology, Health Polytechnic, Ministry of Health, Semarang, Through Training in Making Soy Milk as an Effort to Prevent Anemia Afrianti, Dina; Hartono, Rodhi; Setyowatiningsih, Lilik; Sofyanita, Eko Naning; Wahyudi
Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan (Abdigermas) Vol. 2 No. 1 (2024): Jurnal Ilmiah Pengabdian Kepada Masyarakat Bidang Kesehatan (Abdigermas)
Publisher : CV Media Inti Teknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/abdigermas.v2i1.169

Abstract

Mentoring participants know about anemia and its symptoms. Participants know the equipment and materials needed to make soy milk and know the steps on how to make soy milk and participants are able to give a demonstration of making soy milk to the residents of the target village. Residents of the assisted villages know how to make soy milk. Community service activities with the Entrepreneurship Development Program (PPK) scheme with the theme "Assistance in the Empowerment of Diploma Three Technology Students at the PolkesMar Blood Bank through training in making soy milk (Soymilk) as an effort to prevent anemia" was carried out on Friday 28 July 2023 with a target of 10 people participating. consisting of 8 active students and 2 alumni. The output is in the form of videos and pamphlets on making soy milk that have received IPR certificates as well as the expertise of training participants resulting from a series of training activities on making soy milk (Soymilk) targeting students and alumni. This has also been implemented in community service activities for the target village residents in Pundan Hamlet, Subdistrict. Kebondowo Banyubiru, Semarang district, which will be held on Sunday 15 October 2023. The successful achievement of this activity was that all participants in the training on making soy milk were able to give demonstrations on making soy milk to the residents of the target villages. Residents of the assisted villages were given education about anemia and solutions to preventing anemia, the committee also showed videos of making soy milk, distributed pamphlets and gifts to residents of the assisted villages.
PENGARUH PENGGUNAAN MINYAK KELAPA MURNI SEBAGAI LARUTAN CLEARING PADA SEDIAAN HEPAR MENCIT Sofyanita, Eko Naning; Azahra, Nabila
Jurnal Analis Laboratorium Medik Vol 8 No 1 (2023): JURNAL ANALIS LABORATORIUM MEDIK
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jalm.v8i1.3945

Abstract

Salah satu tahapan dalam pemrosesan jaringan dengan histoteknik adalah clearing yang menggunakan larutan xylol. Xylol sering digunakan sebagai agen clearing karena prosesnya cepat dan harganya tidak terlalu mahal, tetapi penggunaan xylol sudah mulai ditinggalkan karena sifatnya yang karsinogenik. Minyak mempunyai karakter bersifat non polar sehingga dengan sifat non polar dari minyak kelapa ini dapat menghilangkan sisa parafin yang terdapat pada jaringan dan dapat digunakan sebagai alternatif larutan clearing. Tujuan penelitian ini adalah untuk mengetahui pengaruh penggunaan minyak kelapa murni (virgin coconut oil) sebagai alternatif larutan clearing terhadap gambaran makroskopis jaringan hepar mencit (Mus musculus). Metode penelitian ini menggunakan penelitian eksperimental dengan pendekatan one-shot case study. Hasil penelitian ini dilihat dari parameter transparansi dan tekstur menghasilkan 16 (100%), preparat baik sedangkan parameter kemudahan pemotongan didapat 10 sediaan baik (62,5%). Uji Mann-Whitney didapatkan nilai p-value < 0,05 maka ada perbedaan kualitas sediaan jaringan hepar mencit (Mus musculus) yang dijernihkan menggunakan xylol dan minyak kelapa murni (virgin coconut oil). Kesimpulan pada penelitian ini yaitu minyak kelapa murni (virgin coconut oil) dapat digunakan sebagai alternatif larutan clearing berdasarkan gambaran makroskopis jaringan hepar mencit (Mus musculus) dengan hasil kualitas sediaan jaringan yang baik tetapi kualitasnya masih tidak semaksimal penggunaan larutan xylol.
Perbedaan Hasil Pewarnaan Hematoxylin Eosin (HE) pada Histologi Ginjal Mencit (Mus musculus) Berdasarkan Ketebalan Mikrotom: Differences in Hemtoxylin Eosin Staining Results in Mice Kidney Histology (Mus musculus) Based on Microtome Thickness Sofyanita, Eko Naning; Siwi, Utami Purnama
Jurnal Surya Medika (JSM) Vol. 10 No. 1 (2024): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v10i1.5051

Abstract

Tahap pemotongan (sectioning)  menggunakan mikrotom merupakan tahap pembuatan jaringan yang perlu diperhatikan ukuran ketebalannya. Ukuran ketebalan mikrotom yang dapat digunakan yaitu 3-5 μm. Hewan mencit memiliki banyak keunggulan, sedangkan organ ginjal mencit (Mus musculus) merupakan salah satu organ yang sering digunakan dalam penelitian. pewarnaan jaringan yang sering digunakan secara rutin adalah pewarna yang dapat memulas inti dan sitoplasma serta jaringan penyambungnya yaitu pewarnaan Hematoxylin Eosin (HE). Tujuan dari penelitian ini adalah mengetahui perbedaan hasil pewarnaan HE pada histologi ginjal mencit berdasarkan ketebalan mikrotom 3 μm, 6 μm  dan 9 μm. Penelitian ini menggunakan jenis penelitian Eksperimental dengan desain penelitian true experimental post test only control group design. Inti sel tampak berwarna biru keunguan pada kelompok pemotongan mikrotom 3 μm dengan rata-rata nilai 2,97. Sitoplasma tampak jelas dan berwarna merah muda pada kelompok pemotongan mikrotom 3 μm dengan rata-rata nilai 3. Keseragaman warna pada kelompok pemotongan mikrotom 3 μm dengan intensitas warna yang merata pada seluruh lapang pandang dengan rata-rata nilai 3. Hasil uji Kruskal Wallis dan Man Whitney pada ketebalan pemotongan mikrotom 3 μm, 6 μm dan 9 μm menunjukkan adanya perbedaan hasil kualitas pewarnaan sediaan preparat ginjal mencit dengan signifikan p= 0.000. Kesimpulan penelitian ini yaitu pemotongan menggunakan organ ginjal mencit dapat menggunakan ketebalan 3 μm.
Global Research Trends on the Role of Chlorogenic Acid on Antidiabetic Mechanisms and Reproductive Hormone Regulation (2015-2025): A Bibliometric Analysis Sofyanita, Eko Naning; Suwondo, Ari; Nugroho, Heri; Juniarto, Achmad Zulfa
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 8 No. 12 (2025): December 2025
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v8i12.8557

Abstract

Introduction: Chlorogenic acid (CGA) is a natural chemical discovered in a variety of plants that has been associated with numerous health benefits. Recent evidence suggests that CGA impacts reproductive hormone regulation, thus linking metabolic health and endocrine function. Understanding trends and gaps in research at this intersection is crucial. This study characterizes global research patterns, collaboration, and thematic evolution on CGA's antidiabetic activity and its influence on reproductive hormones through bibliometric analysis. Methods: Data were retrieved from the Scopus database using the keywords ("Chlorogenic Acid") AND ("Antidiabetic") AND ("Reproductive Hormone" OR "Testosterone" OR "LH" OR "FSH" OR "Estrogen" OR "Sperm" OR "Fertility") OR ("Reproductive Hormone" OR "Testosterone" OR "LH" OR "FSH" OR "Estrogen" OR "Sperm" OR "Fertility"). Publications from 2015 to 2025 were included. Bibliometric analysis was performed using VOSviewer and Biblioshiny to visualize co-authorship networks, keyword co-occurrence, publication trends, source dynamics, and thematic clusters. Results: A total of 162 relevant publications were identified, with a consistent increase observed from 2015 and a peak in 2024. Egypt, China, South Korea, and Saudi Arabia emerged as leading contributors, concentrating research in Asia and the Middle East. The primary journals were Molecules, Nutrients, and Frontiers in Pharmacology. Keyword mapping identified three principal clusters: phytochemical and antioxidant characterization, metabolic and antidiabetic mechanisms, and hormonal and molecular regulation. Thematic analysis revealed a shift from compound characterization to mechanistic and translational studies integrating metabolism and reproductive endocrinology. Conclusion: Global research increasingly highlights CGA as a bridge between metabolic and hormonal regulation. Our findings show a shift toward interdisciplinary, molecular investigations, but reveal significant gaps in clinical validation and formulation research. Unlocking CGA’s therapeutic potential in metabolic and reproductive health will depend on advanced multiomics, enhanced formulations, and greater global research partnerships.
Co-Authors Achmad Zulfa Juniarto Achmad Zulfa Juniarto Aniesa Izzatun Nafsi Anna Sufi Annisa Anung Sugihartono Ari Suwondo Ari Suwondo Arya Iswara Arya Iswara Auliya, Qurrotu A'yuni Azahra, Nabila Burhannudin Dina Afrianti1 Djoko Priyatno Djoko Priyatno, Djoko Duri, Iin Demiany Elis Susilawati Endang Susilowaty Errina Septiyasari Faiz Shofa Abdillah Hadipranoto, Ichsan Hendra Adistia Bangkit Heri Nugroho Heri Nugroho I Made Wisnu Darma Putra Ichsan Hadipranoto Lilik Setyowatiningsih Maulana, Mochamad Rizal Nabila, Jihan Nanik Aryani Putri Nazhiifah, Tristania Shofi Nur Indah Palupi Nurul Qomariyah NURUL QOMARIYAH Nurul Qomariyah Palupi, Nur Indah PUJI LESTARI Putri Kurniasiwi Qurrotu A’yuni Auliya Raden Mohamad Herdian Bhakti Rihanesa Diana Putri Ririh Jatmi Wikandari Rodhi Hartono Roni Afriansya Rosidah, Umi S.Y. Didik Widiyanto Setyowatiningsih, Lilik Siti Thomas Zulaikhah Siwi, Utami Purnama Susilawati, Elis Swastya Putri, Adita Puspitasari Swastyaputri, Adita Puspitasari Syanubari, Sonnia Pusparindah Taufiqurrachman Nasihun Umi Rosidah WAHYUDI Widiyanto, S.Y. Didik