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All Journal Jurnal Ilmiah Farmasi Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Journal of Islamic Pharmacy Indonesian Journal of Chemistry Pharmasipha Journal of Dedicators Community PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia Jurnal Mandala Pharmacon Indonesia Journal of Telenursing (JOTING) Science Midwifery Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Ilmiah Sains Bengawan :Jurnal Pengabdian Masyarakat Indonesian Journal of Pharmacy and Natural Product Journal of Health Management and Pharmacy Exploration (JOHMPE) Medical Sains : Jurnal Ilmiah Kefarmasian
Nuraini Harmastuti
Program Studi Farmasi, Fakultas Farmasi, Universitas Setia Budi Surakarta
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Development and optimization of curcumin transfersomes in gel formulations as an antioxidant Mointi, Sella Septiyani; Kuncahyo, Ilham; Harmastuti, Nuraini
Science Midwifery Vol 13 No 4 (2025): October: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i4.2139

Abstract

Curcumin, a natural compound with potent antioxidant properties, faces challenges in pharmaceutical use due to its poor water solubility and low bioavailability. To overcome these limitations, curcumin was encapsulated in a transfersome drug delivery system and subsequently incorporated into a gel to enhance topical delivery and improve drug release efficiency. This study aimed to evaluate the influence of phospholipid, Tween 80, and cholesterol ratios on the physicochemical properties of curcumin-loaded transfersomes and to assess the antioxidant activity of the optimized transfersome gel. A Simplex Lattice Design (SLD) using Design Expert software generated 14 formulations varying in the three components. Transfersomes were produced via the thin layer hydration method and analyzed for particle size, zeta potential, and entrapment efficiency (%EE). The resulting gel was characterized for pH, viscosity, spreadability, adhesiveness, diffusion behavior using Franz cells, and antioxidant activity through the DPPH assay. Statistical analyses employed ANOVA, Wilcoxon, and T-tests. The optimized formulation containing 700 mg phospholipid, 200 mg Tween 80, and 50 mg cholesterol yielded particles of 134.627 nm, zeta potential –8.924 mV, and 93.656% EE. Antioxidant evaluation showed IC₅₀ values of 24±1.78 ppm (transfersome) and 42±2.5 ppm (gel), both indicating very strong antioxidant activity. The gel released 23.12 µg/cm² curcumin within 150 minutes.
Effects of Moringa Leaf Extract on a Mouse Model of Dementia on Spatial Memory, MDA Levels, and Hippocampal Pyramidal Cell Count (CA1 & CA3) Melati, Fitri; Purwidyaningrum, Ika; Harmastuti, Nuraini
Journal of Health Management and Pharmacy Exploration Vol. 3 No. 2 (2025): August 2025
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v3i2.633

Abstract

Antioxidants are substances needed by the body to neutralize free radicals and prevent damage caused by free radicals. Moringa leaves contain flavanoids, alkaloids, saponins and tannins that are antioxidants because of their ability to capture free radicals. This study aims to determine the effect of moringa leaf fractions on spatial memory ability using the Radial Arm Maze method, a decrease in malondialdehyde levels and inhibition of damage to the number of hippocampal pyramidal cells in CA1 & CA3 areas. Moringa leaves were extracted using the maceration method with 70% ethanol solvent. Then the ethanol extract of Moringa leaves was fractionated using the liquid-liquid method with n-hexane, ethyl acetate and water as solvents. Next, the mice were subjected to induction treatment with lead acetate, then observed for 21 days with the Radial Arm Maze, then the mice underwent surgery and their brains were removed for MDA level testing and histopathological observation. Data were analyzed statistically using one-way ANOVA (p<0.05) followed by Tukey's test. Based on the results obtained, the ethyl acetate fraction, n-hexane fraction and water fraction can influence the improvement of spatial memory by reducing latency time and type B errors, reducing malondialdehyde levels with TBARS and inhibiting damage to CA1 and CA3 hippocampal pyramidal cells which are characterized by pknotic neuron nuclei (shriveled), dark, solid, and vacuolized.
Pengaruh Suhu Penyimpanan terhadap Kadar Parasetamol Sirup Selama Beyond Use Date Secara Spektrofotometri UV-Vis: Effect of Storage Temperature on Paracetamol Syrup Concentration During Beyond Use Date by UV-Vis Spectrophotometry Indra Meilina Yusefa; Nuraini Harmastuti; Reslely Harjanti
Indonesian Journal of Pharmacy and Natural Product Vol. 7 No. 02 (2024): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ijpnp.v7i02.3344

Abstract

Paracetamol or acetaminophen is a widely used analgesic-antipyretic drug worldwide. Paracetamol in liquid form is preferred because of its easy administration and rapid absorption in the body and large doses are easily adjusted for children. Storage of paracetamol syrup in accordance with the etiquette is at controlled room temperature. Beyond use date (BUD) is the time limit for the use of a drug after it has been formulated, prepared or after its primary packaging has been opened or tampered with. The purpose of this study was to determine the effect of storage temperature on paracetamol syrup levels during BUD. Paracetamol syrup was stored in a room with air conditioning (20-25oC) and without air conditioning (30-40oC) for 14 days. Observation of levels was carried out on days 0, 3, 7, 10 and 14 using UV-Vis spectrophotometry with a wavelength of 247 nm and operating time for 22 minutes. The results of the determination of paracetamol syrup levels after storage for 14 days in a room with air conditioning in generic and trademark samples were 90.05 ± 1.34% and 92.73 ± 1.01%, respectively. Paracetamol syrup levels in a room without air conditioning in generic and trademark samples are 79.07 ± 0.99% and 81.10 ± 2.02%. Storage temperature affects paracetamol syrup levels during storage with a difference in levels of 10.98% for generic samples and 11.63% for trademark samples during BUD.   ABSTRAK Parasetamol merupakan obat analgesik-antipiretik yang banyak digunakan di seluruh dunia. Parasetamol dalam bentuk cairan lebih disukai karena pemberiannya yang mudah dan cepat terabsorpsi dalam tubuh serta dalam pemberian dosis besar mudah disesuaikan untuk anak. Penyimpanan parasetamol sirup yang sesuai dengan etiket adalah pada suhu ruang terkendali. Beyond use date (BUD) adalah batas waktu penggunaan obat setelah diracik, disiapkan atau setelah kemasan primernya dibuka atau dirusak. Tujuan penelitian ini adalah untuk mengetahui pengaruh suhu penyimpanan terhadap kadar parasetamol sirup selama BUD. Parasetamol sirup disimpan pada ruang dengan penyejuk udara (20 – 25oC) dan tanpa penyejuk udara (30 – 40oC) selama 14 hari. Pengamatan kadar dilakukan pada hari ke-0, 3, 7, 10 dan 14 menggunakan spektrofotometri UV-Vis dengan panjang gelombang 247 nm dan waktu operasi selama 22 menit. Hasil penetapan kadar parasetamol sirup setelah penyimpanan selama 14 hari di ruang dengan penyejuk udara pada merek generik dan merek dagang berturut-turut yaitu 90,05 ± 1,34% dan 92,73 ± 1,01%. Kadar parasetamol sirup diruang tanpa penyejuk udara pada merek generik dan merek dagang yaitu 79,07 ± 0,99% dan 81,10 ± 2,02%. Suhu penyimpanan mempengaruhi kadar parasetamol sirup selama penyimpanan dengan selisih kadar 10,98% untuk merek generik dan 11,63% untuk merek dagang selama BUD.
Identifikasi Senyawa Metabolit Sekunder pada Ekstrak dan Fraksi Ekstrak Daun Kelor (Moringa oleifera) dengan Metode Kromatografi Lapis Tipis (KLT) Widayatul Khairi; Gunawan Pamudji Widodo; Nuraini Harmastuti; Safwan Safwan; Abdul Rahman Wahid; Irmatika Hendriyani; Dzun Haryadi Ittiqo
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 6, No 2 (2025): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v6i2.30257

Abstract

AbstrakMoringa oleifera yang dikenal di Indonesia dengan nama kelor dan dikatakan sebagai “the miracle tree” atau pohon ajaib karena secara alamiah sebagai sumber gizi dan obat.Komponenekstrak daun kelor yang ditemukan memiliki golongan flavonoid. Sebagai antioksidan, antidiabetes, antiinflamasi, dan antimikroba, senyawa ini memiliki gugus -OH yang terikat pada cincin benzena. Tujuannya adalah untuk mengidentifikasi senyawa metabolit sekunder pada daun kelor. Ini akan dilakukan dengan menggunakan teknik kromatografi lapis tipis (KLT). Hasil ekstrak dan fraksi daun kelor, termasuk air, etil asetat, dan n-heksan, terdapat senyawa flavonoid, tanin, alkaloid, dan saponin pada fraksi etil asetat sedangkan pada ekstrak dan fraksi air terdapat senyawa tanin, pada fraksi n-heksan terdapat senyawa steroid. Kesimpulan terdapat senyawa metabolit sekunder pada daun kelor (Moringa oleifera).AbstractMoringa oleifera, known in Indonesia as "kelor," is referred to as “the miracle tree” due to its natural nutritional and medicinal properties. The components found in the Moringa leaf extract belong to the flavonoid group. As antioxidants, antidiabetic, anti-inflammatory, and antimicrobial agents, these compounds contain -OH groups attached to a benzene ring. The aim is to identify the secondary metabolites present in Moringa leaves using thin-layer chromatography (TLC) techniques. The study includes extracts and fractions of Moringa leaves, specifically water, ethyl acetate, and n-hexane, showed the presence of flavonoids, tannins, alkaloids, and saponins in the ethyl acetate fraction, while tannins were found in both the extract and water fraction. Additionally, steroids were detected in the n-hexane fraction. In conclusion, Moringa oleifera leaves contain secondary metabolites.
Antioxidant Profiling and GC-MS Analysis of Active Subfractions from Jasminum sambac L. Leaf Extract Megananda Ristya Putri; Iswandi; Nuraini Harmastuti
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.14362

Abstract

Jasmine leaves (Jasminum sambac L.) are known to contain phenolic and flavonoid compounds with antioxidant potential. This study evaluated the antioxidant activities of the ethanol extract, solvent fractions, and subfractions of jasmine leaves. It characterized the chemical profile of the most active subfraction using gas chromatography–mass spectrometry (GC–MS). Jasmine leaves were extracted by maceration using 96% ethanol and subsequently fractionated with n-hexane, ethyl acetate, and water. The ethyl acetate fraction, which exhibited the strongest antioxidant activity, was further separated by vacuum liquid chromatography to obtain subfractions. Antioxidant activity was determined using the DPPH method and expressed as IC₅₀ values. The most active subfraction was analyzed by GC–MS. The results showed that the ethyl acetate fraction had the lowest IC₅₀ among the solvent fractions, while subfraction 1 (SF1) exhibited the strongest antioxidant activity, with an IC₅₀ of 49.78 ppm, indicating strong activity. GC–MS analysis of the most active subfraction suggested the presence of antioxidant-related compound classes with tentative identification. These findings demonstrate that subfractionation enhances antioxidant activity and enriches antioxidant-related constituents in jasmine leaves, while highlighting the need for advanced analytical techniques to confirm compound identities.
OPTIMASI KONSENTRASI PELARUT ETANOL DAN SUHU EKSTRAK DAUN TURI PUTIH (Sesbania grandiflora L.) DENGAN METODE UAE TERHADAP AKTIVITAS ANTIOKSIDAN SECARA FACTORIAL DESIGN Ghani Nurfiana Fadma Sari; Shella Juana Putri; Nuraini Harmastuti
Jurnal Farmasi Indonesia Vol 22 No 2 (2025): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v22i2.2947

Abstract

White Turi leaves (Sesbania grandiflora L.) are widely recognized as ornamental plants and vegetables and are known for their antioxidant properties due to their content of various secondary metabolites, such as alkaloids, saponins, tannins, flavonoids, and terpenoids. This study aimed to optimize solvent concentration and extraction temperature using the ultrasound-assisted extraction (UAE) method and to investigate the antioxidant activity of white turi leaf extracts using a factorial design approach. The UAE method was employed for the extraction process with ethanol concentrations of 70% and 96% and extraction temperatures of 45°C and 50°C as experimental factors. The responses observed included the extraction yield of white turi leaf extract and antioxidant activity expressed as IC₅₀ values. The results revealed that an ethanol concentration of 96% at an extraction temperature of 50°C produced the highest extraction yield of 18.66%. The highest antioxidant activity was observed using 70% ethanol at 45°C, with an IC₅₀ value of 18.86 µg/mL. Based on the factorial design analysis, an ethanol concentration of 70% combined with an ultrasonic extraction temperature of 45°C was selected as the optimal extraction condition for achieving a favorable balance between extraction yield and antioxidant activity.
Co-Authors Abdul Rahman Wahid Ajeng Nanda Sasmita Bahi, Rizky Resvita R. Cristy, Devina Wahyu Astaning Dyah Susilowati Dzun Haryadi Ittiqo Endang Sri Rejeki Endang Sri Rejeki Fachry Abda El Rahman Ghani Nurfiana Fadma Sari Gunawan Pamudji Widodo Hadi Nasbey Harno Dwi Pranowo Ika Purwidyaningrum Ilham Kuncahyo, Ilham Indah Marcelina Indra Meilina Yusefa Irmatika Hendriyani Iswandi Iswandi Jausi Jannah Jonathan Suneidesis Alpons, Gabriel Khoirul Anwar Kurniasari, Fitri Mamik Ponco Rahayu Mardiyono Mardiyono Mauk, Bertha Angela Chameliana Maulita Saraswati Megananda Ristya Putri Melati, Fitri Mointi, Sella Septiyani Puspitasari, Ismi Reslely Harjanti Rina Herowati Rosyidah, Semi Safwan Safwan Sari Astuti Sari Astuti Semi Rosyidah Shella Juana Putri Siti Aisiyah Sofia Mubarika Supriyadi Supriyadi Supriyadi Susilo Margining Raharjo TATI NURHAYATI Titik Sunarni Tri Nur Azizah Tri Wijayanti Tri Wijayanti Turahman, Taufik Turahman, Taufik Wahyu Aji Pangestu, Rochmadani Widayatul Khairi Wiwin Herdwiani Yuliana, Sinta