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All Journal Jurnal Ilmiah Farmasi Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Journal of Islamic Pharmacy Indonesian Journal of Chemistry Pharmasipha Journal of Dedicators Community PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Mandala Pharmacon Indonesia Journal of Telenursing (JOTING) Science Midwifery Lumbung Farmasi : Jurnal Ilmu Kefarmasian SEMAR (Jurnal Ilmu Pengetahuan, Teknologi, dan Seni bagi Masyarakat) Jurnal Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Ilmiah Sains Bengawan :Jurnal Pengabdian Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian
Nuraini Harmastuti
Program Studi Farmasi, Fakultas Farmasi, Universitas Setia Budi Surakarta
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Optimasi Karbopol dan Gliserin pada Sediaan Gel Dispersi Padat Ibuprofen Secara Simplex Lattice Design Wahyu Aji Pangestu, Rochmadani; Aisiyah, Siti; Harmastuti, Nuraini
Jurnal Farmasi (Journal of Pharmacy) Vol. 9 No. 2 (2020): Jurnal Farmasi (Journal of Pharmacy), October 2020
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Ibuprofen is a part of the Non Steroid Anti-Inflamatory Drug (NSAID) that serves as the treatment of pain or inflammation. Ibuprofen is a part of biopharmaceutical classification system (BCS) class II drug with the characteristics of low solubility and high permeability. Solid dispersion may increase solubility. Ibuprofen has a variety of side effects so it need to be made into other routes of administration such as topical. This study was conducted to understand the effect of combinations of carbopol as the gelling agent and glycerin as a penetration enhancer compound to the physical quality and the release of active substances also to determine the optimum formula. This study used simplex lattice design method with two factors which is carbopol and glycerin in formula 1 ; formula 2 ; formula 3 in sequence 100%:0% ; 50%:50% ; 0%:100%. The solid dispersion was made by the melting method, then was tested with FTIR and then was made into a solid dispersion gel of ibuprofen-PEG 6000. The release of substance was tested using franz diffusion cell through a cellophane membrane, then the optimum formula was determined based on the counterplot from Design Expert 10.0.1 trial version with critical parameters of adhesion, viscosity, and penetration of substance. The result of the study showed that carbopol and glycerin affecting the physical quality and the release of a drug in a gel. Glycerin has more impact to the release of the drug. The proportion of carbopol 1,011% and glycerin 7,389% produce the optimum formula with the most excellent physical quality and the release of the drug.
Optimasi Tween 80 dan Etanol pada Sediaan Gel Dispersi Padat Ibuprofen Secara Simplex Lattice Design Jonathan Suneidesis Alpons, Gabriel; Aisiyah, Siti; Harmastuti, Nuraini
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 1 (2021): Jurnal Farmasi (Journal of Pharmacy), April 2021
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Ibuprofen is a part of Non Steroid Anti-Inflamatory Drug (NSAID) that used as treatment of pain or inflammatory. Solid dispersion method may improve the solubility of ibuprofen. Ibuprofen was made into a gel product to overcome the side effect. Addition of an enhancer in a gel may increase the penetration of an active substance. The purpose of this study is to understand the effect of tween 80 and ethanol as an enhancer to penetration and drug release of ibuprofen in gel, the effect to physical quality of gel, and to obtain the optimum formula of the combination of enhancer. This study used simplex lattice design with two factor which is tween 80 and ethanol in gel product formula 1; formula 2; and formula 3 in sequence 100%:0%; 50%:50%; 0%:100%. Solid dispersion of ibuprofen-PEG 6000 was made with melting method and tested with FT-IR before made into gel product. Penetration test is done by using Franz diffusion cell with selofan membrane and the determination of the optimum formula obtained based on counterplot from optimization with design expert 10.0.01 trial version with the parameters of the critical level is viscosity and penetration substanced. The results showed the combination of tween 80 and ethanol could affect viscosity and penetration of active substance, tween 80 had a greater effect than ethanol. The proportion of tween 80 4.681% and ethanol 16.319% produces the optimum formula with the most optimum viscosity, adhesion, and drug penetration
Development and optimization of curcumin transfersomes in gel formulations as an antioxidant Mointi, Sella Septiyani; Kuncahyo, Ilham; Harmastuti, Nuraini
Science Midwifery Vol 13 No 4 (2025): October: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i4.2139

Abstract

Curcumin, a natural compound with potent antioxidant properties, faces challenges in pharmaceutical use due to its poor water solubility and low bioavailability. To overcome these limitations, curcumin was encapsulated in a transfersome drug delivery system and subsequently incorporated into a gel to enhance topical delivery and improve drug release efficiency. This study aimed to evaluate the influence of phospholipid, Tween 80, and cholesterol ratios on the physicochemical properties of curcumin-loaded transfersomes and to assess the antioxidant activity of the optimized transfersome gel. A Simplex Lattice Design (SLD) using Design Expert software generated 14 formulations varying in the three components. Transfersomes were produced via the thin layer hydration method and analyzed for particle size, zeta potential, and entrapment efficiency (%EE). The resulting gel was characterized for pH, viscosity, spreadability, adhesiveness, diffusion behavior using Franz cells, and antioxidant activity through the DPPH assay. Statistical analyses employed ANOVA, Wilcoxon, and T-tests. The optimized formulation containing 700 mg phospholipid, 200 mg Tween 80, and 50 mg cholesterol yielded particles of 134.627 nm, zeta potential –8.924 mV, and 93.656% EE. Antioxidant evaluation showed IC₅₀ values of 24±1.78 ppm (transfersome) and 42±2.5 ppm (gel), both indicating very strong antioxidant activity. The gel released 23.12 µg/cm² curcumin within 150 minutes.
Co-Authors Ajeng Nanda Sasmita Azizah, Tri Nur Bahi, Rizky Resvita R. Cristy, Devina Wahyu Astaning Dyah Susilowati Endang Sri Rejeki Endang Sri Rejeki Fachry Abda El Rahman Ghani Nurfiana Fadma Sari Gunawan Pamudji Widodo Hadi Nasbey Harno Dwi Pranowo Ilham Kuncahyo, Ilham Indah Marcelina Irmatika Hendriyani Ittiqo, Dzun Haryadi Jausi Jannah Jonathan Suneidesis Alpons, Gabriel Khoirul Anwar Kurniasari, Fitri Mamik Ponco Rahayu Mardiyono Mardiyono Mauk, Bertha Angela Chameliana Maulita Saraswati Mointi, Sella Septiyani Puspitasari, Ismi Rosyidah, Semi Safwan Safwan, Safwan Sari Astuti Sari Astuti Semi Rosyidah Siti Aisiyah Sofia Mubarika Supriyadi Supriyadi Supriyadi Susilo Margining Raharjo TATI NURHAYATI Titik Sunarni Tri Nur Azizah Tri Wijayanti Tri Wijayanti Turahman, Taufik Turahman, Taufik Wahid, Abdul Rahman Wahyu Aji Pangestu, Rochmadani Widayatul Khairi Wiwin Herdwiani Yuliana, Sinta