Article Per Year (5 Year)
p-Index From 2021 - 2026
5.052
P-Index
This Author published in this journals
All Journal Jurnal Ilmiah Farmasi Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Indonesian Journal of Chemistry Pharmasipha Journal of Dedicators Community PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia Jurnal Mandala Pharmacon Indonesia Jurnal Kefarmasian AKFARINDO Journal of Telenursing (JOTING) Science Midwifery Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Ilmiah Sains Bengawan :Jurnal Pengabdian Masyarakat Indonesian Journal of Pharmacy and Natural Product Journal of Health Management and Pharmacy Exploration (JOHMPE) Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Medical Sains : Jurnal Ilmiah Kefarmasian
Nuraini Harmastuti
Program Studi Farmasi, Fakultas Farmasi, Universitas Setia Budi Surakarta
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

Published : 37 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 37 Documents
Search

 1   2   3   4 
ANTIDIABETIC ACTIVITIES OF KEMUNING LEAF EXTRACTS (Murraya paniculata) AND MORINGA LEAF (Moringa oleifera) IN DIABETIC RATS Susilo Margining Raharjo; Titik Sunarni; Nuraini Harmastuti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.903

Abstract

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. The development of diabetic complications plays a pathological role in increasing Reactive Oxygen Species (ROS) levels, which induce oxidative stress. The aim of this study was to examine the antidiabetic activities of kemuning and moringa leaves based on glucose, SOD, and GPx levels, and the protective activity of pancreatic cells in STZ-NA-induced rats. The kemuning and moringa leaves were dried, finely powdered, and extracted by the remaceration method using 96% ethanol. The test was carried out on 30 rats that were divided into 6 treatment groups, namely the normal control group, negative control, positive control (glibenclamide), extract dose of 76.5 mg. /200 g BW : 6.5 mg/200 g BW, 114.75 mg/200 g BW : 3.25 mg/200 g BW and 38.25 mg/200 g BW : 9.75 mg/ 200 g BW. The antidiabetic test was carried out using STZ-NA, glucose levels were measured, and SOD and GPx levels in the liver supernatants were measured. Cell protection was tested using the cell damage score method. The data obtained were analyzed using one-way ANOVA variance. The results showed that kemuning and moringa leaves at a dose of 38.25 mg/200 g BW: 9.75 mg/200 g BW were able to lower blood glucose levels, increase the activity of SOD and GPx, and protect pancreatic cell damage in STZ-NA rats. Keywords: Antidiabetic, antioxidant, moringa, kemuning, SOD, GPx
Simvastatin dengan Senyawa Turunan Β-Siklodextrin Cristy, Devina Wahyu Astaning; Harmastuti, Nuraini; Mardiyono, Mardiyono
Journal of Telenursing (JOTING) Vol 6 No 1 (2024): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v6i1.9472

Abstract

This study aims to determine the profile of the inclusion complex formed between simvastatin and β-cyclodextrin and its derivatives. To determine the level of stability and determine the solubility level of the inclusion complex formed between simvastatin and β-cyclodextrin and its derivatives (2-hydroxypropyl-β-cyclodextrin and 2,6-di-O-methyl-β-cyclodextrin) in water solvent.The method used is qualitative descriptive using the molecular docking method, modeling and anchoring the inclusion complex model.The research results show that the simvastatin/HP-β-CD inclusion complex has a higher level of solubility in water solvents compared to the simvastatin/β-CD and simvastatin/DM-β-CD inclusion complexes, with a ΔGsolvation value of -1032.34 kJ/mol.Conclusion: Simvastatin is able to bind to the cavity of 2-hydroxypropyl-β-cyclodextrin, 2,6-di-O-methyl-β-cyclodextrin, and simvastatin/β-cyclodextrin with the following order of bond strength: simvastatin/2-hydroxypropyl-β -cyclodextrin > simvastatin/2,6-di-O-methyl-β-cyclodextrin > simvastatin/β-cyclodextrin. Keywords: Inclusion Complex, Molecular Docking, Molecular Dynamics Simulation, Β-Cyclodextrin, Simvastatin.
PELATIHAN PEMBUATAN AROMATERAPI LAVENDER & GRASS OIL (ALTERNATIF PENCEGAH DBD) DAN LEMON & GREENTEA (KARMINATIF) Turahman, Taufik; Rahayu, Mamik Ponco; Fadma Sari, Ghani Nurfiana; Rejeki, Endang Sri; Harmastuti, Nuraini; Supriyadi, Supriyadi
Bengawan : Jurnal Pengabdian Masyarakat Vol 3 No 1 (2023): Juni
Publisher : Politeknik Indonusa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/jurnal_bengawan.v3i1.81

Abstract

The Lavender and Grass oil Aromatherapy Making Training is a Community Service project to disseminate relevant knowledge and technology that is easy to use. In addition, it provides value by improving skills and motivate to establish a home industry in the pursuit of a small business. A USB Pharmacy lecturer conducted this program for people of the Genengan community, located at RT 08 RW 12, Mojosongo Village, Jebres Sub-district, Surakarta City. Oils from Lemongrass and Lavender Herbs are used in aromatherapy making training. These organic components have not yet been utilized by community members or locals to produce aromatherapy that is beneficial to their health. Typically, pharmacies charge relatively high costs for products that include aromatherapy. It is envisaged that the Geneng community's training in aromatherapy production will boost the village's added value. Making products for aromatherapy using lavender and lemongrass is one of the projects that has the potential to be used as a home industry activity.
PELATIHAN PEMBUATAN NATURAL HERBAL SOAP SEBAGAI UPAYA PENINGKATAN KEWIRAUSAHAAN PKK DESA TRIYAGAN Sari, Ghani Nurfiana Fadma; Rejeki, Endang Sri; Turahman, Taufik; Rahayu, Mamik Ponco; Harmastuti, Nuraini
Bengawan : Jurnal Pengabdian Masyarakat Vol 4 No 1 (2024): Juni
Publisher : Politeknik Indonusa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/jurnal_bengawan.v4i1.110

Abstract

Masyarakat Karangturi desa Triyagan, Kecamatan Mojolaban, Kabupaten Sukoharjo masih memerlukan pelatihan untuk meningkatan perawatan serta kesehatan keluarga terutama menggunakan bahan tradisional yang mudah didapatkan dan menciptakan motivasi perintisan home indutri dalam upaya peningkatan kewirausahaan dan perekonomian warga. Maka dari itu diperlukan adanya kegiatan penyuluhan dan pelatihan pembuatan Natural Herbal Soap. Kegiatan pengabdian kepada masyarakat ini dirancang dalam dua kegiatan, yaitu: Pertama, penyuluhan tentang peran bahan alami tradisional dalam kesehatan. Kedua, pelatihan pembuatan Natural Herbal Soap dari campuran antara minyak (minyak zaitun dan minyak kelapa) dengan larutan alkali (NaOH) sehingga membentuk padatan yang mengental yang disebut trace, kemudian ditambahkan minyak essensial (greentea, chamomile, sereh) secukupnya dan dihomogenkan lalu dibiarkan memadat. Target serta objek dari kegiatan ini adalah masyarakat akan mendapat tambahan keterampilan membuat Natural Herbal Soap yang dapat dilakukan dengan mudah dan dengan modal kecil sehingga dapat sebagai salah satu alternatif peningkatan kewirausahaan keluarga dan juga dapat digunakan untuk peningkatan kesehatan keluarga sehari-hari.
Analisis Kadar Timbal dalam Eyeliner berbagai Merek yang Beredar di Surakarta dengan Metode Spektrofotometri Serapan Atom Mauk, Bertha Angela Chameliana; Harmastuti, Nuraini; Kurniasari, Fitri
Journal of Islamic Pharmacy Vol 9, No 2 (2024): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v9i2.28643

Abstract

Eyeliner merupakan sediaan yang digunakan pada kulit tipis sekitar mata dengan fungsi mempertajam dan memperindah bentuk mata. Eyeliner memiliki pigmen warna dasar emulsi minyak dalam air. Eyeliner mengandung logam timbal yang dapat menyebabkan sakit kepala, dan penggunaan dalam jangka panjang dapat mempengaruhi sistem saraf serta dapat bersifat karsinogenik. Penelitian ini bertujuan untuk menganalisis kadar timbal dalam eyeliner berbagai merek yang beredar di Surakarta dengan menggunakan spektrofotometri serapan atom. Metode penelitian menggunakan tiga merek sampel eyeliner terdaftar Badan Pengawasan Obat dan Makan (BPOM), tiga merek sampel eyeliner tidak terdaftar BPOM, dan tiga merek sampel eyeliner luar negeri yang beredar di Surakarta. Analisis kualitatif dan kuantitatif logam timbal menggunakan instrumen spektrofotometri serapan atom. Hasil uji kualitatif dan kuantitatif dengan spektrofotometri serapan atom menunjukkan bahwa terdapat timbal dalam sampel dengan kadar berturut-turut A1 = 24,4075 ± 2,3970 mg/Kg, A2 = 24,8934 ± 4,4417 mg/Kg, A3 = 51,4224 ± 20,9957 mg/Kg, B1= 296,8730 ± 33,2398 mg/Kg, B2 = 294,8082 ± 26,7292 mg/Kg, B3 = 264,3652 ± 39,3059 mg/Kg, C1 = 177,0400 ± 22,7420 mg/Kg, C2 = 220,0130 ± 39,6887 mg/Kg, dan C3 = 708,4181 ± 163,9650 mg/Kg. Hasil analisis menunjukkan bahwa seluruh sampel tidak memenuhi syarat kadar timbal yang telah ditentukan oleh BPOM Republik Indonesia Nomor 12 tahun 2019 yaitu tidak lebih dari 20 mg/Kg atau 20 mg/L.
Analysis of active compounds in kawista leaf (Limonia acidissima L.) fraction and its antioxidant activity using DPPH method Azizah, Tri Nur; Harmastuti, Nuraini; Wijayanti, Tri
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art9

Abstract

Background: Kawista (Limonia acidissima L.) is a plant that has been studied for its potential as a natural antioxidant. Research regarding kawista leaves has not been carried out to a more specific stage, so further fraction separation is carried out to determine compounds that have potential as antioxidant agents.Objective: This study aimed to determine the antioxidant activity of kawista leaf fractions using the DPPH method and to determine the active compounds in the highest antioxidant agents of kawista leaf fracton.Method: Kawista leaves were extracted by re-maceration using methanol, which was then purified by the liquid-liquid extraction method with the solvents n-hexane, ethyl acetate, and water. Phytochemical studies were carried out on the fractions using TLC on flavonoids, steroids, tannins, saponins, and alkaloids. The fraction was separated by the vacuum liquid chromatography method with 11 eluents, which were then tested for antioxidants and characterization of the most active compounds in the kawista leaf fraction. Then the highest results as antioxidant agents from the fraction were characterized for their active compounds using a spectrophotometer and FTIR.Results: The results of the study showed that the most active purified extract in antioxidant activity was ethyl acetate, which indicates strong antioxidant activity. The combined fraction 2 (F2) indicates flavonoid compounds that played an active role as very strong antioxidants with an AAI value of 3.3808, which is not significantly different from the vitamin C as standard. Flavonoid compounds that have been characterized using a spectrophotometer interpret the wavelength shift data that possible F2 belongs to the flavanon group.Conclusion: Active compounds from kawista leaf fraction (F2) have the highest antioxidant agent, with the possibility that flavonoid compounds from F2 belong to the flavanon group.
Perbandingan Studi Aktivitas Antioksidan Ekstrak Metanol, Etanol 70%, dan Etanol 96% Daun Kawista (Limonia acidissima L.) Tri Nur Azizah; Nuraini Harmastuti; Tri Wijayanti
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.8559

Abstract

Antioksidan alami (berasal dari bahan alami / tanaman) dijadikan alternatif akibat adanya kekhawatiran akan kemungkinan efek samping dari antioksidan sintetik. Salah satu tanaman yang berpotensi sebagai antioksidan alami yaitu kawista (Limonia acidissima L.). Tujuan penelitian ini untuk membandingkan aktivitas antioksidan dari daun kawista dengan proses ekstraksi beberapa pelarut (metanol, etanol 70%, dan etanol 96%). Metode penelitian yang dilakukan meliputi maserasi, identifikasi senyawa, dan pengujian antioksidan dengan metode DPPH. Pengukuran antioksidan menggunakan spektrofotometer UV-Vis dinyatakan dengan nilai IC50 (Inhibitory Concentration 50) yang kemudian dikonversikan ke nilai AAI (Antioxidant Activity Index). Nilai aktivitas antioksidan yang diperoleh paling tinggi dari ekstrak metanol yaitu nilai rata – rata IC50 82,2034 ± 0,5733 dan nilai rata – rata AAI 1,2165 ± 0,00852 artinya mempunyai sifat antioksidan kuat. Aktivitas antioksidan dari ekstrak etanol 70% daun kawista dengan nilai rata – rata IC50 135,5030 ± 7,2238 dan nilai rata – rata AAI 0,7934 ± 0,0382 mempunyai sifat antioksidan sedang. Sedangkan ekstrak etanol 96% dengan nilai rata – rata IC50 123,5900 ± 2,9718 dan nilai rata – rata AAI 0,8094 ± 0,0195 mempunyai sifat antioksidan sedang. Kesimpulannya perbandingan hasil ekstraksi dengan berbagai pelarut menunujukkan aktivitas antioksidan yang berbeda signifikan. Antioksidan tertinggi terdapat pada ekstrak metanol dengan nilai IC50 82,20 ppm dan AAI sebesar 1,22.
Analisis Kandungan Reduktor pada Paprika Merah dan Cabai Hijau Besar (Capsicum annum L.) Menggunakan Metode Spektrofotometri melalui Reaksi Redoks dengan Triiodida Nuraini Harmastuti; Ahmad Ferdinansyah Rafsanjani; Hery Muhamad Ansory; Mira Dia Nofia
Jurnal Farmasi Indonesia Vol 21 No 2 (2024): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v21i2.2633

Abstract

The determination of reducing compounds in plant samples is continuously developed to achieve more practical and efficient analytical methods. This study analyzed the reducing compound content in red bell peppers and large green chilies using UV-Vis spectrophotometry via a redox reaction with triiodide. The results showed that this method can effectively determine reducing compounds in plant samples. The large green chili sample contained 0.01723% reducing compounds, whereas the red bell pepper sample exhibited a higher content of 0.0267%. These findings indicate that red bell peppers have a higher concentration of reducing compounds than large green chilies. This method has the potential to be a reliable approach for analyzing reducing agents in plants and can be further developed for pharmaceutical and food analysis applications.
Kajian Hubungan Kuantitatif Struktur Dan Aktivitas (HKSA) Senyawa Kurkumin Dan Turunannya Sebagai Agen Anti Tumor Darah Terhadap Penghambatan Pertumbuhan Sel K562 Puspitasari, Ismi; Astuti, Sari; Harmastuti, Nuraini
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p65-75

Abstract

Curcumin was reported can suppress the growth of blood tumor cells. This study aims to determine the physical and chemical properties of curcumin derivatives that give affect to antitumor activity of blood cells which were expressed as the best HKSA equation model. This   study   used   curcumin   and   twelve   derivatives   which   have   antitumor   activity parameters of blood cells (K562) as IC50. Parameters of physicochemical properties of curcumin compounds series and their derivatives as descriptors include net charge of atoms in the curcumin framework structure, EHOMO, ELUMO, Log P, E Hid, a, MR, Volume, Surface area (SA), Total Energy, dipole moment (u), Hf, and Mass which are the results of geometric optimization calculations using the PM3 semiempirical method with hyperchem application. HKSA equation model was built using the BuilQSAR statistical calculation analysis. The best HKSA equation model is then validated internally and externally. Calculation of statistical analysis with BuldQSAR, the descriptor that has the most influence is  obtained, namely net  atomic charge, EHOMO,  surface area, dipole moment and  Hf with  linear regression equation: Log 1/IC50 : + 1.7622 (± 0.3655) qC4 - 0.9457 (± 0.1047) E Homo + 0.0013 (0.0002) SA + 0.0575 (± 0.0216) u - 0.0068 (± 0.0004) Hf - 11.4161 (± 1.0440) , n = 10; R = 0.999; R2= 0,9990; SPress = 0.0232. as well as non-linear regression equation : Log 1/IC50 = + 15.1400 (±4.9008) qC7 + 7.4959 (± 5.6081) qC8 - 0.5839 (± 0.1397) qC15 + 0.0005 (± 0.0003) SA - 0.0054 (±0.0008) Hf - 5.7246 (±3.2476), n = 10; R = 0,999, R2 = 0,9977; SPress = 0.0341.
ANALISIS LOGAM TIMBAL (Pb) PADA PENSIL ALIS YANG BEREDAR DI KABUPATEN TULUNGAGUNG SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA) Rosyidah, Semi; Harmastuti, Nuraini; Rejeki, Endang Sri
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p179-186

Abstract

Eyebrow pencil is a cosmetic that is used to correct less symmetrical eyebrows. The colors marketed are very diverse. Lead is also obtained from tools used during the production process. This study aims to determine the lead content in eyebrow pencils and to determine the lead levels in eyebrow pencils circulating in Tulungagung by atomic absorption spectrophotometry (AAS) still meets the requirements of BPOM No. 12 of 2019. Sampling using a purposive sampling technique. Preparation samples were carried out using the dry deconstruction method. The research began with chemical and physical qualitative analysis. The determination of lead levels using AAS at a wavelength of 283.3 nm was then determined. The AAS analytical method is suitable for lead based on the results of method verification meeting the requirements including linearity with a value of r = 0.9929, accuracy of 102%, LOD 0,1189 mg/L, but did not meet the LOQ of 0.3964 mg/L. The results showed that 3 out of 5 samples were positive for lead with levels ranging from 4.9339-5.4896 mg/kg. The results still meet the BPOM contamination limit requirements, which are not more than 20 mg/kg, thus all samples are still within safe limits according to the requirements set by BPOM.
Co-Authors Abdul Rahman Wahid Afif Meilana Sindani Putri Ahmad Ferdinansyah Rafsanjani Ajeng Nanda Sasmita Andri Prasetiyo Bahi, Rizky Resvita R. Cristy, Devina Wahyu Astaning Dyah Susilowati Dzun Haryadi Ittiqo Emmelia Yunitha Endang Sri Rejeki Endang Sri Rejeki Fachry Abda El Rahman Fahrudin Arif Ghani Nurfiana Fadma Sari Gunawan Pamudji Widodo Hadi Nasbey Harno Dwi Pranowo Ika Purwidyaningrum Ilham Kuncahyo Ilham Kuncahyo, Ilham Indah Marcelina Indra Meilina Yusefa Irmatika Hendriyani Iswandi Iswandi Jausi Jannah Jonathan Suneidesis Alpons, Gabriel Jovanka Viona Anggriani Boru Purba Khoirul Anwar Kurnia Nur Indah Kurniasari, Fitri Lalu Sanik Wahyu Fadil Amrulloh Mamik Ponco Rahayu Mardiyono Mardiyono Mardiyono Mardiyono Mauk, Bertha Angela Chameliana Maulita Saraswati Megananda Ristya Putri Melati, Fitri Mira Dia Nofia Mointi, Sella Septiyani Muhamad Ansory, Hery Puspitasari, Ismi Reslely Harjanti Reslely Harjanti Rina Herowati Rosyidah, Semi Safwan Safwan Sari Astuti Sari Astuti Semi Rosyidah Shella Juana Putri Siti Aisiyah Sofia Mubarika Suhartinah Suhartinah Supriyadi Supriyadi Supriyadi Susilo Margining Raharjo TATI NURHAYATI Tika Indrasari Titik Sunarni Tri Nur Azizah Tri Wijayanti Tri Wijayanti Turahman, Taufik Turahman, Taufik Vivin Nopiyanti Wahyu Aji Pangestu, Rochmadani Widayatul Khairi Widodo Priyanto Windia Wulantika Wiwin Herdwiani Yuliana, Sinta