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All Journal Jurnal Ilmiah Farmasi Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Journal of Islamic Pharmacy Indonesian Journal of Chemistry Pharmasipha Journal of Dedicators Community PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Mandala Pharmacon Indonesia Journal of Telenursing (JOTING) Science Midwifery Lumbung Farmasi : Jurnal Ilmu Kefarmasian SEMAR (Jurnal Ilmu Pengetahuan, Teknologi, dan Seni bagi Masyarakat) Jurnal Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Ilmiah Sains Bengawan :Jurnal Pengabdian Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian
Nuraini Harmastuti
Program Studi Farmasi, Fakultas Farmasi, Universitas Setia Budi Surakarta
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Simvastatin dengan Senyawa Turunan Β-Siklodextrin Cristy, Devina Wahyu Astaning; Harmastuti, Nuraini; Mardiyono, Mardiyono
Journal of Telenursing (JOTING) Vol 6 No 1 (2024): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v6i1.9472

Abstract

This study aims to determine the profile of the inclusion complex formed between simvastatin and β-cyclodextrin and its derivatives. To determine the level of stability and determine the solubility level of the inclusion complex formed between simvastatin and β-cyclodextrin and its derivatives (2-hydroxypropyl-β-cyclodextrin and 2,6-di-O-methyl-β-cyclodextrin) in water solvent.The method used is qualitative descriptive using the molecular docking method, modeling and anchoring the inclusion complex model.The research results show that the simvastatin/HP-β-CD inclusion complex has a higher level of solubility in water solvents compared to the simvastatin/β-CD and simvastatin/DM-β-CD inclusion complexes, with a ΔGsolvation value of -1032.34 kJ/mol.Conclusion: Simvastatin is able to bind to the cavity of 2-hydroxypropyl-β-cyclodextrin, 2,6-di-O-methyl-β-cyclodextrin, and simvastatin/β-cyclodextrin with the following order of bond strength: simvastatin/2-hydroxypropyl-β -cyclodextrin > simvastatin/2,6-di-O-methyl-β-cyclodextrin > simvastatin/β-cyclodextrin. Keywords: Inclusion Complex, Molecular Docking, Molecular Dynamics Simulation, Β-Cyclodextrin, Simvastatin.
PELATIHAN PEMBUATAN AROMATERAPI LAVENDER & GRASS OIL (ALTERNATIF PENCEGAH DBD) DAN LEMON & GREENTEA (KARMINATIF) Turahman, Taufik; Rahayu, Mamik Ponco; Fadma Sari, Ghani Nurfiana; Rejeki, Endang Sri; Harmastuti, Nuraini; Supriyadi, Supriyadi
Bengawan : Jurnal Pengabdian Masyarakat Vol 3 No 1 (2023): Juni
Publisher : Politeknik Indonusa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/jurnal_bengawan.v3i1.81

Abstract

The Lavender and Grass oil Aromatherapy Making Training is a Community Service project to disseminate relevant knowledge and technology that is easy to use. In addition, it provides value by improving skills and motivate to establish a home industry in the pursuit of a small business. A USB Pharmacy lecturer conducted this program for people of the Genengan community, located at RT 08 RW 12, Mojosongo Village, Jebres Sub-district, Surakarta City. Oils from Lemongrass and Lavender Herbs are used in aromatherapy making training. These organic components have not yet been utilized by community members or locals to produce aromatherapy that is beneficial to their health. Typically, pharmacies charge relatively high costs for products that include aromatherapy. It is envisaged that the Geneng community's training in aromatherapy production will boost the village's added value. Making products for aromatherapy using lavender and lemongrass is one of the projects that has the potential to be used as a home industry activity.
PELATIHAN PEMBUATAN NATURAL HERBAL SOAP SEBAGAI UPAYA PENINGKATAN KEWIRAUSAHAAN PKK DESA TRIYAGAN Sari, Ghani Nurfiana Fadma; Rejeki, Endang Sri; Turahman, Taufik; Rahayu, Mamik Ponco; Harmastuti, Nuraini
Bengawan : Jurnal Pengabdian Masyarakat Vol 4 No 1 (2024): Juni
Publisher : Politeknik Indonusa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46808/jurnal_bengawan.v4i1.110

Abstract

Masyarakat Karangturi desa Triyagan, Kecamatan Mojolaban, Kabupaten Sukoharjo masih memerlukan pelatihan untuk meningkatan perawatan serta kesehatan keluarga terutama menggunakan bahan tradisional yang mudah didapatkan dan menciptakan motivasi perintisan home indutri dalam upaya peningkatan kewirausahaan dan perekonomian warga. Maka dari itu diperlukan adanya kegiatan penyuluhan dan pelatihan pembuatan Natural Herbal Soap. Kegiatan pengabdian kepada masyarakat ini dirancang dalam dua kegiatan, yaitu: Pertama, penyuluhan tentang peran bahan alami tradisional dalam kesehatan. Kedua, pelatihan pembuatan Natural Herbal Soap dari campuran antara minyak (minyak zaitun dan minyak kelapa) dengan larutan alkali (NaOH) sehingga membentuk padatan yang mengental yang disebut trace, kemudian ditambahkan minyak essensial (greentea, chamomile, sereh) secukupnya dan dihomogenkan lalu dibiarkan memadat. Target serta objek dari kegiatan ini adalah masyarakat akan mendapat tambahan keterampilan membuat Natural Herbal Soap yang dapat dilakukan dengan mudah dan dengan modal kecil sehingga dapat sebagai salah satu alternatif peningkatan kewirausahaan keluarga dan juga dapat digunakan untuk peningkatan kesehatan keluarga sehari-hari.
Analisis Kadar Timbal dalam Eyeliner berbagai Merek yang Beredar di Surakarta dengan Metode Spektrofotometri Serapan Atom Mauk, Bertha Angela Chameliana; Harmastuti, Nuraini; Kurniasari, Fitri
Journal of Islamic Pharmacy Vol 9, No 2 (2024): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v9i2.28643

Abstract

Eyeliner merupakan sediaan yang digunakan pada kulit tipis sekitar mata dengan fungsi mempertajam dan memperindah bentuk mata. Eyeliner memiliki pigmen warna dasar emulsi minyak dalam air. Eyeliner mengandung logam timbal yang dapat menyebabkan sakit kepala, dan penggunaan dalam jangka panjang dapat mempengaruhi sistem saraf serta dapat bersifat karsinogenik. Penelitian ini bertujuan untuk menganalisis kadar timbal dalam eyeliner berbagai merek yang beredar di Surakarta dengan menggunakan spektrofotometri serapan atom. Metode penelitian menggunakan tiga merek sampel eyeliner terdaftar Badan Pengawasan Obat dan Makan (BPOM), tiga merek sampel eyeliner tidak terdaftar BPOM, dan tiga merek sampel eyeliner luar negeri yang beredar di Surakarta. Analisis kualitatif dan kuantitatif logam timbal menggunakan instrumen spektrofotometri serapan atom. Hasil uji kualitatif dan kuantitatif dengan spektrofotometri serapan atom menunjukkan bahwa terdapat timbal dalam sampel dengan kadar berturut-turut A1 = 24,4075 ± 2,3970 mg/Kg, A2 = 24,8934 ± 4,4417 mg/Kg, A3 = 51,4224 ± 20,9957 mg/Kg, B1= 296,8730 ± 33,2398 mg/Kg, B2 = 294,8082 ± 26,7292 mg/Kg, B3 = 264,3652 ± 39,3059 mg/Kg, C1 = 177,0400 ± 22,7420 mg/Kg, C2 = 220,0130 ± 39,6887 mg/Kg, dan C3 = 708,4181 ± 163,9650 mg/Kg. Hasil analisis menunjukkan bahwa seluruh sampel tidak memenuhi syarat kadar timbal yang telah ditentukan oleh BPOM Republik Indonesia Nomor 12 tahun 2019 yaitu tidak lebih dari 20 mg/Kg atau 20 mg/L.
Analysis of active compounds in kawista leaf (Limonia acidissima L.) fraction and its antioxidant activity using DPPH method Azizah, Tri Nur; Harmastuti, Nuraini; Wijayanti, Tri
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art9

Abstract

Background: Kawista (Limonia acidissima L.) is a plant that has been studied for its potential as a natural antioxidant. Research regarding kawista leaves has not been carried out to a more specific stage, so further fraction separation is carried out to determine compounds that have potential as antioxidant agents.Objective: This study aimed to determine the antioxidant activity of kawista leaf fractions using the DPPH method and to determine the active compounds in the highest antioxidant agents of kawista leaf fracton.Method: Kawista leaves were extracted by re-maceration using methanol, which was then purified by the liquid-liquid extraction method with the solvents n-hexane, ethyl acetate, and water. Phytochemical studies were carried out on the fractions using TLC on flavonoids, steroids, tannins, saponins, and alkaloids. The fraction was separated by the vacuum liquid chromatography method with 11 eluents, which were then tested for antioxidants and characterization of the most active compounds in the kawista leaf fraction. Then the highest results as antioxidant agents from the fraction were characterized for their active compounds using a spectrophotometer and FTIR.Results: The results of the study showed that the most active purified extract in antioxidant activity was ethyl acetate, which indicates strong antioxidant activity. The combined fraction 2 (F2) indicates flavonoid compounds that played an active role as very strong antioxidants with an AAI value of 3.3808, which is not significantly different from the vitamin C as standard. Flavonoid compounds that have been characterized using a spectrophotometer interpret the wavelength shift data that possible F2 belongs to the flavanon group.Conclusion: Active compounds from kawista leaf fraction (F2) have the highest antioxidant agent, with the possibility that flavonoid compounds from F2 belong to the flavanon group.
Perbandingan Studi Aktivitas Antioksidan Ekstrak Metanol, Etanol 70%, dan Etanol 96% Daun Kawista (Limonia acidissima L.) Tri Nur Azizah; Nuraini Harmastuti; Tri Wijayanti
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.8559

Abstract

Antioksidan alami (berasal dari bahan alami / tanaman) dijadikan alternatif akibat adanya kekhawatiran akan kemungkinan efek samping dari antioksidan sintetik. Salah satu tanaman yang berpotensi sebagai antioksidan alami yaitu kawista (Limonia acidissima L.). Tujuan penelitian ini untuk membandingkan aktivitas antioksidan dari daun kawista dengan proses ekstraksi beberapa pelarut (metanol, etanol 70%, dan etanol 96%). Metode penelitian yang dilakukan meliputi maserasi, identifikasi senyawa, dan pengujian antioksidan dengan metode DPPH. Pengukuran antioksidan menggunakan spektrofotometer UV-Vis dinyatakan dengan nilai IC50 (Inhibitory Concentration 50) yang kemudian dikonversikan ke nilai AAI (Antioxidant Activity Index). Nilai aktivitas antioksidan yang diperoleh paling tinggi dari ekstrak metanol yaitu nilai rata – rata IC50 82,2034 ± 0,5733 dan nilai rata – rata AAI 1,2165 ± 0,00852 artinya mempunyai sifat antioksidan kuat. Aktivitas antioksidan dari ekstrak etanol 70% daun kawista dengan nilai rata – rata IC50 135,5030 ± 7,2238 dan nilai rata – rata AAI 0,7934 ± 0,0382 mempunyai sifat antioksidan sedang. Sedangkan ekstrak etanol 96% dengan nilai rata – rata IC50 123,5900 ± 2,9718 dan nilai rata – rata AAI 0,8094 ± 0,0195 mempunyai sifat antioksidan sedang. Kesimpulannya perbandingan hasil ekstraksi dengan berbagai pelarut menunujukkan aktivitas antioksidan yang berbeda signifikan. Antioksidan tertinggi terdapat pada ekstrak metanol dengan nilai IC50 82,20 ppm dan AAI sebesar 1,22.
Kajian Hubungan Kuantitatif Struktur Dan Aktivitas (HKSA) Senyawa Kurkumin Dan Turunannya Sebagai Agen Anti Tumor Darah Terhadap Penghambatan Pertumbuhan Sel K562 Puspitasari, Ismi; Astuti, Sari; Harmastuti, Nuraini
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p65-75

Abstract

Curcumin was reported can suppress the growth of blood tumor cells. This study aims to determine the physical and chemical properties of curcumin derivatives that give affect to antitumor activity of blood cells which were expressed as the best HKSA equation model. This   study   used   curcumin   and   twelve   derivatives   which   have   antitumor   activity parameters of blood cells (K562) as IC50. Parameters of physicochemical properties of curcumin compounds series and their derivatives as descriptors include net charge of atoms in the curcumin framework structure, EHOMO, ELUMO, Log P, E Hid, a, MR, Volume, Surface area (SA), Total Energy, dipole moment (u), Hf, and Mass which are the results of geometric optimization calculations using the PM3 semiempirical method with hyperchem application. HKSA equation model was built using the BuilQSAR statistical calculation analysis. The best HKSA equation model is then validated internally and externally. Calculation of statistical analysis with BuldQSAR, the descriptor that has the most influence is  obtained, namely net  atomic charge, EHOMO,  surface area, dipole moment and  Hf with  linear regression equation: Log 1/IC50 : + 1.7622 (± 0.3655) qC4 - 0.9457 (± 0.1047) E Homo + 0.0013 (0.0002) SA + 0.0575 (± 0.0216) u - 0.0068 (± 0.0004) Hf - 11.4161 (± 1.0440) , n = 10; R = 0.999; R2= 0,9990; SPress = 0.0232. as well as non-linear regression equation : Log 1/IC50 = + 15.1400 (±4.9008) qC7 + 7.4959 (± 5.6081) qC8 - 0.5839 (± 0.1397) qC15 + 0.0005 (± 0.0003) SA - 0.0054 (±0.0008) Hf - 5.7246 (±3.2476), n = 10; R = 0,999, R2 = 0,9977; SPress = 0.0341.
ANALISIS LOGAM TIMBAL (Pb) PADA PENSIL ALIS YANG BEREDAR DI KABUPATEN TULUNGAGUNG SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA) Rosyidah, Semi; Harmastuti, Nuraini; Rejeki, Endang Sri
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p179-186

Abstract

Eyebrow pencil is a cosmetic that is used to correct less symmetrical eyebrows. The colors marketed are very diverse. Lead is also obtained from tools used during the production process. This study aims to determine the lead content in eyebrow pencils and to determine the lead levels in eyebrow pencils circulating in Tulungagung by atomic absorption spectrophotometry (AAS) still meets the requirements of BPOM No. 12 of 2019. Sampling using a purposive sampling technique. Preparation samples were carried out using the dry deconstruction method. The research began with chemical and physical qualitative analysis. The determination of lead levels using AAS at a wavelength of 283.3 nm was then determined. The AAS analytical method is suitable for lead based on the results of method verification meeting the requirements including linearity with a value of r = 0.9929, accuracy of 102%, LOD 0,1189 mg/L, but did not meet the LOQ of 0.3964 mg/L. The results showed that 3 out of 5 samples were positive for lead with levels ranging from 4.9339-5.4896 mg/kg. The results still meet the BPOM contamination limit requirements, which are not more than 20 mg/kg, thus all samples are still within safe limits according to the requirements set by BPOM.
Identifikasi Senyawa Metabolit Sekunder pada Ekstrak dan Fraksi Ekstrak Daun Kelor (Moringa oleifera) dengan Metode Kromatografi Lapis Tipis (KLT) Khairi, Widayatul; Widodo, Gunawan Pamudji; Harmastuti, Nuraini; Safwan, Safwan; Wahid, Abdul Rahman; Hendriyani, Irmatika; Ittiqo, Dzun Haryadi
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 6, No 2 (2025): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v6i2.30257

Abstract

AbstrakMoringa oleifera yang dikenal di Indonesia dengan nama kelor dan dikatakan sebagai “the miracle tree” atau pohon ajaib karena secara alamiah sebagai sumber gizi dan obat.Komponenekstrak daun kelor yang ditemukan memiliki golongan flavonoid. Sebagai antioksidan, antidiabetes, antiinflamasi, dan antimikroba, senyawa ini memiliki gugus -OH yang terikat pada cincin benzena. Tujuannya adalah untuk mengidentifikasi senyawa metabolit sekunder pada daun kelor. Ini akan dilakukan dengan menggunakan teknik kromatografi lapis tipis (KLT). Hasil ekstrak dan fraksi daun kelor, termasuk air, etil asetat, dan n-heksan, terdapat senyawa flavonoid, tanin, alkaloid, dan saponin pada fraksi etil asetat sedangkan pada ekstrak dan fraksi air terdapat senyawa tanin, pada fraksi n-heksan terdapat senyawa steroid. Kesimpulan terdapat senyawa metabolit sekunder pada daun kelor (Moringa oleifera).AbstractMoringa oleifera, known in Indonesia as "kelor," is referred to as “the miracle tree” due to its natural nutritional and medicinal properties. The components found in the Moringa leaf extract belong to the flavonoid group. As antioxidants, antidiabetic, anti-inflammatory, and antimicrobial agents, these compounds contain -OH groups attached to a benzene ring. The aim is to identify the secondary metabolites present in Moringa leaves using thin-layer chromatography (TLC) techniques. The study includes extracts and fractions of Moringa leaves, specifically water, ethyl acetate, and n-hexane, showed the presence of flavonoids, tannins, alkaloids, and saponins in the ethyl acetate fraction, while tannins were found in both the extract and water fraction. Additionally, steroids were detected in the n-hexane fraction. In conclusion, Moringa oleifera leaves contain secondary metabolites.
Optimization and Characterization of Naringenin Transfersomes with Simplex Lattice Design and Anti-Aging In Vivo Study Yuliana, Sinta; Kuncahyo, Ilham; Harmastuti, Nuraini
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 1 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i1.782

Abstract

Naringenin acts as an antioxidant, neutralizing free radicals that are present in the atmosphere and which are responsible for a number of adverse effects on the skin, including photoaging, the formation of wrinkles, and a loss of radiance. The objective of this study is to determine the effect of varying phospatidilcholine, cholesterole, and tween 80 on the characteristics of naringenin transfersome and their efficacy as anti-aging agents. A total of 14 naringenin transfersome formulas were subjected to testing using the Design-Expert application, using simplex lattice design method. The particle size, polidispersity index, zeta potential, and % Entrapment efficiency were evaluated. Subsequently, the optimal formula was subjected to in vivo anti-aging testing. The characterization results obtained for the PSA test indicate a range of values between 70 and 90 nm for the naringenin transfersomes. The % Efficiency of Absorption test yielded results between 80 and 92%, while the PDI test exhibited a range close to. The value of zero is obtained for the zeta potential, and the results are distant from this value. The optimum formula, as predicted by the Simplex lattice design method, provides results for the characterization test that are in close alignment with the actual outcomes.
Co-Authors Ajeng Nanda Sasmita Azizah, Tri Nur Bahi, Rizky Resvita R. Cristy, Devina Wahyu Astaning Dyah Susilowati Endang Sri Rejeki Endang Sri Rejeki Fachry Abda El Rahman Ghani Nurfiana Fadma Sari Gunawan Pamudji Widodo Hadi Nasbey Harno Dwi Pranowo Ilham Kuncahyo, Ilham Indah Marcelina Irmatika Hendriyani Ittiqo, Dzun Haryadi Jausi Jannah Jonathan Suneidesis Alpons, Gabriel Khoirul Anwar Kurniasari, Fitri Mamik Ponco Rahayu Mardiyono Mardiyono Mauk, Bertha Angela Chameliana Maulita Saraswati Mointi, Sella Septiyani Puspitasari, Ismi Rosyidah, Semi Safwan Safwan, Safwan Sari Astuti Sari Astuti Semi Rosyidah Siti Aisiyah Sofia Mubarika Supriyadi Supriyadi Supriyadi Susilo Margining Raharjo TATI NURHAYATI Titik Sunarni Tri Nur Azizah Tri Wijayanti Tri Wijayanti Turahman, Taufik Turahman, Taufik Wahid, Abdul Rahman Wahyu Aji Pangestu, Rochmadani Widayatul Khairi Wiwin Herdwiani Yuliana, Sinta