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All Journal HAYATI Journal of Biosciences Jurnal Silvikultur Tropika (JST) Jurnal Floratek Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter BIOTROPIA - The Southeast Asian Journal of Tropical Biology AL KAUNIYAH BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan Journal of Aceh Physics Society Jurnal Penelitian Pendidikan IPA (JPPIPA) Prosiding Seminar Nasional Biologi, Teknologi dan Kependidikan (Biotik) Makara Journal of Science Jurnal Natural Journal of Patchouli and Essential Oil Products Jurnal Ilmiah Mahasiswa Pertanian Heca Journal of Applied Sciences Grimsa Journal of Science Engineering and Technology Biosaintifika: Journal of Biology & Biology Education Biosainsdik: Biologi Sains dan Kependidikan
Essy Harnelly
Biology Department, Faculty Of Mathematics And Natural Sciences, Syiah Kuala University
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Theoretical Evaluation of Michelia Species’ Bioactive Compounds and Theraupetic Potential: A Literature Review Oktaviana, Nurul; Isnaini, Nadia; Harnelly, Essy; Zulkarnain, Zulkarnain; Muhammad, Syaifullah; Misrahanum, Misrahanum
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 2 (2023): December 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i2.12

Abstract

Michelia alba is a multifunctional plant found in Indonesia and is also called magnolia. Michelia alba is a tree known for its essential oil, which has long been used as a fragrance ingredient in perfumes and cosmetics. The potential of M. alba is immense for use in the prevention and treatment of disease as well as the management of human health and wellness. To date, there have been few publications regarding the biological activities of M. alba, focusing on tyrosinase inhibitory, antibacterial, antidiabetic, anti-inflammatory and antioxidant activities. However, M. alba may have additional undiscovered biological activities associated with its bioactive compounds. The purpose of this literature review research is to find out the bioactive compounds and therapeutic potential of the M. alba plant through literature searches that can be a reference for further research. The literature review method is carried out by searching and collecting data from literature sources obtained from several national and international journals that review bioactive compounds and the therapeutic potential of M. alba plants. Based on the literature review, it was found that M. alba has bioactive compounds namely linalool (72.8 flower oil and 80.1% leaf oil), α-terpineol (6.04% flower oil), phenylethyl alcohol (2.58% flower oil), β-pinene (2.39% flower oil) and geraniol (1, 23%) which have therapeutic activities such as mental health disorders, anticancer, anti-inflammatory, antihypertensive, antidiabetic, antihyperlipidemia, antimaagic, antidiarrheal, anti-asthma, and antihyperpigmentation. In traditional medicine it is used to treat fever, syphilis, gonorrhea and malaria, bronchitis, prostatitis, cancer, headache, sinusitis, cough, inflammation of the respiratory tract, chest fullness, flatulence, nausea, body and underarm odor, and vaginal discharge.
Trends in Formulation of Night Cream Containing Essential Oil Isnaini, Nadia; Faradhila, Jihan; Maysarah, Hilda; Prajaputra, Vicky; Harnelly, Essy; Zulkarnain, Zulkarnain; Maryam, Siti; Muhammad, Syaifullah; Haditiar, Yudi; Desiyana, Lydia Septa; Sari, Febia
Journal of Patchouli and Essential Oil Products JOURNAL OF PATCHOULI AND ESSENTIAL OIL PRODUCT : VOLUME 2, ISSUE 2 (DECEMBER 2023)
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jpeop.v2i2.36090

Abstract

Night creams play a pivotal role in skincare routines by safeguarding against nocturnal moisture loss and promoting a smooth, wrinkle-free complexion. However, conventional formulations of night creams often incorporate synthetic active substances, potentially leading to adverse effects over prolonged use. Addressing this concern involves substituting these synthetic compounds with natural ingredients, particularly essential oils, renowned for their diverse skincare benefits encompassing anti-acne, anti-aging, anti-wrinkle, and moisturizing properties. A systematic review was conducted to establish a foundation for future investigations, focusing on the integration of essential oils in night cream formulations. The outcomes revealed that various night cream formulations, enriched with essential oils derived from natural ingredients such as rosemary oil, camellia oil, clove oil, geranium oil, lemongrass oil, rosehip oil, and sandalwood oil, demonstrate remarkable efficacy in preserving skin moisture. The versatility of essential oils has been showcased in the development of night creams, boasting diverse beneficial effects across skincare concerns. This systematic investigation highlights the potential of essential oil-based night creams, which have recently gained traction in the global market. The burgeoning introduction of these products signifies an escalating demand for such skincare solutions and points towards promising prospects for future advancements in essential oil-based night creams.Keywords: essential oils, formulation, natural product chemistry, night cream, patchouli oil, skincare
Antiaging Mechanism of Natural Plant Sources: A Potential Current Product Nafissa, Naja; Isnaini, Nadia; Desiyana, Lydia Septa; Prajaputra, Vicky; Harnelly, Essy; Zulkarnain, Zulkarnain; Maryam, Siti
Journal of Patchouli and Essential Oil Products JOURNAL OF PATCHOULI AND ESSENTIAL OIL PRODUCT : VOLUME 2, ISSUE 2 (DECEMBER 2023)
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jpeop.v2i2.37929

Abstract

The aging process is a multifaceted phenomenon influenced by various intrinsic and extrinsic factors. Oxidative stress, stemming from an imbalance between intracellular antioxidants and the excessive production of reactive oxygen species, is known to accelerate aging. Skin aging manifests through wrinkles, fine lines, and dark spots that become visible on the skin's surface. In modern times, cosmetics are not just associated with beauty but also with achieving younger-looking skin. There is a growing demand for anti-aging cosmetics formulated with natural ingredients. Natural anti-aging ingredients, such as plant extracts and antioxidants, including secondary compounds like phenols, flavonoids, alkaloids, tannins, anthocyanins, and coumarins, have gained popularity due to their potential to counteract the effects of oxidative stress and inflammation. These compounds play a pivotal role in neutralizing free radicals, oxidative stress, promoting collagen and skin elasticity, as well as addressing pigmentation and serving as natural skin-whitening agents. This research aims to explore the anti-aging mechanism of natural lant sources in making potential cosmetic Products.Keywords:antiaging, cosmetics, natural cosmetics, mechanism natural cosmetics
A Systematic Review: Formulation of Facial Wash Containing Essential Oil Syaharani, Cut Puspita Salsabila; Isnaini, Nadia; Harnelly, Essy; Prajaputra, Vicky; Maryam, Siti; Gani, Fadli A.
Journal of Patchouli and Essential Oil Products JOURNAL OF PACTHOULI AND ESSENTIAL OIL PRODUCT : VOLUME 2, ISSUE 1 (JUNE 2023)
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jpeop.v2i1.32261

Abstract

Facial wash is a major need of the community because it is very helpful in removing dirt, dust, dead skin cells, oil, residual cosmetics and provides moisture to the skin. In general, the face wash used by the community is classified as a synthetic product that can damage the skin, one alternative to avoid this by using natural ingredients such as essential oils. Essential oils have many benefits, including as anti-acne, antibacterial, and antioxidant. Therefore, a systematic review was conducted regarding the formulation of essential oils as a face wash that can be a reference in future research. The systematic review method was carried out by collecting data from various literature sources obtained from several research journals that have been published both nationally and internationally accredited reviewing face wash cosmetics containing essential oils. Based on the systematic review, it was found that there are several face wash formulations containing essential oils of patchouli oil, tea tree oil, jasmine oil, cinnamon oil, black cumin seed oil, basil oil, ylang-ylang oil, peppermint oil, turmeric oil, lemongrass oil, lavender oil, and tangerine oil.
DNA Barcoding of Six Commercially Important Groupers (Epinephelidae) from Langsa, Aceh, Indonesia Fadli, Nur; Jumiati, Sri; Razi, Nanda Muhammad; Damora, Adrian; Muchlisin, Zainal A.; Dewiyanti, Irma; Ramadhaniaty, Mutia; Harnelly, Essy; Habib, Ahasan; Siti-Azizah, Mohd Nor
HAYATI Journal of Biosciences Vol. 31 No. 2 (2024): March 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.2.328-335

Abstract

Groupers are among the fish groups that are difficult to recognize due to their high morphological similarities. Therefore, molecular techniques, particularly DNA barcoding, are extensively utilized to differentiate this fish group. This study aimed to analyze and validate six grouper species belonging to the Epinephelidae family that were harvested from Langsa district waters in Aceh province, Indonesia, based on DNA barcode data. It was conducted from June to December 2021, with the fish specimens collected from fishers at fish landing sites and the fish market in Langsa City, Aceh province. A total of 22 grouper sequences belonging to six species were generated, namely Epinephelus coioides, E. bleekeri, E. malabaricus, E. erythrurus, E. sexfasciatus and Mycteroperca poecilonotus (formerly Epinephelus poecilonotus). Genetic distance within these species ranged from 0.10 to 0.73% (average: 0.40%). Notably, E. malabaricus and E. coioides exhibited the closest genetic kinship (4.07%), while E. sexfasciatus and M. poecilonotus displayed the greatest genetic distance (19.33%). This study provides the first DNA reference for grouper in Langsa district, Indonesia, with significant implications for future sustainable grouper management.
COULD DODECANOIC ACID VCO FROM TRADITIONAL ACEH YEAST FERMENTATION USED AS ANTIVIRAL AGENTS AGAINST 2019-NCOV ? Annisa Ammalia Kiti; Zairin Thomy; Essy Harnelly
Jurnal Biologi Sains dan Kependidikan Vol 1, No 1, Mei (2021): BIOSAINSDIK : Jurnal Biologi Sains dan Kependidikan
Publisher : Prodi Tadris Biologi Fakultas Agama Islam Universitas Muhammadiyah Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37598/biosainsdik.v1i1.1013

Abstract

Numerous previous studies have proven the efficacy of dodecanoic acid contained by VCO as an antimicrobial, especially antiviral. The global urgency of COVID-19 treatment caused by the 2019-nCoV virus has prompted many researchers around the world to seek effective drugs to cure this infectious disease. Based on the claim that dodecanoic acid and its derivatives can be used as an antiviral, this study aims to determine the levels of VCO dodecanoic acid produced from the traditional yeast fermentation of Aceh, Indonesia. The making of VCO through fermentation with the addition of starter yeast as much as 10% in coconut milk. Analysis of dodecanoic acid levels was performed using Gas Chromatography-Mass Spectroscopy (GC-MS). The results showed that the composition of dodecanoic acid in VCO-pe was higher than VCO-ti. VCO-pe contains about 44.23% dodecanoic acid, while VCO-ti contains about 43.63% dodecanoic acid. The composition of dodecanoic acid contained in VCO-pe was higher than VCO-ti. The composition of dodecanoic acid in VCO has met APCC standards, namely 43.0% -53.0%. These results could append new information about the application of dodecanoic acid in VCO as an antiviral candidate against 2019-nCoV which causes the COVID-19 outbreak.Keywords: antimicrobial, coronavirus, COVID-19, levels of lauric acid, virgin coconut oil
DNA Barcoding of Commercially Important Groupers (Epinephelidae) in Simeulue and Banyak Islands, Aceh, Indonesia Fadli, Nur; Razi, Nanda Muhammad; Damora, Adrian; Muchlisin, Zainal A.; Ramadhaniaty, Mutia; Rahayu, Sri Riska; Harnelly, Essy; Habib, Ahasan; Siti-Azizah, Mohd Nor
HAYATI Journal of Biosciences Vol. 32 No. 4 (2025): July 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.4.1080-1091

Abstract

The groupers are a group of demersal fish that live in tropical and subtropical areas and are mostly linked to coral reefs. The fish are highly valued in international markets and are subjected to overfishing in the wild. Accurate fish resource identification knowledge is essential for sustainable fisheries management. This research is aimed to generate a reference COI sequence library of grouper species caught in Simeulue and Banyak Islands, Aceh. The study was conducted from April-September 2021 at sixteen fish landing sites in Simeulue and Banyak Islands. In total, this study generated 70 COI sequences representing 20 grouper species. Epinephelus (54%) was the most prevalent grouper genus at the study site, followed by Cephalopholis (19%), Plectropomus (13%), Variola (12%), Hyporthodus (1%), and Anyperodon (1%). According to the IUCN classification, 17 species (85%) fall into the category of Least Concern, two (10%) fall into the category of Vulnerable, and one (5%) falls into the category of Data Deficient. The average genetic distance based on the Kimura-2-Parameter (K2P) between specimens was 0.51% at the species level and 8.34% at the genus level. Overall, this study has provided the COI sequence database of grouper for the Simeulue and Banyak Islands.
Predicting AXL Tyrosine Kinase Inhibitor Potency Using Machine Learning with Interpretable Insights for Cancer Drug Discovery Noviandy, Teuku Rizky; Idroes, Ghifari Maulana; Harnelly, Essy; Sari, Irma; Fauzi, Fazlin Mohd; Idroes, Rinaldi
Heca Journal of Applied Sciences Vol. 3 No. 1 (2025): March 2025
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/hjas.v3i1.270

Abstract

AXL tyrosine kinase plays a critical role in cancer progression, metastasis, and therapy resistance, making it a promising target for therapeutic intervention. However, traditional drug discovery methods for developing AXL inhibitors are resource-intensive, time-consuming, and often fail to provide detailed insights into molecular determinants of potency. To address this gap, we applied machine learning techniques, including Random Forest, Gradient Boosting, Support Vector Regression, and Decision Tree models, to predict the potency (pIC50) of AXL inhibitors using a dataset of 972 compounds with 550 molecular descriptors. Our results demonstrate that the Random Forest model outperformed others with an R² of 0.703, MAE of 0.553, RMSE of 0.720, and PCC of 0.841, showcasing strong predictive accuracy. SHAP analysis identified critical molecular features, such as RNCG and TopoPSA(NO), as key contributors to inhibitor potency, providing interpretable insights into structure-activity relationships. These findings highlight the potential of machine learning to accelerate the identification and optimization of AXL inhibitors, bridging the gap between computational predictions and rational drug design and paving the way for effective cancer therapeutics.
Design and Development of Website and Android-Based Aceh Biodiversity Applications Muhammad Subianto; Essy Harnelly; Alim Misbullah; Razief Perucha Fauzie Afidh; Fikrul Akhyar; Muhammad Irfan; Wira Dharma; Nazaruddin; Zulfan
Jurnal Penelitian Pendidikan IPA Vol 11 No 4 (2025): April
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i4.10535

Abstract

Aceh is an exceptional region in Indonesia characterized by significant biodiversity and abundant natural wealth. Despite these numerous benefits, there is limited information regarding the potential of biodiversity in this region. Therefore, this research aimed to design and develop Website and Android-based applications to facilitate access to information regarding biodiversity in Aceh. In the development process, the Waterfall method was used, and the applications consisted of two main components, namely the back-end and the front-end. The users were divided into three categories, including contributors, verificators, and admins. After the development was complete, functionality testing was conducted using the black box method, and usability was examined using the Post-Study System Usability Questionnaire (PSSUQ). The results of functionality testing showed that both applications operate efficiently, thereby providing users with a satisfying experience when accessing information about Aceh biodiversity. The usability score was approximately 7 for Website-based and 6 for Android-based applications, showing a high level of usability.
ENHANCING CALLUS FORMATION IN TAPAKTUAN PATCHOULI THROUGH IN VITRO OPTIMIZED COMBINATIONS OF PGR Munira, Alya; Khairan, Khairan; Subramaniam, Sreeramanan; Harnelly, Essy
BIOTROPIA Vol. 32 No. 1 (2025): BIOTROPIA Vol. 32 No. 1 April 2025
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11598/btb.2025.32.1.2305

Abstract

Article Highlight- Different varieties of Patchouli exhibited different growth pattern as well as in vitro culture- In order to induce callus, it has been determined that the combination of regulators is necessary.- Benzylaminopurine has been identified as a potential regulator that could be used to further develop the patchouli callus of Tapak Tuan. Abstract: Patchouli is known for its highly demanded essential oil. The Patchouli Tapaktuan variety is the most widely cultivated by local farmers in Aceh due to its high oil yield. Currently, the study and propagation of patchouli through a biotechnological approach is being developed, one of which is in vitro culture method. In this method, suitable Plant Growth Regulators (PGR) are being observed to enhance the growth of the explant. PGRs are synthetic compounds that are added to media in plant tissue culture to stimulate plant growth. This study aimed to analyze and optimize the effect of benzylaminopurine (BAP), thidiazuron (TDZ) combined with Naphthaleneacetic acid (NAA) on the growth of Tapaktuan patchouli leaf callus. This study was carried out by using a completely randomized design with seven treatments.  Each treatment was replicated four times and each replicate contained three explants. The concentrations used were BAP 0.75 mg/L, TDZ 1 mg/L, and NAA in the 0.25 - 0.75 mg/L range. According to this study, combining BAP and NAA was the most effective for inducing callus in Tapaktuan patchouli leaves. The combination of BAP 0.75 mg/L + NAA 0.5 mg/L (treatment A2) was the most effective for inducing callus formation. This treatment resulted in the quickest callus development, the highest percentage of callus formation, and the largest callus diameter. Explants cultured with BAP produced a greenish-yellow callus having the potential for organogenesis culture, which could produce shoots having the ability for producing mass plantlets.
Co-Authors Adrian Damora Agus Sara Alim Misbullah Amirunnas , Amirunnas Annisa Ammalia Kiti Ardhana Yulisma Arif Habibal Umam Ariqah, Nada Cici Ariska A Dina Firmadiana Faradhila, Jihan Fauzi, Fazlin Mohd Fauziah . Fenty Ferayanti Fikrul Akhyar Gani, Fadli A. Habib, Ahasan Hairul Basri Hawati Hawati HENDRIX INDRA KUSUMA Hermanto, Feri Eko Idroes, Ghifari Maulana Iqbar Iqbar Irma Dewiyanti Irma Sari ISKANDAR ZULKARNAIN SIREGAR Isnaini, Nadia Itawarnemi, Hilmina Khairan Khairan Kusuma, Hendrix Lenni Fitri Lydia Septa Desiyana, Lydia Septa M. Satria Fitri Malahayati T. Hanafiah Martunis - Martunis Martunis Maysarah, Hilda Meutia Zahara Mira Humaira Misrahanum Misrahanum MUHAMMAD ADRIYAN FITRA MUHAMMAD BAHI Muhammad Irfan Muhammad Rusdi Muhammad Subianto Munira, Alya Mutia Zahara Nafissa, Naja Nanda Muhammad Razi Nazaruddin Nir Fathiya NITA TAUHIDA NITA TAUHIDA Nur Fadli Nurur Rahmy Oktaviana, Nurul Onny Ulfa Rahayu Prajaputra, Vicky Rahayu, Sri Riska Ramadhaniaty, Mutia Rauzana, Anita Razief Perucha Fauzie Afidh RIDHA UL FAHMI Rina Sriwati Rinaldi Idroes Rizki Amelia Rizki, Alia Rizky Amelia Rusita Fitri Saida Rasnovi SAIDA RASNOVI Saida Rasnovi Samingan Samingan Sari, Febia Saudah Saudah SITI MARYAM Siti-Azizah, Mohd Nor Sreeramanan Subramaniam Sri Jumiati, Sri Sri Wati Suryadi Suryadi Syaharani, Cut Puspita Salsabila Syahraini, Aigia Syaifullah Muhammad Teuku Rizky Noviandy Ulfa hansri Ar-Rasyid Wira Dharma Wira Dharma Yekki Yasmin Yudi Haditiar Yunita Yunita Yurinda Yurinda ZAINAL ABIDIN MUCHLISIN Zairin Thomy Zairin Thomy Zairin Thomy Zairin Thomy Zairin Thomy Zairin Thomy ZAIRIN THOMY Zairin Thomy Zairin Thomy Zakaria, Rahmad Zulfan Zulkarnain Zulkarnain Zulwanis, Zulwanis Zumaidar Zumaidar