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Fahmi Hidayat
Master of Management Graduate Syiah Kuala University Banda Aceh
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DEXAMETHASONE ANALYSIS ON SIX BRANDS OF PACKAGED HERBAL MEDICINE USING THIN LAYER CHROMATOGRAPHY METHOD Fitria, Faizatul; Arifah, Farida Noor; Lukis, Prima Agusti; Rahadi, Anisa Fajduani; Hidayat, Fahmi
Molluca Journal of Chemistry Education (MJoCE) Vol 14 No 2 (2024): MJoCe
Publisher : Program Studi Pendidikan Kimia, FKIP, Universitas Pattimura (Chemistry Education Study Program, Faculty of Teacher Training and Educational Sciences, Pattimura University)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/MJoCEvol14iss2pp77-82

Abstract

ABSTRACT Herbal medicine is used for generations because of its safety and free from adverse side effects, but the healing process takes a long time. This is the background of herbal medicine manufacturers to improve their performance by adding dexamethasone compounds. This compound is a synthesis of corticosteroid hormones whose use must be under the supervision of a doctor because it has side effects of cardiovascular disease, Cushing's syndrome, osteoporosis, hypertension, gastrointestinal ulcers, infections, and cataracts. The presence of this compound can be detected using the Thin Layer Chromatography method by comparing the Rf value of the sample with the standard solution of dexamethasone. The eluents used are methanol, ethyl acetate, and toluene with a ratio of 1:45:55. This method was used to detect dexamethasone content in six samples of packaged herbs circulating in the Mojokerto region, East Java province. Of the six samples analyzed, five of them showed positive results, namely samples A, B, C, D and F with a difference in the Rf value of the sample and standard of each 0.01; 0.01; 0.00; 0.00; and 0.02. Sample E does not contain dexamethasone indicated by the difference in the sample's Rf value against the 0.5 standard. Keywords: Herbal medicine, herbal packaging, dexamethasone, corticosteroids, Thin Layer Chromatography (TLC).
THE EFFECT OF LINGZHI (Ganoderma lucidum) EXTRACT ADDITION ON ANTIOXIDANT ACTIVITY OF HAND AND BODY LOTION FORMULATIONS Hidayat, Fahmi; Rosanti, Aulia Dewi; Fitria, Faizatul; Sa’diyah, Asvikatus
Molluca Journal of Chemistry Education (MJoCE) Vol 14 No 1 (2024): MJoCE
Publisher : Program Studi Pendidikan Kimia, FKIP, Universitas Pattimura (Chemistry Education Study Program, Faculty of Teacher Training and Educational Sciences, Pattimura University)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/MJoCEvol14iss1pp70-76

Abstract

Ganoderma lucidum, lingzhi or reishi mushroom is a plant containing secondary metabolites that are of wide interest due to their biological activities. Among them the most important is its Antioxidant activity. Free radicals are potentially damaging byproducts of metabolism. Antioxidants neutralize free radicals in the body and thus help to protect against disease (source) The study was conducted to determine the antioxidant effect, as measured by DPPH radicals scavenging capability of hand and body lotions with lingzhi mushroom extract included. Maceration was used to extract lingzhi and the yield of extraction is 14.17% The results of the preliminary phytochemical analysis showed that lingzhi has contained compounds related to flavonoid, phenolat, triterpenoid and steroid. The antioxidant activity assay further confirmed the results as lingzhi extract showed very high antioxidant (46.9 ppm) potential when tested against DPPH scavenging by abrogating red purple color at 517nm table(Table.). In addition, the incorporation of lingzhi extract with hand and body lotion also increased antioxidant activity, where 0.75% lingzhi extract was found have to produce most effective DPPH inhibition [IC50 = 28.47 ppm].
Co-Authors Aditya, Muhammad Rifki Affan, Ahmad Agil, Muhamad Said Agung Wahyudi Biantoro Ahmad Khoiril Anam Al-Arief, Yusuf Al-Fajri, Al-Fajri Ali Muhammad Alief Avicenna Luthfie, Alief Avicenna Amal, Amri Arifah, Farida Noor Barkah, Januar Danus, Muhar Dini Noor Arini, Dini Noor Dwirakha, Yusuf Effendy, Nada Mulia Septyani Emma Rosana Febriyanti Fadilla, Raisa Faizatul Fitria Fauzi, Irfan Ahmad Firman Firman Irsan Irsan Jatut Yoga Prameswari Khairuddin - Khairul Fata Kusyairi, Mochamad Irsyad Lukis, Prima Agusti Mariani, Nanik Mukhlis Mukhlis Mukhlis Nasrullah Nasrullah Noor Eka Chandra, Noor Eka Qodir, Isma Hanafiah Qumillaila, Qumillaila Rahadi, Anisa Fajduani Rahmawati, Rahmawati Reyhan, Muhammad Riansyah, Riansyah Rina Listia Rochmah, Ziana Nor Rohid, Burhannudin Rosanti, Aulia Dewi Sari, Ela Sawaty, Ikhwan Sa’diyah, Asvikatus Setiawan, Made Andik Setyonugroho, Ponco Sianna, Sianna Sirajuddin Kamal Sofian, Ian Mochamad St. Aminah Suhardi Suhardi Sukoco, Dear Tanadi, Tjan Stefany Taufik Barlian Triadi, Albert Wangsawan, Indra Wisnu Wardhana Yosi Apriani, Yosi