Garuda - Garba Rujukan Digital

p-Index From 2021 - 2026

2.266

P-Index

This Author published in this journals

All Journal Jurnal Kesehatan Andalas The Indonesian Biomedical Journal Sari Pediatri Molecular and Cellular Biomedical Sciences (MCBS) Buletin Ilmiah Nagari Membangun Journal of Midwifery Majalah Kedokteran Andalas Jurnal Ilmu Kesehatan Indonesia (JIKSI) International Journal of Medicine and Health Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI)

Hirowati Ali

Bagian Biokimia Fakultas Kedokteran Universitas Andalas

Author-ID : 2837049

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

Published : 27 Documents Claim Missing Document

Claim Missing Document

Articles

1 2 3

Hubungan Kadar Serum Aminotransferase dengan Derajat Perlemakan Hati pada Remaja Obesitas Febianne Eldrian; Yusri Dianne Jurnalis; Hirowati Ali; Hafni Bachtiar; Rozetti Rozetti
Sari Pediatri Vol 17, No 5 (2016)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp17.5.2016.361-366

Latar belakang. Prevalensi penyakit perlemakan hati non alkoholik (PPHNA) meningkat bersamaan dengan peningkatan obesitas pada anak dan remaja. Sebagian besar PPHNA asimtomatis sehingga penting deteksi dini terutama pada remaja obes karena progresifitas dapat meningkatkan morbiditas dan mortalitas sirosis pada dewasa muda.Tujuan. Menganalisis hubungan kadar serum aminotransferase (aspartat aminotransferase dan alanin aminotransferase) dengan derajat perlemakan hati pada remaja obesitas.Metode. Penelitian cross sectional pada remaja obesitas di Kota Padang dengan jumlah subyek penelitian 43 orang.Hasil. Rerata kadar serum ALT lebih tinggi daripada rerata kadar serum AST. Tidak ada subyek pada kelompok bukan PPHNA yang mengalami peningkatan kadar serum aminotransferase. Berdasarkan pemeriksaan USG abdomen, gambaran perlemakan hati derajat I (mild), derajat II (moderate), derajat III (severe) berturut-turut 25 (64%), 8 (20,5%), dan 6 (15,2%) orang. Tidak terdapat hubungan antara kadar serum aminotransferase dengan derajat perlemakan hati pada remaja obesitas.Kesimpulan. Rerata kadar serum aminotransferase pada kelompok PPHNA lebih tinggi daripada kelompok bukan PPHNA. Tidak terdapat hubungan antara kadar aminotransferase dengan perlemakan hati pada remaja obes. Berdasarkan pemeriksaan ultrasonografi abdomen sebagian besar perlemakan hati adalah derajat I (mild).

Hubungan Kadar Docosahexaenoic Acid Terhadap Perlemakan Hati Non Alkoholik Remaja Obesitas Dhina Lidya Lestari; Yusri Dianne Jurnalis; Hirowati Ali
Sari Pediatri Vol 23, No 2 (2021)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp23.2.2021.82-7

Latar belakang. Penyakit hati berlemak non alkohol (NAFLD) adalah penyakit yang ditandai dengan timbunan lemak yang signifikan di hepatosit dari parenkim hati yang menyebabkan kerusakan hati berupa peradangan. Prevalensi NAFLD meningkat seiring dengan meningkatnya obesitas pada anak dan remaja. Docosahexaenoic acid (DHA) merupakan salah satu pengobatan farmakologis untuk NAFLD dan belum ada data terbaru yang spesifik untuk pengukuran DHA pada anak NAFLD. Tujuan. Menganalisis hubungan DHA dengan NAFLD , dan mengukur nilai DHA setiap derajat NAFLD. Metode. Lima puluh delapan remaja obesitas (31 laki-laki, 27 perempuan), berusia 14-18 tahun yang terpantau di kota Padang, sejak Juni â€“ Juli 2017. Penelitian ini bersifat observasional cross sectional. Hasil. Tidak ada perbedaan jenis kelamin yang diamati pada NAFLD. Indeks massa tubuh pada kelompok NAFLD lebih tinggi daripada non-NAFLD 30,30Â±4,21kg/m2 vs 28,70Â±2,65 kg/m2. Pengukuran derajat penyakit perlemakan hati non alkohol dengan hasil USG masing-masing derajat ringan, sedang dan berat adalah 12(37,5%), 15(46,8%) dan 5(15,6%). Selain itu, kandungan DHA memiliki perbedaan yang signifikan pada masing-masing kelompok, penyakit perlemakan hati non-alkohol vs non-NAFLD 40,46Â±19,23 menjadi 89,26Â±41,21Âµg/ml dengan p<0,0001. Kesimpulan. Nilai DHA signifikan lebih rendah pada kelompok penyakit hati berlemak non alkohol yang dikonversi dengan non-NAFLD. Manajemen diet dengan DHA tinggi penting untuk mencegah dan mengelola obesitas dengan lebih baik.

EDUKASI KESEHATAN DAN PEMERIKSAAN GOLONGAN DARAH PADA MURID SD NEGERI 13 DI DESA TUNGKAL SELATAN KECAMATAN PARIAMAN UTARA Yustini Alioes; Husnil Kadri; Eti Yerizel; Hirowati Ali; Rauza Sukma Rita; Desy Arisanti
BULETIN ILMIAH NAGARI MEMBANGUN Vol 4 No 2 (2021)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v4i2.289

Elementary school students are consumers who are among those who consume the most food and beverages. Food and drinks sold around the school contain many hazardous substances such as dyes that have been banned from circulating (Rhodamine B in iced drinks, jelly drinks, and so on) and other additives such as formalin which is used as a chewy substance in meatballs sold in carts and restaurants that can cause acute poisonings such as allergies, coughs and chronic poisonings such as cancer of the liver, kidneys and other organs. The purpose of this activity is to increase knowledge about substances in food and an introduction to blood group examination. This activity was carried out at SD Negeri 13 Tungkal Selatan Village in North Pariaman District. The method of activity is in the form of counseling and demonstration. According to the survey before the blood group examination, it turned out that most of the elementary school students did not know their blood type. Before the blood group examination, the students were also given knowledge about determining a person's blood type. After this counseling was carried out, respondents became more aware of the impact of food/snacks on health, and respondents knew their respective blood types. Of the 64 students, there are 22 A, 17 B, 12 AB, 13 O. To avoid problems related to food and blood type. There is a need for continuous health education for elementary school students.

The Correlation of Retinol Level with Hemoglobin Level in Third Trimester of Pregnancy Woman Febry Mutiariami Dahlan; Eryati Darwin; Hirowati Ali
Journal of Midwifery Vol 3, No 1 (2018): Published on June 2018
Publisher : Universitas Andalas

Bleeding is one of the highest causes of maternal death. Anemia is a major cause of bleeding. Anemia in pregnant women is caused by iron deficiency, meanwhile the achievement of giving Fe tablets is quite high. Factors for anemia due to lack of intake of vitamins A, C, B12 and folate.This study aims to determine the Correlation Retinol Level with Hemoglobin Level and Ferritin Level in Pregnant Women Thiird trimester. This study was conducted using cross sectional approach, from Juli 2017 – February 2018 at Lubuk Buaya Health Center, Andalas Health Center and UNAND Biomedical Laboratory using pregnant women in third trimesteras sample with consecutive sampling technique totalling 44 people. Independent variable is retinol level and dependent variable are hemoglobin and ferritin level. Examination using Hematology Analyzer for hemoglobin and ELISA reader for examination of retinol level and ferritin level. Data was performed using a computer program to analyze nprmally distributed data using pearson test and spearman test that are abnormally distributed. Mean of retinol level of respondent was 137,612±21,717 ng/ml, hemoglobin 10,916±0,880 gr/dl and ferritin level 26,681±30,829 ng/ml. From result of analysis pearson test showed that there was a significant correlation between retinol level and hemoglobin level in pregnant women with p=0,001 (p<0,05) dan r=0,473 and there was no significant correlation between retinol level and ferritin level in pregnant women p=0,158 (p>0,05) (r=0,216). The conclusion of this study is that there is a correlation of retinol level with hemoglobin level and no correlation of retinol with ferritin level.

The Effect of Nutrition Counseling on Complementary Feeding Practice of Mothers Having Infant Aged 6-12 Month Yulia Arifin; Masrul Masrul; Hirowati Ali
Journal of Midwifery Vol 4, No 1 (2019): Published on June 2019
Publisher : Universitas Andalas

Nutrition plays an important role in the human life cycle. Nutrition surveillance in the form of Nutritional Status Monitoring in 2016 showed that 38.9% of children under five in Indonesia experienced nutritional problems. One of the efforts to improve the health and nutrition status of the baby is by improving the knowledge and attitude of the mother in giving complimentary food. This study aim is to know the effect of nutrition counseling on feeding practice of mothers having infant aged 6-12 month in pakan rabaa public health center area solok selatan district in 2018.The design of the study was quasi-experimental with the design of the control group pretest-posttest. The sample of this study was 46 experiment group and 46 control group. Sampling was done by Purposive Sampling technique. Data analysis using the chi-square testThe results of the study were the absence of nutritional counseling on knowledge of mothers with p-value 0.361, there was an effect of nutritional counseling on changes in maternal attitudes with p-value of 0,000 and there was also the effect of nutritional counseling on complementary feeding practice with p-value 0.004.The presence of the influence of nutritional counseling on attitudes and practices of complementary feeding. Health workers are expected to be able to spend time giving counseling about complementary feeding practice regularly so that the goal of counseling at the public health center can be achieved.

Elevated Serum Reactive Oxygen Species Level Predicts Early Abortion Joserizal Serudji; Nuzulia Irawati; Johanes Cornelius Mose; Hirowati Ali; Yusrawati Yusrawati
Molecular and Cellular Biomedical Sciences Vol 5, No 1 (2021)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v5i1.192

Background: Impaired trophoblast invasion is associated with early abortion. The calorie needed for the trophoblast cell (TC) invasion is mainly met by adenosine triphosphate (ATP) produced in the mitochondria. Reactive oxygen species (ROS), byproduct of ATP synthesis, plays an important role in cellular physiology, but a high level of ROS may result in deoxyribonucleic acid (DNA) damage or cell dysfunction, thereby impaired TC invasion leading to early abortion. The study aims to determine elevated serum ROS level to predicts early abortion.Materials and method: This was an observational study with a cross-sectional design. Fifty subjects with gestational age less than 12 weeks, consist of 25 early abortions and 25 normal pregnancies subjects, were included in this study. Clinical examination and diagnosis are carried out in 2 Hospitals and 5 Public Health Centers in Padang. Examination of ROS levels was carried out by enzyme-linked immunosorbent assay (ELISA) in the Biomedical Laboratory, Faculty of Medicine, Universitas Andalas. The Mann-Whitney test was used to analyze the difference of serum ROS levels, with a significance level of 0.05.Results: The subjects of the two study groups were equivalent in terms of age, gestational age, and gravidity (p=0.051, p=0.453, and p=1.000). The median ROS levels were found to be 1.36 (1.02-26.30) ng/mL in the early abortion and 1.20 (0.43-2.75) ng/mL in the normal pregnancy (p=0.003).Conclusion: There is a significant difference between ROS levels in early abortion and normal pregnancy.Keywords: ROS, early abortion, normal pregnancy

The Effect of Mesenchymal Stem Cell Wharton Jelly on Alzheimer’s Rat with Y-Maze Test Method Sisca Dwi Yarni; Hirowati Ali; Djong Hon Tjong
Majalah Kedokteran Andalas Vol 44, No 2 (2021): Online July 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v44.i2.p112-116.2021

Objective: This study aims to examine the y-maze test in alzheimer's rat after giving mesenchymal stem cell wharton jelly. Methods: This study used the y-maze test method to test the cognitive test of rat with the Y arm model. The treatment group consisted of a control, AlCl3, MSC-WJ and a combination of AlCl3 and MSC-WJ. The results obtained were analyzed in the form of a percentage. Results: The results of this study showed that the y-maze test showed that MSC-WJ had a significant effect compared to the AlCl3 control group in the alzheimer’s rat, namely 51.33% and 12.31%. Conclusion: In this study it was concluded that that MSC-WJ has a significant effect on alzheimer’s rat with y maze test.Keywords: AlCl3; Alzheimer’s; Mesenchymal Stem Cell Wharton Jelly

Perbedaan Proliferasi Sel Punca Jenis Bone Marrow dan Jenis Wharton’s Jelly Muhammad Arif; Hirowati Ali; Yusticia Katar
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 2 (2021): Juni 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Latar Belakang. Sel punca adalah jenis sel yang dapat berproliferasi dan berdiferensiasi menjadi jenis sel lain yang terdapat pada tubuh manusia. Berkat kemampuannya ini sel punca diharapkan menjadi pilihan terapi regeneratif dalam pelayanan kesehatan. Berbagai macam sumber sel punca di dalam tubuh manusia telah banyak ditemukan, salah satunya sel punca mesenkimal yang berasal dari bone marrow dan Wharton’s jelly. Metode. Penelitian yang dilakukan menggunakan desain true experimental dengan studi in vitro. Penelitian dilakukan di Laboratorium Biomedik Fakultas Kedokteran Universitas Andalas Padang. Sampel penelitian. adalah sel punca mesenkimal jenis bone marrow dan sel punca mesenkimal jenis Wharton’s jelly. Hasil. Hasil dari penelitian didapatkan perbedaan gambaran serta hasil hitung proliferasi antara bone marrow dan Wharton’s jelly. Data akhir dari hasil hitung proliferasi didapatkan Wharton’s jelly lebih banyak dari pada bone marrow. Kesimpulan. Sumber sel yang berbeda serta umur jaringan tersebut ketika diisolasi memberikan pengaruh terhadap hasil proliferasi sel punca. Kata kunci. Sel punca mesenkimal, bone marrow, Wharton’s jelly

Pengaruh Pemberian Ekstrak Buah Pohon Andalas (Morus macraura Miq.) Terhadap Ekspresi Gen ET-1 Pada Tikus Model Aterosklerosis Dio Kurniawan; Intan Putri Syamtoni; Tio Firmansyah; Siti Aisyah; Hirowati Ali
Majalah Kedokteran Andalas Vol 45, No 4 (2022): Online October 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v45.i4.p575-582.2022

Tujuan: mengetahui respon antiinflamasi dari pemberian ekstrak buah pohon andalas (Morus macroura Miq.) terhadap gen ET-1 dan penebalan tunika intima tikus model ateroskerosis. Metode: uji eksperimental. Hewan coba dibagi dalam 6 kelompok, dengan 3 kelompok kontrol dan 3 kelompok perlakuan. Kelompok kontrol negatif tanpa perlakuan, kelompok kontrol positif dengan ligasi arteri karotis dan diet tinggi lemak, kelompok kontrol K hanya dengan ligasi arteri. Untuk semua kelompok perlakuan dilakukan ligasi arteri karotis, pemberian diet tinggi lemak, dan pemberian ekstrak buah pohon andalas 1 ml dengan dosis yang berbeda (100mg/kgBB, 300 mg/kgBB, dan 500 mg/kgBB). Pemberian diet tinggi lemak dilakukan selama 1 minggu. Ekstrak buah andalas diberikan secara oral selama 15 hari. Analisis kuantitatif kadar gen ET-1 dilakukan dengan menggunakan qPCR sedangkan untuk mengetahui respon terhadap penumpukan plak aterosklerosis dilakukan dengan cara pemeriksaan histopatologi. Hasil: Adanya hubungan yang signifikan antara pemberian ekstrak buah pohon andalas terhadap ekspresi gen ET-1 dengan nilai 0,02 (P<0,05) dan adanya pengaruh terhadap penebelan tunika intima tikus aterosklerosis yang dibuktikan dengan gambaran histologi arteri karotis tikus yang menujukkan pengurangan plak aterosklerosis. Kesimpulan: pemberian ekstrak buah pohon andalas dengan dosis 300mg/kgBB berpengaruh paling baik terhadap ekspresi gen ET-1 dan penebalan tunika intima tikus yang diinduksi aterosklerosis.

Pengaruh Ekstrak Kemangi (Ocimum basilicum) Terhadap Ekspresi Interleukin-6 Tikus Diabetes Melitus Gestasional Wahyu Agnata Surya; Hirowati Ali; Dinda Aprilia
Jurnal Ilmu Kesehatan Indonesia Vol 4 No 2 (2023): Juni 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v4i2.756

Latar Belakang: Diabetes melitus gestasional (DMG) merupakan penyakit metabolik berupa gangguan toleransi karbohidrat dengan onset pertama terjadi saat kehamilan. Interleukin-6 (IL-6) diketahui terlibat dalam inflamasi pada DMG. Kemangi (Ocimum basilicum) dilaporkan sebagai tanaman herbal yang mengandung zat aktif yang bersifat anti-inflamasi Objektif: Penelitian ini bertujuan melihat efek ekstrak kemangi terhadap ekspresi IL-6 pada tikus model DMG. Metode: Sampel RNA leukosit berasal dari tikus DMG yang diinduksi streptozotosin sebelumnya. RNA berasal dari tikus hamil normal (K-; n=6), tikus DMG tanpa perlakuan (K+; n=6), tikus DMG yang diberikan ekstrak kemangi secara oral dengan dosis 100 mg/kg (P1; n=6) dan 200 mg/kg (P2; n=6) selama 14 hari. Ekspresi RNA IL-6 dan GAPDH (kontrol internal) diukur menggunakan PCR secara semi-kuantitatif dan visualisasi elektroforesis menggunakan ImageJ. Analisis data menggunakan uji one-way ANOVA dan post-hoc Bonferroni Hasil: Hasil penelitian menunjukkan terdapat perbedaan signifikan penurunan ekspresi IL-6 antara K+ dengan P2 (p<0,01) dan antara P1 dengan P2 (- p<0,001). Kesimpulan: Kesimpulan yang didapat adalah terdapat pengaruh pemberian ekstrak kemangi terhadap ekspresi IL-6 pada tikus DMG.

Co-Authors Afrah Diba Faisal Afriwardi Afriwardi Almurdi Almurdi Amel Yanis Annita Annita Aswiyanti Asri Bestari Jaka Budiman Desmiwarti Desmiwarti Dessy Arisanty Desy Arisanti Desy Arisanti Dhina Lidya Lestari Dinda Aprilia Dio Kurniawan Djong Hon Tjong Effy Huriyati Eryati Darwin Eti Yerizel Fadina Rizki Febianne Eldrian Febry Mutiariami Dahlan Fitri Amita Fitri Ramadhaniati Gusti Revilla Hafni Bachtiar Hafni Bachtiar Hasmiwati Havina Nurul Aizah Hudila Rifa Karmia Hudila Rifa Karmia Husnil Kadri Ilmiawati, Ilmiawati Intan Putri Syamtoni Johanes C Mose Johanes C. Mose Joserizal Serudji Masrul Masrul Masrul Masrul Muhammad Arif Muhammad Faisal Rachman Muhammad Iqbal Dasril Nabila Priscilla Putri Nora Harminarti Nur Indrawati Lipoeto Nuzulia Irawati Rahmadona Rahmadona Ranti Verdiana Rauza Sukma Rita Restu Susanti Rizki Rahmadian Rozetti Rozetti Sisca Dwi Yarni Siti Aisyah Siti Nurhajjah Tio Firmansyah Tofrizal Tofrizal Vivi Sofia Wahyu Agnata Surya Widia Febrina Wildayani, Desi Yuastika Puspita Sari Yulia Arifin Yusrawati Yusrawati Yusri Dianne Jurnalis Yusticia Katar Yustini Alioes Zilfi Yola Pitri

Title

Found 27 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 27 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 27 Documents
Search