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Hubungan antara Tingkat Pengetahuan dan Penggunaan Obat Tradisional dan Suplemen untuk Memelihara Daya Tahan Tubuh selama Masa Pandemi COVID-19 pada Mahasiswa Fakultas Kedokteran Universitas Udayana Ivana, Jocelyn; Ernawati, Desak Ketut; Satriyasa, Bagus Komang; Alit Widhiartini, Ida Ayu
E-Jurnal Medika Udayana Vol 11 No 7 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i7.P10

Abstract

Ketika COVID-19 pertama kali muncul, semua orang berusaha mencari cara untuk mencegah diri agar tidak terinfeksi. Salah satu caranya adalah dengan meningkatkan daya tahan tubuh melalui obat tradisional dan suplemen. Tujuan dari penelitian ini adalah untuk mengetahui apakah ada hubungan antara tingkat pengetahuan dan penggunaan obat tradisional dan suplemen tersebut. Penelitian cross-sectional ini menggunakan simple random sampling untuk mengambil sampelnya. Setelah semua data terkumpul, maka data diolah dengan uji regresi untuk mengetahui apakah penggunaan obat tradisional dan suplemen memiliki korelasi dengan variabel lain seperti angkatan, jenis kelamin, tingkat pengetahuan tentang COVID-19, tingkat pengetahuan tentang obat tradisional, dan tingkat pengetahuan tentang suplemen. Hasil penelitian menemukan terdapat beberapa variabel yang memiliki korelasi seperti tingkat pengetahuan terhadap COVID-19 mempengaruhi penggunaan meniran (p value = 0.001, Exp = 0.117), jenis kelamin (p value = 0.037, Exp = 1.679) dan angkatan 2019 (p value = 0.048, Exp = 1.778) mempengaruhi penggunaan kunyit, tingkat pengetahuan terhadap COVID-19 mempengaruhi penggunaan temulawak (p value = 0.031, Exp = 0.392), serta jenis kelamin (p value = 0.046, Exp = 2.077) dan tingkat pengetahuan terhadap COVID (p value = 0.001, Exp = 4.401) mempengaruhi Vitamin C. Jahe merupakan obat tradisional yang paling banyak digunakan (45,6%) sedangkan Vitamin C merupakan suplemen yang paling banyak digunakan responden (89,5%).
AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN KELOR (Moringa oleifera L.) TERHADAP Staphylococcus aureus ATCC 43300 Wuga, Kristina Supartin Monika; Jawi, I Made; Artini, I Gusti Ayu; Widhiartini, Ida Ayu Alit
E-Jurnal Medika Udayana Vol 13 No 6 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i06.P03

Abstract

Background: Kelor leaves (Moringa oleifera L.) have active compounds such as flavonoid, alkaloid, phenol, tanin, and saponin. The content of these compounds is stated to have antibacterial activity. the development of an alternative treatment of natural ingredients is needed to treat infections caused by Staphylococcus aureus bacteria, one of which is Moringa leaves (Moringa oleifera L.). Objective: To analyze the antibacterial activity from ethanol extract of moringa leaf in inhibiting of Staphylococcus aureus growth at concentrations of 25%, 50%, and 100%. Methods: The method used is a true experimental posttest-only control group in vitro. The samples of this study were divided into five groups: the positive control group (vancomycin) and the negative control group (96% ethanol solvent), with concentrations of 25%, 50%, and 100%. Result: The results proved that the extract of ethanol from moringa leaves without dilution (100% of concentration) showed about zone of inhibition against Staphylococcus aureus ATCC 43300 bacteria with an inhibition diameter of 8.4 mm and the positive control vancomycin has an inhibition zone diameter of 17.4 mm. Conclusion: Moringa leaf ethanol extract showed inhibition against bacterial growth in vitro at a concentration of 100%. Keywords: Antibacterial activity, Moringa oleifera L, Staphylococcus aureus
Aktivitas Antibakteri Ekstrak Etanol Bunga Kamboja Merah (Plumeria rubra L.) terhadap Pertumbuhan Bakteri Methicillin-resistant Staphylococcus aureus (MRSA) Diksha, I Gusti Ngurah Ariestha Satya; Artini, I Gusti Ayu; Trapika, I Gusti Made Gde Surya Chandra; Widhiartini, Ida Ayu Alit
E-Jurnal Medika Udayana Vol 13 No 5 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i05.P13

Abstract

Introduction: MRSA is an antibacterial resistance problem that requires serious treatment. The limitations of antibacterials make it difficult to treat infections. The development of alternative antibacterial is needed. Objectives: This study shows the antibacterial effect of ethanol extract of Plumeria rubra L. flowers against MRSA bacteria. Methods: This research is a true experimental research with the only post-test control group design. The Kirby-Bauer test method was used to evaluate the antibacterial activity of ethanol extract of Plumeria rubra L. flowers with concentrations of 20%, 40%, and 60% in triplicate. The test bacteria used MRSA ATCC 33591 bacteria. Antibacterial activity was assessed from the diameter of the inhibition zone formed in bacterial cultures on agar media. Results: The inhibition zone were not formed after ethanolic extract of Plumeria rubra L. flowers at various concentrations. These were not antibacterial activity shown from Plumeria rubra L. flowers extract at concentrations of 20%, 40%, and 60%. Conclusions: The ethanolic extract of Plumeria rubra L. flowers does not show antibacterial activity against MRSA bacteria. Keywords: Red frangipani flowers (Plumeria rubra L.), antibacterial activity, MRSA.
UJI EFEKTIVITAS EKSTRAK ETANOL DAUN UBI JALAR UNGU (Ipomoea batatas L.) TERHADAP PERTUMBUHAN BAKTERI METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS ATCC 3351 SECARA IN VITRO Pandansari, Ni Wayan Bunga; Ernawati, Desak Ketut; Widhiartini, Ida Ayu Alit
E-Jurnal Medika Udayana Vol 11 No 7 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i7.P18

Abstract

ABSTRAK Daun0ubi0jalar0ungu mengandung senyawa aktif gflavonoid, tfenol, ktanin, dan bsaponin yang dinyatakan memiliki aktivitasdantibakteri. Kandungan senyawa aktif ini potensial dikembangkan sebagai antibakteri Methicillin-Resistant Staphylococcus aureus (MRSA). Pengembangan antibakteri alternatif dari bahan alam diperlukan untuk penanganan infeksi nosokomial. Penelitian eksperimental ini dilakukan untuk membuktikan adanya aktivitaspantibakterihekstrakjetanol0daun0ubi0jalar0ungu terhadap bakteri penyebab infeksi nosokomial dengan menggunakan bakteri standar MRSA ATCC 3351 secara in vitro. Desainlpenelitian merupakanppostutestponlyecontrolkgroup.jAktivitaspantibakterijekstrak etanol daunfubiljalarrungu diuji dengan metode difusilagar (disc diffusion) terhadap ekstrak etanol yang diperoleh dari proses maserasi daun ubi jalar ungu yang dikeringkan dan daun segar pada berbagai konsentrasi bertingkat. Aktifitas antibakteri dinilai berdasarkan pengukuran luas diameter zona hambat yang dihasilkan setelah perlakuan esktrak terhadap kultur bakteri dalam media agar plate. Hasil penelitian menunjukkan tidak adanya daya hambat pada ekstrak segar namun, pada ekstrak kering terdapat daya hambat terhadap bakteri MRSA ATCC 3351. Diameterlzonaihambat yang terbentuk pada kelompok konsentrasi 20%, 40%, dan 80% secara berurutan adalah 6,9 mm, 10mm, dan 11mm. Untuk mengetahui adanya efek perlakuan, dilakukan analisis terhadap Uji Kruskal-Walis. Uji Mann-Whitney menunjukkanjadanya perbedaankyang bermakna padajsetiap kelompok yang dibandingkan, kecuali pada ekstrak 10%. Pada penelitian ini dapat disimpulkan bahwa ekstrak etanol 96% daun ubi jalar ungu kering (Ipomoea batatas L.) memiliki aktivitas antibakteri terhadap MRSA ATCC 3351. Sedangkan pada ekstrak etanol 96% daun ubi jalar ungu segar (Ipomoea batats L.) tidak memiliki daya hambat terhadap pertumbuhan bakteri MRSA. Kata Kunci: Daun ubi jalar ungu (Ipomoea batatas L.), zona hambat, MRSA
The Effect of Oral Chitosan Supplementation on Leptin Levels and HOMA-IR in Male Wistar Rats (Rattus norvegicus) with an Obesity Model Stefani, Lidwina; Pande Dwipayana, I Made; Alit Widhiartini, Ida Ayu; Made Wihandani, Desak; Bayu Mayura, I Putu
Eduvest - Journal of Universal Studies Vol. 5 No. 7 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i7.51526

Abstract

This study investigates the role of chitosan in modulating leptin and insulin levels, key hormones involved in metabolic disorders, and compares its effectiveness with orlistat, a commonly used anti-obesity drug. An experimental post-test only group design was used involving 20 healthy male Wistar rats aged 3–4 months. After a seven-day acclimation, obesity was induced through a high-fat, high-glucose diet. The rats were then divided into five groups: a positive control group (K+) receiving orlistat, a negative control (K−) receiving a standard diet, and three treatment groups receiving chitosan at 2.5% (P1), 5% (P2), and 7.5% (P3) concentrations, respectively, for 14 days. Leptin and HOMA-IR levels were measured via blood samples collected from the retro-orbital sinus. The Kruskal-Wallis test showed significant differences among groups (p<0.05). Mean leptin levels were highest in K− (5.10±0.35 ng/dL) and lowest in K+ (3.03±0.71 ng/dL), while P2 showed a notable reduction (3.71±0.32 ng/dL). HOMA-IR levels followed a similar trend, with the lowest in K+ (1.00±0.08) and significantly reduced in P2 (1.34±0.11) compared to K− (2.29±0.25). Post Hoc analysis confirmed that P2 had significantly better outcomes than K−, though not as effective as orlistat. In conclusion, chitosan—particularly at 5% concentration—can reduce leptin and HOMA-IR levels, improving insulin resistance in obesity, though orlistat remains more effective.
Layanan Home Pharmacy Care terhadap Peningkatan Kepatuhan Terapi pada Pasien Diabetes dan Hipertensi: Tinjauan Sistematis Etik dan Regulasi Widhiartini, Ida Ayu Alit; Ricardo, I Komang Aan Adi; Pebrianti, Ni Putu Wika; Pratama, Putu Yudha Kartika
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 1 (2025): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i1.97

Abstract

Home pharmacy care is a part of community pharmacy service that is critical in improving                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         patient adherence, which is a significant challenge in managing chronic diseases. One approach that can help overcome this problem is the practice of home pharmacy care. The current study aimed to evaluate the role of home pharmacy care interventions can enhance medication adherence among diabetic and hypertensive patients and to examine the ethical and regulatory aspects associated with its implementation. A systematic review was conducted based on the PRISMA guidelines, using the keywords “home pharmacy care” AND (diabetes mellitus OR hypertension) AND kepatuhan, home pharmacy care AND diabetes mellitus AND (adherence OR compliance), home pharmacy care AND hypertension AND (adherence OR compliance) on Google Scholar and PubMed databases with a search time limit from January 2015 to May 2025. The ethical and regulatory analysis was conducted by reviewing secondary literature regulating home pharmacy care and professional codes of ethics. Out of a total of 290 identified articles, only 10 met the inclusion criteria for further analysis. Based on the ten reviewed articles, it was stated that home pharmacy care interventions can enhance medication adherence among patients with diabetes mellitus and hypertension. However, the implementation of this service faces challenges, such as ethical concerns and regulatory limitations. The development of comprehensive regulations and consistent application of the code of ethics are expected to strengthen legal protection for pharmacists and improve the quality of home pharmacy care services.
Effect of Porang (Amorphophallus muelleri Blume) Flour Diet on Postprandial Blood Sugar Rates and Insulin Resistance in Male Wistar Rats (Rattus norvegicus) Diabetes Mellitus Nathasia; Widhiartini, Ida Ayu Alit; Dwipayana, I Made Pande; Wahyuni, Nila; Maratni, Ni Putu Tesi; Hendrayana, Made Agus
HAYATI Journal of Biosciences Vol. 33 No. 1 (2026): January 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.1.95-102

Abstract

Medical nutrition therapy is essential in diabetes management, especially as diabetes is often linked with aging. Porang tuber flour contains glucomannan, a compound with potential glucose-lowering effects. This study aimed to evaluate the effect of porang flour feeding frequency on 2-hour postprandial blood glucose (2hPPBG) and HOMA-IR in diabetic rats. Using a quasi-experimental pre-test and post-test control group design, 21 male Wistar rats were induced with diabetes via streptozotocin and nicotinamide, then randomly assigned to three groups: G0 (control, given aquadest), G1 (porang flour 300 mg/kg BW daily), and G2 (porang flour 300 mg/kg BW every two days). Five rats died during treatment. Wilcoxon test results showed a difference in 2hPPBG levels between each group before and after treatment. There was no decrease in G0 (p = 0.893), but a decrease in G1 (p = 0.043) and G2 (p = 0.028). The difference between HOMA-IR before and after treatment did not decrease in groups G0 (p = 0.345), G1 (p = 0.138), and G2 (p = 0.249). Post hoc test for 2hPPBG levels between groups showed a significant difference between G0 and G1 (p<0.001), a significant difference between G0 and G2 (p<0.001), and no significant difference between G1 and G2 (p = 0.135). One-way ANOVA test of HOMA-IR showed no significant difference between G0, G1, and G2 (p = 0.148). It was concluded that porang flour can reduce 2hPPBG, but not HOMA-IR. There was no difference in 2hPPBG levels between administering porang flour daily and every other day.
Profile Of Antihypertensive Drug Use In Patients With Coronary Artery Disease At Prof. Dr. I.G.N.G. Ngoerah General Hospital (RSUP) In 2023 Arifin, Jeanan Aulia; Widhiartini, Ida Ayu Alit; Jawi , I Made
Eduvest - Journal of Universal Studies Vol. 5 No. 10 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i10.51895

Abstract

Background: Coronary heart disease (CHD) is often triggered by atherosclerosis, with hypertension as a major risk factor. Managing hypertension through lifestyle modification and pharmacological therapy, such as ACE inhibitors, ARBs, beta-blockers, CCBs, and diuretics, is important to prevent further complications. Objective: To determine the profile of antihypertensive drug use in CHD patients at RSUP Prof. Dr. I.G.N.G. Ngoerah Denpasar in 2023. Methods: This was a descriptive study using a cross-sectional design. Data were collected retrospectively from medical records of CHD patients in 2023 after obtaining approval from relevant authorities. Data analysis was performed using IBM SPSS version 26. Results: The majority of patients were male (88%) and aged 56-65 years. Most resided in Denpasar with normal blood pressure and had comorbidities such as hypertension, type 2 diabetes mellitus, and chronic kidney disease. Beta-blockers were the most commonly used antihypertensive agents (32.3%), followed by diuretics (24.4%) and ACE inhibitors (19.6%). Triple-drug combination therapy was the most frequently used regimen, particularly the ACEi + BB combination, commonly administered once daily (OD). Conclusion: Most CHD patients were older males with multiple comorbidities. Beta-blockers were the most frequently prescribed antihypertensive drugs, followed by diuretics and ACE inhibitors. The prevalent use of combination therapy and once-daily regimens indicates an individualized treatment approach based on clinical conditions.
PENGELOLAAN PENGADAAN LOGISTIK FARMASI PADA EMPAT APOTEK JARINGAN DI WILAYAH DENPASAR DAN BADUNG : KAJIAN ETIK DAN REGULASI Widhiartini, Ida Ayu Alit; Sakaningrum, Ni Putu Mirah; Dewi, Putu Diva Candra; Medinna, Balqish Fathoum
JFM (Jurnal Farmasi Malahayati) Vol 8, No 1 (2025)
Publisher : Jurnal Farmasi Malahayati (JFM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jfm.v8i1.16020

Abstract

Apotek jaringan merupakan retail farmasi yang dikelola sebagai suatu kewirausahaan dengan aturan perundangan dan etik yang ketat. Orientasi kewirausahaan di tengah tingginya persaingan retail farmasi menuntut efisiensi dalam berbagai hal termasuk dalam pengadaan logistik kefarmasian obat. Efisiensi pengadaan obat berisiko pada pengabaian etik dan aturan pengelolaan obat di fasilitas pelayanan kefarmasian. Penelitian ini bertujuan untuk mengeksplorasi pengelolaan pengadaan logistik kefarmasian pada apotek jaringan dan merangkum berbagai kendala dan solusi yang dilakukan ditinjau dari sudut pandang etik dan peraturan mengenai pengadaan logistik kefarmasian di Indonesia. Penelitian menggunakan pendekatan kualitatif. Data dikumpulkan selama bulan Juni 2024 melalui wawancara terstruktur menggunakan aplikasi telepon whatsapp terhadap informan tenaga kefarmasian praktek yang bertanggungjawab terhadap proses pengadaan obat pada empat apotek cabang dari tiga (3) apotek jaringan milik swasta dan satu (1) BUMN dan yang ada di wilayah Denpasar dan Badung. Data karakteristik informan dideskripsikan dan data proses pengadaan dikelompokkan menurut: praktek pengadaan, sistem/metode, ketersediaan dokumen mutu (standar operasional prosedur/SOP), informasi kendala dan solusi pengadaan, dan dilakukan kajian etik dan aturan terhadap implementasi pengadaan menggunakan Permenkes No 73 Tahun 2016, Permenkes No 9 Tahun 2017, dan PerBPOM No 24 Tahun 2021. Hasil penelitian menyatakan bahwa praktek pengadaan logistik pada semua apotek jaringan diatur dengan dokumen mutu standar operasional prosedur (SOP) namun hal bertentangan dinyatakan satu (1) apotek yang menyatakan pengadaan dilakukan tanpa menggunakan dokumen surat pesanan yang merupakan aturan pengadaan. Tiga (3) apotek menerapkan metode pengadaan obat mandiri ke distributor, satu (1) menyatakan pengadaan mandiri ke distributor dan pengajuan melalui cabang lain, dan satu (1) apotek menerapkan pengadaan melalui manajemen pusat dengan frekuensi waktu yang bervariasi dari harian, tiga hari per minggu, per minggu, dan per bulan. Semua apotek jaringan menerapkan sistem pengadaan pareto dan ABC dan metode konsumtif, epidemiologi, maupun kombinasinya. Kendala pada apotek jaringan swasta mandiri antara lain kekosongan stok pada distributor sedangkan apotek BUMN terkendala panjangnya alokasi waktu pengadaan akibat waktu tunggu persetujuan manajemen pusat. Solusi yang dilakukan dengan penelusuran distributor lain yang menyediakan obat serupa. Kajian ini menemukan adanya pengabaian etik dan peraturan perundangan terkait pengadaan yang dilakukan tanpa dokumen mutu SOP, SP, dan dilakukan tidak melalui distributor/PBF secara langsung. Permasalahan pengadaan di apotek jaringan memerlukan pertimbangan etik dan kepatuhan tenaga kefarmasian sehingga pengadaan obat bisa berlangsung sesuai dengan ketentuan yang berlaku sehingga adil terhadap penyelenggaraan retail apotek lain.
Protective effects of Gyrinops versteegii leaf ethanol extract on Leydig cells and testosterone under excessive physical activity: an in vivo study Widianti, I Gusti Ayu; Wardana, Nyoman Gede; Widhiartini, Ida Ayu Alit; Pratiwi, Made Sindy Astri; Antari, Ni Wayan Sukma
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i1.28611

Abstract

Background: Excessive physical activity may lead to overtraining syndrome and increased oxidative stress, which can reduce Leydig cell count and testosterone levels. Gaharu (Gyrinops versteegii) leaf ethanol extract contains strong antioxidants that may counteract oxidative damage. However, the effects of excessive physical activity on Leydig cells and testosterone remain unexplored. Purpose: This study aimed to evaluate the protective effects of Gyrinops versteegii leaf ethanol extract on male reproductive parameters under excessive physical activity conditions. Methods: This experimental study employed a randomized, post-test control-group design. Twenty-five adult male Wistar rats were divided into five groups: normal control, excessive physical activity control, and three treatment groups receiving Gyrinops versteegii leaf ethanol extract at 100, 200, and 400 mg/kg BW. Leydig cell counts and serum testosterone levels were analyzed using ANOVA and correlation tests. Results: The highest Leydig cell count and testosterone level were observed in the 200 mg/kgBW group (28.92 cells and 1.822 ng/mL, respectively). Significant differences in Leydig cell counts were observed among groups (p<0.001), and a positive correlation between Leydig cell number and testosterone levels was observed (p=0.006). Conclusion: Gyrinops versteegii leaf ethanol extract demonstrated protective effects against reproductive impairment induced by excessive physical activity in vivo, with an optimal dose of 200 mg/kgBW.