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PEMANFAATAN JAMU HERBAL UNTUK MENINGKATKAN IMUNITAS TUBUH DI ERA PANDEMI COVID-19 I.G.A. Artini; I.G.M.G.S.C. Trapika; N.W.S. Dewi; A.W. Indrayani; I.W. Sumardika; I.M. Jawi; B.K. Satriyasa; I.G.M. Aman; A.N. Mahendra; I.A.A. Widhiartini; D.K. Ernawati
Buletin Udayana Mengabdi Vol 22 No 4 (2023): Buletin Udayana Mengabdi
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/BUM.2023.v22.i04.p02

Abstract

To date, COVID-19 infection still become an important health problem in Indonesia, including Bali. We may concern about this situation since there has been no specific drug or vaccine available against COVID-19 infection. In this new normal era, we should maintain our immunity to prevent the infection. Some herbs potentially possess great effect on maintaining immunity to protect ourselves from COVID-19 infection, such as kunyit, temulawak, jahe, kencur, pegagan and kelor. To date, herbs utilization for health in Banjar Sambahan remains very limited. This is related to the limited skill in processing herbal drink (jamu). This activity aimed to raise participant (PKK women at Banjar Sambahan) knowledge, as well as skills, on producing herbal drinks (jamu/loloh) that potentially increase the immunity during COVID-19 pandemic era. This programme was performed by socialization about herbs utilization for health (especially for immunity), accompanied by training (by video) on producing herbal drink and survey for herbal medicine utilization in community. The results of this programme were video, publication on national journal (SINTA indexed) and presentation on national scientific meeting. It can be concluded that this activity supply knowledge and skill for PKK women at Banjar Sambahan in processing herbal drink for maintaining the immunity against COVID-19 infection. Keywords: covid-19, immune, herbal drink, community service
KESESUAIAN PERESEPAN ANTIBIOTIKA PADA BERBAGAI TINGKAT KEPARAHAN COVID-19 DI PELAYANAN KESEHATAN RUJUKAN Diaz, Leonardo Alpha; Jawi, I Made; Widhiartini, Ida Ayu Alit; Aman, I Gusti Made
E-Jurnal Medika Udayana Vol 12 No 7 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i07.P09

Abstract

COVID-19 telah menghadapkan klinisi dengan sebuah tantangan baru dimana belum ditemukannya terapi definitif dalam penanganan penyakit tersebut hingga tahun 2021. COVID-19 dapat menyebabkan disregulasi daya tahan tubuh pada sebagian pasien, sehingga pasien tersebut menjadi lebih rentan terhadap koinfeksi bakteri. Antibiotika banyak diresepkan sebagai life-saving drugs dalam penanganan/pencegahan infeksi bakteri yang berpotensi meningkatkan morbiditas dan mortalitas pasien COVID-19. Pada penggunaan dalam keadaan darurat, terdapat potensi penggunaan antibiotika menjadi berlebihan dan tidak sesuai dengan pedoman terapi yang ada. Hal tersebut perlu mendapat perhatian lebih sebagai bahan evaluasi dalam pencegahan isu resistensi. Penelitian ini bertujuan untuk mendapatkan gambaran peresepan antibiotika dikaitkan dengan profil keparahan pasien COVID-19. Rancangan penelitian menggunakan desain deskriptif kuantitatif yang pengambilan datanya dilakukan secara retrospektif terhadap sampel rekam medis pasien terkonfirmasi COVID-19 yang dirawat inap pada sebuah rumah sakit rujukan COVID-19 di Provinsi Bali selama tahun 2021. Sampel diambil dengan menggunakan metode simple random sampling. Sebanyak 304 rekam medis dicantumkan dalam penelitian. Data diolah menggunakan statistik deskriptif. Mayoritas pasien berada dalam kelompok umur 25-34 tahun (23,1%), berjenis kelamin perempuan (51,6%) dan termasuk dalam COVID-19 derajat sedang (67,8%). Sebagian besar pasien yang tercatat tidak memiliki komorbid (54,3%). Azithromycin (55,6%), levofloxacin (25,8%), dan imipenem-cilastatin (8,2%) mendominasi peresepan antibiotika dalam penelitian ini. Sebagian besar pasien (62,5%) mendapat peresepan antibiotika yang sesuai dengan Buku Pedoman Tatalaksana COVID-19 Edisi 3. Tidak ditemukan adanya peresepan antibiotika yang masuk ke dalam kategori Reserve berdasarkan ‘AWaRe Classification’ dari WHO. Dapat disimpulkan, mayoritas pasien yang mendapat peresepan antibiotika telah mempertimbangkan buku pedoman yang ada dan klasifikasi aware WHO.
Gambaran Pengetahuan dan Kepatuhan Terapi Pasien Tuberkulosis Paru di Puskesmas Kota Denpasar selama Pandemi COVID-19 Dewi, Kadek Aprilia Sukma; Widhiartini, Ida Ayu Alit; Aman, IGM
E-Jurnal Medika Udayana Vol 12 No 1 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i01.P12

Abstract

Kepatuhan dalam mengonsumsi obat merupakan kunci keberhasilan terapi Tuberkulosis (TB) Paru, dan pengetahuan diketahui sebagai salah satu faktor predisposisi kepatuhan. Keterbatasan pelayanan TB di Puskesmas selama pandemi COVID-19 berisiko pada penurunan pengetahuan dan kepatuhan terapi Obat Anti Tuberkulosis (OAT) pasien TB Paru. Penelitian ini bertujuan untuk menggambarkan pengetahuan dan kepatuhan terapi OAT pasien TB Paru rawat jalan di Puskesmas Kota Denpasar selama pandemi COVID19. Desain penelitian ini mengunakan studi deskriptif observasional potong lintang selama periode MaretAgustus 2021 di lima Puskesmas Kota Denpasar. Pengetahuan dan kepatuhan diukur menggunakan kuesioner pengetahuan yang dibuat peneliti dan Morisky Medication Adherence Scales (MMAS?8). Data diambil secara daring menggunakan aplikasi google form. Berdasarkan tingkat pengetahuan terdapat 37 pasien (73%) memiliki pengetahuan baik, 13 pasien (25%) memiliki pengetahuan cukup, serta 1 pasien (2%) dengan pengetahuan kurang. Sementara berdasarkan tingkat kepatuhan, sebanyak 29 pasien (57%) memiliki kepatuhan tinggi, 19 pasien (37%) memiliki kepatuhan sedang, dan 3 pasien (6%) dengan kepatuhan rendah. Sebagian besar pasien TB Paru rawat jalan di lima Puskesmas Kota Denpasar selama pandemi COVID-19 memiliki pengetahuan yang baik serta kepatuhan yang tinggi. Kata kunci : Tuberkulosis (TB) paru, kepatuhan, pengetahuan.
Hubungan antara Tingkat Pengetahuan dan Penggunaan Obat Tradisional dan Suplemen untuk Memelihara Daya Tahan Tubuh selama Masa Pandemi COVID-19 pada Mahasiswa Fakultas Kedokteran Universitas Udayana Ivana, Jocelyn; Ernawati, Desak Ketut; Satriyasa, Bagus Komang; Alit Widhiartini, Ida Ayu
E-Jurnal Medika Udayana Vol 11 No 7 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i7.P10

Abstract

Ketika COVID-19 pertama kali muncul, semua orang berusaha mencari cara untuk mencegah diri agar tidak terinfeksi. Salah satu caranya adalah dengan meningkatkan daya tahan tubuh melalui obat tradisional dan suplemen. Tujuan dari penelitian ini adalah untuk mengetahui apakah ada hubungan antara tingkat pengetahuan dan penggunaan obat tradisional dan suplemen tersebut. Penelitian cross-sectional ini menggunakan simple random sampling untuk mengambil sampelnya. Setelah semua data terkumpul, maka data diolah dengan uji regresi untuk mengetahui apakah penggunaan obat tradisional dan suplemen memiliki korelasi dengan variabel lain seperti angkatan, jenis kelamin, tingkat pengetahuan tentang COVID-19, tingkat pengetahuan tentang obat tradisional, dan tingkat pengetahuan tentang suplemen. Hasil penelitian menemukan terdapat beberapa variabel yang memiliki korelasi seperti tingkat pengetahuan terhadap COVID-19 mempengaruhi penggunaan meniran (p value = 0.001, Exp = 0.117), jenis kelamin (p value = 0.037, Exp = 1.679) dan angkatan 2019 (p value = 0.048, Exp = 1.778) mempengaruhi penggunaan kunyit, tingkat pengetahuan terhadap COVID-19 mempengaruhi penggunaan temulawak (p value = 0.031, Exp = 0.392), serta jenis kelamin (p value = 0.046, Exp = 2.077) dan tingkat pengetahuan terhadap COVID (p value = 0.001, Exp = 4.401) mempengaruhi Vitamin C. Jahe merupakan obat tradisional yang paling banyak digunakan (45,6%) sedangkan Vitamin C merupakan suplemen yang paling banyak digunakan responden (89,5%).
AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN KELOR (Moringa oleifera L.) TERHADAP Staphylococcus aureus ATCC 43300 Wuga, Kristina Supartin Monika; Jawi, I Made; Artini, I Gusti Ayu; Widhiartini, Ida Ayu Alit
E-Jurnal Medika Udayana Vol 13 No 6 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i06.P03

Abstract

Background: Kelor leaves (Moringa oleifera L.) have active compounds such as flavonoid, alkaloid, phenol, tanin, and saponin. The content of these compounds is stated to have antibacterial activity. the development of an alternative treatment of natural ingredients is needed to treat infections caused by Staphylococcus aureus bacteria, one of which is Moringa leaves (Moringa oleifera L.). Objective: To analyze the antibacterial activity from ethanol extract of moringa leaf in inhibiting of Staphylococcus aureus growth at concentrations of 25%, 50%, and 100%. Methods: The method used is a true experimental posttest-only control group in vitro. The samples of this study were divided into five groups: the positive control group (vancomycin) and the negative control group (96% ethanol solvent), with concentrations of 25%, 50%, and 100%. Result: The results proved that the extract of ethanol from moringa leaves without dilution (100% of concentration) showed about zone of inhibition against Staphylococcus aureus ATCC 43300 bacteria with an inhibition diameter of 8.4 mm and the positive control vancomycin has an inhibition zone diameter of 17.4 mm. Conclusion: Moringa leaf ethanol extract showed inhibition against bacterial growth in vitro at a concentration of 100%. Keywords: Antibacterial activity, Moringa oleifera L, Staphylococcus aureus
Aktivitas Antibakteri Ekstrak Etanol Bunga Kamboja Merah (Plumeria rubra L.) terhadap Pertumbuhan Bakteri Methicillin-resistant Staphylococcus aureus (MRSA) Diksha, I Gusti Ngurah Ariestha Satya; Artini, I Gusti Ayu; Trapika, I Gusti Made Gde Surya Chandra; Widhiartini, Ida Ayu Alit
E-Jurnal Medika Udayana Vol 13 No 5 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i05.P13

Abstract

Introduction: MRSA is an antibacterial resistance problem that requires serious treatment. The limitations of antibacterials make it difficult to treat infections. The development of alternative antibacterial is needed. Objectives: This study shows the antibacterial effect of ethanol extract of Plumeria rubra L. flowers against MRSA bacteria. Methods: This research is a true experimental research with the only post-test control group design. The Kirby-Bauer test method was used to evaluate the antibacterial activity of ethanol extract of Plumeria rubra L. flowers with concentrations of 20%, 40%, and 60% in triplicate. The test bacteria used MRSA ATCC 33591 bacteria. Antibacterial activity was assessed from the diameter of the inhibition zone formed in bacterial cultures on agar media. Results: The inhibition zone were not formed after ethanolic extract of Plumeria rubra L. flowers at various concentrations. These were not antibacterial activity shown from Plumeria rubra L. flowers extract at concentrations of 20%, 40%, and 60%. Conclusions: The ethanolic extract of Plumeria rubra L. flowers does not show antibacterial activity against MRSA bacteria. Keywords: Red frangipani flowers (Plumeria rubra L.), antibacterial activity, MRSA.
UJI EFEKTIVITAS EKSTRAK ETANOL DAUN UBI JALAR UNGU (Ipomoea batatas L.) TERHADAP PERTUMBUHAN BAKTERI METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS ATCC 3351 SECARA IN VITRO Pandansari, Ni Wayan Bunga; Ernawati, Desak Ketut; Widhiartini, Ida Ayu Alit
E-Jurnal Medika Udayana Vol 11 No 7 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i7.P18

Abstract

ABSTRAK Daun0ubi0jalar0ungu mengandung senyawa aktif gflavonoid, tfenol, ktanin, dan bsaponin yang dinyatakan memiliki aktivitasdantibakteri. Kandungan senyawa aktif ini potensial dikembangkan sebagai antibakteri Methicillin-Resistant Staphylococcus aureus (MRSA). Pengembangan antibakteri alternatif dari bahan alam diperlukan untuk penanganan infeksi nosokomial. Penelitian eksperimental ini dilakukan untuk membuktikan adanya aktivitaspantibakterihekstrakjetanol0daun0ubi0jalar0ungu terhadap bakteri penyebab infeksi nosokomial dengan menggunakan bakteri standar MRSA ATCC 3351 secara in vitro. Desainlpenelitian merupakanppostutestponlyecontrolkgroup.jAktivitaspantibakterijekstrak etanol daunfubiljalarrungu diuji dengan metode difusilagar (disc diffusion) terhadap ekstrak etanol yang diperoleh dari proses maserasi daun ubi jalar ungu yang dikeringkan dan daun segar pada berbagai konsentrasi bertingkat. Aktifitas antibakteri dinilai berdasarkan pengukuran luas diameter zona hambat yang dihasilkan setelah perlakuan esktrak terhadap kultur bakteri dalam media agar plate. Hasil penelitian menunjukkan tidak adanya daya hambat pada ekstrak segar namun, pada ekstrak kering terdapat daya hambat terhadap bakteri MRSA ATCC 3351. Diameterlzonaihambat yang terbentuk pada kelompok konsentrasi 20%, 40%, dan 80% secara berurutan adalah 6,9 mm, 10mm, dan 11mm. Untuk mengetahui adanya efek perlakuan, dilakukan analisis terhadap Uji Kruskal-Walis. Uji Mann-Whitney menunjukkanjadanya perbedaankyang bermakna padajsetiap kelompok yang dibandingkan, kecuali pada ekstrak 10%. Pada penelitian ini dapat disimpulkan bahwa ekstrak etanol 96% daun ubi jalar ungu kering (Ipomoea batatas L.) memiliki aktivitas antibakteri terhadap MRSA ATCC 3351. Sedangkan pada ekstrak etanol 96% daun ubi jalar ungu segar (Ipomoea batats L.) tidak memiliki daya hambat terhadap pertumbuhan bakteri MRSA. Kata Kunci: Daun ubi jalar ungu (Ipomoea batatas L.), zona hambat, MRSA
The Effect of Oral Chitosan Supplementation on Leptin Levels and HOMA-IR in Male Wistar Rats (Rattus norvegicus) with an Obesity Model Stefani, Lidwina; Pande Dwipayana, I Made; Alit Widhiartini, Ida Ayu; Made Wihandani, Desak; Bayu Mayura, I Putu
Eduvest - Journal of Universal Studies Vol. 5 No. 7 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i7.51526

Abstract

This study investigates the role of chitosan in modulating leptin and insulin levels, key hormones involved in metabolic disorders, and compares its effectiveness with orlistat, a commonly used anti-obesity drug. An experimental post-test only group design was used involving 20 healthy male Wistar rats aged 3–4 months. After a seven-day acclimation, obesity was induced through a high-fat, high-glucose diet. The rats were then divided into five groups: a positive control group (K+) receiving orlistat, a negative control (K−) receiving a standard diet, and three treatment groups receiving chitosan at 2.5% (P1), 5% (P2), and 7.5% (P3) concentrations, respectively, for 14 days. Leptin and HOMA-IR levels were measured via blood samples collected from the retro-orbital sinus. The Kruskal-Wallis test showed significant differences among groups (p<0.05). Mean leptin levels were highest in K− (5.10±0.35 ng/dL) and lowest in K+ (3.03±0.71 ng/dL), while P2 showed a notable reduction (3.71±0.32 ng/dL). HOMA-IR levels followed a similar trend, with the lowest in K+ (1.00±0.08) and significantly reduced in P2 (1.34±0.11) compared to K− (2.29±0.25). Post Hoc analysis confirmed that P2 had significantly better outcomes than K−, though not as effective as orlistat. In conclusion, chitosan—particularly at 5% concentration—can reduce leptin and HOMA-IR levels, improving insulin resistance in obesity, though orlistat remains more effective.
Layanan Home Pharmacy Care terhadap Peningkatan Kepatuhan Terapi pada Pasien Diabetes dan Hipertensi: Tinjauan Sistematis Etik dan Regulasi Widhiartini, Ida Ayu Alit; Ricardo, I Komang Aan Adi; Pebrianti, Ni Putu Wika; Pratama, Putu Yudha Kartika
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 1 (2025): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i1.97

Abstract

Home pharmacy care is a part of community pharmacy service that is critical in improving                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         patient adherence, which is a significant challenge in managing chronic diseases. One approach that can help overcome this problem is the practice of home pharmacy care. The current study aimed to evaluate the role of home pharmacy care interventions can enhance medication adherence among diabetic and hypertensive patients and to examine the ethical and regulatory aspects associated with its implementation. A systematic review was conducted based on the PRISMA guidelines, using the keywords “home pharmacy care” AND (diabetes mellitus OR hypertension) AND kepatuhan, home pharmacy care AND diabetes mellitus AND (adherence OR compliance), home pharmacy care AND hypertension AND (adherence OR compliance) on Google Scholar and PubMed databases with a search time limit from January 2015 to May 2025. The ethical and regulatory analysis was conducted by reviewing secondary literature regulating home pharmacy care and professional codes of ethics. Out of a total of 290 identified articles, only 10 met the inclusion criteria for further analysis. Based on the ten reviewed articles, it was stated that home pharmacy care interventions can enhance medication adherence among patients with diabetes mellitus and hypertension. However, the implementation of this service faces challenges, such as ethical concerns and regulatory limitations. The development of comprehensive regulations and consistent application of the code of ethics are expected to strengthen legal protection for pharmacists and improve the quality of home pharmacy care services.
Effect of Porang (Amorphophallus muelleri Blume) Flour Diet on Postprandial Blood Sugar Rates and Insulin Resistance in Male Wistar Rats (Rattus norvegicus) Diabetes Mellitus Nathasia; Widhiartini, Ida Ayu Alit; Dwipayana, I Made Pande; Wahyuni, Nila; Maratni, Ni Putu Tesi; Hendrayana, Made Agus
HAYATI Journal of Biosciences Vol. 33 No. 1 (2026): January 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.1.95-102

Abstract

Medical nutrition therapy is essential in diabetes management, especially as diabetes is often linked with aging. Porang tuber flour contains glucomannan, a compound with potential glucose-lowering effects. This study aimed to evaluate the effect of porang flour feeding frequency on 2-hour postprandial blood glucose (2hPPBG) and HOMA-IR in diabetic rats. Using a quasi-experimental pre-test and post-test control group design, 21 male Wistar rats were induced with diabetes via streptozotocin and nicotinamide, then randomly assigned to three groups: G0 (control, given aquadest), G1 (porang flour 300 mg/kg BW daily), and G2 (porang flour 300 mg/kg BW every two days). Five rats died during treatment. Wilcoxon test results showed a difference in 2hPPBG levels between each group before and after treatment. There was no decrease in G0 (p = 0.893), but a decrease in G1 (p = 0.043) and G2 (p = 0.028). The difference between HOMA-IR before and after treatment did not decrease in groups G0 (p = 0.345), G1 (p = 0.138), and G2 (p = 0.249). Post hoc test for 2hPPBG levels between groups showed a significant difference between G0 and G1 (p<0.001), a significant difference between G0 and G2 (p<0.001), and no significant difference between G1 and G2 (p = 0.135). One-way ANOVA test of HOMA-IR showed no significant difference between G0, G1, and G2 (p = 0.148). It was concluded that porang flour can reduce 2hPPBG, but not HOMA-IR. There was no difference in 2hPPBG levels between administering porang flour daily and every other day.