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Journal : MAHESA : Malahayati Health Student Journal

 1 
Pengaruh Pemberian Minuman Sopi Mayang Beralkohol terhadap Jumlah Spermatozoid, Pada Tikus Putih (Rattus norvegicus) Jantan Sanaky, Marliyati; Idris, Irfan; Rafiah, Siti; Arsyad, Aryadi
MAHESA : Malahayati Health Student Journal Vol 4, No 11 (2024): Volume 4 Nomor 11 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i11.15041

Abstract

ABSTRACT The alcoholic Sopi drink comes from palm trees (Arenga pinnata MERR), a type of palm tree spread throughout almost all of Indonesia. The alcohol in the traditional Sopi drink is ethanol (CH3CH2-OH) from fermented sap. This study aimed to examine the effect of Sopi Mayang drink on the increase in cytochrome P450 mRNA expression, increase in CYP2E1 protein levels and decrease in the number of spermatozoids using male white rats. This research is laboratory experimental, using the Randomized Post-test Only Control Group Design. Giving Sopi Mayang with a dose of 2.7 ml decreased the number of spermatozoids, namely 33,815,000, compared to the control group without giving Sopi Mayang, namely 56,680,000 (p = 0.0001). Sopi Mayang, with a dose of 4.05 ml, decreased sperm count from 33,815,000 to 22,334,775 (p= 0.0001). Sopi Mayang, with a dose of 5.4 ml, decreased sperm count from 22,865,000 to 18,250,309 (p=0.0001). There was a decrease in the number of spermatozoids in mice given Sopi Mayang. Keywords: Alcohol, Sopi Mayang, Spermatozoid, white rats ABSTRAK Minuman Sopi beralkohol berasal dari  pohon Enau/Aren (Arenga pinnata MERR) termasuk salah satu jenis tanaman palma, yang tersebar hampir di seluruh wilayah Indonesia. Alkohol yang terkandung dalam minuman tradisional Sopi adalah etanol (CH2CH3-OH) dari fermentasi nira. Penelitian ini ditujukan untuk melihat pengaruh minuman Sopi Mayang terhadap jumlah peningkatan ekspresi mRNA sitokrom P450, peningkatan kadar protein CYP2E1dan penurunan jumlah spermatozoid dengan menggunakan tikus putih jantan. Penelitian ini adalah eksperimental laboratoris, dengan menggunakan rancangan The Randomized Post-test Only Control Group Design. Pemberian Sopi Mayang dengan dosis 2,7 ml terjadi penurunan jumlah spermatozoid yaitu 33.815.000  dibandingkan dengan kelompok kontrol  tanpa pemberian  Sopi Mayang yaitu 56.680.000 (p = 0,0001). Sopi Mayang dengan dosis 4,05 ml terjadi penurunan jumlah sperma dari 33.815.000 menjadi 22.334.775 (p= 0,0001).  Sopi Mayang dengan dosis 5,4 ml terjadi penurunan jumlah sperma dari 22.865.000 menjadi 18.250.309 (p=0,0001). Terjadi penurunan jumlah spermatozoid, pada tikus yang diberikan Sopi Mayang. Kata Kunci: Alkohol, Sopi Mayang, Spermatozoid, Tikus Putih
Co-Authors Abadullah, Meutiah Mutmainnah Abustani, Muthiah Adnan, Endy Allo, Sarjani Linggi Am, Nasrudin Amran, Muhammad Yunus Amru, Khaeriah Andi Kurnia Bintang, Andi Kurnia Arbaim Hasyar , Andi Rizky Arief, Nila Ardilla Arif Santoso Ariyandy, Andi Arsyad, Muhammad Aryadi Asih, Puji BS. Bahar, Ashari Bukhari, Agussalim Dahniarti, Dhany Din Syafruddin Djabir, Yulia Yusrini Djaharuddin, Irawaty Dwi Kesuma Sari Gafur, Rahmi Hadi, Anto J. Halik, Handayani Hammado, Nurussyariah Hasyim, Ammar A. Irawan Yusuf Irma Rahayu, Irma Ismail, Amirah Febrianti Itani, Kei Iyori, Mitsuhiro Jannata, Rahma Winahyu Kasim, Hasim Liong Boy Kurniawan, Liong Boy Mallisa, Hilda Emma Meryana*, A. Kurnia Bintang**, Muh. Akbar**, Susi Aulina**, Yudy Goysal**, Arifin Limoa*** Minarti, Deri Lidya Mulyamin, Winda Nakamura, Kurumi Nindrahayu, Nindrahayu Nurisyah, Sitti Paharu, Kabah Pratiwi, Hamria Prihantono, Prihantono Rafiah, Siti Rambulangi, Samrichard RR. Ella Evrita Hestiandari Sanaky, Marliyati Satriana Satriana Tadjuddin Chalid, Maisuri Tombeg, Zadrak Wardihan Sinrang, Andi Widaningsih, Yuyun Wuysang, Audry Devisanty Yetti R, Erni Yoshida, Shigeto Yustisia, Ika Yusuf Yenni Zainal, Kartika H.