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All Journal HAYATI Journal of Biosciences AL KAUNIYAH Jurnal Biologi Universitas Andalas JURNAL PENGABDIAN KEPADA MASYARAKAT Journal of Tropical Biodiversity and Biotechnology Jurnal Dinamika Pengabdian (JDP) Medical Laboratory Technology Journal Jurnal Biologi Tropis JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Hilirisasi IPTEKS (JHI) Jurnal Pengabdian kepada Masyarakat Nusantara Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Journal of Tropical Pharmacy and Chemistry
Putra Santoso
Universitas Andalas
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Journal : Medical Laboratory Technology Journal

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Catechin Isolates from Gambir (Uncaria gambir Roxb) Maintain Glucose Homeostasis in Diabetic Model Rat Rita, Rauza Sukma; Yetti, Husna; Santoso, Putra; Afriani, Nita
Medical Laboratory Technology Journal Vol. 10 No. 2 (2024): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v10i2.621

Abstract

The prevalence of diabetes mellitus is rising globally. Oxidative stress, which can result from hyperglycemia in diabetes, might have negative consequences. An antioxidant is needed to prevent hyperglycemia. Cathechin isolates are derived from gambir, which has many antioxidants. This study examines catechin isolates from gambir (Uncaria gambir Roxb.) effect on glucose homeostasis in rats induced by alloxan. For this experiment, 35 male rats were employed. Male rats were given alloxan (150 mg/BW, IP), and after 72 hours, blood glucose levels were assessed. If blood glucose levels exceeded 200 mg/dl, three oral catechin isolates were administered (T1=10 mg/kg/day, T2=20 mg/kg/day, and T3=40 mg/kg/day). Following blood collection on the experiment's last day, fasting blood glucose, glucagon and insulin levels were measured. Catechin isolates decreased blood glucose levels in all treatment groups compared to the positive control group (T1 = 150.750 ± 14.359 mg/dl; T2 = 159.750 ± 15.434 mg/dl, and T3 = 153.375 ± 20.207 mg/dl vs 385 ± 60.989 mg/dl) significantly (p value-0.05). A decrease in glucagon serum level was also observed in the treatment group vs positive control (T1: 193.855 ± 36.009 pg/ml, T2 = 286.689 ± 20.313 pg/ml, and T3 = 319.462 ± 30.060 pg/ml vs  529.825 ± 74.279 pg/ml), significantly. Catechine isolates in the T3 group showed an increase in insulin serum level compared to the positive control group significantly (T3 = 216.640 ± 38.230 µIU/ml vs 69.833 ± 3.071 µIU/ml). In conclusion, catechin isolates from gambir decreased blood glucose levels by reducing glucagon and increasing insulin serum levels.
Co-Authors . Mansyurdin Adelia, sabbrina Adilla, Ardis Trianita Afriani, Nita Afriani, Yona Aini, Wardahtul Aini, Wardatul Alimuddin Tofrizal Asful, Ferdhinal Ashrifurrahman, Ashrifurrahman Asih, Enda Tarni Aszareta, Muhammad Andoni Aziz, M. Abdul Belahusna, Dinda Fadhilah Bramadi Arya Dahelmi Dahelmi Delfi, Shyla Aulia Dinda Fadhilah Belahusna Efendi, Rilwan Efrizal Efrizal Eli Ratni Elni Fatimah Elni Fatimah Eti Yerizel Fadhilah, Diana Fadil, Muhammad Syukri Fadilaturahmah Fadilaturahmah Fadillah Fadillah Fadillah Fajri Hidayat Feskaharni Alamsjah Firman Syukri Hamdi Ibrahim, Muhammad Hari Marta Saputra Hasmiandy Hamid Henny Herwina Hermeria, Noveriza Husna Yetti Idris, Muhamma Ilham Samudra, Muhammad Jabang Nurdin Janra, Muhammad Nazri Jasmi Jasmi Jasmi Jefrial Santoso Maliza, Rita Marchellino Irwan, Reziq Maya Sari Miftahul Ilmi Muhammad Afif Muhammad Idris Muhammad Idris Muhammad Idris Muhammad Nazri Janra Nabilah Rahmachila Azura Nadira Nurul Fathiyah Nadjmir, Mikail Nazri Janra, Muhammad Netti Marusin Netti Marusin Nofrita Nofrita Nofrita Nofrita Nurhafitri, Amanda Pasha, Gusti Ari Afrilya Petrovsky, Ivan Pratama Elisa, Tasya Putri Pratama, Raihan Anugrah Puspita, Ayumi Rizci Puti Khairunnajwa Amar Putri Pratama Elisa, Tasya Putri, Mellanie Alia Putri, Suci Indah Putri, Syntia Mai r maliza, rita Rarastoeti Pratiwi Rauza Sukma Rita Resti Rahayu Resti Rahayu Ridho, Muhammad Syifa'ur Rilwan Efendi Robby Jannatan Rusiati, Anisa Rahman Sayati Mandia Siagian, Marhamah Sinurat, Arthauly Yopita Syabila, Hutri Dinda Syaifullah Syaifullah Syakira Tiara Rezvi Syamsuardi Syamsuardi Tofrizal Tofrizal, Alimuddin Wellyalina, Wellyalina Wilson Novarino Yona Afriani Yulmira Yanti Zaini Zaini Zikrah, Azizah Amatu Zozy Aneloi Noli Zulkarnain, Alivia