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All Journal International Journal of Public Health Science (IJPHS) Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Medula JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Surya Masyarakat PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) DIKEMAS (Jurnal Pengabdian Kepada Masyarakat) Jurnal farmasi UIN Alauddin Makassar Jurnal Surya Masyarakat Borneo Journal Of Pharmascientech Jurnal Kesehatan Pharmaceutical Sciences and Research (PSR) Journal of Food and Pharmaceutical Sciences Borneo Journal of Pharmacy Clinical and Pharmaceutical Sciences Journal

Azis Ikhsanudin

Fakultas Farmasi, Universitas Ahmad Dahlan Yogyakarta

Author-ID : 285619

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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FORMULASI DAN KARAKTERISASI SEDIAAN HIDROGEL MINYAK CENGKEH (Syzygium aromaticum) BERBASIS KITOSAN Pertiwi, Deasy Vanda; Ikhsanudin, Azis; Sugihartini, Nining
Media Farmasi: Jurnal Ilmu Farmasi Vol 14, No 1: Maret 2017
Publisher : Universitas Ahmad Dahlan

Eugenol merupakan kandungan utama minyak cengkeh yang memiliki potensi sebagai anti inflamasi. Bentuk sediaan yang berupa cairan berminyak menimbulkan ketidaknyamanan dan tidak bertahan lama untuk kontak dengan kulit sehingga efikasi yang diharapkan tidak tercapai jika digunakan langsung pada permukaan kulit. Oleh karena itu, dibutuhkan sistem sediaan yang dapat menghantarkan obat menembus kulit dengan lebih baik. Hidrogel adalah sediaan semipadat yang diharapkan dapat diaplikasikan sebagai pembawa minyak cengkeh, sehingga akan meningkatkan kenyamanan dan efikasinya. Pembuatan hidrogel minyak cengkeh dilakukan dengan memformulasikan minyak cengkeh, surfaktan tween 80 dan propilen glikol (PG) menjadi emulsi. Desain formula dibuat menggunakan Design Expert 10 trial. Formula emulsi yang optimum selanjutnya diformulasikan dengan basis gel kitosan konsentrasi 4% dan 5%. Hidrogel minyak cengkeh diformulasikan menjadi emulsi yang selanjutnya ditambahkan ke dalam basis gel berupa kitosan. Dari hasil uji karakterisasi gel diperoleh bentuk emulgel berwarna putih kekuningan dengan pH 6. Uji daya sebar menunjukkan formula 1 dengan basis kitosan 5% memiliki daya sebar yang paling baik, yaitu 5,1 cm. Hasil uji daya lekat menunjukkan bahwa keempat formula memenuhi syarat uji daya lekat, yaitu tidak kurang dari 4 detik. Dari uji karakteristik, formula F1 5% merupakan formula yang optimal karena memenuhi semua persyaratan sifat fisik. Hal tersebut menunjukkan bahwa minyak cengkeh dapat menghasilkan sediaan gel yang baik dengan basis kitosan.

PENGEMBANGAN PRODUK MAKANAN BERBAHAN TALAS GUNA MENINGKATKAN KETRAMPILAN BERBASIS EKONOMI MANDIRI PADA ANGGOTA BINA KELUARGA LANSIA DI DESA SENDANGSARI, KAB.SLEMAN, DAERAH ISTIMEWA YOGYAKARTA Matahari, Ratu; Utami, Fitriana Putri; Ikhsanudin, Azis
DIKEMAS (Jurnal Pengabdian Kepada Masyarakat) Vol 2, No 1 (2018)
Publisher : Politeknik Negeri Madiun

Sendangsari merupakan sebuah desa yang terletak di Kecamatan Minggir, Kabupaten Sleman Yogyakarta. Potensi alam yang dimiliki oleh Desa Sendangsari yaitu berupa tanaman tanaman lompong (Colocasia esculenta L. Schoot) atau biasa disebut Talas yang hingga saat ini daun tanaman tersebut masih dimanfaatkan sebagai bahan pakan ternak dan umbi diolah dengan teknik rebus ataupun goreng padahal tanaman tersebut bernilai gizi dan bisa diolah menjadi pangan sehat untuk lansia. Tujuan kegiatan pengabdian kepada masyarakat ini adalah untuk memberikan edukasi terkait pengembangan pengolahan bahan pangan lokal, meningkatkan nilai ekonomis tanaman Lompong (Talas) dan ketrampilan anggota Bina Keluarga Lansia (BKL) melalui pelatihan pengolahan produk makanan berbahan Talas yaitu brownies talas kukus, semprong talas, dan cookis talas. Produk olahan yang telah dihasilkan kemudian diproduksi dalam skala industry rumah tangga untuk meningkatkan kemandirian perekonomian lansia.

Knowledge, precautionary actions, and perceived risk of COVID-19 among Indonesian people Ratih Oktri Nanda; Lolita Lolita; Wiwik Indayati; Ivong Rusdiyanti; Azis Ikhsanudin; Silvia Mareti
International Journal of Public Health Science (IJPHS) Vol 10, No 1: March 2021
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v10i1.20589

Novel coronavirus was first identified in China in December 2019, causing several cases of the new type of pneumonia. The exported cases were found in other countries, including countries in the Southeast Asia region. At the same time, no cases were confirmed in Indonesia. We aimed to assess COVID-19 related knowledge, precautionary actions, and perceived risk among general Indonesian population when there were no confirmed cases in Indonesia. This study was a descriptive cross-sectional study involving 382 participants aged 17 years and above residing in Indonesia. The data was collected through the online questionnaire from February 19th to February 29th 2020. The average score of COVID-19 related knowledge was 88.0%, whereas 83.8% of the participants had a high level of knowledge. The average score of taking precautionary actions was 77.4% and 65.7% had a high level of performance. In terms of the perceived risk of COVID-19, only 11.3% of the participants perceived themselves likely to acquire COVID-19 when compared with other diseases or accidents. The perceived risk of COVID-19 was significantly associated with precautionary action (p<0.05). Perceived risk of COVID-19 was at a low level when there were no confirmed cases. Effective strategies of risk communication are needed to improve precautionary actions to prevent COVID-19.

Knowledge and quality of life among Indonesian students during the COVID-19 pandemic Prasojo Pribadi; Lolita Lolita; Rayi Citra Ayu Pangestuti; Heni Lutfiyati; Silvia Mareti; Azis Ikhsanudin
International Journal of Public Health Science (IJPHS) Vol 10, No 2: June 2021
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v10i2.20819

The increasing of online coronavirus disease-2019 (COVID-19) information-sharing in digital media can contribute to the emergence of misinformation in public. Much insufficient knowledge will confuse public understanding and affect their quality of life. The study purposed to assess the knowledge and its influence on Indonesian students' quality of life during the COVID-19 crisis. A cross-sectional study was conducted between October and December 2020 by distributing online questionnaires. The data analysis was run through the Spearman correlation method by using SPSS version 21.0. A total of 200 respondents aged over 17 years were recruited using a snowball sampling technique. Most study respondents had insufficient knowledge about COVID-19, 23% of them had moderate knowledge, and only 17.5% had high knowledge. They obtained primary sources of COVID-19 information from social media platforms. The results showed that health science students have a better understanding than social science students (ρ<0.001). The level of knowledge has a significant associated with psychological domain (ρ=0.020), environmental domain (ρ=0.046), and overall quality of life (ρ=0.047). Thus, the media control center is vital to encounter valid information in providing better knowledge and quality of life during a pandemic.

Larvicidal activity of granulated pharmaceutical products using Indonesian holy basil leaf extract Azis Ikhsanudin; Lolita Lolita; Zayyana Septya Ramadani
International Journal of Public Health Science (IJPHS) Vol 10, No 4: December 2021
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v10i4.21004

Ocimum sanctum Linn, known as holy basil, is a larvicide, which is relatively safe compared to synthetic insecticides. This study investigates the larvicidal activity of a granule formulation of Indonesian holy basil leaf extract against third larval instar of Aedes aegypti. The extract of holy basil leaves was obtained by a maceration process with 96% ethanol. The granule was formulated with various concentrations of holy basil leaf extract, including F1 (2000 ppm), F2 (4000 ppm), and F3 (6000 ppm). The extract contained terpenoid, alkaloid, saponin, flavonoid, and polyphenol compounds. The extract granules had a moisture content of 3.01%, flowability of 1.51 seconds, and dispersion time of 1.09 seconds. The mortality rates of mosquitos treated with the different formulation groups were significantly different from positive control with values of 25.33% (F1), 50.67% (F2), and 90.67% (F3). In conclusion, the granulated formulation of holy basil leaf extract has a larvicidal LC50 of 4405.803 ppm and LC90 of 6080.714 ppm. Therefore, a granulated pharmaceutical product derived from holy basil leaf extract could be developed as a potent larvicide to control dengue fever.

Anti-inflammatory activity of Indonesian nutmeg seeds (Myristica fragrans Houtt): A topical gel formulation Azis Ikhsanudin; Lolita Lolita; Daniar Dyanas Rais
International Journal of Public Health Science (IJPHS) Vol 10, No 3: September 2021
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v10i3.20921

Herbal medicines have been shown as anti-inflammatory with potentially lesser side effects. The active compound of nutmeg seed is proven to accelerate the healing process of inflammation. This study aimed to evaluate the gel formulation of Indonesian nutmeg (Myristica fragrans Houtt) seed extract for anti-inflammatory activity. A true experimental post test only with control group design was used in this study. The gel was formulated with various concentrations of nutmeg seed extract, namely formulations F1 (0%), F2 (2%), F3 (4%), F4 (8 %), and F5 (12%). Analysis of variance (ANOVA) followed by the least significant difference (LSD) methods were performed with SPSS version 22. The results showed that all formulas had an opaque physical appearance, brownish-yellow color, soft texture, and aromatic odor. The increase of extract concentration in gel formula will affect the adhesion and spreadability. F5 showed the highest anti-inflammatory activity compared to other groups. This formula was generally identified as having a good physical appearance, homogeneity, and stability with a pH value of 6.16±0.24, adhesiveness of 51.12±0.15 sec, and a spreadability of 19.54±0.12 cm2. Therefore, Indonesian nutmeg has the potential to be well-acceptable as a candidate for topical anti-inflammatory agents in global health benefits.

COVID-19 risk perception among Indonesians in early stage of the outbreak Ratih Oktri Nanda; Lolita Lolita; Wiwik Indayati; Ivong Rusdiyanti; Nurjannah Nurjannah; Azis Ikhsanudin; Silvia Mareti
International Journal of Public Health Science (IJPHS) Vol 10, No 2: June 2021
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v10i2.20678

Indonesia confirmed its first coronavirus disease 19 (COVID-19) case on 2nd March 2020, when other countries have already reported several numbers in the previous month. This study aimed to explore the risk perception of Indonesians in the early stage of the COVID-19 outbreak. This cross-sectional study was conducted among 495 participants using a web-based questionnaire. Primary data were collected from 3rd to 27th March 2020 including the perceived severity, vulnerability, threat, self, and response efficacy of the participants. The results showed that the perceived threat of the outbreak in its early stage is the second highest compared to other diseases. The perceived severity among the participants was high. However, they had a low vulnerability. Those in the middle region showed a higher level of self and response efficacy. Meanwhile, people who work as private sector employee (β=0.146, p=0.004), live in the western region (β=-0.184, p=0.000), with a higher knowledge score (β=0.096, p=0.032) had a higher perceived threat. These results found those who had high knowledge, was also had higher perceived risk. The most important of these studies have determined various factors related to risk perception, thus it could be good preliminary evidence for public health authorities to arrange an effective way for epidemic control.

COVID-19 risk perceptions among healthcare workers during early “new behavior norms” phase Lolita Lolita; Azis Ikhsanudin
International Journal of Public Health Science (IJPHS) Vol 11, No 1: March 2022
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v11i1.21252

The coronavirus disease 2019 (COVID-19) pandemic poses a serious health threat among Indonesian healthcare workers. As front-line workers, they were facing higher risk due to the prolonged exposure of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to explore various factors affecting perceived risk among healthcare professionals. A cross-sectional study was conducted among health practitioners who met the inclusion criteria of being over the age of 17 years and resided in Indonesia. This study was conducted during the early "new normal behavior" period from April to July 2020. The sampling technique was convenience sampling which involved collecting data through the online questionnaire. The data were analyzed through the Spearman correlation method using SPSS version 22.0. A total of 248 respondents were included in the final analysis. Overall, age (p=0.017) and health status (p=0.001) significantly affected the COVID-19 risk perception among healthcare workers. Therefore, comprehensive COVID-19 risk communication should be established to optimize health behavior and crisis control management among healthcare workers.

Formulasi dan Uji Antijerawat Gel Ekstrak Etanol 70% Buah Belimbing Wuluh (Averrhoa Bilimbi Linn.) terhadap Bakteri Propionibacterium acnes Azis Ikhsanudin; Siti Mardhiyah
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 5, No 1 (2017)
Publisher : Halu Oleo University

ABSTRACT Belimbing wuluh fruit known have flavonoids that has a function as natural anti bacterial for acne treatmeant. To easer in using it, so it formulated in the form of gel. The aims of research was to know the influence of variation concentration ethanol extract 70% belimbing wuluh fruit to physical characteristic of gel and antibacterial activity of Propionibacterium acnes which a bacteria causes acne. Belimbing wuluh fruit extract was obtained by maceration. Extract formulated in the form of gel with variation concentration 4,17%w/v, 8,33% w/v, 12,5%w/v, 16,67%w/v, and 20,83%w/v. Antibacterial activity test was conducted by cup plate technique difusion methode and physical characteristic test covered organoleptic test, spreadibility test, and adhesivity test. The result of antibacterial test and physical characteristic test were analyzed statistically using Kruskall Wallis test and Mann Whitney test with 95% level confidence. The result of research showed that with an increasing concentration of extract could affect physical characteristic of gel and will increase antibacterial activity. The higher concentration extract, the color of gel obtained more concentrated, pH of gel be acid, decreasing adhesive power, spread power obtained smaller and inhibition diameter obtained bigger. The result of research obtained that formula 2 was a good formula with pH value 5, average adhesive power was 4,63 seconds ± 0,57, average spread power was 11,34 cm2 ± 0,44 and average diameter obstruent was 5 mm ±1,41. Based on the research could be concluded that gel extract ethanol 70% belimbing wuluh (Averrhoa bilimbi Linn) fruit had antibacteria activity against Propionibacterium acnes. Minimal concentration which could inhibit growth that bacteria found at concentration 5% and formula which had a good physical characteristic at formula 2.Keywords : Gel, Etanolic extract 70%; Averrhoa Bilimbi Linn, Propionibacterium acnes.

Protection Effect of Self-Nanoemulsifying Drug Delivery System (SNEDDS) Piroxicam as Ulcerogenic Agent towards Malondialdehid Level and Protein Expression of Caspase-3, COX-1, COX-2 at Rat Gastric Iis Wahyuningsih; Kurnia Ambarwati; Erninda Ayu Hapsari; Afifah Fauziyyah; Azis Ikhsanudin; Deasy Vanda Pertiwi; Wahyu Widyaningsih
Journal of Food and Pharmaceutical Sciences Vol 8, No 2 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.732

The aim of this study was to determine the protection effect of SNEDDS piroxicam ulcerogenic agent against malondialdehyde (MDA) level and protein expression of caspase-3, COX-1, COX-2. The research was conducted using the test animals as much as 30 male white Sprague dawley (SD) rats aged 1-2 months with a weight of 100-200 grams divided into 5 groups. Treatment was given for 28 days orally. On the 29th day blood samples were also taken for the determination of MDA (Malondialdehid) levels by Thiobarbituric Acid Reactive Substance (TBARs) method using a visible spectrophotometer. Rats were sacrificed, then gastric organs were taken for immunohistochemical testing of caspase-3 and COX-1 expression, COX-2. The statistical analysis showed that the piroxicam SNEDDS group and the piroxicam suspension group decreased expression of the caspase-3 protein, increased COX-1 expression, decreased COX-2 and significantly decreased MDA levels. The piroxicam-containing SNEDDS (Self-Nanoemulsifying Drug Delivery System) form has protection against ulcogenic piroxicam.

Co-Authors . Lolita Ambar Yunita Nugraheni Danang Yulianto Daniar Dyanas Rais Deasy Vanda Pertiwi Dewi Noor Azizah Dewi Noor Azizah Dhadhang Wahyu Kurniawan Endah Nurlaela Endah Nurlaela Erninda Ayu Hapsari Fasyir, Syaima' Rihan Fasyir, Syaima’ Rihan fatima, fatma fatma fatima Fatma Nuraisyah, Fatma Fauziyyah, Afifah Firdaus, Rizqi Amalia Fitriana Putri Utami Gunanti, Faril Hanisari, Putri Hendra Darmawan Heni Lutfiyati Iis Wahyuningsih Ivong Rusdiyanti Khoirot, Asiilah Fatihatul Kurnia Ambarwati Kurniawati, Lindha Kusrinanti, Nabillah Ainun Larasati, Febrilla Ayu Ligawa, Yuniar Nabilla Lina Widiyastuti Lolita Lolita Lolita Lovita Ningsih Luthfiah Saraswati, Hasna Makwa, Nidaul Muhammad Muhlis Nabila, Nabila Nining Sugihartini Niswara, Anggita Kamalia Noorlina Noorlina Noorlina, Noorlina Noorlina, Noorlina NORMA HAYATI Norma Hayati, Norma Novita, Sisri Novitasari, Putri Rachma Nurjannah Nurjannah Nurlaela, Endah Pertiwi, Deasy Vanda Prasojo Pribadi Puspitasari, Kartini Raharjo, Satriyo Dwi Ramdhani, Merry Ratih Oktri Nanda Ratu Matahari Ratu Matahari Rayi Citra Ayu Pangestuti Rungprai, Daraporn Silvia Mareti Siti Fatmawati Fatimah, Siti Fatmawati Siti Mardhiyah Sudarmanto, B.S. Ari Sukmaningtyas, Rachmawati Sulaiman, Teuku Nanda Saifullah Syarifah, Nur Bidayah Tajjudin, Saiful Nizam Tri Hastuti, Haadiyatul Triandika, Rifaldy Utami, Fitriana Putri Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Widiyastuti, Lina Wiwik Indayati Woro Supadmi zai, Khadijah Zayyana Septya Ramadani

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