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All Journal HAYATI Journal of Biosciences International Journal of Biosciences and Biotechnology METAMORFOSA Journal of Biological Sciences Buletin Udayana Mengabdi Jurnal Biologi Udayana Bumi Lestari Saintek Perikanan : Indonesian Journal of Fisheries Science and Technology JURNAL HUBUNGAN INTERNASIONAL Buletin Anatomi dan Fisiologi (Bulletin of Anatomy and Physiology) Bawal : Widya Riset Perikanan Tangkap Folia Medica Indonesiana SIMBIOSIS Jurnal Biologi Udayana
Ngurah Intan Wiratmini
Program Studi Biologi Fakultas MIPA Universitas Udayana, Bali
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Neuroscience Public Health

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Estrous cycle and uterine weight of ovariectomized menopause female rat models after treatment with Leucaena leucocephala (Lam.) de Wit leaf extract Wiratmini, Ngurah Intan; Sukmaningsih, Anak Agung Sagung Alit; Setyawati, Iriani
Folia Medica Indonesiana Vol. 60, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. This study found that Leucaena leucocephala leaf ethanol extract has the ability to stimulate the growth of vaginal epithelial cells in ovariectomised rats. 2. Leucaena leucocephala leaf extract can be developed as a safe and cost-effective natural alternative for hormone replacement therapy in premenopausal women and livestock. Highlights: 1. This study found that Leucaena leucocephala leaf ethanol extract has the ability to stimulate the growth of vaginal epithelial cells in ovariectomised rats. 2. Leucaena leucocephala leaf extract can be developed as a safe and cost-effective natural alternative for hormone replacement therapy in premenopausal women and livestock. Abstract Hormone replacement therapy has adverse effects that may cause additional health problems, such as hot flashes, cancer, ischemic stroke, and death. Phytoestrogen is an alternative ingredient used for hormone replacement therapy with less risk. The Leucaena leucocephala (Lam.) de Wit plant is widely used as a medicinal ingredient and animal feed. This study aimed to determine the effect of Leucaena leucocephala leaf extract on the uterine weight and estrous cycle of ovariectomized rats. This research used a completely randomized control design, which included two treatment groups (P1 and P2) and two control groups (negative (K-) and positive (K+)) with six replications in each group (n=24). The negative control (K-) was given 2 mL of corn oil, while K+ received 0.1 mg/kg bw of 17β-estradiol. P1 and P2 were administered 250 and 300 mg/kg bw of Leucaena leucocephala leaf extract, respectively. The extract was administered daily by gavage for 30 days. Estrous cycle data were obtained on day 31 by previously collecting vaginal swabs twice a day for 15 days. After the rats were sacrificed under anesthesia using chloroform, they underwent surgery to remove the uterine organs for weight measurement. The data were analyzed for normality and homogeneity using the Shapiro-Wilk and Levene tests. The data distribution were not normal, so the Kruskal Wallis test was used to test the hypothesis. If there was a difference between controls and treatments, the analysis continued with the Mann-Whitney test (p<0.05). The controls and treatments exhibited a significant difference in the length of each phase and overall estrous cycle. The post hoc Duncan test revealed that the highest uterine weight was found in 17β-estradiol treated rat. It was significantly different with both extracts treated rats. Both extract effect on uterine weight were not significantly difference. In conclusion, administering Leucaena leucocephala leaf extract results in an increased uterine weight and a normal estrous cycle in ovariectomized rats.
Eksplorasi metode kultur tiga-dimensi sel punca mesenkim: suatu kajian pustaka Widia Meliawati; Ngurah Intan Wiratmini; Elrade Rofaani
Jurnal Biologi Udayana Vol. 29 No. 1 (2025): JURNAL BIOLOGI UDAYANA
Publisher : Program Studi Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JBIOUNUD.2025.v29.i01.p02

Abstract

Kultur tiga dimensi sel punca mesenkim mempunyai lingkungan physicochemical yang relevan secara in vivo. Metode ini mampu mengatasi keterbatasan pada kultur sel 2D dalam meniru morfologi dan fisiologi sel. Penelitian kajian pustaka ini mengeksplorasi berbagai metode kultur 3D, seperti scaffolds berbasis biomaterial, scaffolds berbasis polimer sintetis, metode tanpa berbasis scaffolds, dan kultur berbasis hidrogel yang dianalisa untuk mengevaluasi keunggulan, kekurangan, dan potensinya. Hasil kajian menunjukkan bahwa berbagai macam kultur tiga dimensi menghasilkan spheroid dengan potensi yang berbeda, namun mampu mendukung interaksi antar sel dan interaksi sel-matriks ekstraseluler, meningkatkan viabilitas, dan derivat metabolik sel punca mesenkim untuk digunakan dalam metode pengobatan terkini. Kultur tiga dimensi juga memberikan lingkungan yang stabil untuk pemeliharaan sel karena distribusi oksigen dan nutrisi yang tersebar secara merata sehingga tidak menyebabkan manfaat dari sel punca mesenkim hilang. Dapat disimpulkan bahwa metode kultur tiga dimensi pada sel punca mesenkim mampu mengatasi keterbatasan pada kultur secara dua dimensi karena memiliki lingkungan fisiologis yang mirip jaringan asli. Teknik kultur tiga dimensi dapat meningkatkan interaksi antar sel dan sel dengan matriks ekstraseluler untuk meningkatkan viabilitas, proliferasi, diferensiasi, dan derivat metabolik pada sel punca mesenkim.
KARAKTERISASI DAN ANALISIS POLA PERTUMBUHAN IKAN KEMBUNG (Rastrelliger sp.) YANG DIDARATKAN DI TEMPAT PELELANGAN IKAN KEDONGANAN, BALI: CHARACTERIZATION AND GROWTH PATTERN ANALYSIS OF IKAN KEMBUNG (Rastrelliger sp.) LANDED AT KEDONGANAN FISH AUCTION SITE, BALI Revael Sihombing; Ni Made Suartini; Ngurah Intan Wiratmini
SIMBIOSIS Simbiosis Volume 13 No. 2 2025
Publisher : Program Studi Biologi Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JSIMBIOSIS.2025.v13.i02.p04

Abstract

ABSTRACT One of Bali's largest fish potential areas is Kedonganan, a coastal region where the majority of residents are fishermen. Kedonganan waters represent a highly promising fish landing site due to its direct proximity to the Indian Ocean. Based on preliminary surveys and interviews with local fishermen, the dominant small pelagic fish species frequently landed in large quantities at the Kedonganan Fish Auction (TPI) are mackerel fish (Rastrelliger sp.). This study aims to investigate the morphology, morphometrics, and growth patterns of these species landed at TPI Kedonganan. This research employed survey and interview methods. The variables examined include fish morphology, fish morphometrics consisting of 15 characters, and the growth patterns of mackerel fish (Rastrelliger sp.). The findings reveal that mackerel fish (Rastrelliger sp.) exhibit a fusiform body shape, terminal mouth, forked caudal fin, and cycloid scales. Morphometric measurements showed an average total length of 217.8 cm. The growth pattern of mackerel fish includes negative allometric (b<3).
Co-Authors A.A.S. A. Sukmaningsih AA Istri Mas Padmiswari Anak Agung Gde Raka Dalem Apriliani, Sinta Arnenda, Gussasta Levi Bram Setyadji Dessy Sukma Wirastuti Elfira Dzikri Ashfahani Elrade Rofaani G.A.A Rina Febrina Gussasta Levi Arnenda I Gede Wiranatha I GUSTI AYU MANIK ERMAYANTI I Made Sara Wijana I Made Sara Wijana I Putu Ari Wijana Dipa I Wayan Andi Yoga Kurniawan I Wayan Kasa I.M.A.S. Wijaya Ida Ayu Nopiari Ida Ayu Ratih Purnama Dewi Inna Narayani Iriani Setyawati IRIANI SETYAWATI Jaqueline Sudiman Job Nico Subagio Joko Raharjo, Sentot Joko Wiryatno Luh Putu Wrasiati MADE PHARMAWATI Maria Antonia Margaretha Ferandez Maria Antonia Margaretha Fernandez Mery Wintari Muyasaroh, Chanif Lutfiyati Ni Desak Made Aprilia Dewi Ni Komang Tia Pramesti Ni Luh Eka Setiasih Ni Luh Suriani Ni Made Rai Suarni Ni Made Suartini Ni Putu Adriani Astiti Ni Putu Ayu Dewi Wijayanti Ni Putu Sri Risa Dewi Ni Wayan Adya Puttry Purna Yogini Ni Wayan Sudatri Putu Titah Kawitri Resen Revael Sihombing Salsabillah Rahma SANG KETUT SUDIRGA shanon lestari Sistra, Kanigara Anupama Siti Masnunah Sri Sulastri Sukma Sushanti Sukmaningsih, A. A.S.A. Wahyu Puji Lestari WAHYU WIDOWATI Widia Meliawati